Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 56, Issue 9, Pages 4976-4979Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00650-12
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Funding
- National Sciences and Engineering Council
- Cangene Corporation
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Phenotypic tolerances to antibiotics of mature and young Pseudomonas aeruginosa PAO1 biofilms and released planktonic bacteria were compared for four antibiotics. Resistance levels were similar for gentamicin and ciprofloxacin but differed for ceftazidime and meropenem. beta-Lactamase mapping showed that, after 5 h of ceftazidime exposure, mature biofilms produced more beta-lactamase than young biofilms, facilitating the growth of released planktonic bacteria. This shows the importance of early treatment and choice of antibiotics for P. aeruginosa biofilm infections.
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