The Therapeutic Potential of LRRK2 and α-Synuclein in Parkinson's Disease

Ubiquitination of α-synuclein and autophagy in Parkinson's disease

(2014) Simone Engelender   Autophagy

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

(2008) Dennis W. Dickson et al.   ACTA NEUROPATHOLOGICA

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Alpha- and Gamma-Synuclein Proteins Are Present in Cerebrospinal Fluid and Are Increased in Aged Subjects with Neurodegenerative and Vascular Changes

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein

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A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

(2008) Tomoki Kuwahara et al.   HUMAN MOLECULAR GENETICS

Intramolecular Activation Mechanism of theDictyosteliumLRRK2 Homolog Roco Protein GbpC

(2008) Wouter N. van Egmond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Optimized Method for Histological Detection of Dopaminergic Neurons in Drosophila melanogaster

(2008) Daria Drobysheva et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Ancient Origin of the Parkinson Disease Gene LRRK2

(2008) Ignacio Marín   JOURNAL OF MOLECULAR EVOLUTION

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

LRRK2 Gly2019Ser penetrance in Arab–Berber patients from Tunisia: a case-control genetic study

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Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

(2008) Danling Wang et al.   Molecular Neurodegeneration

The Role of Alpha-Synuclein in Neurodegenerative Diseases: A Potential Target for New Treatment Strategies?

(2008) M. Windisch et al.   Neurodegenerative Diseases

Parkinson disease and risk of mortality: A prospective comorbidity-matched cohort study

(2008) J. A. Driver et al.   NEUROLOGY

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease

(2008) M. Westerlund et al.   NEUROSCIENCE

Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra

(2008) Baek-Soo Han et al.   NEUROSCIENCE LETTERS

Deep brain stimulation for Parkinson’s disease

(2008) Patricia Limousin et al.   Neurotherapeutics

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One

GATA transcription factors directly regulate the Parkinson's disease-linked gene  -synuclein

(2008) C. R. Scherzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Drosophila model for LRRK2-linked parkinsonism

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat

(2008) W.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

(2008) H. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA interference mediated silencing of α-synuclein in MN9D cells and its effects on cell viability

(2008) Dong-Mei Liu et al.   Neuroscience Bulletin

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics

Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease

(2007) Josephine A. Wright et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Management of non-motor symptoms in advanced Parkinson disease

(2007) Daniel D. Truong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for α-synuclein fibrils in vitro

(2007) Mie Hirohata et al.   NEUROPHARMACOLOGY

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING