Review
Chemistry, Multidisciplinary
Joshua C. Nwabuife, Calvin A. Omolo, Thirumala Govender
Summary: This review provides an overview of the resistance mechanisms, causes, and approaches to overcome resistance to CIP. It critically evaluates various nano delivery systems for the delivery of CIP against infections caused by E. coli, P. aeruginosa, S. aureus, and MRSA. Future research directions for optimizing nano delivery systems are also highlighted.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Microbiology
Sushmita Sridhar, Sally Forrest, Derek Pickard, Claire Cormie, Emily A. Lees, Nicholas R. Thomson, Gordon Dougan, Stephen Baker
Summary: Antimicrobial resistance is a critical global health crisis, with rising resistance to fluoroquinolones such as ciprofloxacin. Research has shown that clinical isolates of Salmonella enterica serovar Typhimurium adapt to high concentrations of ciprofloxacin in a way that promotes intracellular survival, with different isolates responding heterogeneously to the drug.
Article
Chemistry, Applied
Dhuha Al-Wahaib, Ali El-Dissouky, Nada M. Abrar, Tarek E. Khalil
Summary: A series of ruthenium (II) complexes derived from the reaction between cis-bis (2,2 '-bipyridine) dichloro ruthenium (II) dihydrate and enaminone derivatives of ciprofloxacin were synthesized and characterized. The complexes exhibited higher antibacterial activities compared to the parent ciprofloxacin antibiotic, and the enaminone derivatives were identified as pi-acceptor ligands.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Su-Su Meng, Yue-Ming Yu, Fan-Zhi Bu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li
Summary: A cocrystallization tactic was used to optimize the physical and chemical properties of an antibacterial drug and improve its pharmacokinetic characteristics, while enhancing its antibacterial efficacy through the formation of a salt cocrystal with a phenolic acid nutrient.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Ran Tao, Yin Lu, Wubing Xia, Changwei Zhang, Chengzhang Wang
Summary: This study successfully prepared a ruthenium coordination polymer composite with chitosan quaternary ammonium polymers and shikimic acid. The composite showed good antibacterial properties, with a strong inhibitory effect against S. aureus and the ability to disrupt their biofilm formation. Further mechanism studies revealed that the composite influenced the cell membrane integrity and intracellular Ca2+ levels of S. aureus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Cephas Amoah, Collins Obuah, Michael Kojo Ainooson, Christian Kwaku Adokoh, Alfred Muller
Summary: A series of pyrazolyl sulfonamide compounds were successfully synthesized through a multi-step method, forming complexes with palladium(ii). These compounds showed strong antibacterial activity in screening tests, indicating potential medicinal value.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Omar Awad Alsaidan, Ameeduzzafar Zafar, Mohd Yasir, Sami Alzarea, Mohammed Alqinyah, Mohammad Khalid
Summary: This study aimed to develop an in-situ gel system loaded with ciprofloxacin (CIP) to improve therapeutic efficacy. The optimized CIP-BLO formulation was successfully incorporated into an in-situ gel system. The results showed that CIP-BLO-opt-IG3 significantly improved the therapeutic activity of CIP, increased corneal residence time, and exhibited higher antimicrobial activity.
Article
Biochemistry & Molecular Biology
Kouadio Ibrahime Sinan, Abdurrahman Aktumsek, Maria De La Luz Cadiz-Gurrea, Francisco Javier Leyva-Jimenez, Alvaro Fernandez-Ochoa, Antonio Segura-Carretero, Jasmina Glamocilja, Marina Sokovic, Marija Nenadic, Gokhan Zengin
Summary: The study revealed the chemical composition, antioxidant, enzyme inhibitory, and antimicrobial activities of solvent extracts from different parts of Uapaca togoensis. Results showed that the extracts exhibited varying levels of bioactivities, depending on extraction solvents and plant parts, indicating the potential therapeutic value of U. togoensis as a natural source of bioactive compounds, with bioinformatics analysis suggesting modulation of cancer-related pathways.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Pharmacology & Pharmacy
Meng-Meng Wang, Gang Hao, Yu-Chen Qu, Li Chen, Wen-Yan Hua, Shun-Lin Zong, Meng Wang, Cun-Jin Su, Quan-Ying Zhang, Zi-Yan Du, Yun-Li Yu
Summary: This study investigated the impact of fluoroquinolones on bile acid metabolism and gut microbiota. The results showed that different fluoroquinolones have distinct effects on bile acid profiles and intestinal bacteria, providing guidance for the selection of appropriate fluoroquinolones to treat infectious diseases.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Microbiology
Vanessa Duncan, Daniel Smith, Laura Simpson, Emma Lovie, Laura Katvars, Leon Berge, Jennifer Robertson, Shane Smith, Carol Munro, Derry Mercer, Deborah O'Neil
Summary: Fungi cause disease in nearly one billion individuals worldwide, and current antifungal agents face challenges such as emerging and drug-resistant fungi, toxicity, and drug-drug interactions. The development of NP339, a polyarginine peptide with potent antifungal activity against various pathogenic fungi, presents a promising solution to these challenges. NP339 targets fungal cell membranes specifically, demonstrating rapid fungicidal activity without inducing resistance, suggesting its potential as a differentiated antifungal candidate for serious fungal diseases.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Khushbu Farva, Huma Sattar, Hayat Ullah, Abdur Raziq, Muhammad Danish Mehmood, Afrasiab Khan Tareen, Imrana Niaz Sultan, Quratulaain Zohra, Muhammad Waseem Khan
Summary: This study aimed to optimize microbial and molecular techniques for detecting cariogenic pathogens in dental caries patients, determine the prevalence of cariogenic bacteria based on socioeconomic, climatological, and hygienic factors, and evaluate the antimicrobial activity of selected synthetic antibiotics and herbal extracts. Oral samples from 900 patients were screened for bacterial strains, and plant extracts such as ginger and amla were tested for their antimicrobial activity against isolated strains. Synthetic antibiotics and plant extracts showed effective antimicrobial activity, with ginger and amla extracts recording the highest inhibition zones. This study concluded that ginger and amla extracts could serve as alternative treatments for dental diseases.
Article
Biochemistry & Molecular Biology
Maria Elena Marcocci, Bianka Gabriela Jackowska, Carla Prezioso, Virginia Protto, Marta De Angelis, Francesco Saverio Di Leva, Bruno Casciaro, Alfonso Carotenuto, Maria Luisa Mangoni, Anna Teresa Palamara, Valeria Pietropaolo, Giovanna De Chiara, Lucia Nencioni
Summary: Natural occurring peptides like temporin G (TG) could be potential drugs to combat diseases caused by HSV-1 and JCPyV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Nurzia Mohamad, Mazween Mohamad Mazlan, Intan Syafinaz Mohamed Amin Tawakkal, Rosnita A. Talib, Lau Kia Kian, Mohammad Jawaid
Summary: This study utilized polybutylene succinate as the main polymeric material and different active agents to prepare active films via solvent casting method. The active films have the potential to be used in food packaging applications with inhibitory effects against Staphylococcus aureus.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Chemistry, Inorganic & Nuclear
Sajjad Ali, Muhammad Jahangir, Asma Zaidi, Zia-ul Hassan, Xiuhuan Li, Pengfei Li, Muhammad Inam-u-llah, Muhammad Riaz, Majid Ali, Syed Majid Bukhari, Huaiji Zheng
Summary: In this study, four new mixed ligand metal complexes were synthesized and characterized. The complexes showed significant antibacterial, antifungal, and antidiabetic activities, making them potential candidates for drug development.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Agriculture, Multidisciplinary
Zheng Peng, Mengni He, Xinyu Yang, Juan Zhang
Summary: In this study, a novel bacteriocin, HA2-5, was isolated and purified from Bacillus haynesii HA2, which effectively killed Propionibacterium acnes through membrane disruption. HA2-5 exhibited excellent stability and tolerance to various conditions and showed preferred antibacterial activity against gram-positive pathogens. These findings suggest that bacteriocin HA2-5 has the potential to be used as an alternative to antibiotics for acne treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Geriatrics & Gerontology
Virgilio Hernandez-Ruiz, Emmanuel Forestier, Gaetan Gavazzi, Tristan Ferry, Nicolas Gregoire, Dominique Breilh, Marc Paccalin, Sylvain Goutelle, Claire Roubaud-Baudron
Summary: Some studies suggest that the subcutaneous route could be an alternative to intravenous administration of antibiotics, particularly for time dependent antibiotics and certain patient populations. However, clinical evidence regarding the benefits and risks of subcutaneous antibiotic administration is still scarce and of low level. Further clinical studies are needed to assess the pharmacokinetic/pharmacodynamic properties of subcutaneous antibiotic administration.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Review
Pharmacology & Pharmacy
Nicolas Gregoire, Alexia Chauzy, Julien Buyck, Blandine Rammaert, William Couet, Sandrine Marchand
Summary: Daptomycin is an important antibiotic in the treatment of severe Gram-positive infections due to its low level of resistance. It requires complexation with calcium for antibacterial action and is mainly eliminated renally, necessitating dosage adjustment for patients with renal insufficiency. Therapeutic drug monitoring may be necessary for certain patient populations to ensure clinical efficacy and limit the risk of adverse effects.
CLINICAL PHARMACOKINETICS
(2021)
Article
Infectious Diseases
Kevin Brunet, Francois Arrive, Jean-Philippe Martellosio, Isabelle Lamarche, Sandrine Marchand, Blandine Rammaert
Summary: This study aimed to describe the impact of corticosteroids on alveolar macrophage (AM) capacities to control fungal growth. Corticosteroids enhanced fungal growth of L. corymbifera through inhibition of AM phagocytosis and oxidative burst.
Article
Biochemistry & Molecular Biology
Aline da Graca Sampaio, Aline Vidal Lacerda Gontijo, Gabriela de Morais Gouvea Lima, Maria Alcioneia Carvalho de Oliveira, Laura Soares Souto Lepesqueur, Cristiane Yumi Koga-Ito
Summary: The study evaluated the potential use of EA/HP-beta-CD for treating oral candidiasis, demonstrating its antifungal and anti-inflammatory effects in reducing the invasive capacity of C. albicans.
Article
Pharmacology & Pharmacy
Aline Vidal Lacerda Gontijo, Andre V. G. Cavalieri
Summary: This study formulates an optimal control problem for dosage selection of colistin based on a PK model, minimizing deviations of colistin concentration to a target value and allowing a specific dosage optimization for a given individual. The optimal loading dose regimen for patients should be divided into two or more administrations to attain the target concentration quickly, with a high first loading dose followed by much lower ones, which is not easily obtained by trial and error. The refined optimization of antibiotic dosage using this method shows significant improvement in treatment, avoiding subtherapeutic or toxic concentrations, especially for last-resort antibiotics like colistin.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
(2021)
Article
Chemistry, Multidisciplinary
Maria Alcioneia Carvalho de Oliveira, Gabriela de Morais Gouvea Lima, Thalita M. Castaldelli Nishime, Aline Vidal Lacerda Gontijo, Beatriz Rossi Canuto de Menezes, Marcelo Vidigal Caliari, Konstantin Georgiev Kostov, Cristiane Yumi Koga-Ito
Summary: The study demonstrated that cold atmospheric plasma (CAP) has inhibitory effects on wound-related multispecies biofilms with low cytotoxicity and genotoxicity to mammalian cells, suggesting its potential application in wound care.
APPLIED SCIENCES-BASEL
(2021)
Article
Microbiology
N. Layios, C. Visee, V Mistretta, R. Denooz, N. Maes, J. Descy, F. Frippiat, S. Marchand, N. Gregoire
Summary: This article describes the population pharmacokinetics of temocillin administered via continuous infusion versus intermittent infusion in critically ill patients with pneumonia. The study also examines the penetration ratios of the drug in the epithelial lining fluid/plasma and determines the probability of achieving target concentrations for a range of MICs. The results show that continuous infusion provides better PK/PD indexes but still falls below recommended doses for systemic infections, unless the patient has moderate renal impairment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Grace Akrong, Alexia Chauzy, Vincent Aranzana-Climent, Mathilde Lacroix, Luc Deroche, Laure Prouvensier, Julien M. Buyck, William Couet, Sandrine Marchand
Summary: The inoculum effect of Acinetobacter baumannii on polymyxin B activity was evaluated and a PKPD model was developed to capture this phenomenon. The results showed that polymyxin B displayed reduced activity with increasing starting inoculum. However, there were no significant effects on the studied genes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Microbiology
Aline Vidal Lacerda Gontijo, Sharlene Lopes Pereira, Herval de Lacerda Bonfante
Summary: Carbapenem-resistant Acinetobacter baumannii, a pathogen with high resistance to most antibiotics, is a top priority for new therapies. Repurposing drugs may be a fast and cost-effective strategy for treating infections caused by this pathogen. This review critically evaluates the antimicrobial activity of repurposed drugs for carbapenem-resistant A. baumannii infections, considering their toxicity and side effects. Fusidic acid and colistin, possibly in combination with a third drug, show the most favorable applicability in terms of tolerated toxicity and achieving satisfactory plasma concentrations.
CURRENT MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Aline Vidal Lacerda Gontijo, Andre V. G. Cavalieri
Summary: This study developed a framework to determine the loading dose parameters for colistin therapy based on patient characteristics such as renal function and weight. The optimal dose and waiting time were determined to minimize deviation between plasma concentration and target value. The results showed that individualized loading doses and intervals are necessary to avoid toxic or subtherapeutic concentrations.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
(2023)
Article
Infectious Diseases
Aart van der Meijden, Vincent Aranzana-Climent, Heleen van der Spek, Brenda C. M. de Winter, William Couet, Joseph Meletiadis, Anouk E. Muller, Sanne van den Berg
Summary: In this study, the pharmacokinetics and pharmacodynamics of polymyxin B were determined in neutropenic infected mice. The fAUC/MIC index was found to best describe the drug’s effectiveness. However, the standard dosing regimen did not achieve the PK/PD targets for the majority of clinical isolates, suggesting that polymyxin B may be ineffective as monotherapy for serious infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Romain Aubry, Julien Buyck, Laure Prouvensier, Jean-Winoc Decousser, Patrice Nordmann, Sebastian G. Wicha, Sandrine Marchand, Nicolas Gregoire
Summary: The study characterized the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin against multidrug-resistant Klebsiella pneumoniae. While synergy or antagonism were observed under specific conditions, overall an additive interaction was found between the antibiotics. Simulations indicated that the combination at clinical concentrations should prevent the emergence of resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)