Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 56, Issue 6, Pages 3457-3460Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.06102-11
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- Johnson Johnson
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We evaluated ceftobiprole against the well-characterized Enterococcus faecalis strain OG1RF (with and without the beta-lactamase [Bla] plasmid pBEM10) in a murine urinary tract infection (UTI) model. Ceftobiprole was equally effective for Bla(+) and Bla(-) OG1 strains, while ampicillin was moderately to markedly (depending on the inoculum) less effective against Bla(+) than Bla(-) OG1 strains. These data illustrate an in vivo effect on ampicillin of Bla production by E. faecalis and the stability and efficacy of ceftobiprole in experimental UTI.
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