Article
Oncology
Katsuaki Yoneda, Miyu Fujii, Aoi Imaoka, Remi Kobayashi, Ryoya Hayashi, Yuya Yoshida, Takeyuki Kohno, Takumi Tsuji
Summary: Our study demonstrated that treatment with EDR reduced hair loss caused by CPA in a dose-independent manner above 3%, indicating potential applications beyond chemotherapy. The EDR 3% and EDR 30% groups showed higher hair coverage scores and larger hair follicle areas compared to the EDR 0% group, along with increased IGF-1 expression levels in dermal papilla cells, suggesting a preventive effect against CIA.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Dermatology
Jessica Mounessa, Joseph V. Caravaglio, Renee Domozych, Stephanie Chapman, Robert P. Dellavalle, Cory A. Dunnick, David Norris
Summary: This study investigated commonly prescribed medications associated with alopecia and identified 13 drugs with strong evidence supporting their association with hair loss. Few high-level evidence studies have been conducted on this topic. Further research is needed to understand the mechanisms of hair loss for effective management.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Iain S. Haslam, GuiXuan Zhou, GuoJiang Xie, Xu Teng, XiuLan Ao, ZhiPeng Yan, Eleanor Smart, David Rutkowski, Justyna Wierzbicka, YongJian Zhou, Zhen Huang, YanDing Zhang, Nilofer Farjo, Bessam Farjo, Ralf Paus, ZhiCao Yue
Summary: Chemotherapy-induced hair loss (CIA) is a major issue in clinical oncology. Research has shown that downregulation of the Shh signaling pathway in hair follicles is a critical early event in CIA. Inhibition of Shh signaling leads to hair loss, while activation of the MAPK pathway is a key upstream event that can be manipulated to rescue CIA. Targeting the intrafollicular MAPK-Shh axis may provide a promising strategy for managing CIA.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Eunjin Lee, Mingyu Kim, You Jeong Lee
Summary: Alopecia areata (AA) is a common autoimmune disease characterized by the destruction of hair follicles in the skin. Expanded Tregs alone are insufficient for the treatment of AA and require combined immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Oncology
Versha A. Pleasant, Ava S. Purkiss, Sofia D. Merjaver
Summary: Chemotherapy-induced alopecia (CIA) is a devastating side effect of breast cancer treatment that affects all racial groups, but holds unique historical, social, political, and cultural significance for Black patients. Oncologists should strive to understand the impact of CIA on their Black patients.
Article
Oncology
Stacy D'Andre, Sean McAllister, Jasdeepa Nagi, Karthik Giridhar, Eduardo Ruiz-Macias, Charles Loprinzi
Summary: Topical cannabinoids may be helpful for patients with chemotherapy-induced peripheral neuropathy, with further research needed to determine their efficacy and mechanisms of action.
INTEGRATIVE CANCER THERAPIES
(2021)
Article
Biology
Lucas Solyano Almeida de Oliveira, Sara Raquel de Moura Bandeira, Rodrigo Lopes Gomes Goncalves, Benedito Pereira de Sousa Neto, Diana Carvalho de Rezende, Antonio Carlos dos Reis-Filho, Ian Jhemes Oliveira Sousa, Flaviano Ribeiro Pinheiro-Neto, Boris Timah Acha, Gabriela do Nascimento Caldas Trindade, Lazaro Gomes do Nascimento, Damiao Pergentino de Sousa, Fernanda Regina de Castro Almeida, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo, Francisco de Assis Oliveira
Summary: The study found that isopropyl gallate (IPG) can alleviate ifosfamide (IFOS)-induced hemorrhagic cystitis by enhancing antioxidant activity and anti-inflammatory mechanisms. This suggests that IPG may be a promising adjuvant therapy for oxazaphosphorine-based chemotherapy treatments.
Article
Oncology
Yosuke Aoyama, Eri Hoshino, Akihiko Shimomura, Chikako Shimizu, Tomoko Taniyama, Manami Tada, Nao Yoshida, Hitomi Sato, Kiyomi Nonogaki, Kazumasa Yamamoto, Taro Yamanaka, Rika Kizawa, Takeshi Yamaguchi, Kiyo Tanaka, Yoko Kobayashi, Nobuko Tamura, Yuko Tanabe, Yuji Miura, Yuichiro Kikawa, Juhee Cho, Hidetaka Kawabata
Summary: The study confirmed the psychometric validity of the Japanese version of CADS (CADS-J) for assessing distress associated with Chemotherapy-induced alopecia (CIA), indicating its potential use in daily practice and research studies.
Article
Behavioral Sciences
Anish A. Sarkar, David M. Allyn, Rona J. Delay, Eugene R. Delay
Summary: Taste buds in the oral cavity have a complex immune system that regulates normal functions and inflammatory reactions. Cyclophosphamide disrupts the taste system, inducing inflammation in taste buds and affecting taste function. Pretreatment with the antioxidant drug amifostine may reduce the adverse effects of CYP on the taste system.
Article
Oncology
Anne Versluis, Kirsten van Alphen, Wouter Dercksen, Henk de Haas, Corina van den Hurk, Ad A. Kaptein
Summary: Objective Chemotherapy-induced alopecia (CIA) is a common and distressing side effect of chemotherapy treatment. This study aimed to assess the illness perceptions of female patients dealing with CIA and their associations with various factors. The results indicated that patients understood their hair loss but lacked understanding of managing it, negatively impacting their lives. The study also compared the illness perceptions of patients with CIA to other samples and found that patients with CIA felt less able to manage their hair loss.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Environmental Sciences
Reem S. Alruhaimi
Summary: This study investigated the role of arbutin (ARB) against cyclophosphamide (CP)-mediated oxidative and inflammatory reactions and hepatotoxicity. The results revealed that ARB exerted a protective effect on CP-induced liver injury by modulating the Nrf2/HO-1 pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Medicinal
Mi Hye Kim, Sang Jun Park, Woong Mo Yang
Summary: This study confirmed the pharmacological relevance of Decursin in chemotherapy-induced alopecia, demonstrating its significant promotion of hair growth and restoration of hair follicles. Decursin can impact various biological processes, including cellular response to chemical stimulus, apoptosis, PI3K-AKT signaling pathway, and MAPK signaling pathway.
Article
Dermatology
Davide Fattore, Vincenzo Picone, Maria Vastarella, Gabriella Fabbrocini, Maria Teresa Cantelli
Summary: Radiation-induced alopecia (RIA) is a side effect of cranial radiation therapy, which can be temporary or permanent. Proton therapy (PT) is a specific type of radiation therapy used in the treatment of brain tumors and can sometimes cause proton-induced alopecia (PIA), a rare subtype of RIA. This article reports a case of PIA in a patient following PT treatment for a meningioma of the frontal region.
SKIN APPENDAGE DISORDERS
(2023)
Article
Biochemical Research Methods
Jiahong Han, Nian Sun, Junjia Xing, Xuan Fei, Enbo Cai, Fengyan Su
Summary: Specnuezhenide has a therapeutic effect on chemotherapy-induced myelosuppression. It promotes the proliferation and differentiation of hematopoietic progenitor cells, regulates the cell cycle and cytokine expression, and increases the expression levels of key proteins in the MAPK signaling pathway.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Cell Biology
Yingyan Chen, Leilei Ai, Yingyi Zhang, Xiang Li, Shiqian Xu, Weijie Yang, Jiamin Jin, Yerong Ma, Zhanhong Hu, Yinli Zhang, Yan Rong, Songying Zhang
Summary: This study reveals the association between epigenetic regulation and CTX-induced ovarian damage. Decreased EZH2 and H3K27me3 levels lead to increased apoptosis of GCs. The H3K27me3-demethylase inhibitor, GSK-J4, shows promise in mitigating GC apoptosis and abnormal gene upregulation, thus potentially protecting female fertility during chemotherapy.
CELL DEATH DISCOVERY
(2023)
Article
Biotechnology & Applied Microbiology
McKinzie Fruchtl, Joshua Sakon, Robert Beitle
BIOTECHNOLOGY PROGRESS
(2015)
Article
Biochemical Research Methods
Ryan Bauer, Katarzyna Janowska, Kelly Taylor, Brad Jordan, Steve Gann, Tomasz Janowski, Ethan C. Latimer, Osamu Matsushita, Joshua Sakon
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
McKinzie Fruchtl, Joshua Sakon, Robert Beitle
JOURNAL OF BIOTECHNOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Nalinikanth Kotagiri, Joshua Sakon, Haewook Han, Vladimir P. Zharov, Jin-Woo Kim
Article
Oncology
Ranjitha Katikaneni, Tulasi Ponnapakkam, Andrew Seymour, Joshua Sakon, Robert Gensure
Review
Pharmacology & Pharmacy
T. Ponnapakkam, R. Katikaneni, J. Sakon, R. Stratford, R. C. Gensure
DRUG DISCOVERY TODAY
(2014)
Article
Biochemistry & Molecular Biology
Perry Caviness, Ryan Bauer, Keisuke Tanaka, Katarzyna Janowska, Jeffrey Randall Roeser, Dawn Harter, Jes Sanders, Christopher Ruth, Osamu Matsushita, Joshua Sakon
Article
Chemistry, Medicinal
Robert Stratford, Christopher Vu, Joshua Sakon, Ranjitha Katikaneni, Robert Gensure, Tulasi Ponnapakkam
JOURNAL OF PHARMACEUTICAL SCIENCES
(2014)
Article
Materials Science, Paper & Wood
Kalavathy Rajan, Angele Djioleu, Gurshagan Kandhola, Nicole Labbe, Joshua Sakon, Danielle Julie Carrier, Jin-Woo Kim
Article
Materials Science, Paper & Wood
Gurshagan Kandhola, Angele Djioleu, Kalavathy Rajan, Joseph Batta-Mpouma, Nicole Labbe, Joshua Sakon, Benjamin A. Babst, Anindya Ghosh, Danielle Julie Carrier, Jin-Woo Kim
Summary: Cellulose nanocrystals (CNCs) are renewable and biocompatible nanomaterials with unique properties. The production and properties of CNCs from different wood species were investigated. The results showed that the type of wood species had an impact on the yield, purity, and properties of CNCs. This study provides insights into optimizing CNC production and usage for different applications.
Article
Biochemistry & Molecular Biology
Jin-Woo Kim, Joseph Batta-Mpouma, Gurshagan Kandhola, Joshua Sakon
Summary: Cellulose nanocrystals (CNCs) can be crosslinked to form nanoparticle-based hydrogels with tunable physicochemical properties, which improves the instability issue of CNCs in moist environments. The strength of intermolecular hydrogen bonding can be controlled by the type and concentration of crosslinkers as well as the CNC concentration. By changing the crosslinking conditions, the surface chemistry of CNCs can be transformed from hydrophilic to hydrophobic, and the topology and aqueous stability of self-assembled structures can be tuned.
Article
Biotechnology & Applied Microbiology
Gurshagan Kandhola, Angele Djioleu, Kalavathy Rajan, Nicole Labbe, Joshua Sakon, Danielle Julie Carrier, Jin-Woo Kim
BIORESOURCES AND BIOPROCESSING
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Ryan Bauer, Katarzyna Janowska, Keisuke Tanaka, Osamu Matsushita, Joshua Sakon
Meeting Abstract
Biochemistry & Molecular Biology
Perry Carter Caviness, Takaki Koide, Osamu Matsushita, Joshua Sakon
Meeting Abstract
Biochemistry & Molecular Biology
Christopher Eric Ruth, Joshua Sakon