Journal
ANTI-CANCER DRUGS
Volume 22, Issue 1, Pages 35-45Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CAD.0b013e32833fde29
Keywords
apoptosis; cell cycle; colon cancer; protopanaxadiol derivatives; semisynthesis
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Funding
- NIH/NCCAM [P01 AT004418, R21 AT003255, K01 AT005362]
- NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE [P01AT004418, K01AT005362] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [R21AT003255] Funding Source: NIH RePORTER
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Protopanaxadiol (PPD), an aglycon of ginseng saponins, has shown anticancer activity in earlier studies. Here, we have reported the semisynthesis of nine PPD derivatives with acetyl substitutions. Subsequently, the antiproliferative effects of these nine analogs on different human cancer cell lines have been investigated. Compounds 1, 3, and 5 showed more significant and more potent antiproliferative activity compared with PPD and other derivatives. A flow cytometric assay indicated that compounds 1, 3, and 5 arrested cell cycle progression in the G1 phase and significantly induced apoptosis of cancer cells. Anti-Cancer Drugs 22: 35-45 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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