Review
Pharmacology & Pharmacy
Mark Redell, Glenn S. Tillotson
Summary: This article reviews the real-world implications associated with lack of testing and reporting current carbapenem breakpoints and identifies potential barriers to their implementation. The results show that failure to adopt revised breakpoints can lead to negative clinical outcomes and increased costs, but there are also highlighted impediments for laboratories in implementing breakpoint updates. Practical steps to implement revised breakpoints are proposed, emphasizing the importance of accurate and relevant susceptibility results for clinicians.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Anne F. Luetkemeyer, Deborah Donnell, Julia C. Dombrowski, Stephanie Cohen, Cole Grabow, Clare E. Brown, Cheryl Malinski, Rodney Perkins, Melody Nasser, Carolina Lopez, Eric Vittinghoff, Susan P. Buchbinder, Hyman Scott, Edwin D. Charlebois, Diane V. Havlir, Olusegun O. Soge, Connie Celum
Summary: In this study, it was found that doxycycline postexposure prophylaxis significantly reduced the incidence of sexually transmitted infections (STIs) among MSM and transgender women. The use of doxycycline was shown to be effective in preventing STIs in this population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Wannisa Meepoo, Tassanee Jaroensong, Chantima Pruksakorn, Jatuporn Rattanasrisomporn
Summary: This study investigated bacterial identification and antimicrobial susceptibility in chronic rhinitis in cats. The results showed that rhinitis was more likely to occur in younger and young adult cats, with Pseudomonas spp. being the main bacterial species, followed by Pasteurella spp., Staphylococcus spp., and E. coli. Antimicrobials such as amikacin, imipenem, and meropenem exhibited high activity against most bacterial species. However, the use of antimicrobials in certain categories should be avoided in companion animals. The findings emphasize the importance of appropriate antimicrobial usage based on guidelines and susceptibility testing.
Article
Veterinary Sciences
Charlotte Langhorne, Suman Das Gupta, Sara Horsman, Caitlin Wood, Benjamin J. Wood, Leslie Barker, Ania Deutscher, Rochelle Price, Michael R. Mcgowan, Mark Humphris, Shahab Ranjbar, Joerg Henning, Justine S. Gibson
Summary: This study retrospectively analyzed the mastitis-causing organisms isolated from bovine milk samples in Australia. The study identified temporal, geographical, and seasonal patterns of occurrence for these organisms and reported their in vitro susceptibility. The findings emphasized the importance of further research into specific risk factors to improve mastitis control and treatment.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Yufei Zhao, Yiping Zhu, Bo Liu, Junpeng Mi, Nan Li, Weisen Zhao, Rongzheng Wu, Gilbert Reed Holyoak, Jing Li, Dejun Liu, Shenming Zeng, Yang Wang
Summary: This retrospective study investigated the bacterial characteristics and antimicrobial susceptibility pattern of donkeys with endometritis. The results showed that Gram-negative bacteria were the most common isolates, and multidrug resistance was detected. Bacteria identification and antimicrobial susceptibility testing are highly recommended before the treatment of uterine infections in donkeys.
VETERINARY SCIENCES
(2022)
Article
Endocrinology & Metabolism
Asegdew Atlaw, Habtamu Biazin Kebede, Abdurezak Ahmed Abdela, Yimtubezinash Woldeamanuel
Summary: Multi-drug resistant bacteria were found in diabetic foot ulcer infections, highlighting the importance of early diagnosis, pathogen identification, and antibiotic susceptibility testing.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Colin N. Lam, Misha G. Mehta-Kolte, Natacha Martins-Sorenson, Barbara Eckert, Patrick H. Lin, Kristina Chu, Arrash Moghaddasi, Dylan Goldman, Hai Nguyen, Ryan Chan, Laxmi Nukala, Shawn Suko, Brett Hanson, Richard Yuan, Kyle C. Cady
Summary: Bacterial transduction particles play a crucial role in molecular biology, and are currently attracting interest in the diagnostic and therapeutic fields. Developing effective transduction reagents remains a challenge, but the use of a synthetic biology platform shows promise for future rapid diagnostic assays.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Infectious Diseases
Marianne Moerer, Antina Luebke-Becker, Astrid Bethe, Roswitha Merle, Wolfgang Baeumer
Summary: The aim of this study was to investigate the impact of the second amendment to the Regulation of Veterinary Pharmacies (TaHAV) in 2018 on the occurrence of antimicrobial resistance in selected bacterial pathogens isolated from dogs and cats in Germany. The study found that the amendment led to an increase in sample submissions in Germany. The highest resistance rates were found for Staphylococcus pseudintermedius, Staphylococcus aureus, and Escherichia coli, while resistance rates were low for Pasteurella multocida and β-hemolytic streptococci. Significant decreases in resistance rates were observed for S. pseudintermedius against penicillin G and ampicillin, S. felis against amoxicillin-clavulanic acid and cefovecin, and S. aureus against enrofloxacin.
Article
Public, Environmental & Occupational Health
Amina Akram Asif, Khalid Mahmood, Saba Riaz, Timothy McHugh, Sikander Sultan
Summary: This 7-year retrospective study aimed to identify the bacteria responsible for adult VP shunt infections and determine their drug susceptibility patterns. The study found that both Gram-negative and Gram-positive bacteria were involved in these infections, with Acinetobacter species, Pseudomonas species, and coagulase-negative Staphylococcus being the predominant bacteria. However, the effectiveness of carbapenem and beta-lactam/beta-lactamase inhibitor combination drugs decreased significantly for the common Gram-negative causative agents, suggesting the need for alternative antibiotics and preventive measures.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Chemistry, Analytical
Enhui Wu, Jia Yi, Baohong Liu, Liang Qiao
Summary: A rapid bacterial viability assessment and antimicrobial susceptibility testing method using LDI-MS technology was developed, showing higher efficiency than traditional methods. This method demonstrated high efficiency with different bacterial species and antibiotic drugs, and can be applied to human body fluid samples for antibiotic drug screening.
Article
Agriculture, Dairy & Animal Science
Ryan M. Knuth, Kelly L. Woodruff, Gwendolynn L. Hummel, Jordan D. Williams, Kathleen J. Austin, Whitney C. Stewart, Hannah C. Cunningham-Hollinger, Bledar Bisha
Summary: Subclinical mastitis is a common intramammary disease in sheep production systems. This study aimed to quantify its prevalence, evaluate the impact of bedding treatments and weaning treatments on subclinical mastitis, and identify levels of antimicrobial resistance in milk-derived bacteria. The study found that subclinical mastitis is prevalent throughout lactation and the levels of antimicrobial resistance in milk-derived bacteria are generally low.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Mengistu Hailemariam, Tsegaye Alemayehu, Bereket Tadesse, Netsanete Nigussie, Asnakech Agegnehu, Techilo Habtemariam, Mulubrhan Ali, Enkosilassie Mitiku, Elshaday Azerefegne
Summary: This study conducted a retrospective analysis of microbiological findings at Hawassa public hospital, revealing a bacterial infection prevalence of 32.6% and higher rates of bacterial bloodstream infection in children. Identified bacterial isolates were all multi-drug resistant, with Staphylococcus aureus having the highest proportion of multi-drug resistance.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Neele J. Froboese, Franziska Schuler, Alexander Mellmann, Marc T. Hennies, Evgeny A. Idelevich, Frieder Schaumburg
Summary: The study found that the likelihood of different antimicrobial susceptibility is low among phenotypic variants, supporting a strategy to test only one isolate per variant to guide antimicrobial treatment.
MICROBIOLOGY SPECTRUM
(2021)
Article
Multidisciplinary Sciences
Komal Umashankar Rao, Domhnall Iain Henderson, Nitya Krishnan, Manoj Puthia, Izabela Glegola-Madejska, Lena Brive, Fanny Bjarnemark, Anna Millqvist Fureby, Karin Hjort, Dan I. Andersson, Erik Tenland, Erik Sturegard, Brian D. Robertson, Gabriela Godaly
Summary: A fungal peptide was found to effectively reduce tuberculosis load and synergize with current TB drugs. The peptide remained stable in circulation and showed efficacy against drug-resistant bacteria.
SCIENTIFIC REPORTS
(2021)
Article
Reproductive Biology
Wallaya Phongphaew, Mintraporn Kongtia, Kiyeon Kim, Kaitkanoke Sirinarumitr, Theerapol Sirinarumitr
Summary: The study compared the prevalence of bacterial species and results of drug susceptibility testing of bacteria isolated from prostatic fluids and urine samples from dogs with prostatitis and cystitis. Staphylococcus spp., Escherichia coli, Pseudomonas spp., Streptococcus spp., Proteus mirabilis, and Klebsiella pneumoniae were the major species detected, with Staphylococcus spp. and Escherichia coli being the most prevalent. Imipenem and gentamicin were found to be the most potent antimicrobial drugs, but caution is needed when administering imipenem for treating prostatitis and cystitis in dogs. Additionally, there were no significant differences in antimicrobial drug susceptibility trends between prostatic fluid and urine samples.
Review
Gastroenterology & Hepatology
William D. Chey, Eric D. Shah, Herbert L. DuPont
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2020)
Article
Immunology
Yoav Golan, Herbert L. DuPont, Fernando Aldomiro, Erin H. Jensen, Mary E. Hanson, Mary Beth Dorr
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Taniya Golder, Asish Kumar Mukhopadhyay, Hemanta Koley, Ranjan Kumar Nandy
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2020)
Review
Immunology
Thandavarayan Ramamurthy, Ranjan K. Nandy, Asish K. Mukhopadhyay, Shanta Dutta, Ankur Mutreja, Keinosuke Okamoto, Shin-Ichi Miyoshi, G. Balakrish Nair, Amit Ghosh
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Correction
Immunology
Yoav Golan, Herbert L. DuPont, Fernando Aldomiro, Erin H. Jensen, Mary E. Hanson, Mary Beth Dorr
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Sathursha Gunaratnam, Mathieu Millette, Lynne McFarland, Herbert L. DuPont, Monique Lacroix
Summary: This paper discusses the potential of opportunistic pathogenic bacteria to cause disease when disrupting the normal microbiome, and current therapeutic strategies for Clostridioides difficile, including disrupting virulence factor production through interfering with quorum sensing systems. Probiotics and other QS inhibitors targeting QS systems may represent important new directions for the treatment and prevention of C. difficile infections.
MICROBIAL PATHOGENESIS
(2021)
Article
Infectious Diseases
Kathryn M. Thomson, Calie Dyer, Feiyan Liu, Kirsty Sands, Edward Portal, Maria J. Carvalho, Matthew Barrell, Ian Boostrom, Susanna Dunachie, Refath Farzana, Ana Ferreira, Francis Frayne, Brekhna Hassan, Ellis Jones, Lim Jones, Jordan Mathias, Rebecca Milton, Jessica Rees, Grace J. Chan, Delayehu Bekele, Abayneh Mahlet, Sulagna Basu, Ranjan K. Nandy, Bijan Saha, Kenneth Iregbu, Fatima Modibbo, Stella Uwaezuoke, Rabaab Zahra, Haider Shirazi, Najeeb U. Syed, Jean-Baptiste Mazarati, Aniceth Rucogoza, Lucie Gaju, Shaheen Mehtar, Andre N. H. Bulabula, Andrew Whitelaw, Johan G. C. van Hasselt, Timothy R. Walsh
Summary: When advocating antibiotic treatments, accessibility and affordability must be considered, tailored to the variance in economic health structures across low- and middle-income countries. Funding comes from The Bill & Melinda Gates Foundation. This article is published under an Open Access license.
LANCET INFECTIOUS DISEASES
(2021)
Article
Immunology
Charles Darkoh, Kadiatou Keita, Chioma Odo, Micah Oyaro, Eric L. Brown, Cesar A. Arias, Blake M. Hanson, Herbert L. DuPont
Summary: A study found that vancomycin nonsusceptible strains of Clostridioides difficile are circulating in patient populations, posing a serious challenge to treatment as vancomycin is a first-line antibiotic for CDI. Routine susceptibility testing may be necessary.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Debjit Chakraborty, Suman Kanungo, Ranjan Kumar Nandy, Alok Kumar Deb, Asish Kumar Mukhopadhyay, Shanta Dutta
Summary: Cholera remains a major issue in India, but faces challenges such as lack of a national control plan, inaccurate reporting, infrastructure and vaccine distribution issues.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Robert Orenstein, Erik R. Dubberke, Sahil Khanna, Christine H. Lee, David Yoho, Stuart Johnson, Gail Hecht, Herbert L. DuPont, Dale N. Gerding, Ken F. Blount, Sarah Mische, Adam Harvey
Summary: In this Phase 2 trial, RBX2660 was found to be safe and effective in reducing the recurrence of rCDI compared to a historical control group. Microbiome changes in participants treated with RBX2660 were consistent with protective changes against C. difficile recurrence.
BMC INFECTIOUS DISEASES
(2022)
Letter
Immunology
Charles Darkoh, Herbert L. DuPont, Cesar A. Arias, Micah Oyaro, Eric L. Brown, Blake M. Hanson
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Microbiology
Herbert L. L. DuPont, Zhi-Dong Jiang, Ashley S. S. Alexander, Andrew W. W. DuPont, Eric L. L. Brown
Summary: IgA-coated bacteria in the gut provide important homeostatic functions and their impairment is associated with dysbiosis. Fecal microbiota transplantation has been successful in engrafting healthy microbiota and metabolites, with IgA-coated bacteria being transferred to recipients. The evaluation of the IgA-biome should be included in FMT studies, using metagenomic methods to better identify and compare microbiota data.
Article
Neurosciences
Eric L. Brown, Heather T. Essigmann, Kristi L. Hoffman, Ashley S. Alexander, Michael Newmark, Zhi-Dong Jiang, Jessika Suescun, Mya C. Schiess, Craig L. Hanis, Herbert L. DuPont
Summary: Parkinson's disease is a heterogeneous neurodegenerative disorder with distinct gut microbiome patterns. This study characterized the IgA-Biome of individuals with different clinical subtypes of Parkinson's disease and identified unique bacterial profiles associated with these subtypes.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Rebecca Milton, David Gillespie, Calie Dyer, Khadijeh Taiyari, Maria J. Carvalho, Kathryn Thomson, Kirsty Sands, Edward A. R. Portal, Kerenza Hood, Ana Ferreira, Thomas Hender, Nigel Kirby, Jordan Mathias, Maria Nieto, William J. Watkins, Delayehu Bekele, Mahlet Abayneh, Semaria Solomon, Sulagna Basu, Ranjan K. Nandy, Bijan Saha, Kenneth Iregbu, Fatima Z. Modibbo, Stella Uwaezuoke, Rabaab Zahra, Haider Shirazi, Syed U. Najeeb, Jean-Baptiste Mazarati, Aniceth Rucogoza, Lucie Gaju, Shaheen Mehtar, Andre N. H. Bulabula, Andrew C. Whitelaw, Timothy R. Walsh, Grace J. Chan
Summary: This study aimed to determine the incidence and associations with neonatal sepsis and all-cause mortality in facility-born neonates in low-income and middle-income countries (LMICs). Findings reveal a high incidence of neonatal sepsis and its significant impact on mortality rates in LMICs.
LANCET GLOBAL HEALTH
(2022)
Article
Oncology
Hiba Ali, Shruti Khurana, Weijie Ma, Yuanzun Peng, Zhi-Dong Jiang, Herbert DuPont, Hao Chi Zhang, Anusha S. Thomas, Pablo Okhuysen, Yinghong Wang
Summary: Patients with cancer who underwent FMT for rCDI showed a high response rate and no serious adverse events or mortality within 30 days. However, additional antibiotic use for complications from chemotherapy or immunosuppression may negatively affect the efficacy of FMT in this population with advanced cancer.