Article
Chemistry, Analytical
Taekeon Jung, Young-Ran Yun, Jaehyun Bae, Sung Yang
Summary: By integrating magnetic particle conjugation for bacteria concentration and separation, a new impedimetric bacteria-detection sensor has been developed for rapid and accurate detection of low bacteria concentrations in food samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Nanoscience & Nanotechnology
Tom Elkeles, Sinwook Park, Jorg G. Werner, David A. Weitz, Gilad Yossifon
Summary: This work presents the dielectrophoresis and in situ electrorotation characterization of reversible stimuli-responsive dynamic microcapsules that can change their physicochemical properties under varying pH conditions. The study shows that the conductivity of the capsules' shells is most influenced by pH and provides insight into the characteristic time scales of physical processes through transient response measurements. Additionally, the magnetic manipulation of microcapsules with embedded magnetic nanoparticles for lab-on-chip tasks is demonstrated, along with the on-chip determination of their physicochemical state using electrorotation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Kai Zhao, Penglu Zhao, Jianhong Dong, Yunman Wei, Bin Chen, Yanjuan Wang, Xinxiang Pan, Junsheng Wang
Summary: This study demonstrates the successful isolation of circulating tumor cells (CTCs) from blood cells using a combination of dielectrophoresis and magnetophoresis in a microfluidic chip. The results show the potential application of this method in diagnostics.
Article
Biochemical Research Methods
Mingyang Cui, Minji Kim, Patricia B. Weisensee, J. Mark Meacham
Summary: The study investigated the thermal biocompatibility of PDMS-based and glass-based SAW devices under different operating conditions. Results showed that the PDMS-based system could damage cells at high input power, while the glass-based hybrid system exhibited better thermal biocompatibility.
Article
Biotechnology & Applied Microbiology
Y-Van Tran Thi, Bao-Anh Hoang, Hang Tran Thanh, Thu-Hang Nguyen, Thao Pham Ngoc, Hang Bui Thu, Nam Nguyen Hoang, Tung Thanh Bui, Trinh Chu Duc, Loc Do Quang
Summary: In this study, a microfluidic technology is proposed for the detection and separation of circulating tumor cells (CTCs) from the whole blood. The technology offers advantages of high efficiency, low cost, portability, and reduction in sample processing steps.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Alexander Edthofer, Jakub Novotny, Andreas Lenshof, Thomas Laurell, Thierry Baasch
Summary: Acoustophoresis has become a popular tool in clinical and biomedical research for separating microparticles and cells based on their properties. One important application is measuring cell compressibility, which can be extracted from acoustic migration experiments. However, accurate measurement and calibration of acoustic energy density is crucial for reliable results. Polystyrene microparticles are commonly used as reference particles, but our study shows significant variation in their material properties, suggesting caution when using them as references.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Zhimin Chai, Anthony Childress, Ahmed A. Busnaina
Summary: Nanofabrication based on directed assembly, utilizing external fields to interact with nanoelements and assemble functional structures, is attracting more interest recently due to its low cost and additive manufacturing advantages. The external fields used in directed assembly include electric, fluidic flow, magnetic, and optical fields.
Article
Chemistry, Multidisciplinary
Kyriacos Yiannacou, Vipul Sharma, Veikko Sariola
Summary: This study demonstrates a programmable microfluidic chip based on ultrasonic waves, which utilizes a machine learning algorithm to manipulate milliliter-sized droplets in two dimensions. The research proves the flexibility and robustness of this method, providing a new approach for the development of programmable microfluidic devices.
Article
Physics, Applied
R. Weser, H. Schmidt
Summary: It has been shown that efficient generation of mechanical driving forces in fluids at the microscale can be accomplished using acoustic actuators. Understanding the lateral distribution of surface displacement amplitude at the fluid-substrate interface is crucial for achieving full control of fluidic actuation, especially in SAW-based actuators.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Chemistry, Analytical
Jishou Piao, Lu Liu, Long Cai, Hyok Chol Ri, Xiangzi Jin, Huaze Sun, Xiangfan Piao, Hai-bo Shang, Xuejun Jin, Qiaosheng Pu, Yong Cai, Zhongping Yao, Donatella Nardiello, Maurizio Quinto, Donghao Li
Summary: This paper introduces a highly accurate size-based microparticle separation technique, in which magnetic nanoparticles are manipulated by an external magnetic field to collide with microparticles for high-accuracy separation. The method has achieved good results in the analysis of cancer cells.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Ghazaleh Gharib, Ismail Butun, Zulal Muganli, Gul Kozalak, Ilayda Namli, Seyedali Seyedmirzaei Sarraf, Vahid Ebrahimpour Ahmadi, Ercil Toyran, Andre J. van Wijnen, Ali Kosar
Summary: Both passive and active microfluidic devices are widely used in biomedical and chemical applications. Passive devices are limited by their geometry-dependence, while active devices include sensors and transducers for disease diagnosis and organ modeling. Microfluidic devices are fabricated using various techniques and have broad utility in detecting diagnostic biomarkers and organ-on-chip approaches.
Article
Chemistry, Analytical
Yan Xu, Beibei Chen, Man He, Zewei Cui, Bin Hu
Summary: This study developed an all-in-one microfluidic chip system for efficient separation and quantitative analysis of rare CTCs and their ASGPR surface biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yan Xu, Beibei Chen, Man He, Zewei Cui, Bin Hu
Summary: This study developed an all-in-one microfluidic chip system combined with single cell-inductively coupled plasma mass spectrometry (SC-ICP-MS) for efficient separation and quantitative analysis of circulating tumor cells (CTCs). The method showed high separation efficiency and purity, allowing for accurate analysis of surface receptors on CTCs, which can be useful for studying targeted drug delivery in cancer therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Physics, Fluids & Plasmas
Shahrokh Sepehrirahnama, Sebastian Oberst, Yan Kei Chiang, David Powell
Summary: Acoustophoresis, which involves manipulating scatterers in an acoustic field, often neglects geometric asymmetry but it has been shown to have significant effects on radiation torque. This work presents a generalized formalism for acoustic radiation force and torque that includes Willis coupling terms to consider the impact of geometric asymmetry. By breaking the symmetry of a sphere, the study investigates the effects of intrusion and protrusion on force and torque, showing systematic changes.
Article
Chemistry, Analytical
Jishou Piao, Lu Liu, Long Cai, Hyok Chol Ri, Xiangzi Jin, Huaze Sun, Xiangfan Piao, Hai-bo Shang, Xuejun Jin, Qiaosheng Pu, Yong Cai, Zhongping Yao, Donatella Nardiello, Maurizio Quinto, Donghao Li
Summary: The development of new technologies for the separation, selection, and isolation of microparticles has become increasingly important in recent years. This paper proposes a highly accurate size-based microparticle separation technique called rotating magnetic chromatography. By utilizing magnetic nanoparticles in a microfluidic separation channel, microparticles are separated based on their dimensions with high accuracy and reproducibility. This breakthrough technique has unmatched sub-micrometer cell separation capabilities and can unlock new perspectives in scientific fields such as medical oncology.
ANALYTICAL CHEMISTRY
(2022)
