Article
Biochemistry & Molecular Biology
Risa Tomioka-Inagawa, Keita Nakane, Torai Enomoto, Masayuki Tomioka, Tomoki Taniguchi, Takashi Ishida, Kaori Ozawa, Kimiaki Takagi, Hiroki Ito, Shinichi Takeuchi, Makoto Kawase, Kota Kawase, Daiki Kato, Manabu Takai, Koji Iinuma, Shigeaki Yokoi, Masahiro Nakano, Takuya Koie
Summary: This study evaluated the therapeutic effect of pembrolizumab for metastatic urothelial carcinoma and found that the neutrophil-to-lymphocyte ratio (NLR) was an important predictive factor for clinical outcomes.
Article
Medicine, General & Internal
Daniel Balan, Mihai Dorin Vartolomei, Annamaria Magdas, Noemi Balan-Bernstein, Septimiu Toader Voidazan, Orsolya Martha
Summary: In this study, it was found that bladder cancer patients with IMPROVE score greater than 4 had higher NLR, LMR, and lymphocyte values. The IMPROVE score was significantly influenced by lymphocyte count and NLR value. Patients with NMIBC with low lymphocytes and NLR > 3 were at a higher risk of developing venous thromboembolic events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Worapat Attawettayanon, Teeranop Choorit, Virote Chalieopanyarwong, Choosak Pripatnanont
Summary: NLR and PLR are useful in assessing survival outcomes of nonmetastatic RCC patients, with high PLR being an independent prognostic factor; Elevated NLR and anemia were significantly associated with cancer-specific survival.
ASIAN JOURNAL OF SURGERY
(2021)
Review
Nutrition & Dietetics
Lei Peng, Chunyang Meng, Jinze Li, Chengyu You, Yuelin Du, Wei Xiong, Zhongyou Xia, Dehong Cao, Yunxiang Li
Summary: This meta-analysis revealed that the preoperative CONUT score is a potential independent predictor of the postoperative prognosis of RCC/UTUC patients. A high CONUT predicts worse overall survival, cancer-specific survival, disease-free survival, and recurrence-free survival in patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Multidisciplinary Sciences
Jiujun Zhu, Dechuang Jiao, Yajie Zhao, Xuhui Guo, Yue Yang, Hui Xiao, Zhenzhen Liu
Summary: Neutrophils and lymphocytes play crucial roles in breast cancer development and progression. The Neutrophil to lymphocyte ratio (NLR) has been shown to be a valuable prognostic marker for evaluating BC patients. Lower baseline NLR values are associated with a higher likelihood of achieving pathological complete response (pCR) following neoadjuvant chemotherapy (NCT) treatment.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jiyun Park, Jun Park, Jung Hee Shin, Young-Lyun Oh, Hyun-Ae Jung, Man-Ki Chung, Jun-Ho Choe, Yong-Chan Ahn, Sun-Wook Kim, Jae-Hoon Chung, Tae-Hyuk Kim, Jae-Myoung Noh
Summary: The study found that high NLR before and after radiotherapy was associated with poor survival in patients with anaplastic thyroid cancer (ATC), indicating the importance of host immunity in ATC patients. This suggests that this finding may provide important information for designing future investigations on the impact of immune system modulating therapy in ATC.
Article
Oncology
Shigemasa Takamizawa, Tatsunori Shimoi, Natsuko Satomi-Tsushita, Shu Yazaki, Toshihiro Okuya, Yuki Kojima, Hitomi Sumiyoshi-Okuma, Tadaaki Nishikawa, Maki Tanioka, Kazuki Sudo, Emi Noguchi, Kan Yonemori
Summary: This study aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor for capecitabine-treated patients with metastatic or recurrent breast cancer. The results showed that NLR independently predicted progression-free survival (PFS), but not overall survival (OS), in capecitabine-treated patients, despite being a useful prognostic factor for other chemotherapies.
Article
Oncology
Mehmet Zahid Kocak, Seda Coban, Murat Araz, Melek Karakurt Eryilmaz, Mehmet Artac
Summary: The aim of this study was to determine the prognostic value of the prognostic nutritional index (PNI), the neutrophil to lymphocyte ratio (NLR), and the platelet to lymphocyte ratio (PLR) and their dynamic changes on survival outcomes in metastatic colorectal cancers (mCRC). The results showed that negative delta PNI is an independent predictor of poor prognosis in patients with colon cancer.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Qiang Hu, Weipu Mao, Tiange Wu, Zhipeng Xu, Junjie Yu, Can Wang, Saisai Chen, Shuqiu Chen, Bin Xu, Yueshuang Xu, Ming Chen
Summary: In RCC patients undergoing laparoscopic partial or radical nephrectomy, NLR and PLR were identified as biomarkers of systemic inflammation associated with increased risk of sarcopenia. The best cutoff points for predicting sarcopenia risk were NLR >2.88 and PLR >135.63, with higher levels indicating a greater risk. Adjusting for various variables, patients with NLR >2.88 and PLR >135.63 had significantly higher risks of developing sarcopenia compared to those with lower NLR or PLR levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Weelic Chong, Zhenchao Zhang, Rui Luo, Jian Gu, Jianqing Lin, Qiang Wei, Bingshan Li, Ronald Myers, Grace Lu-Yao, William Kevin Kelly, Chun Wang, Hushan Yang
Summary: In patients with detectable CTCs, the use of NLR could further classify patients into different risk groups, suggesting a complementary role for NLR in CTC-based prognostic stratification in mCRPC.
Article
Oncology
Guen Tae Kim, Eun Young Kim, Su-Hyun Shin, Hyowon Lee, Se Hee Lee, Ki-Young Sohn, Jae Wha Kim
Summary: PD-L1 antibody is an immune checkpoint inhibitor with fewer side effects and higher tumor-specific reactions. However, tumor resistance weakens the effectiveness of ICI. Therefore, developing combination therapies to enhance the anticancer effect of ICI is crucial.
Article
Oncology
Mateusz Adamkiewicz, Piotr Bryniarski, Maksymilian Kowalik, Bartlomiej Burzynski, Pawel Rajwa, Andrzej Paradysz
Summary: In this study, we found that neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are independent prognostic markers of progression. Among them, the model including stage, grade, age, gender, and LMR had the highest prognostic value (area under curve [AUC] = 0.756), with a cut-off point for LMR at 3.25.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Giovanni Salzano, Francesco Perri, Fabio Maglitto, Giulia Togo, Gianluca Renato De Fazio, Michela Apolito, Federica Calabria, Claudia Laface, Luigi Angelo Vaira, Umberto Committeri, Mario Balia, Ettore Pavone, Corrado Aversa, Francesco Antonio Salzano, Vincenzo Abbate, Alessandro Ottaiano, Marco Cascella, Mariachiara Santorsola, Roberta Fusco, Luigi Califano, Franco Ionna
Summary: This study retrospectively reviewed data of LSCC patients and found a significant correlation between high NLR values and neck occult metastasis, with an NLR value of 2.26 corresponding to a 20% probability of OM.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Jing-Houng Wang, Yen-Yang Chen, Kwong-Ming Kee, Chih-Chi Wang, Ming-Chao Tsai, Yuan-Hung Kuo, Chao-Hung Hung, Wei-Feng Li, Hsiang-Lan Lai, Yen-Hao Chen
Summary: Atezolizumab plus bevacizumab has been approved as the first-line treatment for unresectable hepatocellular carcinoma. This study examined the efficacy and safety of this treatment in real-world clinical practice and found that it is effective and well-tolerated. In addition, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were identified as independent prognostic factors for progression-free survival (PFS).
Article
Urology & Nephrology
Yoshiyuki Akiyama, Aya Niimi, Yasuhiko Igawa, Akira Nomiya, Yuta Yamada, Yusuke Sato, Taketo Kawai, Daisuke Yamada, Haruki Kume, Yukio Homma
Summary: The study evaluated the outcomes of partial and total cystectomy in patients with refractory Hunner-type interstitial cystitis (HIC). Total cystectomy provided reliable pain relief and improved quality of life, while partial cystectomy had poorer results and more complications.
LUTS-LOWER URINARY TRACT SYMPTOMS
(2022)
Article
Urology & Nephrology
Keita Kobayashi, Hideyasu Matsuyama, Taketo Kawai, Atsushi Ikeda, Makito Miyake, Koshiro Nishimoto, Yuto Matsushita, Kazumasa Komura, Takashige Abe, Haruki Kume, Hiroyuki Nishiyama, Kiyohide Fujimoto, Masafumi Oyama, Hideaki Miyake, Keiji Inoue, Takahiko Mitsui, Mutsushi Kawakita, Chikara Ohyama, Atsushi Mizokami, Hajime Kuroiwa
Summary: The study evaluated the efficacy of photodynamic diagnosis-transurethral resection of bladder tumor for high-risk non-muscle invasive bladder cancer, showing a significantly lower residual tumor rate in the photodynamic diagnosis group compared to the white-light group.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Tomoyuki Kaneko, Kazuki Yanagida, Kentaro Matsui, Masaki Kimura, Taketo Kawai, Yukio Yamada, Keisuke Ishii, Taketo Kurozumi, Takashi Suzuki, Yoshinobu Watanabe, Hirotaka Kawano, Tetsuya Sakamoto, Tohru Nakagawa
Summary: 4.5% of patients with pelvic fractures had genitourinary injuries, with bladder, kidney, urethral, and testis injuries occurring at rates of 2.0%, 1.2%, 1.2%, and 0.5%, respectively. Patients with genitourinary injuries were younger, had higher intensive care unit admission rates, longer hospital stays, and longer intensive care unit stays compared to those without such injuries. Genitourinary injuries were not associated with in-hospital mortality.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Urology & Nephrology
Katsuhiro Makino, Yusuke Sato, Ryosuke Takenaka, Hideomi Yamashita, Yoshiyuki Akiyama, Yuta Yamada, Masaki Nakamura, Taketo Kawai, Daisuke Yamada, Motofumi Suzuki, Haruki Kume
Summary: This study aimed to evaluate the incidence and predictive factors of radiation cystitis following external beam radiation therapy for prostate cancer. The results showed that radiation therapy was the sole risk factor associated with the development of radiation cystitis.
UROLOGIA INTERNATIONALIS
(2023)
Article
Oncology
Taketo Kawai, Satoru Taguchi, Tohru Nakagawa, Jun Kamei, Yu Nakamura, Daisuke Obinata, Kenya Yamaguchi, Tomoyuki Kaneko, Shigenori Kakutani, Mayuko Tokunaga, Yukari Uemura, Yusuke Sato, Yutaka Enomoto, Hiroaki Nishimatsu, Tetsuya Fujimura, Hiroshi Fukuhara, Satoru Takahashi, Haruki Kume
Summary: In this retrospective multicenter study, the association between the incidence of immune-related adverse events (irAEs) and the efficacy of pembrolizumab in urothelial carcinoma (UC) was assessed using time-dependent analysis. The study found that the occurrence of irAEs, especially grade 1-2 irAEs, could be a significant predictor of favorable prognoses in patients with UC who have undergone pembrolizumab treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Taro Teshima, Yukari Kobayashi, Taketo Kawai, Yoshihiro Kushihara, Koji Nagaoka, Jimpei Miyakawa, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Daisuke Yamada, Nobuyuki Tanaka, Tatsuhiko Tsunoda, Haruki Kume, Kazuhiro Kakimi
Summary: This study investigated the immune cell phenotypes of UC patients receiving PEM treatment and found that senescent and exhausted CD8+ T cells were correlated with other cell phenotypes but not with clinical benefit. However, decreased peripheral mMDSC counts after PEM treatment were associated with improved overall survival.
Article
Urology & Nephrology
Kazuma Sugimoto, Satoru Taguchi, Kenjiro Kishitani, Taketo Kawai, Kazuki Masuda, Yu Nakamura, Manami Kinjo, Mitsuhiro Tambo, Jimpei Miyakawa, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Daisuke Yamada, Tohru Nakagawa, Hiroshi Fukuhara, Haruki Kume
Summary: This study compared the oncological and toxicological outcomes of full-dose GC, dose-reduced GC, and GCa in real-world patients with aUC. Unlike in the clinical trial setting, there were almost no significant differences among the three regimens.
Article
Immunology
Satoru Taguchi, Taketo Kawai, Sebastiano Buti, Melissa Bersanelli, Yukari Uemura, Kenjiro Kishitani, Jimpei Miyakawa, Kazuma Sugimoto, Yu Nakamura, Fusako Niimi, Tomoyuki Kaneko, Jun Kamei, Daisuke Obinata, Kenya Yamaguchi, Shigenori Kakutani, Koichiro Kanazawa, Yuriko Sugihara, Mayuko Tokunaga, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Daisuke Yamada, Yutaka Enomoto, Hiroaki Nishimatsu, Tetsuya Fujimura, Hiroshi Fukuhara, Tohru Nakagawa, Satoru Takahashi, Haruki Kume
Summary: This study aimed to validate a "drug score" for assessing patients with urothelial carcinoma receiving immunotherapy. The results showed that the drug score classified patients into three risk groups with significantly different survivals. The score was validated in bladder cancer but not in upper-tract urothelial cancer.
Article
Multidisciplinary Sciences
Yuji Hakozaki, Yuta Yamada, Yuta Takeshima, Satoru Taguchi, Taketo Kawai, Masaki Nakamura, Takuya Iwaki, Taro Teshima, Yoshitaka Kinoshita, Yoshiyuki Akiyama, Yusuke Sato, Daisuke Yamada, Motofumi Suzuki, Haruki Kume
Summary: The study aimed to identify prognostic factors in metastatic castration-resistant prostate cancer (mCRPC) patients and propose a new risk model. Clinical data of 102 mCRPC patients who received treatment between 2005 and 2018 at the University of Tokyo Hospital were retrospectively analyzed. The study found that low hemoglobin levels, short time to nadir PSA, and rapid PSA doubling time were independent prognostic factors for overall survival (OS).
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Satoru Taguchi, Taketo Kawai, Yoshiki Ambe, Kenjiro Kishitani, Kazuma Sugimoto, Jimpei Miyakawa, Yu Nakamura, Michio Noda, Tomoyuki Kaneko, Jun Kamei, Daisuke Obinata, Kenya Yamaguchi, Shigenori Kakutani, Yoshitsune Furuya, Yujiro Sato, Yukari Uemura, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Daisuke Yamada, Yutaka Enomoto, Hiroaki Nishimatsu, Tetsuya Fujimura, Hiroshi Fukuhara, Tohru Nakagawa, Satoru Takahashi, Haruki Kume
Summary: Enfortumab vedotin (EV) was found to be superior to non-platinum-based chemotherapy as later-line treatment for advanced urothelial carcinoma. However, this study compared EV with platinum rechallenge and found similar oncological outcomes between the two treatments.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Yoshiyuki Akiyama, Aya Niimi, Akira Nomiya, Satoru Taguchi, Yuta Yamada, Yusuke Sato, Taketo Kawai, Daisuke Yamada, Haruki Kume, Yukio Homma
Summary: This study examines the real-world data of intravesical dimethyl sulfoxide (DMSO) therapy for Hunner-type interstitial cystitis (HIC) in Japan. The results demonstrate that intravesical DMSO therapy according to the approved standardized regimen is safe, moderately effective, and well-tolerated for treating HIC.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Medicine, Research & Experimental
Tomoyuki Kaneko, Kazuki Yanagida, Kentaro Matsui, Taketo Kawai, Yukio Yamada, Keisuke Ishii, Taketo Kurozumi, Takashi Suzuki, Yoshinobu Watanabe, Hirotaka Kawano, Tetsuya Sakamoto, Tohru Nakagawa
Summary: This study aimed to describe the voiding patterns of patients after surgical treatment of pelvic fractures and determine the predictive factors of lower urinary tract injuries (LUTIs) and spontaneous voiding failure among patients with surgically treated pelvic fractures. The study found that 10% of patients with surgically treated pelvic fractures were not able to void spontaneously at discharge, and spontaneous voiding failure was related to injury severity.
Article
Urology & Nephrology
Takuya Iwaki, Yoshiyuki Akiyama, Hirokazu Nosato, Manami Kinjo, Aya Niimi, Satoru Taguchi, Yuta Yamada, Yusuke Sato, Taketo Kawai, Daisuke Yamada, Hidenori Sakanashi, Haruki Kume, Yukio Homma, Hiroshi Fukuhara
Summary: In this study, a deep learning system was developed to identify Hunner lesions in patients with interstitial cystitis using artificial intelligence. The system demonstrated diagnostic accuracy exceeding that of human expert urologists in detecting Hunner lesions, assisting physicians with proper diagnosis.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Article
Urology & Nephrology
Yukio Yamada, Tohru Nakagawa, Jimpei Miyakawa, Taketo Kawai, Satoru Taguchi, Mariko Tabata, Tomoyuki Kaneko, Akira Ishikawa, Hideyo Miyazaki, Yasushi Kondo, Akihiko Matsumoto, Akihiro Naito, Masahiro Hikatsu, Yoichi Fujii, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Akira Nomiya, Daisuke Yamada, Taro Murata, Motofumi Suzuki, Yutaka Enomoto, Hiroaki Nishimatsu, Takumi Takeuchi, Yoshinori Tanaka, Haruki Kume
Summary: The purpose of this study was to further classify patients with pT3 upper tract urothelial carcinoma (UTUC) into different survival outcome groups based on tumor location and site of invasion. The results showed that pT3b UTUC was significantly associated with worse histological features compared to pT3a UTUC, resulting in unsatisfactory survival outcomes.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Takahiro Oshina, Satoru Taguchi, Jimpei Miyakawa, Yoshiyuki Akiyama, Yusuke Sato, Taketo Kawai, Hiroshi Fukuhara, Tohru Nakagawa, Haruki Kume
Summary: This study reviewed 80 patients with urothelial carcinoma involving the ureterovesical junction, finding diverse symptoms and reasons for diagnosis, as well as various surgical treatments with different cancer-specific survival outcomes. T stage (≥ T2) was identified as an independent predictor of shorter cancer-specific survival in these patients, highlighting the need for optimized treatment strategies for better clinical outcomes.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)
