Article
Infectious Diseases
Andreea Paula Cozma, Cristina Mihaela Rimbu, Flavia Zendri, Iuliana Elena Maciuca, Dorina Timofte
Summary: This study found a high prevalence of faecal carriage of extended-spectrum cephalosporin-resistant Enterobacterales in healthy pets and humans in Romanian households and shelters, with bidirectional clonal transmission likely between dogs and humans. Fourier Transform Infrared Spectroscopy (FTIR) was demonstrated to be valuable in antimicrobial resistance surveillance for both humans and animals.
Article
Infectious Diseases
Man Zhang, Xiaohua Qin, Baixing Ding, Zhen Shen, Zike Sheng, Shi Wu, Yang Yang, Xiaogang Xu, Fupin Hu, Xiaoqin Wang, Yu Zhang, Minggui Wang
Summary: Intestinal carriage of ESBL-PE is common in elderly people, with antibiotic exposure, age, and nursing home residence as independent risk factors. Increased frequency of antimicrobial exposure is associated with higher carriage risk.
Article
Microbiology
Francois Javaudin, Pascale Bemer, Eric Batard, Emmanuel Montassier
Summary: The study investigated the efficacy of oral and rectal phage therapy in reducing ESBL E. coli gut carriage in mice. The results showed transient reduction in bacterial concentration with oral phage administration, but no significant change in bacterial titre in certain models, indicating the challenges of phage therapy in reducing carriage of multidrug-resistant bacteria.
Article
Biochemical Research Methods
Mary Rao, Anna Laidlaw, Leo Li, Kristian Young, Sandeep Tamber
Summary: Various methods were compared for isolating 3GC resistant Enterobacteriaceae from retail meats, with differences in performance observed among different enrichment broths and selective agars. An antibiotic-free enrichment broth, two selective agars, and an isolate screening strategy were recommended for effective isolation and further confirmation of taxonomy and resistance. Antibiotic susceptibility testing and/or PCR screening for blaSHV or blaTEM were suggested for identifying ESBL producing strains among the 3GC resistant meat isolates. Adoption of this approach by the research community will facilitate more effective monitoring of antibiotic resistance rates and trends among foodborne Enterobacteriaceae.
JOURNAL OF MICROBIOLOGICAL METHODS
(2021)
Article
Immunology
Judith A. Anesi, Ebbing Lautenbach, Pranita D. Tamma, Kerri A. Thom, Emily A. Blumberg, Kevin Alby, Warren B. Bilker, Alissa Werzen, Pam Tolomeo, Jacqueline Omorogbe, Lisa Pineles, Jennifer H. Han
Summary: The study identified several risk factors for ESBL-EB BSIs among solid organ transplant recipients, including prior ESBL-EB colonization, corticosteroid-containing immunosuppression regimen, corticosteroid treatment for acute rejection, and exposure to certain antibiotics. Further studies and interventions are needed to explore and address these modifiable risk factors in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Upendo O. Kibwana, Joel Manyahi, Helene Heitmann Sandnes, Bjorn Blomberg, Stephen E. Mshana, Nina Langeland, Sabrina J. Moyo
Summary: This study investigated ESBL-PE colonization among children with febrile illnesses in Dar es Salaam, Tanzania and found a high prevalence of ESBL-PE fecal carriage among children with bloodstream infections. The colonization of ESBL-PE was identified as a risk factor for ESBL-BSI.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Karuna E. W. Vendrik, Elisabeth M. Terveer, Ed J. Kuijper, Sam Nooij, Eline Boeije-Koppenol, Ingrid M. J. G. Sanders, Emilie van Lingen, Hein W. Verspaget, Eric K. L. Berssenbrugge, Josbert J. Keller, Joffrey van Prehn
Summary: The study evaluated the effectiveness of the donor-screening protocol of the Netherlands Donor Faeces Bank, showing that healthy donors may become colonised with multidrug-resistant organisms during donation activities, but the screening protocol was effective in reducing the spread of such organisms.
LANCET INFECTIOUS DISEASES
(2021)
Article
Microbiology
Teresita de Jesus Bello Gonzalez, Francesca Marcato, Eduardo de Freitas Costa, Henry van den Brand, Fleur A. Hoorweg, Maaike Wolthuis-Fillerup, Bas Engel, Sabine K. Schnabel, Cornelis G. van Reenen, Michael S. M. Brouwer
Summary: The prevalence of Extended-Spectrum Cephalosporin-Resistant (ESC-R) Escherichia coli colonization in Dutch veal farms increased significantly after the arrival of calves. Individual antibiotic treatments and batch antibiotic treatments may be associated with the colonization frequency.
VETERINARY MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Zui Wang, Qin Lu, Xiaohui Mao, Li Li, Junfeng Dou, Qigai He, Huabin Shao, Qingping Luo
Summary: ESBL-producing E.coli strains isolated from chickens in central China showed high resistance to cephalosporins and harbored diverse ESBL-encoding genes. These strains pose a significant public health risk.
Article
Multidisciplinary Sciences
Nina Doerr, Nadine Dietze, Norman Lippmann, Arne C. Rodloff
Summary: With the rise of ESBLs and CTX-M enzymes, antimicrobial treatment of enterobacterial infections is increasingly challenging. Our study characterized ESBL-positive E. coli strains from blood cultures of patients in Germany, with the presence of CMY-2, CTX-M-14 and CTX-M-15 genes investigated. The results highlight the correlation between blood culture and stool specimens, emphasizing the importance of screening programs for high-risk patients.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Demissew Shenkute, Melese Hailu Legese, Berhanu Yitayew, Asaye Mitiku, Getabalew Engidaye, Saba Gebremichael, Daniel Asrat, Yimtubezinash Woldeamanuel
Summary: This study revealed a high prevalence of gastrointestinal colonization of ESBL-PE among hospitalized patients at Debre Berhan Comprehensive Hospital, with E. coli and K. pneumoniae being the predominant strains. The resistance rates to antibiotics like ampicillin were also high. History of antibiotic use, admission in neonatal intensive care unit, and presence of chronic disease were identified as independent risk factors for ESBL-PE fecal carriage.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
William C. Shropshire, Benjamin Strope, Selvalakshmi Selvaraj Anand, Jordan Bremer, Patrick McDaneld, Micah M. Bhatti, Anthony R. Flores, Awdhesh Kalia, Samuel A. Shelburne
Summary: Using whole-genome sequencing, this study characterized the molecular epidemiology of extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R-Ec) infections at a cancer center in Houston. The study identified a temporal dynamic of ESC-R-Ec infections, with peaks occurring in the last 6 months of the year, and a stable proportion of STc131 strains throughout the study period. The study also revealed the presence of genetically diverse ESC-R-Ec clonal complexes during infection peaks.
Article
Oncology
Wubalech Temsegen, Kasahun Gorems, Mekidim Mekonnen, Diriba Fufa, Tesfaye Kassa
Summary: This study revealed alarmingly high carriage rates of ESBL and CPE among all study participants. The isolates also showed increased resistance rates to alternative drugs and had multiple antibiotic-resistant patterns. Hence, it is important to emphasize strict adherence to antimicrobial stewardship program as well as infection prevention and control practices.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Immunology
Ebbing Lautenbach, Mosepele Mosepele, Rachel M. Smith, Ashley Styczynski, Robert Gross, Leigh Cressman, Anne Jaskowiak-Barr, Kevin Alby, Laurel Glaser, Melissa Richard-Greenblatt, Laura Cowden, Kgotlaetsile Sewawa, Dimpho Otukile, Giacomo M. Paganotti, Margaret Mokomane, Warren B. Bilker, Naledi Mannathoko
Summary: This study conducted a survey in six sites in Botswana and identified risk factors for extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) colonization, including healthcare exposure, travel, livestock farming, and presence of an ESCrE-colonized household member. These findings are crucial for informing strategies to reduce the spread of ESCrE.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Shuliang Zhou, Sulin Mi, Xin Rao, Qi Zhang, Shiwen Wei, Meng Xiao, Zhiyong Peng, Jing Wang
Summary: This study evaluated the role of individualized active surveillance using Xpert Carba-R in reducing the risk of carbapenem-resistant microorganisms (CRO) in ICU. The use of Xpert Carba-R for monitoring the presence of carbapenem resistance genes was associated with a lower CRO risk. Among the 3,765 patients admitted to Zhongnan Hospital of Wuhan University, 390 manifested the presence of CRO, indicating a prevalence of 10.36%. Individualized active surveillance using Xpert Carba-R may be effective in reducing the overall incidence of CRO in ICU.
SCIENTIFIC REPORTS
(2023)