Article
Biochemistry & Molecular Biology
Jia-feng Tang, Guo-li Li, Tao Zhang, Yu-mei Du, Shi-ying Huang, Jian-hua Ran, Jing Li, Di-long Chen
Summary: In this study, it was found that HHT effectively inhibits the proliferation of melanoma cells by inducing DNA damage, apoptosis, and cell cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effect of HHT on melanoma, providing evidence for its potential as an anti-melanoma agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Food Science & Technology
Silu Hou, Yuqiang Cheng, Zhaofei Wang, Luming Xia, Jian Wang, Hengan Wang, Jianhe Sun, Jingjiao Ma, Yaxian Yan
Summary: This study investigated the toxic effects of deoxynivalenol (DON) on gastric mucosal epithelial cells and found that DON can inhibit cell activity, induce DNA damage, apoptosis, and cell cycle arrest. These findings are important for understanding the cytotoxicity and gastric diseases caused by DON.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Siddavaram Nagini, Ramesh Nivetha, Manikandan Palrasu, Rajakishore Mishra
Summary: Nimbolide, a major limonoid constituent of neem, has garnered research attention for its anticancer properties. It has been shown to inhibit proliferation of cancer cells, overcome multidrug resistance, and enhance therapeutic outcomes. Nimbolide's ability to modulate signaling networks and molecular targets make it a valuable addition to the anticancer drug arsenal.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Jiajing Niu, Jiamei Wang, Qi Zhang, Zhihua Zou, Yushuang Ding
Summary: The study revealed that sublethal doses of cinobufagin suppressed the viability of cancer cells by inducing oxidative stress, leading to DNA damage and cell cycle regulation that ultimately resulted in the induction of apoptosis.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Ya-jun Hou, Dawei Li, Weiqi Wang, Leilei Mao, Xiaoyan Fu, Baoliang Sun, Cundong Fan
Summary: This study evaluated the anticancer effects and mechanism of NT157 against human glioma growth, and found that NT157 alone inhibited glioma cell growth by regulating cell cycle, promoting apoptosis, and inducing DNA damage and dysfunction of signaling pathways. Combined treatment with TRAIL further enhanced apoptosis by upregulating DR5 and inducing DNA damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Dan Liu, Ye Cheng, Zhipeng Tang, Xueying Mei, Xiangyu Cao, Jianli Liu
Summary: This study reveals that acrolein induces DNA damage and mitochondrial apoptosis in human bronchial epithelial cells, which may be the pivotal factors mediating its cytotoxicity.
Article
Environmental Sciences
Xiang Liu, Jin-Cheng Ye, Fen Li, Rong-Jun Gao, Xiao-Xiao Wang, Ji-Liang Cheng, Bai-Lin Liu, Lei Xiang, Yan-Wen Li, Quan-Ying Cai, Hai-Ming Zhao, Ce-Hui Mo, Qing X. Li
Summary: This study investigated the toxicity mechanism of microcystin-LR (MC-LR) on the earthworm intestine at both the individual and cellular levels. The results showed that increasing MC-LR doses and exposure time led to a decrease in earthworm bodyweight and survival rate in soil. Dose-dependent intestinal lesions and disturbances in enzymatic activities were observed, which resulted in intestinal dysfunction. Excessive generation of reactive oxygen species caused DNA damage and lipid peroxidation in intestinal cells, leading to cell cycle arrest and apoptosis. MC-LR exhibited high toxicity to earthworms and posed ecological risks to terrestrial ecosystems.
Article
Biochemistry & Molecular Biology
Wujiu Jiang, Qiqi Qin, Xiyuan Xiao, Yuxing Tan
Summary: In this study, eight new diorganotin(IV) complexes were synthesized and their structures were characterized. The antiproliferative activity of the complexes was tested, and complex 1c showed stronger antitumor activity, inducing cell apoptosis and DNA damage.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qinqin Xu, Ryan P. Mackay, Adam Y. Xiao, John A. Copland, Paul M. Weinberger
Summary: ATC is a highly lethal malignancy with no effective treatment currently available. YM155, identified as a promising candidate in a high-throughput screen, shows potential as a targeted therapy for ATC by inhibiting proliferation of cancer cells while sparing normal cells, inducing DNA damage, cell cycle arrest, and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Pharmacology & Pharmacy
Zixuan Liu, Qiushuang Zhu, Erqun Song, Yang Song
Summary: The study demonstrated that PBDEQ exposure could induce DNA damage, cell apoptosis, and G2/M phase cell arrest in a p53-dependent manner. Activation of p53 coordinated cell cycle progression, alleviated DNA damage, and ultimately mitigated apoptosis in BV2 cells. Antioxidant NAC inhibited p53 activation upon PBDEQ exposure, suggesting that PBDEQ-induced DNA damage and p53 activation were mediated by reactive oxygen species (ROS).
Article
Biochemistry & Molecular Biology
Feng-Lung Tsai, Han-Li Huang, Mei-Jung Lai, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang
Summary: The study found that MPT0G236, a pan-HDAC inhibitor, specifically targets malignant tumor cells and exhibits significant anticancer activity in human colorectal cancer cells, making it a potential candidate for colorectal cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Gazdova, Radka Michalkova, Martin Kello, Maria Vilkova, Zuzana Kudlickova, Janette Baloghova, Ladislav Mirossay, Jan Mojzis
Summary: This study focused on investigating the antiproliferative effects of chalcone hybrids, particularly the chalcone-acridine hybrid 1C, in melanoma cancer cells. The study revealed that 1C exhibited potent antiproliferative effects by inducing cell cycle arrest and apoptosis. Additionally, the study found that 1C modulated the expression or phosphorylation of specific cell cycle-associated proteins and activated the DNA damage response pathway. Furthermore, 1C also induced apoptosis by causing mitochondrial dysfunction and activating caspase 3/7. The study suggests that the chalcone-acridine hybrid 1C may have potential as an antimelanoma agent in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Darja Koutova, Negar Maafi, Darina Muthna, Karel Kralovec, Jana Kroustkova, Filip Pidany, Abdul Aziz Timbilla, Eva Cermakova, Lucie Cahlikova, Martina Rezacova, Radim Havelek
Summary: The isoquinoline alkaloids found in Amaryllidaceae have potential for the development of new drugs. In this study, the cytotoxic activities of montanine and its derivatives were evaluated against multiple cancer cell lines, and it was found that montanine exhibited the most potent antiproliferative activity and induced apoptosis in MOLT-4 cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Dahye Yun, So Young Yoon, Soo Jung Park, Yoon Jung Park
Summary: Herbal plants enriched with isoquinoline alkaloids have been used in traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. These alkaloids induce cell death through cell cycle arrest, apoptosis, and autophagy. The molecular mechanisms of these effects may involve binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
