Article
Surgery
Milos Sladojevic, Igor Koncar, Petar Zlatanovic, Zeljka Stanojevic, David Matejevic, Sasenka Vidicevic Novakovic, Jelena Tasic, Perica Mutavdzic, Ivan Tomic, Aleksandra Isakovic, Lazar Davidovic
Summary: The study found a significant correlation between ILT volume and the largest AAA diameter, but no statistical significance in relation to proteolytic activity and protein content of the vascular wall. However, a positive correlation was found between ILT and catalase activity in the AAA wall. Future studies are needed to investigate the impact of ILT on aneurysm progression.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Benjamin T. Ledford, Adam W. Akerman, Kui Sun, David C. Gillis, Jenna M. Weiss, Johnny Vang, Smaranda Willcox, Tristan D. Clemons, Hiroaki Sai, Ruomeng Qiu, Mark R. Karver, Jack D. Griffith, Nick D. Tsihlis, Samuel Stupp, John S. Ikonomidis, Melina R. Kibbe
Summary: This study reports the development of injectable supramolecular nanofibers that target fragmented elastin, matrix metalloproteinase 2, and membrane type 1 matrix metalloproteinase to reduce the risks associated with a ruptured abdominal aortic aneurysm. The results show that one of the nanofibers was able to better localize to the aneurysm tissue and had an optimal dose.
Article
Chemistry, Multidisciplinary
Mohammed Almijalli
Summary: This research utilized computer modeling to study the impact of intraluminal thrombus (ILT) on abdominal aortic aneurysm (AAA) rupture, and found that ILT does not lead to local hypoxia as previously theorized.
APPLIED SCIENCES-BASEL
(2021)
Article
Biophysics
Alexis Throop, Martina Bukac, Rana Zakerzadeh
Summary: This study investigates the biomechanical role of intraluminal thrombus (ILT) in abdominal aortic aneurysm (AAA). The results demonstrate that while ILT can reduce wall stress, it significantly decreases oxygen transport within the tissue, leading to wall hypoxia.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Craig N. Morrell, Doran Mix, Anu Aggarwal, Rohan Bhandari, Matthew Godwin, Phillip Owens, Sean P. Lyden, Adam Doyle, Krystin Krauel, Matthew T. Rondina, Amy Mohan, Charles J. Lowenstein, Sharon Shim, Shaun Stauffer, Vara Prasad Josyula, Sara K. Ture, David Yule, Larry E. Wagner, John M. Ashton, Ayman Elbadawi, Scott J. Cameron
Summary: Biomechanical platelet activation may be a potential mechanism behind resistance to antiplatelet medication. A study on patients with abdominal aortic aneurysms (AAA) found that activation of olfactory receptor pathway is associated with AAA progression. A molecule activating platelet olfactory receptor was identified and shown to inhibit platelet activation and AAA growth.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Surgery
Arjet Helena Margaretha Nievergeld, Esther Jorien Maas, Joerik de Ruijter, Judith Helena Cornelia Fonken, Marcus Rodolph Henricus Maria van Sambeekan, Richard Godfried Paulus Lopata
Summary: This study proposed a semi-automatic segmentation method for abdominal aortic aneurysms and their intraluminal thrombus based on 3D ultrasound, and validated the results with computed tomography. The study found strong correlations between vessel and lumen distensibility with blood pressure, and also a correlation between lumen distensibility and ILT thickness.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Mostafa Rezaeitaleshmahalleh, Nan Mu, Zonghan Lyu, Weihua Zhou, Xiaoming Zhang, Todd E. Rasmussen, Robert D. McBane III, Jingfeng Jiang
Summary: The objective is to predict the growth status of abdominal aortic aneurysms (AAA) using the structural information of intraluminal thrombus (ILT) through an automated workflow. Deep-learning image segmentation models were used to generate 3D geometrical AAA models, followed by automated analysis and classification using a support vector machine. The most accurate predictive model considered four geometrical parameters, two parameters quantifying the constitution of ILT, antihypertensive medication, and the presence of co-existing coronary artery disease, achieving an AUROC of 0.89 and a total accuracy of 83%.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eva Aalbregt, Reza Indrakusuma, Hamid Jalalzadeh, R. Nils Planken, Joost van Schuppen, Lilian Meijboom, Ron Balm, Aart J. Nederveen, Kak Khee Yeung, Pim van Ooij
Summary: 4D flow MRI is a reliable method for assessing the hemodynamics within AAA, but there is no correlation between hemodynamic parameters and maximum diameter, ILT volume and growth rate.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Surgery
Regent Lee, Ismail Cassimjee, Honglei Huang, Pierfrancesco Lapolla, Elisha Ngetich, Anirudh Chandrashekar, Philip Charles, Benedikt Kessler, Roman Fischer, Ashok Handa
Summary: This study discovered novel biomarkers for predicting AAA growth using a mass spectrometry proteomics pipeline. These biomarkers, including Attractin, showed significant correlation with future AAA growth and could be used to predict the growth of AAA.
Article
Engineering, Multidisciplinary
Jie-min Zhan, Tian-dong Lu, Zhi-yun Yang, Wen-qing Hu, Wei Su
Summary: This study conducted numerical simulations and experiments on patient-specific normal abdominal aorta and abdominal aortic aneurysm (AAA) models with intraluminal thrombus (ILT), which were reconstructed from CT angiography (CTA) images published online. The distribution of wall shear stress (WSS), oscillatory shear index (OSI), and relative residence time (RRT) were compared between the normal abdominal aorta and AAA under rest and exercise conditions. The results indicated that ILT deposition positions were associated with low WSS, high OSI, and high RRT regions, and the distribution of AAA wall parameters correlated with nearby vortex structures and influenced ILT formation and development. Additionally, high WSS, low OSI, and low RRT regions in the middle and lower aneurysm walls under exercise condition reduced the risk of ILT formation and development.
ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS
(2022)
Review
Medicine, General & Internal
Andres Schanzer, Gustavo S. Oderich
Summary: Repair of abdominal aortic aneurysm is recommended in men with an aneurysm of 5.5 cm or more and in women with an aneurysm of 5.0 cm or more. Endovascular aortic aneurysm repair has lower risk of perioperative complications and death compared to open surgical repair, but there is no long-term survival advantage. Long-term imaging surveillance is recommended after endovascular repair.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Yu Fu, Haole Liu, Kexin Li, Panpan Wei, Naqash Alam, Jie Deng, Meng Li, Haibin Wu, Xue He, Haiwen Hou, Congcong Xia, Rong Wang, Weirong Wang, Liang Bai, Baohui Xu, Yankui Li, Yi Wu, Enqi Liu, Sihai Zhao
Summary: CRP deficiency suppresses AAA by reducing aneurysmal elastin destruction, macrophage accumulation, and matrix metalloproteinase 2 expression
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jakub Toczek, Kiran Gona, Yongjian Liu, Azmi Ahmad, Mean Ghim, Devi Ojha, Gunjan Kukreja, Mani Salarian, Hannah Luehmann, Gyu Seong Heo, Raul J. Guzman, Cassius I. Ochoa I. Chaar, George Tellides, Abdulrahman H. M. Hassab, Yunpeng Ye, Kooresh I. Shoghi, Mohamed A. Zayed, Robert J. Gropler, Mehran M. Sadeghi
Summary: This study describes a novel positron emission tomography radioligand that targets matrix metalloproteinases (MMPs), which play a key role in abdominal aortic aneurysm (AAA). The radioligand showed favorable stability, biodistribution, and specific binding to human tissues, setting the stage for translational imaging studies of vessel wall MMP activity and inflammation in AAA.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Aldona Siennicka, Monika Adamowicz, Natalie Grzesch, Magdalena Klysz, Jaroslaw Wozniak, Miloslaw Cnotliwy, Katarzyna Galant, Maria Jastrzebska
Summary: This study compared the levels of inflammatory mediators in different thicknesses of intraluminal thrombus (ILT) and adjacent abdominal aortic aneurysm (AAA) walls. The results showed that neutrophil elastase, TNF-a, and IL-6 levels were significantly higher in thick ILT and aneurysmal walls covered by thick ILT. Positive correlations were also found between thick ILT and the adjacent wall, as well as thin ILT and the adjacent wall. These findings suggest that neutrophil mediators and inflammatory cytokines may accumulate differently in AAA tissues based on ILT thickness, potentially weakening the AAA wall.
Article
Hematology
Xia Guo, Dunpeng Cai, Kun Dong, Chenxiao Li, Zaiyan Xu, Shi-You Chen
Summary: DOCK2 is identified as a novel regulator for AAA formation, playing a role in promoting vascular inflammation and elastin degradation by upregulating MCP-1 and MMP2 expression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Letter
Surgery
Aminder A. Singh, Jonathan R. Boyle, Ian Chetter, Florian Falter
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Peripheral Vascular Disease
Said Ibeggazene, Andrew Stirrup, Sean Pymer, Joanne Palmer, Paris L. Cai, George E. Smith, Ian C. Chetter
Summary: This study investigated the diagnostic performance of the Edinburgh Claudication Questionnaire (ECQ) as a screening tool for suspected intermittent claudication patients. The results showed that the ECQ had a poor diagnostic performance and novel, low-resource diagnostic tools are needed for this population.
Article
Surgery
Yousef Shahin, Simon Dixon, Karen Kerr, Trevor Cleveland, Stephen D. Goode
Summary: This study aimed to compare the survival and cost-effectiveness of endovascular aneurysm repair (EVAR) and conservative management in patients with poor cardiopulmonary exercise test (CPET) metrics. The study found that EVAR significantly improved survival compared with conservative management, and was also cost-effective.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Ross Lathan, Misha Sidapra, Marina Yiasemidou, Judith Long, Joshua Totty, George Smith, Ian Chetter
Summary: Since the COVID-19 pandemic, there has been a rapid uptake and utilization of telemedicine in healthcare, providing a key opportunity for surgical site infection surveillance. This review aims to comprehensively synthesize available evidence for the diagnostic accuracy of all forms of telemedicine monitoring for surgical site infections.
Review
Dermatology
Louise Hitchman, Joshua Totty, George E. Smith, Daniel Carradice, Maureen Twiddy, Cynthia Iglesias, David Russell, Ian C. Chetter
Summary: Emerging evidence suggests that ESWT may improve time to DFU healing, but the certainty of its effectiveness is low, limiting its translation into routine clinical practice.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Nutrition & Dietetics
Liam Irvin, Leigh A. Madden, Phil Marshall, Rebecca V. Vince
Summary: Personal exercise programmes have been widely used for weight loss and improving quality of life in obese patients. The shift towards digital programmes has gained momentum, particularly during the SARS-CoV-2 pandemic, due to their wider reach and lower cost. This review evaluates the current status of digital exercise programme delivery, emphasizing personalization. The findings suggest that apps can be beneficial for low-intensity approaches and improving adherence, although not all apps are evidence-based. Professional support is generally necessary to achieve weight loss goals.
Article
Dermatology
Louise H. Hitchman, Joshua P. Totty, Paris Cai, George E. Smith, Daniel Carradice, Ian C. Chetter
Summary: This study assessed the feasibility of using extracorporeal shockwave therapy (ESWT) for diabetic foot ulcers (DFUs) and explored its potential clinical effects on wound healing and patient-reported benefits. The results showed that recruiting and retaining patients for single-arm ESWT studies is feasible, with no serious adverse events or side-effects. Some DFUs healed during follow-up and quality of life (QoL) scores improved.
JOURNAL OF WOUND CARE
(2023)
Article
Biophysics
Desmond M. Connolly, Leigh A. Madden, Victoria C. Edwards, Timothy J. D'Oyly, Stephen D. R. Harridge, Thomas G. Smith, Vivienne M. Lee
Summary: This study found that under hypobaric conditions, the significant increase in the cytokine interleukin-6 (IL-6) was associated with venous gas emboli (microbubble) load. Levels of C-reactive protein and complement peptide C5a remained persistently elevated at T24, suggesting incomplete recovery the day after exposure.
AEROSPACE MEDICINE AND HUMAN PERFORMANCE
(2023)
Article
Surgery
J. Heinz, J. Walshaw, J. Y. Kwan, J. Long, D. Carradice, J. Totty, K. M. Kontouli, P. Lainas, L. Hitchman, G. Smith, B. Huo, H. Guadalajara, D. Garcia-Olmo, D. Sharma, C. S. Biyani, J. Tomlinson, M. Loubani, R. Galli, R. Lathan, I. Chetter, M. Yiasemidou
Summary: This study aims to identify variations in SSI prevention practices within and between different surgical fields and countries, and provide references to help standardize SSI prevention practices.
FRONTIERS IN SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Bradley Doyle, Leigh A. Madden, Nicole Pamme, Huw S. Jones
Summary: The study focuses on naturally circulating drug metabolites and the development of synthesis methods using glass microfluidic reactors for efficient conversion of resorufin into resorufin sulfate and resorufin glucuronide through sulfonation and glucuronidation reactions. The use of surface-immobilised enzymes in flow chemistry allows for simple collection of the product without the need for complex separation from a biological matrix. The yields obtained from the flow chemistry methods are significantly higher than those from static test tube reactions, indicating the potential for scalable synthesis of metabolites for pharmacology studies.
Review
Surgery
Arthur J. M. Lim, Abduraheem H. Mohamed, Louise H. Hitchman, Ross Lathan, Bharadhwaj Ravindhran, Misha M. Sidapra, George Smith, Ian C. Chetter, Daniel Carradice
Summary: This systematic review and meta-analysis compared the outcomes of mechanochemical ablation (MOCA) and endovenous thermal ablation (EVTA). MOCA had a lower rate of anatomical occlusion after 1 year and 2-3 years, but there was no difference in procedural and postprocedural pain.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Bharadhwaj Ravindhran, Nicole Schafer, Annabel Howitt, Daniel Carradice, George Smith, Ian Chetter
Summary: This systematic review summarizes the current evidence on the molecular mechanisms of action of NPWT. The review finds that NPWT can stimulate the modulation of cytokines and growth factors, promoting an anti-inflammatory response.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2023)
Article
Surgery
Louise H. Hitchman, Abduraheem Mohamed, George E. Smith, Sean Pymer, Ian C. Chetter, James Forsyth, Daniel Carradice
Summary: The study assessed access to varicose vein treatments in the NHS and the impact of EBI. Many local varicose vein commissioning policies were found not compliant with NICE CG168, leading to a significant proportion of patients not receiving the recommended treatment.
BRITISH JOURNAL OF SURGERY
(2023)
