Review
Medicine, General & Internal
Tomohiro Oishi, Kazunobu Ouchi
Summary: This article provides a review of the recent trends in the epidemiology, diagnosis, and treatment of MRMP. The increasing prevalence of macrolide-resistant Mycoplasma pneumoniae poses a challenge to the treatment of MP infections. Alternative therapies have been introduced, but there is insufficient data available.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Mariana M. Lanata, Huanyu Wang, Kathy Everhart, Melisa Moore-Clingenpeel, Octavio Ramilo, Amy Leber
Summary: The study found that rates of MRMp infections in children in central Ohio are low, but patients with MRMp had longer hospitalizations, were more likely to have received previous macrolides, and were more likely to have switched to alternative antimicrobial drugs compared to patients with MSMp. MRMp-infected patients also had approximately 5-fold greater odds of pediatric intensive care unit admission.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Xue Wang, Maozhong Li, Ming Luo, Qin Luo, Lu Kang, Hui Xie, Yiting Wang, Xiali Yu, Aihua Li, Mei Dong, Fang Huang, Cheng Gong
Summary: The objective of this study was to explore the characteristics of Mycoplasma pneumoniae (MP) epidemics in Beijing, China. The results showed that the MP positive rate among acute respiratory tract infection (ARTI) patients in Beijing was 6.16%, with prevalence mainly occurring between August and January, peaking in October. The increase in MP detection rate coincided with the reported number of pneumonia patients in hospitals. Co-infection with other respiratory pathogens was found in 27.1% of MP-positive patients. The dominant MP genotype was type 1, and the macrolide-resistant rate exceeded 90%, with A2063G mutation accounting for 99.0% of macrolide-resistant MP infections.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Medicine, General & Internal
Hye Young Han, Ki Cheol Park, Eun-Ae Yang, Kyung-Yil Lee
Summary: Early corticosteroid therapy was found effective in reducing morbidity for children with pneumonia caused by macrolide-resistant or macrolide-sensitive Mycoplasma pneumoniae infections. There were no significant differences observed in clinical and laboratory parameters between patients treated with early dose-adjusted corticosteroids for resistant or sensitive strains. Higher-dose steroid treatment might be needed for patients with prolonged fever or elevated biomarkers despite usual steroid therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Jing Li, Liyong Liu, Lihua He, Fanliang Meng, Jianzhong Zhang, Fei Zhao
Summary: This study investigated the biological characteristics and effect of antibiotic treatment for different Mycoplasma pneumoniae isolates co-infecting the same patient. The proportion of macrolide-resistant M. pneumoniae monoclones in the specimen cultures collected rose from 70.8% to 95.7% at the time of discharge, indicating an increase in macrolide-resistant strains after treatment but the persistence of macrolide-susceptible strains.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Review
Pediatrics
Maodong Leng, Junmei Yang, Juanjuan Zhou
Summary: The study reviews the features, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae (M. pneumoniae; MRMP) infection in children, aiming to provide a better understanding of this infection and address the associated problems. Mutations in the V region of the 23S rRNA gene of M. pneumoniae genome are correlated with macrolide resistance. P1-1, MLVA4-5-7-2, and ST3 are usually the dominant genetic types in MRMP epidemics. Combined serological testing and PCR may be a more cautious approach to reduce macrolide consumption and antibiotic selective pressure. Molecular methods can be used for the diagnosis of MRMP through detection of single-nucleotide mutations in the V region of the 23S rRNA gene. Routine macrolide treatment for macrolide-sensitive Mycoplasma pneumoniae (MSMP) infections may be effective, but limited for severe MRMP infections. Additional corticosteroids may be necessary for the treatment of severe MRMP infections in children in China during the MRMP era.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Li-Ju Lai, Vincent Chin-Hung Chen, Yao-Hsu Yang, Kai-Liang Kao, Ko-Jung Chen, Ying-Ching Wang, Shu- Wu
Summary: Patients with Mycoplasma infection may have an increased risk of developing corneal diseases, specifically keratitis.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
M. Sung, H-J Choi, M-H Lee, J-Y Lee, H-B Kim, Y-M Ahn, J-K Kim, H-Y Kim, S-S Jung, M. Kim, E-K Kang, E-A Yang, S-J Lee, Y. Park, J-H Seo, E. Lee, E-S Yang, K-S Park, M. Shin, H-L Chung, Y-Y Jang, B-S Choi, H. Kim, J-A Jung, S-T Yu, E-J Roh, E-S Lee, J-T Kim, B-S Kim, Y-H Hwang, I-S Sol, H-J Yang, M-Y Han, H-Y Yew, H-M Cho, Y-H Hn, D-H Im, K. Hwang, J. Yoo, S-O Jung, Y-H Jeon, J-Y Shim, E-H Chung
Summary: This study investigated the prevalence of macrolide-resistant M. pneumoniae with respiratory virus co-infection and antibiotic prescriptions in children with CAP in four provinces in Korea. The findings showed significant differences across regions in terms of MRMP pneumonia with virus co-infection and antibiotic prescriptions.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Microbiology
Daniel Hubert, Roger Dumke, Stefan Weichert, Sybille Welker, Tobias Tenenbaum, Horst Schroten
Summary: During a school outbreak of severe Mycoplasma pneumoniae infections in southwest Germany, the development of macrolide resistance was reported. Through a case series analysis of hospitalized children with M. pneumonia infection, a cluster of patients with emerging macrolide-resistant M. pneumoniae (MRMP) was identified. Further studies are needed to confirm a potential link between macrolide resistance and disease severity.
Article
Immunology
Meng-Hsiu Yen, Dah-Chin Yan, Chao-Jan Wang, Kuo-Chien Tsao, Yi-Chuan Huang, Shao-wen Cheng, Cheng-Hsun Chiu, Yhu-Chering Huang, Tzou-Yien Lin
Summary: A study conducted in Taiwan showed an increasing trend of macrolide resistance in children with Mycoplasma pneumoniae infection. There were no significant differences in clinical features and laboratory data between macrolide-resistant and macrolide-susceptible infections. Pleural effusion and macrolide resistance were found to be independently associated.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
M. Sung, H-J Choi, M-H Lee, J-Y Lee, H-B Kim, Y-M Ahn, J-K Kim, H-Y Kim, S-S Jung, M. Kim, E-K Kang, E-A Yang, S-J Lee, Y. Park, J-H Seo, E. Lee, E-S Yang, K-S Park, M. Shin, H-L Chung, Y-Y Jang, B-S Choi, H. Kim, J-A Jung, S-T Yu, E-J Roh, E-S Lee, J-T Kim, B-S Kim, Y-H Hwang, I-S Sol, H-J Yang, M-Y Han, H-Y Yew, H-M Cho, H-Y Kim, Y-H Hn, D-H Im, K. Hwang, J. Yoo, S-O Jung, Y-H Jeon, J-Y Shim, E-H Chung
Summary: This study investigated the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia with respiratory virus co-infection and antibiotic prescriptions in children with community-acquired pneumonia (CAP) in four provinces in Korea. The findings showed regional and temporal variations in the prevalence of MRMP pneumonia and antibiotic prescriptions.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Immunology
Damon Getman, Seth Cohen, Alice Jiang
Summary: This study evaluated the distribution of macrolide-resistant Mycoplasma genitalium in female urogenital specimens and found complex combinations of specimen types and sequence phenotypes. Vaginal swab sampling showed the highest sensitivity for detecting macrolide-resistant urogenital tract infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Ti-An Tsai, Chang-Ku Tsai, Kuang-Che Kuo, Hong-Ren Yu
Summary: Mycoplasma pneumoniae is increasingly becoming resistant to macrolide antibiotics in Taiwan, leading to treatment challenges and the need for alternative therapies such as tetracyclines or fluoroquinolones. Refractory MPP is characterized by an excessive immune response, which may be modulated by corticosteroids as a potential treatment option.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Huei-Min Hung, Chih-Hsien Chuang, Yi-Yin Chen, Wei-Chao Liao, Shiao-Wen Li, Ian Yi-Feng Chang, Chih-Ho Chen, Ting-Hsuan Li, Ya-Yu Huang, Yi-Chuan Huang, Yi-Ching Chen, Kuo-Chien Tsao, Yhu-Chering Huang, Cheng-Hsun Chiu, Tzou-Yien Lin, Yu-Chia Hsieh
Summary: This study evaluated the clinical manifestations and clonal relatedness of M. pneumoniae circulating among children in Taiwan, finding that 77% of patients had macrolide resistance, with ST3 and its variant ST17 being the predominant clones. The study highlights the increasing complexity in treating pneumonia due to the rise in macrolide resistance.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Yun Jung Choi, Eun Hee Chung, Eun Lee, Chul-Hong Kim, Yong Ju Lee, Hyo-Bin Kim, Bong-Seong Kim, Hyung Young Kim, Yoojung Cho, Ju-Hee Seo, In Suk Sol, Myongsoon Sung, Dae Jin Song, Young Min Ahn, Hea Lin Oh, Jinho Yu, Sungsu Jung, Kyung Suk Lee, Ju Suk Lee, Gwang Cheon Jang, Yoon-Young Jang, Hai Lee Chung, Sung-Min Choi, Man Yong Han, Jung Yeon Shim, Jin Tack Kim, Chang-Keun Kim, Hyeon-Jong Yang, Dong In Suh
Summary: This study aims to compare the characteristics of macrolide-refractory Mycoplasma pneumoniae pneumonia (MrMP) and macrolide-sensitive Mycoplasma pneumoniae pneumonia (MSMP) in Korean children. The results showed that MrMP patients had longer fever duration and more severe clinical and radiographic findings compared to MSMP patients. Therefore, prompt management with alternative agents is necessary for these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Hideto Teranishi, Nanae Ohzono, Norikazu Inamura, Atsushi Kato, Tokio Wakabayashi, Hiroto Akaike, Kihei Terada, Kazunobu Ouchi
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2015)
Article
Microbiology
Yasuhiro Kawai, Naoyuki Miyashita, Mika Kubo, Hiroto Akaike, Atsushi Kato, Yoko Nishizawa, Aki Saito, Eisuke Kondo, Hideto Teranishi, Satoko Ogita, Takaaki Tanaka, Kozo Kawasaki, Takashi Nakano, Kihei Terada, Kazunobu Ouchi
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2013)
Article
Infectious Diseases
Norikazu Inamura, Naoyuki Miyashita, Shunji Hasegawa, Atsushi Kato, Yoko Fukuda, Aki Saitoh, Eisuke Kondo, Hideto Teranishi, Tokio Wakabayashi, Hiroto Akaike, Takaaki Tanaka, Satoko Ogita, Takashi Nakano, Kihei Terada, Kazunobu Ouchi
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2014)
Article
Oncology
Hideto Teranishi, Nanae Ohzono, Ippei Miyata, Shoko Wakabayashi, Mina Kono, Sahoko Ono, Atsushi Kato, Aki Saito, Eisuke Kondo, Yuuhei Tanaka, Hiroto Akaike, Tomohiro Oishi, Naoki Ohno, Kihei Terada, Kazunobu Ouchi
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2018)
Article
Microbiology
Atsushi Kato, Ippei Miyata, Yuhei Tanaka, Tomohiro Oishi, Hideto Teranishi, Hiroto Akaike, Naoki Ohno, Hiroshi Nakajima, Yutaka Kouguchi, Kazunobu Ouchi
JOURNAL OF MEDICAL MICROBIOLOGY
(2019)
Article
Microbiology
Tomohiro Oishi, Kento Takahashi, Shoko Wakabayashi, Yoshitaka Nakamura, Sahoko Ono, Mina Kono, Atsushi Kato, Aki Saito, Eisuke Kondo, Yuhei Tanaka, Hideto Teranishi, Hiroto Akaike, Takaaki Tanaka, Ippei Miyata, Satoko Ogita, Naoki Ohno, Takashi Nakano, Kazunobu Ouchi
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Infectious Diseases
Tomohiro Oishi, Yoko Fukuda, Shoko Wakabayashi, Mina Kono, Sahoko Ono, Atsushi Kato, Eisuke Kondo, Yoshitaka Nakamura, Yuhei Tanaka, Hideto Teranishi, Hiroto Akaike, Takaaki Tanaka, Ippei Miyata, Satoko Ogita, Naoki Ohno, Takashi Nakano, Kazunobu Ouchi
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2020)
Article
Infectious Diseases
Yoshitaka Nakamura, Tomohiro Oishi, Kazunari Kaneko, Tsuyoshi Kenri, Takaaki Tanaka, Shoko Wakabayashi, Mina Kono, Sahoko Ono, Atsushi Kato, Eisuke Kondo, Yuhei Tanaka, Hideto Teranishi, Hiroto Akaike, Ippei Miyata, Satoko Ogita, Naoki Ohno, Takashi Nakano, Kazunobu Ouchi
Summary: The study investigated the prevalence of Mycoplasma pneumoniae infections among Japanese children since 2008, finding that the annual rate of macrolide-resistant M. pneumoniae infections peaked in 2012 and then decreased annually until 2015. However, there was an increase in 2016 before decreasing again in 2018. The study also observed differences in the occurrence rate of macrolide-resistant M. pneumoniae among different p1 genotypes.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Tomohiro Oishi, Aki Saito, Yoko Fukuda, Atsushi Kato, Eisuke Kondo, Hideto Teranishi, Hiroto Akaike, Ippei Miyata, Naoki Ohno, Kazunobu Ouchi
Summary: The study found that children with neurologic impairment who develop pneumonia and receive tube feeding and/or have tracheostomy are more prone to multi-drug resistant (MDR) pathogens. Treatment success with broad-spectrum antibiotics was higher in these patients. Therefore, guidelines for treating pneumonia in children with neurologic impairment should take into account the risk factors for MDR pathogens.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Pediatrics
Yuhei Tanaka, Tomohiro Oishi, Sahoko Ono, Mina Kono, Atsushi Kato, Ippei Miyata, Naoki Ohno, Kazunobu Ouchi
Summary: This study reviewed clinical records of 108 pediatric patients with febrile UTIs and found Escherichia coli to be the most common pathogen. Monotherapy with third-generation cephalosporins was effective for treating UTIs caused by E. coli, and combination therapy with ampicillin may not be necessary.
PEDIATRICS INTERNATIONAL
(2021)
Article
Infectious Diseases
Ippei Miyata, Atsushi Kato, Kazunobu Ouchi
Summary: The study evaluated antibody titers against Y. pseudotuberculosis-derived mitogen in immunoglobulin products, which are suggestive of mediating Kawasaki disease-like manifestation. Trace, but detectable titer was found in the products. Thus, attention is required when evaluating anti-Y. pseudotuberculosis-derived mitogen IgG titers in patient sera post intravenous immunoglobulin therapy.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Immunology
Takaaki Tanaka, Tomohiro Oishi, Ippei Miyata, Shoko Wakabayashi, Mina Kono, Sahoko Ono, Atsushi Kato, Yoko Fukuda, Aki Saito, Eisuke Kondo, Hideto Teranishi, Yuhei Tanaka, Tokio Wakabayashi, Hiroto Akaike, Satoko Ogita, Naoki Ohno, Takashi Nakano, Kihei Terada, Kazunobu Ouchi
EMERGING INFECTIOUS DISEASES
(2017)
