Review
Clinical Neurology
Srinivasarao Repudi, Daniel J. Steinberg, Nimrod Elazar, Vanessa L. Breton, Mark S. Aquilino, Afifa Saleem, Sara Abu-Swai, Anna Vainshtein, Yael Eshed-Eisenbach, Bharath Vijayaragavan, Oded Behar, Jacob J. Hanna, Elior Peles, Peter L. Carlen, Rami Aqeilan
Summary: WWOX-related epileptic encephalopathy (WOREE) syndrome is a neurodevelopmental disorder caused by bi-allelic mutations in the WWOX gene, leading to symptoms such as intractable epilepsy and developmental delay. Studies in mice and human brain organoids have shown evidence of myelination defects and hyperexcitability associated with WWOX function.
Review
Neurosciences
Christi R. P. Sullivan, Sarah Olsen, Alik S. Widge
Summary: DBS is a promising intervention for treatment-resistant psychiatric disorders, but response rates in randomized controlled trials are much lower, research focuses on targeting and personalized imaging, neglecting the fact that disorders stem from dysfunction in distributed brain networks.
Article
Clinical Neurology
Allison Gallucci, Dipan C. Patel, K'Ehleyr Thai, Jonathan Trinh, Rosalie Gude, Devika Shukla, Susan L. Campbell
Summary: Our study reveals that the diversity of gut microbiota is significantly altered in TMEV-infected mice 5-7 days post-infection, showing a beta diversity separation in TMEV-infected mice depending on seizure phenotype, and a lower abundance of genus Allobaculum in TMEV-infected mice regardless of seizure phenotype. Conversely, a specific reduction in the S-equol-producing genus Adlercreutzia was identified as a microbial hallmark of seizure phenotype post-TMEV infection. Electrophysiological recordings indicated that exogenous S-equol modifies cortical neuronal physiology and ameliorates TMEV-induced hyperexcitability in entorhinal cortex neurons.
Article
Neurosciences
Yifeng Shi, Mengqi Wang, Linglong Xiao, Luolan Gui, Wen Zheng, Lin Bai, Bo Su, Bin Li, Yangyang Xu, Wei Pan, Jie Zhang, Wei Wang
Summary: Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is effective for refractory obsessive-compulsive disorder (OCD). This study investigated the neurobiological mechanisms of OCD and the effect of NAc-DBS. The results showed that NAc-DBS modulated electrophysiological activities and neurotransmitter levels in the NAc, suggesting a potential therapeutic effect of NAc-DBS for OCD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Stephen K. Agadagba, Lee Wei Lim, Leanne Lai Hang Chan
Summary: The mammalian brain consists of interconnected neurons forming complex networks. Neuromodulation, achieved through electrical or chemical stimuli, can alter neuronal network activity and has both therapeutic and research potential. Transcorneal electrical stimulation (TES) is a non-invasive neuromodulation technique that can beneficially affect the brain through the eyes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hanna Vila-Merkle, Alicia Gonzalez-Martinez, Rut Campos-Jimenez, Joana Martinez-Ricos, Vicent Teruel-Marti, Arantxa Blasco-Serra, Ana Lloret, Pau Celada, Ana Cervera-Ferri
Summary: The study investigated the neural oscillations in an anxiety model and the therapeutic effects of infralimbic deep brain stimulation in mood disorders. It was found that the anxiogenic drug altered the oscillatory profile in the neural network, while deep brain stimulation could reverse these effects.
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
F. Buehning, L. Miguel Telega, Y. Tong, J. Pereira, V. A. Coenen, M. D. Doeroessy
Summary: The study investigated the acute effects of MFB DBS on neuronal oscillations in different neuronal populations related to the pathophysiology of depression. MFB DBS differentially affected neuronal oscillations in the mPFC, NAc, and VTA across SD and FSL rats, with a significant increase in low gamma oscillations in the mPFC of FSL rats.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biology
David J. Ottenheimer, Madelyn M. Hjort, Anna J. Bowen, Nicholas A. Steinmetz, Garret D. Stuber
Summary: This study demonstrates the stable encoding of cue-reward learning by individual prefrontal neurons and reveals a certain advantage of the prefrontal cortex in value coding.
Review
Clinical Neurology
Bernadette C. M. van Wijk, Rob M. A. de Bie, Martijn Beudel
Summary: Deep brain stimulation (DBS) treatment has been effective in suppressing symptoms of Parkinson's disease, but patients may experience fluctuations in symptom severity throughout the day. Adaptive DBS (aDBS) aims to optimize treatment by adjusting stimulation settings based on the presence or absence of symptoms. This research synthesis focuses on the correlation between local field potential (LFP) signal features and specific PD motor symptoms, particularly bradykinesia and rigidity.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Raghavan Gopalakrishnan, David A. Cunningham, Olivia Hogue, Madeleine Schroedel, Brett A. Campbell, Ela B. Plow, Kenneth B. Baker, Andre G. Machado
Summary: The robust connections between the cerebellum and contralateral sensorimotor cerebral hemisphere play an important role in human behavior. The reduction of cerebellar metabolism due to damage to the sensorimotor cortex is related to poor rehabilitative outcomes. Understanding the cerebellar physiology and cortico-cerebellar coherence (CCC) after stroke may help in developing techniques for motor rehabilitation. The study found strong coupling between the ipsilesional cortex and the cerebellar dentate nucleus in the low beta band during motor control, supporting the use of the cerebello-thalamo-cortical pathway for neuromodulation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Prachi Patel, Bahar Khalijhinejad, Jose L. Herrero, Stephan Bickel, Ashesh D. Mehta, Nima Mesgarani
Summary: This study reports the significant improvement of speech perception in noise through electrical brain stimulation of implanted intracranial electrodes. The stimulation enhanced the subjective quality and objective intelligibility of speech sounds compared to background noises. The findings suggest a potential neuroprosthetic solution to assist in the challenging task of speech perception in noise.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Linda J. Dalic, Aaron E. L. Warren, Kristian J. Bulluss, Wesley Thevathasan, Annie Roten, Leonid Churilov, John S. Archer
Summary: In this study, deep brain stimulation to the centromedian thalamic nucleus (CM-DBS) was found to reduce electrographic seizures in patients with Lennox-Gastaut syndrome (LGS), with 50% of participants experiencing a >= 50% reduction in diary-recorded seizures after 3 months of stimulation.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Christiane Gimenes, Maria Luiza Motta Pollo, Eduardo Diaz, Eric L. Hargreaves, Detlev Boison, Luciene Covolan
Summary: This study demonstrates that ANT-DBS interferes with the kindling process and reduced seizure activity was maintained after a stimulation-free period of one week. Our findings suggest that ANT-DBS might have additional therapeutic benefits to attenuate seizure progression in epilepsy.
Review
Medicine, General & Internal
Jolanta Strzelecka, Dariusz Wojciech Mazurkiewicz, Tymon Skadorwa, Jakub S. Gasior, Sergiusz Jozwiak
Summary: This study provides an overview of the literature on photo-dependent reflex seizures and differentiates between various types of reflex seizures. Differentiating between these types of seizures is crucial for determining the appropriate duration of treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Mathematical & Computational Biology
Hil G. E. Meijer, Tahra L. Eissa, Bert Kiewiet, Jeremy F. Neuman, Catherine A. Schevon, Ronald G. Emerson, Robert R. Goodman, Guy M. McKhann, Charles J. Marcuccilli, Andrew K. Tryba, Jack D. Cowan, Stephan A. van Gils, Wim van Drongelen
JOURNAL OF MATHEMATICAL NEUROSCIENCE
(2015)
Article
Neurosciences
Jyothsna Suresh, Mihailo Radojicic, Lorenzo L. Pesce, Anita Bhansali, Janice Wang, Andrew K. Tryba, Jeremy D. Marks, Wim van Drongelen
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Mathematical & Computational Biology
Jack D. Cowan, Jeremy Neuman, Wim van Drongelen
JOURNAL OF MATHEMATICAL NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Tahra L. Eissa, Koen Dijkstra, Christoph Brune, Ronald G. Emerson, Michel J. A. M. van Putten, Robert R. Goodman, Guy M. McKhann, Catherine A. Schevon, Wim van Drongelen, Stephan A. van Gils
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Mathematical & Computational Biology
Lorenzo L. Pesce, Hyong C. Lee, Mark Hereld, Sid Visser, Rick L. Stevens, Albert Wildeman, Wim van Drongelen
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2013)
Article
Engineering, Biomedical
Bing Leung Patrick Cheung, Robert Nowak, Hyong Chol Lee, Wim van Drongelen, Barry D. Van Veen
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2012)
Article
Engineering, Biomedical
Puneet Rana, John Lipor, Hyong Lee, Wim van Drongelen, Michael H. Kohrman, Barry Van Veen
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2012)
Article
Chemistry, Multidisciplinary
Giuseppe Portale, Dario Cavallo, Giovanni Carlo Alfonso, Daniel Hermida-Merino, Martin van Drongelen, Luigi Balzano, G. W. M. Peters, J. G. P. Goossens, Wim Bras
JOURNAL OF APPLIED CRYSTALLOGRAPHY
(2013)
Article
Biochemistry & Molecular Biology
Yelena Y. Grinberg, Wim van Drongelen, Richard P. Kraig
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Mechanics
J. D. Cowan, J. Neuman, B. Kiewiet, W. van Drongelen
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2013)
Article
Materials Science, Multidisciplinary
Martin van Drongelen, Dario Cavallo, Luigi Balzano, Giuseppe Portale, Iakovos Vittorias, Wim Bras, Giovanni C. Alfonso, Gerrit W. M. Peters
MACROMOLECULAR MATERIALS AND ENGINEERING
(2014)
Article
Multidisciplinary Sciences
Thomas Charles Butler, Marc Benayoun, Edward Wallace, Wim van Drongelen, Nigel Goldenfeld, Jack Cowan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Neurosciences
Tahra L. Eissa, Andrew K. Tryba, Charles J. Marcuccilli, Faiza Ben-Mabrouk, Elliot H. Smith, Sean M. Lew, Robert R. Goodman, Guy M. McKhann, David M. Frim, Lorenzo L. Pesce, Michael H. Kohrman, Ronald G. Emerson, Catherine A. Schevon, Wim van Drongelen
Proceedings Paper
Neurosciences
Jack D. Cowan, Jeremy Neuman, Wim van Drongelen
CRITICALITY IN NEURAL SYSTEMS
(2014)