Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 92, Issue 1, Pages 9-12Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.14-0140
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Funding
- FIC NIH HHS [D43 TW001589] Funding Source: Medline
- NIAID NIH HHS [R01 AI095916, R01 AI093635] Funding Source: Medline
- NIGMS NIH HHS [R25 GM055036] Funding Source: Medline
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Parasite antigen diversity poses an obstacle to developing an effective malaria vaccine. A protein microarray containing Plasmodium falciparum apical membrane antigen 1 (AMA1, n = 57) and merozoite surface protein 1 19-kD (MSP1(19), n = 10) variants prevalent at a malaria vaccine testing site in Bandiagara, Mali, was used to assess changes in seroreactivity caused by seasonal and lifetime exposure to malaria. Malian adults had significantly higher magnitude and breadth of seroreactivity to variants of both antigens than did Malian children. Seroreactivity increased over the course of the malaria season in children and adults, but the difference was more dramatic in children. These results help to validate diversity-covering protein microarrays as a promising tool for measuring the breadth of antibody responses to highly variant proteins, and demonstrate the potential of this new tool to help guide the development of malaria vaccines with strain-transcending efficacy.
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