Article
Behavioral Sciences
Andrew Dawson, Paola Ortelli, Adrian Carter, Davide Ferrazzoli, Nadeeka N. Dissanayaka, Andrew Evans, Yann Chye, Valentina Lorenzetti, Giuseppe Frazzitta, Murat Yucel
Summary: Dopaminergic medications can induce impulsive-compulsive behaviors in Parkinson's disease patients. However, the neurocognitive implications of this are unclear. A study was conducted on PD patients with and without ICBs, revealing heightened incentive motivation, choice impulsivity, and reactive aggression in those with ICBs.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Alexander K. Song, Kaitlyn R. Hay, Paula Trujillo, Megan Aumann, Adam J. Stark, Yan Yan, Hakmook Kang, Manus J. Donahue, David H. Zald, Daniel O. Claassen
Summary: This study demonstrates that reward-based behaviors in Parkinson's disease are regulated by ventral striatal dopamine release, and suggests that loss of inhibitory feedback from midbrain autoreceptors may underlie the manifestation of impulsive-compulsive behaviors.
Article
Clinical Neurology
Michele Fusaroli, Emanuel Raschi, Manuela Contin, Luisa Sambati, Marco Menchetti, Angelo Fioritti, Elisabetta Poluzzi
Summary: The study aimed to create a comprehensive list of possible manifestations of drug-induced Impulse Control Disorders in Parkinson's disease and test it on pharmacosurveillance data. 66 conditions were identified as possible Impulse Control Disorders, including pathological gambling, shopping, eating and sexuality, dopamine dysregulation syndrome, hobbyism and punding.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Health Care Sciences & Services
Anna Fedosova, Nataliya Titova, Zarema Kokaeva, Natalia Shipilova, Elena Katunina, Eugene Klimov
Summary: This study evaluated the role of various genes in the pathogenesis of ICD in PD patients. The results suggest that polymorphisms in genes such as DBH, BDNF, DRD2, and ACE are associated with an increased risk of ICD development in Russian subjects with PD.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mechelle M. Lewis, Lauren J. Van Scoy, Sol De Jesus, Jonathan G. Hakun, Paul J. Eslinger, Julio Fernandez-Mendoza, Lan Kong, Yang Yang, Bethany L. Snyder, Natalia Loktionova, Sridhar Duvvuri, David L. Gray, Xuemei Huang, Richard B. Mailman
Summary: Current pharmacotherapy has limited efficacy and intolerable side effects in late-stage Parkinson's disease patients. A study was conducted to explore the efficacy of a D-1/5 dopamine agonist in these patients. Caregiver assessment was used as the primary efficacy measure, and the results showed that the D-1/5 agonist had better efficacy compared to levodopa in most patients.
Review
Clinical Neurology
Giacomo Grassi, Giovanni Albani, Federica Terenzi, Lorenzo Razzolini, Silvia Ramat
Summary: Managing impulsive and compulsive behaviors in PD patients remains a significant challenge for clinicians due to limited pharmacological treatment options. Further research and controlled trials are needed to explore promising approaches such as atomoxetine and non-invasive neuromodulation techniques.
NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Lanxiao Cao, Tian Xu, Gaohua Zhao, Dayao Lv, Jinyu Lu, Guohua Zhao
Summary: This meta-analysis indicates that males, young age, early disease onset, long disease duration, depression, levodopa dosage, dopamine receptor agonists, and amantadine are risk factors for impulsive-compulsive behaviors in Parkinson's disease patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Tian Xu, Lanxiao Cao, Wenying Long, Guohua Zhao
Summary: This study demonstrated that the C-QUIP is a valid and rapid screening tool for assessing ICRDs in PD patients. Risk factors for ICRDs include higher Hoehn and Yahr staging, NMSS and HAMD scores, as well as larger medication dosages.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Nicky Edelstyn, Elisa Di Rosa, Alice Martini
Summary: This review article integrates findings from published research on impulsive-compulsive behaviors in Parkinson's disease, aiming to identify their basic correlates. The key findings are that patients with ICBs showed abnormal dopaminergic activity in the striatum and reduced fronto-striatal connectivity. These findings are consistent with evidence of psychological dysfunction in cognitive control, reward-driven decision-making, and negative affect.
EUROPEAN NEUROLOGY
(2023)
Article
Neuroimaging
Ikko Kimura, Gajanan S. Revankar, Kotaro Ogawa, Kaoru Amano, Yuta Kajiyama, Hideki Mochizuki
Summary: This study used structural and resting-state functional magnetic resonance imaging to identify the cortico-striatal network involved in impulsive compulsive behaviors (ICBs) and found differences in these networks between patients with impulse control disorder (ICD) and dopamine dysregulation syndrome (DDS).
NEUROIMAGE-CLINICAL
(2023)
Article
Toxicology
Kwang-Hyun Hur, Youyoung Lee, Audrey Lynn Donio, Jae-Gyeong Lee, Bo-Ram Lee, Seon-Kyung Kim, Seolmin Yoon, Yong-Sup Lee, Hyoung-Chun Kim, Seok-Yong Lee, Choon-Gon Jang
Summary: This study investigated the neurotoxic effects of Mepirapim and found that it causes Parkinson's disease-related symptoms and maladaptation of the dopamine system in mice.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Clinical Neurology
Xiaobo Zhu, Jing Gan, Na Wu, Ying Wan, Lu Song, Zhenguo Liu, Yu Zhang
Summary: This study explored the predictors of impulse control behaviors (ICBs) in Parkinson's disease (PD) and the biological correlates of ICBs. Over a period of 5 years, the prevalence of ICBs increased in PD while it decreased in healthy controls. The presence of ICBs in PD was associated with depression, anxiety, autonomic dysfunction, and excessive daytime sleepiness, but not with cognitive dysfunction or motor severity. Treatment with dopamine agonists and certain baseline characteristics were identified as predictors for the development of ICBs in early PD.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Siobhan Reilly, Simran Dhaliwal, Usman Arshad, Antonella Macerollo, Nusrat Husain, Antonio Da Costa
Summary: There is evidence that rivastigmine is beneficial for rapid eye movement sleep behavior disorder (RBD) and apathy in Parkinson's disease patients without dementia. There is also high level evidence that rivastigmine reduces the risk of falls.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Qian Zhang, XiangTing Chen, FeiFei Chen, SiYuan Wen, ChangQing Zhou
Summary: Compared with levodopa, dopamine agonists (DAs) as initial treatment are associated with lower incidences of motor complications in early Parkinson's disease (PD). There is no strong evidence that a given DA is more potent in lower incidences of motor complications than another. We performed a network meta-analysis of levodopa versus DAs as monotherapy in early PD to assess the risk of motor complications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Emma McIntosh, Seamus Kent, Alastair Gray, Carl E. Clarke, Adrian Williams, Crispin Jenkinson, Natalie Ives, Smitaa Patel, Caroline Rick, Keith Wheatley, Richard Gray
Summary: The study found that initial treatment with levodopa is highly cost-effective compared with levodopa-sparing therapies, and monoamine oxidase type B inhibitors as initial levodopa-sparing therapy were more cost-effective, with similar quality-adjusted life-years but lower costs than dopamine agonists.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Verena Rass, Ronny Beer, Alois Josef Schiefecker, Mario Kofler, Anna Lindner, Philipp Mahlknecht, Beatrice Heim, Victoria Limmert, Sabina Sahanic, Alex Pizzini, Thomas Sonnweber, Ivan Tancevski, Christoph Scherfler, Laura Zamarian, Rosa Bellmann-Weiler, Guenter Weiss, Atbin Djamshidian, Stefan Kiechl, Klaus Seppi, Judith Loeffler-Ragg, Bettina Pfausler, Raimund Helbok
Summary: Neurological symptoms were prevalent at the 3-month follow-up in COVID-19 patients, with smelling disorders being persistent in a large proportion of patients even after recovery from the acute infection.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Laura Zamarian, Elfriede Karner, Thomas Bodner, Atbin Djamshidian, Margarete Delazer
Summary: This study reveals the differential effects of education on cognitive performance in older patients with cognitive decline. Higher education is advantageous for verbal memory, executive functions, object naming, and constructional praxis tests, but less beneficial at lower global mental status levels.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Letter
Clinical Neurology
Kathrin Marini, Klaus Seppi, Lena Tschiderer, Stefan Kiechl, Heike Stockner, Peter Willeit, Johann Willeit, Atbin Djamshidian, Gregorio Rungger, Werner Poewe, Philipp Mahlknecht
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Beatrice Heim, Philipp Ellmerer, Ambra Stefani, Anna Heidbreder, Elisabeth Brandauer, Birgit Hogl, Klaus Seppi, Atbin Djamshidian
Summary: The study found that both patients with restless legs syndrome (RLS) augmentation alone or with impulse control disorder (ICD) symptoms perform poorly in decision-making. Further research is needed to investigate whether rapid and hasty decision-making are early signs of augmentation in RLS.
Article
Neurosciences
Margarete Delazer, Laura Zamarian, Atbin Djamshidian
Summary: The study highlighted the differences in kinematographic features of handwriting between Alzheimer's disease (AD) patients and normal aging individuals, showing that AD patients had less automated movements, lower writing velocity, and frequency. The correlation between writing performance and automated movements was significant, indicating a higher level of automaticity in handwriting for patients with fewer errors. Alphabetical writing correctness and some kinematographic measures in non-alphabetical writing showed excellent diagnostic values. No difference in writing pressure application between patients and controls was found. This suggests that writing disorders in AD are multi-componential and not limited to one processing level.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Pedro Barbosa, Atbin Djamshidian, Andrew John Lees, Thomas Treharne Warner
Summary: This study investigated the brain samples of Parkinson's disease (PD) patients who received apomorphine treatment. It found that apomorphine can be used as an alternative treatment for patients with previous impulsive compulsive behaviors (ICBs) due to its low risk of recurrence.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2022)
Article
Clinical Neurology
Christine Eckhardt, Florian Krismer, Eveline Donnemiller, Sabine Eschlboeck, Alessandra Fanciulli, Cecilia Raccagni, Sylvia Boesch, Katherina Mair, Christoph Scherfler, Atbin Djamshidian, Christian Uprimny, Bernhard Metzler, Klaus Seppi, Werner Poewe, Stefan Kiechl, Irene Virgolini, Gregor K. Wenning
Summary: The purpose of this study was to evaluate the diagnostic accuracy of the dual imaging method combining cardiac iodine-(123)-metaiodobenzylguanidine single-photon emission computed tomography combined with low-dose chest computed tomography compared to routine cardiac scintigraphy, and assess regional differences in tracer distribution and the relationships between imaging and autonomic function in Parkinson's disease and multiple system atrophy.
CLINICAL AUTONOMIC RESEARCH
(2022)
Article
Clinical Neurology
Beatrice Heim, Philipp Ellmerer, Ambra Stefani, Melanie Bergmann, Elisabeth Brandauer, Klaus Seppi, Birgit Hoegl, Atbin Djamshidian
Summary: This study identified several factors associated with augmentation in restless legs syndrome (RLS) patients, such as longer disease duration, higher severity scores, higher medication doses, and higher levels of alexithymia. These factors may assist clinicians in carefully screening and treating patients to prevent the challenging side effect of augmentation.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Verena Rass, Bogdan-Andrei Ianosi, Laura Zamarian, Ronny Beer, Sabina Sahanic, Anna Lindner, Mario Kofler, Alois Josef Schiefecker, Philipp Mahlknecht, Beatrice Heim, Victoria Limmert, Thomas Sonnweber, Alex Pizzini, Piotr Tymoszuk, Christoph Scherfler, Atbin Djamshidian, Stefan Kiechl, Ivan Tancevski, Klaus Seppi, Bettina Pfausler, Judith Loeffler-Ragg, Raimund Helbok
Summary: The study found that about one-third of patients experienced impaired HR-QoL 3 months after COVID-19 diagnosis. Factors associated with impaired HR-QoL included younger age, longer hospitalization, impaired sleep, and anxiety symptoms.
QUALITY OF LIFE RESEARCH
(2022)
Review
Neurosciences
Beatrice Heim, Marina Peball, Johannes Hammermeister, Atbin Djamshidian, Florian Krismer, Klaus Seppi
Summary: The study evaluated the diagnostic accuracy of transcranial sonography for differential diagnosis of Parkinson's disease and essential tremor. The results showed that substantia nigra hyperechogenicity has high diagnostic accuracy for discriminating between Parkinson's disease and essential tremor. TCS is a low-cost, widely available, non-invasive, and radiation-free marker.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Pedro Barbosa, Sean S. O'Sullivan, Eileen Joyce, Andrew J. Lees, Thomas T. Warner, Atbin Djamshidian
Summary: This study compared the clinical and neuropsychological features of Parkinson's disease patients with punding and hobbyism to PD controls. Patients with punding showed increased anxiety and frontal lobe dysfunction, while those with hobbyism exhibited similar levels of anxiety and motor fluctuations.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Clinical Neurology
Verena Rass, Ronny Beer, Alois Josef Schiefecker, Anna Lindner, Mario Kofler, Bogdan Andrei Ianosi, Philipp Mahlknecht, Beatrice Heim, Marina Peball, Federico Carbone, Victoria Limmert, Philipp Kindl, Lauma Putnina, Elena Fava, Sabina Sahanic, Thomas Sonnweber, Wolfgang N. Loescher, Julia Wanschitz, Laura Zamarian, Atbin Djamshidian, Ivan Tancevski, Gunter Weiss, Rosa Bellmann-Weiler, Stefan Kiechl, Klaus Seppi, Judith Loeffler-Ragg, Bettina Pfausler, Raimund Helbok
Summary: The study showed that around 15% of patients experienced new or persistent neurological disorders 1 year after COVID-19, with 59% reporting symptoms such as fatigue, concentration difficulties, forgetfulness, and sleep disturbances. Neurological examination revealed findings in 64% of patients, with 51% showing objective hyposmia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Marina Peball, Klaus Seppi, Florian Krismer, Hans-Gunther Knaus, Sabine Spielberger, Beatrice Heim, Philipp Ellmerer, Mario Werkmann, Werner Poewe, Atbin Djamshidian
Summary: Nabilone may have beneficial effects on sleep outcomes in Parkinson's disease patients with sleep problems.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Meeting Abstract
Clinical Neurology
A. Fasano, S. O'Sullivan, A. Johansson, J. Parra, A. Saad, L. Bergmann, U. Krikmann, M. Simu
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
Marlene Panzer, Andre Viveiros, Benedikt Schaefer, Nadja Baumgartner, Klaus Seppi, Atbin Djamshidian, Theodor Todorov, William J. H. Griffiths, Eckart Schott, Markus Schuelke, Dennis Eurich, Albert Friedrich Stattermayer, Adrian Bomford, Pierre Foskett, Julia Vodopiutz, Rudolf Stauber, Elke Pertler, Bernhard Morell, Herbert Tilg, Thomas Mueller, Stefan Kiechl, Raul Jimenez-Heredia, Karl Heinz Weiss, Si Houn Hahn, Andreas Janecke, Peter Ferenci, Heinz Zoller
Summary: This study evaluated the prevalence and disease mechanism of the synonymous variant c.2292C>T (p.Phe764=) in Wilson disease. It was found that this variant has a higher allele frequency in Wilson disease patients and causes abnormal mRNA processing of ATP7B transcripts.
HEPATOLOGY COMMUNICATIONS
(2022)
