Article
Microbiology
Marjorie Vieira Batista, Maria Piedad Ussetti, Ying Jiang, Dionysios Neofytos, Anita Cassoli Cortez, Diego Feriani, Jayr Schmidt-Filho, Ivan Leonardo Avelino Franca-Silva, Issam Raad, Ray Hachem
Summary: This study compares the clinical outcomes and safety of Isavuconazole, Voriconazole, and an amphotericin B-based regimen in treating invasive fungal infections (IFIs) in immunocompromised patients with malignancies and transplants. Isavuconazole shows better safety profile compared to Voriconazole and amphotericin B. Factors such as age, obesity, renal insufficiency, and diabetes do not affect the response to antifungal therapy and overall outcome.
Article
Microbiology
Ali Atoui, Nadine Omeirat, Omar Fakhreddine, Raquelle El Alam, Zeina Kanafani, Iman Abou Dalle, Ali Bazarbachi, Jean El-Cheikh, Souha S. Kanj
Summary: The study showed that using voriconazole as primary prophylaxis in allo-HCT is effective in reducing the incidence of fungal infections, with probable invasive aspergillosis being the main type of infection. Further research comparing different antifungal agents in this setting is needed.
Article
Pharmacology & Pharmacy
Tianrong Xun, Yan Rong, Bin Lv, Jinfei Tian, Qing Zhang, Xixiao Yang
Summary: This study aimed to investigate the pharmacokinetic interactions and potential mechanisms between atorvastatin (ATO) and voriconazole (VOR). Results from patient and rat models showed that VOR significantly reduced the metabolism of ATO and slowed the formation of its metabolites. In vitro studies demonstrated that VOR inhibited the metabolism of ATO and testosterone. These findings are important for dose adjustment and the design of rational treatment regimens for fungal infections in patients with dyslipidemia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Abhishek Shettar, Vijay Kumar Shankar, Srinivas Ajjarapu, Vijay I. Kulkarni, Micheal A. Repka, S. Narasimha Murthy
Summary: The study developed a stable oil/PEG voriconazole cream as an alternative for treating fungal skin infections. Compared to oral and intravenous administration, percutaneous delivery through creams or hydrogels may be more effective in avoiding side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tehreem Mumtaz, Naveed Ahmed, Najam ul Hassan, Malik Badshah, Samiullah Khan, Asim Ur Rehman
Summary: This study developed novel VRC-loaded polymeric nanoparticles for enhanced topical delivery. The optimized nanoparticles exhibited extended release of VRC at skin pH and effectively deposited in the skin layers. The final formulation showed potential antifungal activity and non-irritant nature in animal experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Infectious Diseases
Miriam Alisa Knoll, Stephan Steixner, Cornelia Lass-Flo
Summary: New molecular-based diagnostic methods play an important role in the early diagnosis of fungal infections, but conventional tests are often overlooked. This article provides best practice recommendations for direct microscopy in diagnosing fungal infections, including when to perform direct microscopy, the main fungal morphologies, pitfalls, and how to report the results to clinicians. Direct microscopy has important diagnostic value in many samples, surpassing culture methods.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Qianting Yang, Jiao Xie, Yan Cai, Na Wang, Yan Wang, Li Zhang, Youjia Li, Jingjie Yu, Ya Li, Haitao Wang, Kanghuai Zhang
Summary: This study compared the efficacy and safety of different combinations of antifungal drugs in intensive-care unit patients. The results showed that CAS monotherapy had good outcomes for empirical and preemptive therapy. CAS+VOR or CAS+L-AmB achieved similar outcomes to monotherapy for targeted therapy, but CAS+VOR had a lower mortality rate for invasive fungal infection compared to VOR monotherapy.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Xuezhou Cai, Wei Li, Jian Yang, Guangjie Wu, Jianxin Song, Xuepeng Gong, Dong Liu, Yan He
Summary: This study compared the safety and efficacy between two groups of patients with hepatic dysfunction receiving different dosages of voriconazole (400mg/day vs 200mg/day) for the treatment of invasive fungal infections. The results showed that halving the maintenance dose can ensure efficacy and safety.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, General & Internal
Youran Cai, Shimei Song, Yiying Chen, Xuyang Xu, Wenjin Zou
Summary: This study retrospectively analyzed the efficacy and safety of oral voriconazole as a primary treatment for fungal keratitis. The results indicated that oral voriconazole monotherapy was successful in patients with fungal keratitis. Patients with ulcers larger than 5 x 5 mm(2) and hypopyon were less likely to respond to this treatment.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Victoria Diaz-Tome, Carlos Bendicho-Lavilla, Xurxo Garcia-Otero, Ruben Varela-Fernandez, Manuel Martin-Pastor, Jose Llovo-Taboada, Pilar Alonso-Alonso, Pablo Aguiar, Miguel Gonzalez-Barcia, Anxo Fernandez-Ferreiro, Francisco J. Otero-Espinar
Summary: The study developed natamycin/voriconazole formulations to improve the treatment of fungal keratitis by enhancing the solubility, permanence, and safety of natamycin. These formulations demonstrated improved corneal permeability and antifungal activity, suggesting their potential significance in treating fungal keratitis.
Article
Infectious Diseases
L. Ostrosky-Zeichner, M. H. Nguyen, J. Bubalo, B. D. Alexander, M. H. Miceli, P. G. Pappas, J. Jiang, Y. Song, G. R. Thompson
Summary: This study evaluated the usage of mold-active triazoles (MATs) in the treatment of invasive fungal infections (IFIs) through a real-world disease registry. The results showed that most patients completed their MAT therapy and had a successful response, and prophylaxis patients did not develop breakthrough IFIs. Adverse drug reactions were uncommon.
INFECTIOUS DISEASES AND THERAPY
(2022)
Review
Gastroenterology & Hepatology
Phillipp Hartmann, Bernd Schnabl
Summary: Liver and biliary diseases have a significant impact on global health, with the intestinal bacterial microbiome playing a well-established role. However, the role of the fungal microbiome, or mycobiome, has been overlooked for a long time. Recent studies have highlighted the importance of the mycobiome in hepatobiliary diseases, particularly the involvement of the Candida genus. This article compares colonization and infection, describes mycobiome findings in healthy and diseased states, and discusses the potential for modulating the gut mycobiome to improve hepatobiliary conditions.
JOURNAL OF HEPATOLOGY
(2023)
Article
Infectious Diseases
Haotian Yang, Runxuan Du, Xiaoqing Xing, Ying Li, Bo Qiu
Summary: This study aims to investigate the correlation between the administered dose of voriconazole and its efficacy in treating invasive fungal infection. The results showed a significant correlation between the steady-state serum trough concentration of voriconazole and treatment efficacy. There was also a significant positive correlation between the steady-state trough serum concentration and the administered dose of voriconazole.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Review
Medicine, General & Internal
George R. Thompson, Jo-Anne H. Young
Summary: Aspergillosis is an opportunistic fungal infection that poses a particular risk for patients with neutrophil defects and causes diverse clinical syndromes. This review discusses current understanding and advances in diagnosis and treatment of aspergillosis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Na Liu, Jie Tu, Yahui Huang, Wanzhen Yang, Qingwen Wang, Zhuang Li, Chunquan Sheng
Summary: Invasive fungal infections (IFIs) are a serious public health threat with high incidence and mortality, especially in cancer patients undergoing chemotherapy. However, the limited availability of effective and safe antifungal agents, coupled with the development of drug resistance, hinders successful antifungal therapy. Therefore, new antifungal agents with novel modes of action, favorable pharmacokinetic profiles, and anti-resistance activity are urgently needed. This review summarizes new antifungal targets, target-based inhibitor design, and prodrug design strategies to improve the physicochemical and pharmacokinetic properties of antifungal agents. Dual-targeting antifungal agents offer a promising strategy for the treatment of resistant infections and cancer-associated fungal infections.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Immunology
Emmanuel Roilides, Fabianne Carlesse, Heidi Leister-Tebbe, Umberto Conte, Jean L. Yan, Ping Liu, Margaret Tawadrous, Jalal A. Aram, Flavio Queiroz-Telles, Natalia Dmitrieva, Sandra Arnold, Antonio Arrieta, Fabio Motta, Cheng-Hsun Chiu, Giuseppe Gentile, Chuhl Joo Lyu, Brian Patrick Lee, Marc Mazade, Vassiliki Syriopoulou, Jeffery Auletta, Audra Deveikis, Jaime Deville, Jong Jin Seo, Alexey Maschan, Josep Sanchez De Toledo Codina, Kang-Hsi Wu
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2019)
Article
Infectious Diseases
Wolfgang W. Wicha, William A. Craig, David Andes
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Public, Environmental & Occupational Health
Jeremy S. Stultz, Sandra R. Arnold, Chasity M. Shelton, Bindiya Bagga, Kelley R. Lee
AMERICAN JOURNAL OF INFECTION CONTROL
(2019)
Article
Microbiology
Angelica de L. Rodriguez Lopez, Myung-Ryul Lee, Nathan B. Wang, Kaitlin K. Dunn, Hiram Sanchez, Namrata Raman, David R. Andes, David M. Lynn, Sean P. Palecek
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Pediatrics
Cristin Q. Fritz, Kathryn M. Edwards, Wesley H. Self, Carlos G. Grijalva, Yuwei Zhu, Sandra R. Arnold, Jonathan A. McCullers, Krow Ampofo, Andrew T. Pavia, Richard G. Wunderink, Evan J. Anderson, Anna M. Bramley, Seema Jain, Derek J. Williams
Article
Microbiology
Alexander J. Lepak, Miao Zhao, Karen Marchillo, Jamie VanHecker, David R. Andes
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Editorial Material
Immunology
David Andes
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Immunology
Leigh M. Howard, Kathryn M. Edwards, Yuwei Zhu, Carlos G. Grijalva, Wesley H. Self, Seema Jain, Krow Ampofo, Andrew T. Pavia, Sandra R. Arnold, Jonathan A. McCullers, Evan J. Anderson, Richard G. Wunderink, Derek J. Williams
Summary: Clinical features did not reliably distinguish HMPV-associated pneumonia from other pathogens. HMPV-associated pneumonia was less severe than bacterial and adult RSV pneumonia, but was otherwise as or more severe than other common pathogens.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Leigh M. Howard, Kathryn M. Edwards, Yuwei Zhu, Derek J. Williams, Wesley H. Self, Seema Jain, Krow Ampofo, Andrew T. Pavia, Sandra R. Arnold, Jonathan A. McCullers, Evan J. Anderson, Richard G. Wunderink, Carlos G. Grijalva
Summary: The study found that PIV was more commonly detected in children, but often co-detected with other pathogens. Clinical features of PIV-1, PIV-2, and PIV-3 infections were similar in children and adult pneumonia patients. In children, PIV pneumonia was less severe than bacterial pneumonia.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Jeremy S. Stultz, Tabitha Bice, Kimberly Johnstone, Connor M. Stuart, Chasity M. Shelton, Sandra R. Arnold, Bindiya Bagga, Kelley R. Lee
Summary: The study found that the susceptibility of AmpC organisms to TGC was negatively correlated with TGC utilization, and limiting TGC exposure to <= 48 hours may help reduce resistance of AmpC organisms in future infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Medicine, Research & Experimental
Tonny J. Oyana, Jagila Minso, Tamekia L. Jones, Jonathan A. McCullers, Sandra R. Arnold, Stephania A. Cormier
Summary: This study investigated the geospatial patterns of community-acquired pneumonia in children and found an association between PM2.5 exposure and high-risk areas for pneumonia. Children with private insurance and bacterial infections had a decreased risk of residing in high-risk areas for pneumonia.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Infectious Diseases
Kathryn P. Goggin, Nicholas Beckmann, Kristen Bettin, Maria Carrillo-Marquez, Joshua Wood, Sandra R. Arnold
Summary: The article describes a patient whose exposure history became significant upon obtaining 16S next generation sequencing results from a surgical specimen, revealing a novel pathogen Bacteroides pyogenes. The exposure history of the pathogen plays an important role in diagnosis and treatment.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Infectious Diseases
Charles R. Woods, John S. Bradley, Archana Chatterjee, Lawson A. Copley, Joan Robinson, Matthew P. Kronman, Antonio Arrieta, Sandra L. Fowler, Christopher Harrison, Maria A. Carrillo-Marquez, Sandra R. Arnold, Stephen C. Eppes, Laura P. Stadler, Coburn H. Allen, Lynnette J. Mazur, C. Buddy Creech, Samir S. Shah, Theoklis Zaoutis, David S. Feldman, Valery Lavergne
Summary: This clinical practice guideline for the diagnosis and treatment of acute hematogenous osteomyelitis in children was developed by a multidisciplinary panel representing PIDS and IDSA. The recommendations are based on evidence from systematic literature reviews and follow a standardized methodology for rating the certainty of the evidence and strength of recommendation using the GRADE approach.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Jeremy S. Stultz, Natalie Francis, Samantha Ketron, Bindiya Bagga, Chasity M. Shelton, Kelley R. Lee, Sandra R. Arnold
Summary: The study found that using narrow-spectrum antibiotics for pediatric UTI treatment is an appropriate choice, and factors such as age, circumcision status, ethnicity, and recent hospitalization are associated with antibiotic susceptibility. In addition, factors like urine white blood cell count and having only one narrow-spectrum treatment option are related to the use of unnecessarily broad-spectrum antibiotics for treatment.
JOURNAL OF PHARMACY TECHNOLOGY
(2021)
Meeting Abstract
Psychology, Developmental
Cliff Costello, Taylor Mobley, Sandra Arnold, Michelle Bowden
JOURNAL OF ADOLESCENT HEALTH
(2020)
