Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 54, Issue 9, Pages 3988-3990Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00067-10
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Funding
- Human Frontiers Science Program [RGY0069/2008-C]
- DARPA
- USDA [WIS00974]
- Searle Scholar Award
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Bacterial cytoskeletal proteins are an emerging set of targets for antibiotic development. This paper describes oligochlorophen analogs based on the monomer 4-chloro-2,6-dimethylphenol as antimicrobial agents against Bacillus anthracis. The most potent analogs have a MIC of 160 to 320 nM against B. anthracis and may target the cytoskeletal protein FtsZ. B. anthracis develops resistance to the oligochlorophens at a rate of 4.34 x 10(-10) per generation, which is similar to 10-fold lower than that of commercial antibiotics used to treat this human pathogen.
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