Article
Infectious Diseases
Haffsatou Sawadogo, Issiaka Soulama, Adama Zida, Cheikna Zongo, Patindoilba Marcel Sawadogo, Kiswendsida Thierry Guiguemde, Seni Nikiema, Salimata Emilie Badoum, Salam Sawadogo, Aicha Tou, Salif Sombie, Chanolle Tchekounou, Sindie Samuel Serme, Rasmata Ouedraogo-Traore, Tinga Robert Guiguemde, Aly Savadogo
Summary: This study investigated the genetic diversity of Plasmodium falciparum and the mutation prevalence in the dhfr and dhps genes in postpartum infected placentas. The results showed a high genetic diversity in msp1 and msp2, suggesting that mutant genotypes in dhfr and dhps could be potential early warning factors for the increase in sulfadoxine-pyrimethamine resistance.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Chemistry, Medicinal
Loeki Enggar Fitri, Aulia Rahmi Pawestri, Nuning Winaris, Agustina Tri Endharti, Alif Raudhah Husnul Khotimah, Hafshah Yasmina Abidah, John Thomas Rayhan Huwae
Summary: Malaria elimination is targeted to be achieved by 2030 in Indonesia, but the development and spread of antimalarial resistance poses a significant risk to the national malaria control programs. Resistance has been reported in two human species of Plasmodium, P. falciparum and P. vivax. Understanding the mechanisms of antimalarial drugs and their development of resistance could provide insights for designing future treatment guidelines and control programs in Indonesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Immunology
He Yan, Jun Feng, Jian-hai Yin, Fang Huang, Xiang-li Kong, Kang-ming Lin, Tao Zhang, Xin-yu Feng, Shui-sen Zhou, Jian-ping Cao, Zhi-gui Xia
Summary: A high prevalence of point mutations in the pfdhfr and pfdhps genes of P. falciparum isolates was detected among Chinese migrant workers returning from Africa. The most common haplotype was the triple mutation IRN in pfdhfr, and the predominant alleles were K540E and S436A in pfdhps. The majority of combined haplotypes carried the CIRNI-SGKAA quadruple allele combination.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kiran Raj Awasthi, Jonine Jancey, Archie C. A. Clements, Justine Leavy
Summary: This qualitative study explored the knowledge, attitudes, and behavior towards malaria prevention and treatment among residents of rural villages in Khatyad Rural Municipality, Nepal. The majority of participants had knowledge about the causes and complications of malaria, and were aware of the availability of free anti-malarial medicines at public health facilities. Limited supply of medications and diagnostics at public health facilities led some patients to seek care at private hospitals. Factors such as treatment costs, distance to health facilities, and decision-making authority within households influenced health-related decisions.
Article
Microbiology
Jonas A. Kengne-Ouafo, Saikou Y. Bah, Alison Kemp, Lindsay Stewart, Lucas Amenga-Etego, Kirk W. Deitsch, Julian C. Rayner, Oliver Billker, Fred N. Binka, Colin J. Sutherland, Gordon A. Awandare, Britta C. Urban, Bismarck Dinko
Summary: Recent advances in transcriptomic analysis have greatly improved our understanding of the developmental biology of malaria parasites. However, most studies have relied on laboratory strains and have not assessed the transcriptomes of clinical isolates. This study compared the global transcriptome of mid-stage gametocytes from three clinical isolates with a laboratory strain, revealing both consistencies and differences in gene expression.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Jonas A. Kengne-Ouafo, Saikou Y. Bah, Alison Kemp, Lindsay Stewart, Lucas Amenga-Etego, Kirk W. Deitsch, Julian C. Rayner, Oliver Billker, Fred N. Binka, Colin J. Sutherland, Gordon A. Awandare, Britta C. Urban, Bismarck Dinko
Summary: Recent advances in transcriptomic analysis have greatly enhanced our understanding of the developmental biology of malaria parasites. However, there is a lack of assessment on the transcriptomes of clinical isolates circulating in human populations. In this study, RNA-seq was used to compare the global transcriptome of mid-stage gametocytes derived from clinical isolates with a reference laboratory strain. The results showed differences in gene expression profiles between the clinical isolates and the reference strain, suggesting increased investment in gametocytogenesis in clinical isolates.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Jyoti Kumari, Vikash Kumar, Ankita Behl, Raj Kumar Sah, Geeta Kumari, Swati Garg, Aashima Gupta, S. Nazar Mohomed Mohaideen, Sadat Shafi, Soumya Pati, Kirandeep Samby, Jeremy Burrows, Narla Mohandas, Shailja Singh
Summary: The study shows that erythritol, a sugar substitute, has potential as a therapeutic intervention against drug-resistant malaria parasite Plasmodium falciparum. Erythritol effectively inhibits parasite growth and development, as well as invasion and egress processes. It also demonstrates inhibitory effects on liver stage and transmission stage parasites. In addition, erythritol has a cytokine-modulating effect and affects ammonia release across the parasite. The findings suggest that erythritol could be a promising lead compound for anti-malarial drugs and can be combined with existing drugs without losing efficacy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Editorial Material
Immunology
Jonathan S. Schultz, Kimberly E. Mace, Kathrine R. Tan
Summary: The increase in international travel during the COVID-19 pandemic recovery period is expected to lead to an increase in imported malaria cases in the US. Prevention, timely diagnosis, and appropriate treatment are crucial in minimizing imported malaria morbidity and mortality. Intravenous artesunate (IVAS) is now available for severe malaria treatment in the US. Hospitals and pharmacists should have a malaria treatment plan that includes stocking artemether-lumefantrine for uncomplicated malaria and ensuring access to IVAS for severe cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Richard Owden Mwaiswelo, Billy Ngasala, Dominick Msolo, Eliningaya Kweka, Bruno P. Mmbando, Andreas Martensson
Summary: This study assessed the safety and effectiveness of a single dose of 0.25 mg/kg primaquine in reducing transmission of Plasmodium falciparum gametocytes in individuals with no, reduced, or increased CYP2D6 enzyme activity. The results showed that the use of primaquine was safe and effective in reducing gametocyte transmission.
Article
Biochemical Research Methods
Sony Shrestha, Amuza Byaruhanga Lucky, Awtum Marie Brashear, Xiaolian Li, Liwang Cui, Jun Miao
Summary: This study profiled the histone post-translational modifications (PTMs) in the development of Plasmodium falciparum gametocytes, revealing novel PTM sites and distinct patterns from asexual stages. The results suggest that these PTMs play critical roles in gametocyte development and provide insights into the epigenetic regulation in the life cycle of the malaria parasite.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Infectious Diseases
Angela Patricia Guerra, Mario Javier Olivera, Liliana Jazmin Cortes, Stella M. Chenet, Alexandre Macedo de Oliveira, Naomi W. Lucchi
Summary: This study evaluated the presence of gene polymorphisms associated with chloroquine and sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Quibdo, Colombia. The findings confirm the fixation of resistant alleles for chloroquine and pyrimethamine and suggest that these drugs are not suitable for use in Colombia. However, full resistance to sulfadoxine has not been achieved in the region.
Review
Biochemistry & Molecular Biology
Vikash Kumar, Ankita Behl, Rumaisha Shoaib, Mohammad Abid, Maxim Shevtsov, Shailja Singh
Summary: In this review, we summarize the information on prefoldin family members in archaea and humans, and analyze the unexplored subunits of Plasmodium falciparum (Pf). By comparing with the homologs in archaea and H. sapiens, we enhance the understanding of the functions, structure, and substrate binding mechanism of Pf prefoldin. Our review also highlights the importance of certain PfPFD subunits in malaria parasite biology, as well as their up-regulation during different stages of the parasite life cycle.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Immunology
Kasia Stepniewska, Georgina S. Humphreys, Bronner P. Goncalves, Elaine Craig, Roly Gosling, Philippe J. Guerin, Ric N. Price, Karen Barnes, Jaishree Raman, Menno R. Smit, Umberto D'Alessandro, Will J. R. Stone, Anders Bjorkman, Aaron M. Samuels, Maria Arroyo-Arroyo, Guido J. H. Bastiaens, Joelle M. Brown, Alassane Dicko, Badria B. El-Sayed, Salah-Eldin G. Elzaki, Alice C. Eziefula, Simon Kariuki, Titus K. Kwambai, Amanda E. Maestre, Andreas Martensson, Dominic Mosha, Richard O. Mwaiswelo, Billy E. Ngasala, Joseph Okebe, Michelle E. Roh, Patrick Sawa, Alfred B. Tiono, Ingrid Chen, Chris J. Drakeley, Teun Bousema
Summary: A meta-analysis of individual patients was conducted to assess the gametocytocidal and transmission-blocking activities of single-dose primaquine. The results showed that primaquine, when administered with artemisinin-based combination therapies, can effectively reduce the gametocyte carriage rate after 7 and 14 days, especially in patients with existing gametocytes at the start of treatment. Furthermore, the combination of primaquine and artemether-lumefantrine showed a faster decline in gametocyte carriage compared to the combination with dihydroartemisinin-piperaquine. Additionally, the addition of 0.25 mg/kg primaquine can nearly completely prevent transmission to mosquitoes.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Parasitology
Rini Chaturvedi, Jyoti Chhibber-Goel, Ishika Verma, Sreehari Gopinathan, Suhel Parvez, Amit Sharma
Summary: The study collected data on sulfadoxine-pyrimethamine resistance mutations from 2005 to 2019, finding that pyrimethamine-resistant double mutations are widespread in Asia, the Middle East, and the Indian sub-continent, while triple mutations prevail in Africa and South America. Single point mutations in sulfadoxine resistance dominate globally.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Parasitology
Rodrigue Roman Dongang Nana, Suzanne Sandrine Beack Bayengue, Martin Luther Koanga Mogtomo, Anne Rosalie Ngono Ngane, Vineeta Singh
Summary: This study investigated the presence of drug-resistant alleles in asymptomatic malaria-infected individuals in Cameroon. The results showed the presence of mutant alleles and various SNPs associated with resistance to sulfadoxine-pyrimethamine. Regular profiling of drug resistance markers in asymptomatic populations is crucial for malaria control and elimination programs.
PARASITOLOGY INTERNATIONAL
(2023)
Review
Clinical Neurology
Jill F. Lebov, Linda M. Brown, Pia D. M. MacDonald, Kevin Robertson, Natalie M. Bowman, Stephen R. Hooper, Sylvia Becker-Dreps
PEDIATRIC NEUROLOGY
(2018)
Article
Pediatrics
Pia D. M. MacDonald, E. Wayne Holden
Article
Parasitology
Ram Suresh Bharti, Kapil Vashisht, Naseem Ahmed, Ajay Nayak, Veena Pande, Neelima Mishra
Article
Infectious Diseases
Supriya Sharma, Kamlesh Kaitholia, Ram Suresh Bharti, Mrigendra Pal Singh, Neelima Mishra
INFECTION GENETICS AND EVOLUTION
(2020)
Article
Multidisciplinary Sciences
Doreen Collins, Sarah Rhea, Boubacar Ibrahima Diallo, Mariama Boubacar Bah, Facinet Yattara, Rachelle Goman Keleba, Pia D. M. MacDonald
Editorial Material
Public, Environmental & Occupational Health
Sandra I. McCoy, Pia D. M. MacDonald
PUBLIC HEALTH REPORTS
(2020)
Article
Public, Environmental & Occupational Health
Kathryn E. L. Grimes, Bonaventure Fuamba Ngoyi, Kristen B. Stolka, Jennifer J. Hemingway-Foday, Leopold Lubula, Mathias Mossoko, Antoine Okitandjate, Pia D. M. MacDonald, Amy Nelson, Sarah Rhea, Benoit Kebela Ilunga
FRONTIERS IN PUBLIC HEALTH
(2020)
Article
Infectious Diseases
Rati Devendra, Vinodkumar Gupta, Rajasubramaniam Shanmugam, M. P. S. S. Singh, Purushottam Patel, Neena Valecha, Neelima Mishra, Naseem Ahmed, S. L. Hoti, Harsha V. Hegde, Prashant Warang, Ashish Chiddarwar, Prabhakar Kedar, Pramod Mayekar, Malay B. Mukherjee
INFECTION GENETICS AND EVOLUTION
(2020)
Review
Parasitology
Savitri Tiwari, Nivedita Sharma, Guru Prasad Sharma, Neelima Mishra
Summary: The malaria-causing parasite Plasmodium falciparum poses a severe threat to human health globally, it employs an NADPH-dependent thioredoxin and glutathione system to counteract oxidative stress. The parasite relies on a set of peroxiredoxins and members of the thioredoxin superfamily to maintain its redox balance.
PARASITOLOGY RESEARCH
(2021)
Article
Infectious Diseases
Bridget J. Kelly, Brian G. Southwell, Lauren A. McCormack, Carla M. Bann, Pia D. M. MacDonald, Alicia M. Frasier, Christine A. Bevc, Noel T. Brewer, Linda B. Squiers
Summary: Most Americans were willing to get a COVID-19 vaccine, but several vulnerable populations reported low willingness. Public health efforts should address these gaps as national implementation efforts continue. Black respondents were less willing than White respondents to get vaccinated, while Hispanic respondents were more willing. Females, those without insurance, and some younger age groups were also less willing to get vaccinated.
BMC INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Lauren A. McCormack, Linda Squiers, Alicia M. Frasier, Molly Lynch, Carla M. Bann, Pia D. M. MacDonald
Summary: The study found that the general knowledge about COVID-19 and the virus was relatively low among the US public at the beginning of the outbreak, especially among certain populations such as those with low education and income levels, unemployed individuals, Hispanic and non-Hispanic Black people, and young adults. Non-Hispanic Black respondents were less knowledgeable about COVID-19 and the virus compared to non-Hispanic White respondents with higher education levels.
PUBLIC HEALTH REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Jennifer J. Hemingway-Foday, Bonaventure Fuamba Ngoyi, Christian Tunda, Kristen B. Stolka, Kathryn E. L. Grimes, Leopold Lubula, Mathias Mossoko, Benoit Ilunga Kebela, Linda M. Brown, Pia D. M. MacDonald
Article
Public, Environmental & Occupational Health
Claire J. Standley, Pia D. M. MacDonald, Aurelia Attal-Juncqua, Alpha Mahmoud Barry, Ebi Celestin Bile, Doreen L. Collins, Salomon Corvil, Diallo Boubabar Ibrahima, Jennifer J. Hemingway-Foday, Rebecca Katz, Kathy J. Middleton, Eileen M. Reynolds, Erin M. Sorrell, Soumah Mohamed Lamine, Abdoulaye Wone, Lise D. Martel
Article
Public, Environmental & Occupational Health
Amy L. Nelson, Lauren Bradley, Pia D. M. MacDonald
FRONTIERS IN PUBLIC HEALTH
(2018)
Article
Public, Environmental & Occupational Health
Kristen B. Stolka, Bonaventure Fuamba Ngoyi, Kathyrn E. L. Grimes, Jennifer J. Hemingway-Foday, Leopold Lubula, Alain Nzanzu Magazani, Joseph Bikuku, Mathias Mossoko, Leonie Manya Kitoto, Sylvie Mpangi Bashilebo, Dieudonne Lufwa Maya, Benoit Kebela Ilunga, Sarah Rhea, Pia D. M. MacDonald