Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kangsan Kim, Qinbo Zhou, Alana Christie, Christina Stevens, Yuanqing Ma, Oreoluwa Onabolu, Suneetha Chintalapati, Tiffani Mckenzie, Vanina Toffessi Tcheuyap, Layton Woolford, He Zhang, Nirmish Singla, Pravat Kumar Parida, Mauricio Marquez-Palencia, Ivan Pedrosa, Vitaly Margulis, Arthur Sagalowsky, Zhiqun Xie, Tao Wang, Steffen Durinck, Zora Modrusan, Somasekar Seshagiri, Payal Kapur, James Brugarolas, Srinivas Malladi
Summary: In this study, the authors explore the determinants of vascular invasion and metastasis in RCC patients with tumor thrombi (TT). They found that tumor thrombi associated with metastases are characterized by higher grade, mTOR activation, and a particular immune contexture. TT grade is a better predictor of metastasis than overall tumor grade.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Claudia Curci, Angela Picerno, Nada Chaoul, Alessandra Stasi, Giuseppe De Palma, Rossana Franzin, Paola Pontrelli, Giuseppe Castellano, Giovanni B. Pertosa, Luigi Macchia, Vito Francesco Di Lorenzo, Carlo Sabba, Anna Gallone, Loreto Gesualdo, Fabio Sallustio
Summary: Studies have shown that Adult Renal Stem/Progenitor Cells (ARPCs) can regulate immune responses by inducing Tregs and DN T cell modulation, which play a crucial role in maintaining immune tolerance and preventing autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sebastian Bittner, Brigitte Ruhland, Veronika Hofmann, Lisa Schmidleithner, Kathrin Schambeck, Asmita Pant, Philipp Stueve, Michael Delacher, Bernd Echtenacher, Matthias Edinger, Petra Hoffmann, Michael Rehli, Claudia Gebhard, Nicholas Strieder, Thomas Hehlgans, Markus Feuerer
Summary: In this study, the researchers introduced synthetic biosensors called artificial immune receptors (AIRs) to modulate regulatory T cells (Treg cells). These AIRs enable Treg cells to sense inflammation and activate specific signaling pathways. In animal models, Treg cells expressing AIRs provided better protection against graft-versus-host disease compared to control Treg cells. The expression and signaling of these artificial immune receptors in human Treg cells suggest the potential application of Treg cell-based therapy for various inflammation-driven diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Zhilin Long, Chengfang Sun, Min Tang, Yin Wang, Jiayan Ma, Jichuan Yu, Jingchao Wei, Jianzhu Ma, Bohan Wang, Qi Xie, Jiaming Wen
Summary: This study characterized the cellular architecture and gene regulatory features of clear cell renal cell carcinoma (ccRCC) using single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq). Key transcription factors (TFs) and their prognostic significance were identified, and targeting these TFs decreased tumor cell proliferation. Additionally, the study analyzed the regulatory elements and intercellular communications within the tumor microenvironment. The findings provide insights into the cellular heterogeneity of ccRCC and potential therapeutic targets.
Article
Medicine, General & Internal
Dana E. Rollison, Jane L. Messina, Basil S. Cherpelis, Neil A. Fenske, Michael J. Schell, Dennis O. Adeegbe, Yayi Zhao, Rossybelle P. Amorrortu, Afua A. Akuffo, Rebecca S. Hesterberg, Pearlie K. Epling-Burnette
Summary: Higher levels of circulating CCR4(hi) Tregs are associated with an increased risk of subsequent cuSCC, especially among highly UV-exposed individuals. This suggests potential opportunities for screening, prevention, and treatment based on the biology of Tregs in UVR-associated skin damage.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jinxin Li, Huimin Sun, Meiling Fu, Zeyuan Zheng, Chunlan Xu, Kunao Yang, Yankuo Liu, Zuodong Xuan, Yang Bai, Jianzhong Zheng, Yue Zhao, Zhiyuan Shi, Chen Shao
Summary: This study demonstrates that high expression of TOPK in RCC promotes PD-L1 expression by activating ERK2 and TGF-beta/Smad pathways. TOPK is also shown to inhibit CD8(+) T cell infiltration and function, promoting immune escape in RCC. Inhibition of TOPK enhances CD8(+) T cell infiltration, activation, anti-PD-L1 therapeutic efficacy, and synergistically enhances anti-RCC immune response.
Article
Oncology
Ling Ding, Yuning Yang, Yang Ge, Qin Lu, Zixing Yan, Xuzheng Chen, Jian Du, Sassan Hafizi, Xiaohui Xu, Jiannan Yao, Jian Liu, Zhiyun Cao, Nathaniel Weygant
Summary: This study demonstrates that the small molecule kinase inhibitor DCLK1-IN-1 effectively inhibits DCLK1 phosphorylation and stemness related properties of RCC cells, showing potential as an immunotherapy agent and in combination therapy with anti-PD1. Clinical analysis suggests that DCLK1 predicts RCC survival and its expression is correlated with immune cell infiltration and immunosuppressive macrophage populations.
Article
Oncology
Khalid W. Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G. Jegga, Yi Zheng, Fukun Guo
Summary: Targeting Cdc42 in Treg cells has shown promising therapeutic potential in cancer immunotherapy, by enhancing antitumor T-cell immunity without triggering autoimmune reactions. This approach involves inducing Treg cell instability through Cdc42 targeting, leading to improved immune responses against tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Summary: Regulatory T cells play a crucial role in controlling autoimmunity and inflammation. Inhibiting the Itk signaling pathway can increase the frequency of noncanonical Tregs and reduce the incidence of acute graft-versus-host disease without affecting graft-versus-leukemia effects. Targeting Itk signaling could be a potential therapeutic strategy for autoimmune disorders.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Sara Ness, Shiming Lin, John R. Gordon
Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Ke Wu, Xinyi Zheng, Zhixian Yao, Zhong Zheng, Wenjie Huang, Xingyu Mu, Feng Sun, Zhihong Liu, Junhua Zheng
Summary: Research indicates that CD45RO+CD8+ T cells play a critical role in inhibiting the progression of clear cell renal carcinoma (ccRCC) through multiple signaling pathways, demonstrating significant clinical importance as potential indicators in ccRCC patients.
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Article
Oncology
Fangzhou Li, Xufeng Peng, Jiale Zhou, Qi Chen, Yonghui Chen
Summary: This study evaluated the role and expression of MEK5 signaling in ccRCC and determined its relevance to the mTOR signaling pathway. The results showed that MEK5 expression was significantly increased in ccRCC and activated the mTOR pathway, regulating cell proliferation, migration, and clone formation in ccRCC. Targeted inhibition of MEK5 may represent a promising new strategy for treating ccRCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Immunology
Etienne Masle-Farquhar, Yogesh Jeelall, Jacqueline White, Julia Bier, Elissa K. Deenick, Robert Brink, Keisuke Horikawa, Christopher Carl Goodnow
Summary: This study investigated the effects of CARD11 gene mutations on B and T lymphocytes in a disease associated with B cell expansion and T cell anergy, as well as in certain lymphomas. The results showed that the mutations increased the activation and proliferation of B and T lymphocytes following antigen receptor stimulation, and led to increased expression of checkpoint molecules on T cells. This study reveals CARD11 as an important positive regulator of T cells and highlights the cell-intrinsic effects of CARD11 mutations on T cell malignancies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Jana Ihlow, Sophia Gross, Leonie Busack, Anne Floercken, Julia Jesse, Michaela Schwarz, Nina Rosa Neuendorff, Ann-Christin Von Bruenneck, Ioannis Anagnostopoulos, Seval Tuerkmen, Igor Wolfgang Blau, Thomas Burmeister, David Horst, Lars Bullinger, Joerg Westermann
Summary: This retrospective study analyzed the prognostic impact of early bone marrow assessment in 1,008 newly diagnosed acute myeloid leukemia patients. It found that early blast persistence had a negative prognostic impact on overall survival, event-free survival, and relapse-free survival. However, patients who achieved at least partial remission and subsequent blast clearance showed improved outcomes. The study suggests that the time slope of remission can inform post-induction therapy decision-making.
Letter
Peripheral Vascular Disease
Lajos Marko, Anne Dorr, Peter Linz, Anton H. van den Meiracker, Ingrid M. Garrelds, Titus Kuehne, Ralf Dechend, A. H. Jan Danser, Anne Floercken, Dominik N. Mueller
Meeting Abstract
Oncology
Viktor Grunwald, Martin Boegemann, Mohammad-Reza Rafiyan, Guenter Niegisch, Marco Julius Schnabel, Anne Florcken, Christoph Maintz, Mark-Oliver Zahn, Anke Wortmann, Andreas Hinkel, Jochen Casper, Christopher Darr, Thomas Hilser, Matthias Schulze, Disorn Sookthai, Caroline Schoenherr, Philipp Ivanyi
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
M. Johannsen, C. Stoll, M. Raida, B. van Oorschot, A. Floercken
Summary: This article is part of the German interdisciplinary S3-guideline focusing on providing guidance on supportive therapy and complementary medicine for patients with advanced or metastatic renal cell carcinoma. It emphasizes the importance of palliative care and pain management for these patients.
WORLD JOURNAL OF UROLOGY
(2022)
Editorial Material
Oncology
Julia Gogolok, Anne Floercken
Article
Oncology
Jana Kaethe Striefler, Maren Schmiester, Franziska Brandes, Anne Doerr, Stefan Pahl, David Kaul, Daniel Rau, Eva-Maria Dobrindt, Georgios Koulaxouzidis, Lars Bullinger, Sven Maerdian, Anne Floercken
Summary: This retrospective analysis of adult Ewing family of tumors patients found that age, tumor size, and metastasis status have an impact on clinical presentation and outcomes. Older patients may have poorer prognosis. Further studies are needed to explore optimized treatment protocols for adult EFT patients.
Article
Oncology
Marta Kobus, Siyer Roohani, Felix Ehret, Anne Floercken, Jana Kaethe Striefler, Franziska Brandes, Sven Maerdian, Daniel Rau, Silvan Wittenberg, Robert Oellinger, David Kaul
Summary: This study evaluated the predictors of outcome in patients with localized high-grade STS. The results suggest that neoadjuvant RCT may improve local control and freedom from distant metastases in these patients, but it is also associated with increased toxicities.
RADIATION ONCOLOGY
(2022)
Review
Oncology
Siyer Roohani, Felix Ehret, Marta Kobus, Anne Floercken, Sven Maerdian, Jana Kaethe Striefler, Daniel Rau, Robert Oellinger, Armin Jarosch, Volker Budach, David Kaul
Summary: This systematic review summarizes the current evidence on preoperative hypofractionated radiotherapy (HFRT) for the treatment of soft tissue sarcomas (STS). The results show that HFRT courses do not increase adverse events rates compared to normofractionated radiotherapy and may improve therapy adherence and cost-effectiveness. The evidence is mostly derived from retrospective data and phase II trials, and there is a lack of published randomized phase III trials comparing normofractionated and HFRT in STS.
RADIATION ONCOLOGY
(2022)
Meeting Abstract
Hematology
Sophia Gross, Jana Ihlow, Leonie Busack, Kacper Adamiak, Jens F. Schrezenmeier, Julia Jesse, Michaela Schwarz, Anne Floercken, Kathrin Rieger, Jan Kronke, Philipp le Coutre, Vivien Boldt, Ann-Christin Von Bruenneck, David Horst, Thomas Burmeister, Igor Wolfgang Blau, Ulrich Keller, Lars Bullinger, Joerg Westermann
Article
Oncology
Eva Roser, Philipp Harter, Dario Zocholl, Dominik Denschlag, Radoslav Chekerov, Pauline Wimberger, Christian Kurzeder, Annette Hasenburg, Mustafa-Zelal Muallem, Alexander Mustea, Guenter Emons, A. G. Zeimet, Felix Beck, Tjadina Arndt, Sara Y. Brucker, Stefan Kommoss, Florian Heitz, Julia Welz, Eva-Katharina Egger, Matthias Kalder, Paul Buderath, Maximilian Klar, Christian Marth, Uwe Andreas Ulrich, Michael Weigel, Lea Traub, Christoph Anthuber, Hans Strauss, Lars Hanker, Theresa Link, Karol Kubiak, Badrig Melekian, Daniela Hornung, Martin Poelcher, Bjoern Lampe, Thomas Krauss, Ulrich Keilholz, Anne Floercken, Klaus Pietzner, Jalid Sehouli
Summary: This study aimed to describe the treatment strategies used in patients with gynecological sarcomas. The results showed heterogeneous treatment methods, and further research is needed to implement new treatment strategies.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Siyer Roohani, Felix Ehret, Eilis Perez, David Capper, Armin Jarosch, Anne Floercken, Sven Maerdian, Daniel Zips, David Kaul
Summary: This study describes the clinical course of five sarcoma patients who underwent DNA methylation-based profiling and the impact of the sarcoma classifier on treatment decisions. The results show that the sarcoma classifier can assist in diagnosis and guide treatment decisions in certain cases.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Jana K. Striefler, Phung T. Binder, Franziska Brandes, Daniel Rau, Silvan Wittenberg, David Kaul, Siyer Roohani, Armin Jarosch, Frederik M. Schaefer, Robert Oellinger, Sven Maerdian, Lars Bullinger, Kai -Uwe Eckardt, Jan Kruse, Anne Floercken
Summary: This study retrospectively analyzed sarcoma patients admitted to the ICU from 2005 to 2022. Sex, tumor localization, therapeutic intention, line of chemotherapy, SAPS II score, and SOFA score significantly impacted overall survival. The study confirms the predictive relevance of established sepsis and performance scores in sarcoma patients.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Elena Hofmann, Saskia Preissner, Moritz Hertel, Robert Preissner, Carsten Rendenbach, Anne Floercken, Max Heiland
Summary: This study aimed to evaluate the impact of adjuvant or neoadjuvant chemotherapy on the survival outcomes of patients with craniofacial bone sarcomas. The results showed that patients who received neoadjuvant chemotherapy had better survival rates compared to those who received adjuvant chemotherapy. Further randomized controlled studies are needed to validate these findings.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Viktor Gruenwald, Martin Boegemann, Reza Rafyian, Guenter Niegisch, Marco Schnabel, Anne Floercken, Michael Maasberg, Christoph Maintz, M. -O. Zahn, Anke Wortmann, Andreas Hinkel, Jochen Casper, Christopher Darr, Thomas Hilser, Matthias Schulze, Disorn Sookthai, Caroline Schonherr, Philipp Ivanyi
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Meeting Abstract
Oncology
Marit Ahrens, Bernard Escudier, John Haanen, Ekaterini Boleti, Marine Gross-Goupil, Marc-Oliver Grimm, Sylvie Negrier, Philippe Barthelemy, Gwenaelle Gravis, Philipp Ivanyi, Jens Bedke, Daniel Castellano, Andrej Panic, Begona Mellado, Pablo Maroto, Sylvie Rottey, Stefanie Zschaebitz, Anne Floercken, Martin Boegemann, Tom Waddell, Cristina Suarez Rodriguez, Anja Lorch, Dorothee Deckbar, Arndt Hartmann, Lothar Bergmann
ONCOLOGY RESEARCH AND TREATMENT
(2022)