Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sam O. Kleeman, Mattia Cordioli, Paul R. H. J. Timmers, Atlas Khan, Pinkus Tober-Lau, Florian Kurth, Vadim Demichev, Hannah Meyer, James F. Wilson, Markus Ralser, Krzysztof Kiryluk, Andrea Ganna, Kenneth Baillie, Tobias Janowitz
Summary: This study found a significant association between cystatin C production and the severity and mortality of COVID-19 in patients, suggesting its potential use in stratifying patients and its functional role in the host response to COVID-19.
Article
Peripheral Vascular Disease
Yujia Zhai, Bizhong Che, Yang Liu, Hao Peng, Aili Wang, Yanbo Peng, Jing Chen, Yonghong Zhang, Tan Xu, Chongke Zhong, Jiang He
Summary: This study investigated whether different blood pressure management strategies should be used for acute stroke patients with or without impaired renal function. The results showed that early antihypertensive treatment had no effect on clinical outcomes in ischemic stroke patients with different renal function status.
Article
Medicine, General & Internal
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Summary: This retrospective study reviewed the estimated glomerular filtration rates (eGFR) calculated by three equations and investigated the changes in prevalence of chronic kidney diseases. The study found that the prevalence of decreased eGFR increased with age and that the equation based on CKD-EPI 2021 had a lower prevalence compared to the other equations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Mohammad Hamidi, Catherine L. O'Grady, Sacha D. Brown, Amanda K. Arrington, Lilah Morris-Wiseman, Taylor S. Riall, Mohammad Khreiss
Summary: Lower preoperative eGFR levels (<60 mL/min/1.73m(2)) in patients undergoing pancreatectomy are associated with adverse outcomes, including prolonged length of stay, adverse discharge disposition, higher complication rates, and increased mortality risk.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Multidisciplinary Sciences
Jane Ha, Cheol Woong Jung, Sunkyu Choi, Myung-Gyu Kim, Jun Gyo Gwon, Joong Kyung Kim, Chan-Duck Kim, Ji Won Min, Jaeseok Yang, Curie Ahn
Summary: Comparing kidney transplantations from donors with acute kidney injury to those from non-AKI donors through matching, it was found that although transplantations from AKI donors had a higher incidence of delayed graft function, the overall graft function was comparable.
Article
Urology & Nephrology
Remi Lenain, Camille Prouteau, Aghiles Hamroun, Yohann Foucher, Magali Giral, Mehdi Maanaoui, Marc Hazzan
Summary: This study examined the impact of deceased donor acute kidney injury (AKI) on long-term graft survival in kidney transplant recipients. The results showed that ongoing AKI, undetermined AKI/CKD, and recovery from AKI were associated with a decreased graft survival.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Oncology
Yakup Iriagac, Eyyup Cavdar, Kubilay Karaboyun, Seher Yildiz Tacar, Fatma Nihan Akkoc Mustafayev, Emir Celik, Okan Avci, Sadi Kerem Okutur, Lokman Koral, Nebi Serkan Demirci, Alpaslan Ozgun, Erdogan Selcuk Seber
Summary: This study found a reversible decrease in renal functions in patients using crizotinib. When evaluating renal functions in these patients, using non-creatinine-based calculations can provide more accurate results.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Ravi B. Patel, Gregg C. Fonarow, Stephen J. Greene, Shuaiqi Zhang, Brooke Alhanti, Adam D. DeVore, Javed Butler, Paul A. Heidenreich, Joanna C. Huang, Michelle M. Kittleson, Karen E. Joynt Maddox, James J. McDermott, Anjali Tiku Owens, Pamela N. Peterson, Scott D. Solomon, Orly Vardeny, Clyde W. Yancy, Muthiah Vaduganathan
Summary: This study evaluated the care patterns and outcomes in heart failure patients with different degrees of kidney function. It found that patients with comorbid heart failure and kidney disease are not optimally treated with evidence-based medical therapies, leading to increased mortality risk. Further efforts are needed to mitigate the risks in these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Takahisa Hiramitsu, Yuki Hasegawa, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, Takaaki Kobayashi, Kazuharu Uchida, Yoshihiko Watarai
Summary: This study developed prediction models for perioperative estimated glomerular filtration rates (eGFR) in kidney transplant recipients and found that these predictions can independently predict graft survival.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Avner Thaler, Nurit Omer, Nir Giladi, Tanya Gurevich, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Meir Kestenbaum, Jesse M. Cedarbaum, Avi Orr-Urtreger, Shani Shenhar-Tsarfaty, Anat Mirelman
Summary: The study aimed to evaluate the association between biochemical markers, PD severity, and prodromal PD probability score among carriers of GBA and LRRK2 mutations. The results showed that sub-clinical renal impairment is linked to an increased likelihood of prodromal PD, regardless of genetic status, suggesting a potential role of kidney function in PD pathogenesis.
JOURNAL OF NEUROLOGY
(2021)
Article
Transplantation
Hans-Joachim Anders, Gema M. Fernandez-Juarez, Augusto Vaglio, Paola Romagnani, Juergen Floege
Summary: The management of immune-mediated kidney diseases focuses on controlling the underlying immune disease process and the non-immune mechanisms of chronic kidney disease (CKD) progression. Non-pharmacological interventions, such as reducing salt intake and regular physical activity, along with approved drug interventions, can help attenuate CKD progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Timothy L. Pruett, Gabriel R. Vece, Robert J. Carrico, David K. Klassen
Summary: Despite a shortage of kidney supply in the US, kidneys from older deceased donors are underutilized due to concerns about graft quality and transplant durability. However, the study found that one-year graft survival does not significantly differ based on donor age, with the primary factor affecting longevity being the level of kidney function gained post-transplantation. Effective decision-making tools are needed to ensure transplanting older kidneys provides sufficient renal function to justify the procedure.
Article
Medicine, General & Internal
Rocco Papalia, Biagio Zampogna, Guglielmo Torre, Giuseppe Francesco Papalia, Ferruccio Vorini, Marco Bravi, Erika Albo, Antonio De Vincentis, Vincenzo Denaro
Summary: This retrospective study evaluated the correlation between preoperative and perioperative factors and the length of hospital stay in total hip arthroplasty patients. Factors such as operative time, preoperative serum creatinine, intraoperative blood loss, and surgical approach were found to significantly correlate with increased hospitalization length. Logistic regression model showed an AUC of 0.748, indicating the important role of various variables in influencing hospital stay length.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Pierre-Yves Charles, Marion Vallet, Renaud De la Faille, Pierre Merville, Severine Lagarde, Nicolas Grenier, Claire Lebely, Benoit Lepage, Julien Allard, Nassim Kamar, Ivan Tack
Summary: The study evaluated renal adaptation following nephrectomy according to menopausal status in women and found that menopausal status did not influence kidney adaptation, indicating it is not a potential limiting factor for living kidney donation.
JOURNAL OF NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Edward D. Percy, Morgan Harloff, Sameer Hirji, Richard J. Tartarini, Siobhan McGurk, Olena Cherkasky, Tsuyoshi Kaneko
Summary: This study examines the influence of complications on midterm survival in patients undergoing transcatheter aortic valve replacement. The findings show that severe stroke is associated with decreased 5-year survival, while the impact of paravalvular leak on survival is not significant. Therefore, strategies to reduce the incidence of stroke and paravalvular leak should be prioritized to improve long-term outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Paige Newell, Edward Percy, Sameer Hirji, Morgan Harloff, Siobhan McGurk, Alexandra Malarczyk, Muntasir Chowdhury, Farhang Yazdchi, Tsuyoshi Kaneko
Summary: This study aimed to assess whether the volume-outcome relationships are mitigated at high-volume mitral repair centers between high-volume (HV) and low-volume (LV) surgeons. The results showed that despite higher repair conversion rates in LV surgeons, their short-term and long-term outcomes were similar to those of HV surgeons.
ANNALS OF THORACIC SURGERY
(2023)
Article
Surgery
Carmen Lefaucheur, Kevin Louis, Anna B. Morris, Jean-Luc Taupin, Peter Nickerson, Anat R. Tambur, Howard M. Gebel, Elaine F. Reed
Summary: This consensus report provides clinical practice recommendations in kidney, heart, lung, and liver transplantation based on expert assessment of quality and strength of evidence regarding the relationship between anti-HLA donor-specific antibodies and transplant outcome. The recommendations address major clinical problems in transplantation, including the clinical implications of positive posttransplant DSA detection, the relevance of posttransplant DSA assessment for diagnosis and treatment management, and the relevance of posttransplant DSA for allograft prognosis and risk stratification.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Aparna C. Swaminathan, Alec McConnell, Sarah Peskoe, Mustafa R. Bashir, Erika Bush Buckley, Courtney W. Frankel, Daniel J. Turner, Patrick J. Smith, Lorenzo Zaf, Lianne G. Singer, Laurie D. Snyder
Summary: This study investigated the relationship between multiple frailty models before lung transplantation and short-term outcomes after surgery. It found that cumulative deficit models of frailty were associated with outcomes within the first 90 days, while phenotypic frailty was associated with 1-year survival.
Editorial Material
Surgery
Sameer A. Hirji, Edward Percy, Lena Trager, Krish C. Dewan, Laura Seese, Ayman Saeyeldin, Jennifer Hubbard, Mohammad A. Zafar, Daniel Rinewalt, Ahmed Alnajar, Paige Newell, Tsuyoshi Kaneko, Sary Aranki, Prem Shekar
CURRENT PROBLEMS IN SURGERY
(2023)
Review
Surgery
Sameer A. Hirji, Edward Percy, Lena Trager, Krish C. Dewan, Laura Seese, Ayman Saeyeldin, Jennifer Hubbard, Mohammad A. Zafar, Daniel Rinewalt, Ahmed Alnajar, Paige Newell, Tsuyoshi Kaneko, Sary Aranki, Prem Shekar
CURRENT PROBLEMS IN SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Anubodh S. S. Varshney, David D. D. Berg, Guohai Zhou, Lauren Sinnenberg, Sameer Hirji, Ersilia M. M. DeFilippis, Hari R. R. Mallidi, David A. A. Morrow, Daniel Rinewalt, Michael M. M. Givertz
Summary: This study aimed to describe outcomes of bridging strategies in patients with ADHF-CS bridged to LVAD or HTx. The study found that different bridging strategies were associated with different outcomes, with the highest mortality rate observed in patients bridged with TMCS. LVAD recipients had higher rates of post-operative complications compared to HTx recipients.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu Sa, Jef Van den Eynde, Matheus Simonato, Sameer Hirji, Ozgun Erten, Xander Jacquemyn, Panagiotis Tasoudis, Alexander Dokollari, Serge Sicouri, Alexander Weymann, Arjang Ruhparwar, Rakesh Arora, Marie- Annick Clavel, Philippe Pibarot, Basel Ramlawi
Summary: The study found that ViV-TAVI is associated with a decreased risk of all-cause mortality in the short term after the procedure compared to redo SAVR. However, over time, redo SAVR seems to be protective against all-cause mortality. These results should be interpreted with caution as they are based on pooled data from observational studies, and further clinical trials are needed.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jamie L. Todd, Jeremy M. Weber, Francine L. Kelly, Megan L. Neely, Andrew Nagler, Dylan Carmack, Courtney W. Frankel, David M. Brass, John A. Belperio, Marie M. Budev, Matthew G. Hartwig, Tereza Martinu, John M. Reynolds, Pali D. Shah, Lianne G. Singer, Laurie D. Snyder, S. Sam Weigt, Scott M. Palmer
Summary: This study found an association between reduced levels of club cell secretory protein (CCSP) in bronchoalveolar lavage fluid (BALF) and the development of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. Decreased CCSP in early post-transplant BALF may indicate an increased risk of later CLAD.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Virology
Lorenzo Zaffiri, Joshua E. Messinger, Erika J. Bush, Janet S. Staats, Prekshaben Patel, Scott M. Palmer, Kent J. Weinhold, Laurie D. Snyder, Micah A. Luftig
Summary: Reactivation of Epstein-Barr virus (EBV) is often seen in lung transplant recipients (LTRs), but the cellular immune responses to EBV in adult LTRs have not been fully described. In this study, we found significant changes in CD4/CD8 ratio, EBV-specific CD8(+)CD69(+) T cell responses, and NK cell phenotypic changes in adult LTRs with EBV-associated diseases. These findings provide valuable insights into the immune responses to EBV in adult LTRs and may contribute to improved management of EBV-related complications.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Asishana Osho, Marcelo F. F. Fernandes, Ram Poudel, James de Lemos, Haoyun Hong, Juan Zhao, Shen Li, Kathie Thomas, Daniel S. S. Kikuchi, Jessica Zegre-Hemsey, Nasrien Ibrahim, Nilay S. S. Shah, Lori Hollowell, Jacqueline Tamis-Holland, Christopher B. B. Granger, Mauricio Cohen, Timothy Henry, Alice K. K. Jacobs, James G. G. Jollis, Clyde W. W. Yancy, Abhinav Goyal
Summary: This study analyzed data from the American Heart Association registry and found that contemporary systems of care for ST-segment-elevation myocardial infarction (STEMI) in the United States may not effectively reduce racial and ethnic disparities in treatment goals and mortality.
Article
Surgery
Georgina Rowe, George Gill, M. Mujeeb Zubair, Qiudong Chen, Jason Thomas, Shrishiv A. A. Timbalia, Asishana A. A. Osho, Dominic Emerson, Richard Kim, Michael E. E. Bowdish, Joanna Chikwe, Joseph W. W. Turek
Summary: This study aimed to evaluate the characteristics and outcomes of children undergoing repeat heart transplantation in the United States based on the underlying diagnosis. The long-term outcomes remain poor for patients undergoing repeat heart transplantation, particularly those with an inter-transplant interval <3.6 years. The underlying diagnosis does not impact outcomes after repeat transplantation, after accounting for other risk factors.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
George Gill, Georgina Rowe, M. Mujeeb Zubair, Qiudong Chen, Jason Thomas, Peter Chiu, Asishana Osho, Vikram Sood, Kurt R. Schumacher, Dominic Emerson, Michael E. Bowdish, Joanna Chikwe, Francis Fynn-Thompson
Summary: The age difference between donors and recipients has an impact on the survival rate after adolescent heart transplantation. An age difference greater than 11 years is associated with higher long-term mortality.
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jason Thomas, Qiudong Chen, Amy Roach, Stanley Wolfe, Asishana A. Osho, Vinay Sundaram, Steven A. Wisel, Dominick Megna, Dominic Emerson, Lawrence Czer, Fardad Esmailian, Joanna Chikwe, Irene Kim, Pedro Catarino
Summary: The utilization and outcomes of concurrently procured DCD livers and kidneys were evaluated in this study. It was found that in-situ thoracoabdominal normothermic regional perfusion was associated with increased utilization of DCD livers and a lower incidence of delayed graft function in concurrently procured DCD kidneys.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
W. M. Tsuang, Ml Neely, S. M. Palmer, LG. Singer, M. Budev, P. Shah, J. A. Belperio, J. M. Reynolds, L. D. Snyder
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)