NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

(2013) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity

(2013) Jean-Philippe Surivet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional characterization of the NfxB repressor of the mexCD-oprJ multidrug efflux operon of Pseudomonas aeruginosa

(2013) A. Purssell et al.   MICROBIOLOGY-SGM

In Vitro Pharmacodynamics of AZD5206 against Staphylococcus aureus

(2012) V. H. Tam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Allosteric inhibition of the DNA-dependent ATPase activity of Escherichia coli DNA gyrase by a representative of a novel class of inhibitors

(2012) Adam B. Shapiro et al.   BIOCHEMICAL PHARMACOLOGY

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

(2012) P. D. Tamma et al.   CLINICAL MICROBIOLOGY REVIEWS

First Clinical Cases of OXA-48-Producing Carbapenem-Resistant Klebsiella pneumoniae in the United States: the "Menace" Arrives in the New World

(2012) A. J. Mathers et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile

(2012) Folkert Reck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antagonistic Interactions of Pseudomonas aeruginosa Antibiotic Resistance Mechanisms in Planktonic but Not Biofilm Growth

(2011) Xavier Mulet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives

(2011) Frédéric Collin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity

(2011) Folkert Reck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pseudomonas aeruginosa: all roads lead to resistance

(2011) Elena B.M. Breidenstein et al.   TRENDS IN MICROBIOLOGY

N-Benzyl-3-sulfonamidopyrrolidines Are a New Class of Bacterial DNA Gyrase Inhibitors

(2011) Marie H. Foss et al.   ACS Medicinal Chemistry Letters

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

Quinolones: Action and Resistance Updated

(2009) Karl Drlica et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Has the era of untreatable infections arrived?

(2009) D. M. Livermore   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases

(2008) M. T. Black et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY