☆ 4.7 Article

VIM-15 and VIM-16, two new VIM-2-like metallo-β-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Volume 52, Issue 8, Pages 2977-2979

Publisher

AMER SOC MICROBIOLOGY

DOI: 10.1128/AAC.00175-08

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Microbiology Pharmacology & Pharmacy

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Abstract

Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.

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