Efficacy of platinum-based chemotherapy in triple-negative breast cancer patients with metastases confined to the lungs: a single-institute experience

The role of platinum-based chemotherapy (PBCT) in the treatment of triple-negative breast cancer (TN BC) is still undetermined. The aim of this study was to compare the efficacy of PBCT versus non-PBCT in patients with lung metastasis from TN BC. Clinical data on patients diagnosed and treated for lung metastasis from TNBC between 2004 and 2012 at the Cancer Institute and Hospital, Chinese Academy of Medical Sciences, were retrospectively analyzed. Of the 79 patients identified, 34 received PBCT and 45 received non-PBCT. The median progression-free survival was 10 months [95% confidence interval (Cl) 6.6-13.4 months] in the platinum-based group and 5 months (95% Cl 3.7-6.3 months) in the nonplatinum group (P=0.002); overall survival was also significantly improved (32 vs. 21 months, P = 0.002). In the multivariate analysis for the entire cohort, first-line PBCT (hazard ratio 0.425; 95% Cl 0.251-0.720; P = 0.001) and presentation of symptoms related to lung metastasis (hazard ratio 2.237; 95% Cl 1.180-4.240; P = 0.014) were associated independently with survival. Our results support the use of PBCT in the first-line treatment of lung metastasis from TN BC. Anti-Cancer Drugs 25:1089-1094 (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.