Article
Agriculture, Dairy & Animal Science
Zixuan Li, Chong Peng, Gerui Zhang, Yuanyu Shen, Yuxuan Zhang, Cong Liu, Mengda Liu, Fangkun Wang
Summary: This study investigated the prevalence and antimicrobial resistance characteristics of Proteus mirabilis (P. mirabilis) in conventional broiler-fattening farms in Shandong Province, China. The results showed that the P. mirabilis strains isolated from these farms displayed a high level of antimicrobial resistance and carried multiple drug-resistance genes. The study suggested that P. mirabilis strains in Shandong may pose a potential risk to humans.
Article
Microbiology
Mona Shaaban, Soha Lotfy Elshaer, Ola A. Abd El-Rahman
Summary: This study aimed to determine the prevalence of β-lactamases, AmpC, and carbapenemases in Proteus mirabilis isolated from clinical specimens. The results showed a high level of antibiotic resistance, with 41.4% of isolates being multidrug-resistant. The most detected genes were bla(SHV), bla(AmpC), and bla(VIM-1). Additionally, some strains produced both ESBL and AmpC, and there were even strains that co-produced ESBL, AmpC, and carbapenemases. Moreover, genetic analysis based on ERIC patterns revealed high genetic diversity.
Article
Zoology
Qian Kang, Xue Wang, Jianan Zhao, Zhihui Liu, Fang Ji, Han Chang, Jianchun Yang, Shijia Hu, Ting Jia, Xiaojia Wang, Jiagui Tang, Guoying Dong, Guocheng Hu, Jing Wang, Yanyu Zhang, Jianhua Qin, Chengmin Wang
Summary: The multidrug resistance (MDR) in Proteus mirabilis clinical isolates from wildlife is a growing public health concern. These isolates show higher resistance to commonly used clinic drugs compared to those from humans, indicating the need to pay attention to wild animals carrying MDR clinical isolates.
INTEGRATIVE ZOOLOGY
(2021)
Article
Microbiology
Jun Kwon, Myoung-Hwan Yang, Hyoung-Joon Ko, Sang-Guen Kim, Chul Park, Se-Chang Park
Summary: This study analyzed the antibiotic resistance pattern of Proteus mirabilis, an emerging pathogen, and found a high resistance-pattern ratio. Prudent and selective use of antibiotics is necessary to prevent antibiotic resistance.
Article
Infectious Diseases
Jing Yang, Ge Shan, Guangchao Yu, Jie Wei, Qinghuan Zhang, Wen Su, Qiuping Lin, Zhixiong Zheng, Guangliang Wu, Guangtian Li, Qing Chang, Hong Yuan, Yanju He, Yanling Chen, Yi Zhang, Haile Huang, Wan Hu, Rongqing Song, Yuqing Weng, Xiaobin Li, Shengming Liu
Summary: This study reports the whole genome sequence of multidrug-resistant P. mirabilis PM1162 and explores its antibiotic resistance genes and their genetic environments. The analysis reveals the presence of multiple drug resistance-related gene regions in this strain, providing a deeper understanding of its resistance mechanism and elucidating the horizontal spread of its resistance genes, which can serve as a basis for the containment and treatment of the bacteria.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Infectious Diseases
Zana Rubic, Silvija Soprek, Marko Jelic, Anita Novak, Ivana Goic-Barisic, Marina Radic, Arjana Tambic-Andrasevic, Marija Tonkic
Summary: This study investigated the genetic relatedness and molecular resistance mechanisms of AmpC-producing multidrug-resistant Proteus mirabilis isolates in a university hospital. The isolates showed resistance to various antibiotics and carried different resistance genes. Alternative antibiotics were found to be efficient in vitro against these isolates, suggesting potential for sparing carbapenem usage.
MICROBIAL DRUG RESISTANCE
(2021)
Article
Immunology
Ying Li, Ming Yin, Chengju Fang, Yu Fu, Xiaoyi Dai, Wei Zeng, Luhua Zhang
Summary: Due to high resistance and virulence potential, multidrug-resistant (MDR) P. mirabilis has become a significant pathogen in catheter-associated urinary tract infections, posing a public health risk. This study investigated the resistance characteristics and virulence potential of a collection of clinical isolates. The findings highlight the urgent threat to public health posed by the prevalence of MDR P. mirabilis with high virulence potential. Evaluation: 5 out of 10.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Bindu Kiranmayi Chinnam, Subhashini Nelapati, Srinivasa Rao Tumati, Suresh Bobbadi, Venkata Chaitanya Peddada, Bhavana Bodempudi
Summary: Proteus mirabilis is commonly found in soil and water, and can cause serious infections in humans, including complex urinary tract infections. A study analyzing samples from animal-origin foods and animal intestinal samples recovered 232 P. mirabilis isolates, with 72 of them producing beta-lactamase. The genetic relationships between isolates from different sources were identified through further genotyping.
JOURNAL OF FOOD PROTECTION
(2021)
Article
Microbiology
Amelie Lombes, Remy A. Bonnin, Frederic Laurent, Helene Guet-Revillet, Emmanuelle Bille, Vincent Cattoir, Marie-Sarah Fangous, Cecile Le Brun, Vincent Fihman, Frederic Janvier, Marie-Pierre Otto, Anais Potron, Stephane Corvec, Louise Ruffier D'Epenoux, Assaf Mizrahi, Laurent Dortet
Summary: This multicentric study in French hospitals found that 26.9% of amoxicillin-clavulanate-resistant Proteus mirabilis isolates produced the OXA-23 carbapenemase. The study also identified a screening cutoff of <11 mm for the inhibition zone diameter around the amoxicillin-clavulanate disc to accurately detect these OXA-23 producers. Whole-genome sequencing confirmed that these OXA-23 producers belonged to the same lineage known to disseminate OXA-23 or OXA-58 in P. mirabilis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Sonsiray Alvarez Narvaez, Susan Sanchez
Summary: A novel genetic element, IME2287, was found in the accessory genome of the MDR clone 2287 of Rhodococcus equi, potentially explaining its success in infecting foals.
Article
Infectious Diseases
Zhou Song, Chang-Wei Lei, Lei Zuo, Cui Li, Yu-Long Wang, Yi-Ming Tian, Hong-Ning Wang
Summary: This study characterized the whole genome sequence of a multidrug-resistant Proteus mirabilis strain isolated from a swine farm in China, revealing a novel integrative and conjugative element. The findings highlight the importance of studying genetic rearrangement and diversity of ICE.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Microbiology
Wan-Qing Ma, Ying-Yue Han, Lin Zhou, Wen-Qi Peng, Ling-Ya Mao, Xue Yang, Qin Wang, Tie-Jun Zhang, Hong-Ning Wang, Chang-Wei Lei
Summary: Proteus mirabilis strains with high genetic diversity and multidrug resistance, including clinically important antimicrobial resistance genes, were found in retail meat and aquatic products in Chinese food markets, highlighting the importance of this issue for food safety and human health.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Ahmed Esmael, Sabah A. Abo-Elmaaty, Esraa M. Khafaga, Soheir Abdelrahman, Mervat G. Hassan
Summary: Three novel bacteriophages active against multidrug-resistant Proteus mirabilis were isolated and characterized, showing strong lytic activity and a narrow host range. These phages demonstrated stability, different genome sizes, and the potential to reduce and eradicate biofilms formed by MDR Proteus mirabilis.
ARCHIVES OF VIROLOGY
(2021)
Article
Infectious Diseases
Boheng Ma, Xuechun Wang, Changwei Lei, Yizhi Tang, Juan He, Yufeng Gao, Yu Zhang, Hongning Wang
Summary: The study identified three new variants of PmGRI1 in Proteus mirabilis, as well as a hybrid structure formed by a multidrug-resistant Tn7-like-HN2p transposon and a genomic island PmGRI1-HN2p. All variants underwent homologous recombination, with one variant experiencing genomic rearrangement. The heterozygous structure contained various antimicrobial resistance genes, enriching the research base of multidrug resistance genomic islands.
Article
Pharmacology & Pharmacy
S. A. Hassoubah
Summary: This study examined a multidrug-resistant Citrobacter freundii recovered from a dog with kennel cough, and found that it harbored multiple antibiotic resistance genes, which could potentially lead to severe infections in humans.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Infectious Diseases
R. Izdebski, M. Biedrzycka, P. Urbanowicz, W. Papierowska-Kozdoj, M. Dominiak, D. Zabicka, M. Gniadkowski
Summary: The increase in NDM-1-positive E. hormaechei cases in Poland is a result of uncontrolled spread of NDM-1-producing K. pneumoniae genotypes. Different E. hormaechei lineages have acquired NDM-encoding plasmids in various locales, leading to consecutive outbreaks.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Pawel Urbanowicz, Radoslaw Izdebski, Marta Biedrzycka, Elzbieta Literacka, Waleria Hryniewicz, Marek Gniadkowski
Summary: This study provides a comprehensive analysis of MBL-producing P. putida group isolates from Poland, revealing high diversity and the presence of three international lineages, each internally diversified by MBL-encoding structures.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Infectious Diseases
Ewa Wardal, Dorota Zabicka, Waleria Hryniewicz, Ewa Sadowy
Summary: The study characterized the epidemiological situation of vancomycin-resistant Enterococcus faecalis in Polish hospitals. The majority of isolates belonged to clonal complexes CC2 and CC87, indicating a polyclonal group. The repUS1(pVEF1)-vanA plasmids were the main factor behind the acquisition of vancomycin resistance in E. faecalis circulating in Polish hospitals.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
M. Biedrzycka, R. Izdebski, P. Urbanowicz, M. Polanska, W. Hryniewicz, M. Gniadkowski, E. Literacka
Summary: A new multidrug-resistant lineage of ST23 Klebsiella pneumoniae has emerged in Europe, posing a potential threat to public health. Some isolates have multiple virulence loci, while others are more abundant in plasmids.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Paola Morici, Cosmeri Rizzato, Emilia Ghelardi, Gian Maria Rossolini, Antonella Lupetti
Summary: This study describes the synergistic effect between rifampicin and hLF1-11 against multidrug-resistant Klebsiella pneumoniae. The results suggest that hLF1-11 induces a transient loss of membrane potential and increased cell membrane permeability, allowing rifampicin to enter the bacterial cell.
MICROBIOLOGY SPECTRUM
(2023)
Editorial Material
Medicine, General & Internal
Daniele Roberto Giacobbe, Vincenzo Di Pilato, Ilias Karaiskos, Tommaso Giani, Anna Marchese, Gian Maria Rossolini, Matteo Bassetti
Summary: Antimicrobial resistance, particularly carbapenem resistance in Gram-negative bacteria, poses a significant global health threat. The emergence of carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) has presented clinicians with unique challenges in managing severe infections. This article discusses the evolution of treatment strategies for KPC-Kp infections over the past decade, guided by clinical evidence and advances in diagnostics.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Karolina Wegrzynska, Jaroslaw Walory, Radoslaw Charkiewicz, Marzena Anna Lewandowska, Izabela Wasko, Aleksandra Kozinska, Piotr Majewski, Anna Baraniak
Summary: Accurate and rapid identification of COVID-19 is critical. The GenBody COVID-19 Ag rapid antigen tests showed high sensitivity and specificity, making them suitable for diagnosis and timely isolation and treatment of COVID-19 patients, contributing to the better control of virus spread.
Article
Genetics & Heredity
Weronika Puzia, Jan Gawor, Robert Gromadka, Anna Skoczynska, Ewa Sadowy
Summary: This study aimed to obtain and compare the complete genomic sequences of two pneumococcal isolates. Comparative analysis revealed several instances of recombination involving not only pneumococci but also potentially other streptococci as donors.
Article
Infectious Diseases
M. Biedrzycka, P. Urbanowicz, D. Zabicka, W. Hryniewicz, M. Gniadkowski, R. Izdebski
Summary: This study elucidates the role of the Klebsiella oxytoca species complex (KoSC) in the epidemiology of VIM-type MBL-producing Enterobacterales in Poland. K. oxytoca was found to be the predominant species, and clonal expansion of the K. oxytoca-In237-like lineage was identified as the main driver for the high prevalence of VIM producers. The enhanced epidemic potential of this organism poses a danger on an international scale.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Immunology
Jaroslaw Walory, Iza Ksiazek, Michal Karynski, Anna Baraniak
Summary: This study found that the BNT162b2 vaccine had strong immunogenicity, but antibody levels declined over time, potentially contributing to breakthrough infections. Booster doses significantly enhanced antibody levels and provided longer-lasting immunity compared to breakthrough infection.
Article
Engineering, Chemical
Annamaria Alabiso, Sara Frasca, Valerio Cantelmo, Marco Maria D'Andrea, Roberto Braglia, Francesco Scuderi, Fiammetta Costa, Saverio Savio, Roberta Congestri, Luciana Migliore
Summary: In the context of regenerative circular economy and Sustainable Development Goals, water demand and wastewater production are significant environmental concerns. Zero Mile system has been developed to address these issues by reusing dishwasher wastewater for fertilization and subsequent rinsing cycle, using a biofilter composed of a specific microbial consortium. Tests showed the consortium's capability to thrive in dishwasher wastewater and its high bioremediation efficiency.
Article
Infectious Diseases
Ewa Wardal, Dorota Zabicka, Tomasz Skalski, Joanna Kubiak-Pulkowska, Waleria Hryniewicz, Ewa Sadowy
Summary: This study characterized a vanA and vanB gene-carrying Enterococcus faecium isolate that was resistant to tigecycline, linezolid, and vancomycin. The isolate was collected from a hematoma of a patient hospitalized in an intensive care unit in Poland. The findings highlight the presence of multiple resistance determinants in a single hospital strain.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Infectious Diseases
Weronika Puzia, Jan Gawor, Robert Gromadka, Karolina Zuchniewicz, Izabela Wrobel-Pawelczyk, Patrycja Ronkiewicz, Agnieszka Golebiewska, Waleria Hryniewicz, Ewa Sadowy, Anna Skoczynska
Summary: The introduction of PCV has reduced pneumococcal infections, but non-vaccine serotypes, particularly NVT 19A, have become the main cause of invasive pneumococcal disease worldwide. This study aimed to characterize serotype 19A invasive pneumococci of GPSC1/CC320 in Poland before the introduction of PCV and compare them to isolates from other countries.
INFECTIOUS DISEASES AND THERAPY
(2023)
Letter
Infectious Diseases
Nicla Giovacchini, Alberto Antonelli, Elia Taddei, Tommaso Giani, Gian Maria Rossolini
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)