Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 9, Pages 4422-4423Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00564-11
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Funding
- NIH Centers for AIDS at Albert Einstein College of Medicine [AI-051519]
- National Institutes of Health [AI26170]
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A search to identify new mechanisms of isoniazid resistance in Mycobacterium bovis led to the isolation of mutants defective in mycothiol biosynthesis due to mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants showed low-level resistance to isoniazid but were highly resistant to ethionamide. This study further illustrates that mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species.
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