Article
Medicine, General & Internal
Neel Patel, Sandeep Singh, Rupak Desai, Aakash Desai, Mohammed Nabeel, Neil Parikh, Gagandeep Singh, Smit Patel, Radhika Parikh, Supriya Mahajan
Summary: Hospital quality improvement and hospital performance are commonly evaluated using parameters such as average length of stay (LOS), patient safety measures and rates of hospital readmission. 30-day readmission (30-DR) rates are widely used as a quality indicator and a quantifiable metric for hospitals since patients are often readmitted for the exacerbation of conditions from index admission. The study reported the 30-DR rates of patients with asthma using a national dataset for the year 2013.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Engineering, Biomedical
John A. Berkebile, Samer A. Mabrouk, Venu G. Ganti, Adith Srivatsa, Jesus Antonio Sanchez-Perez, Omer T. Inan
Summary: This study evaluated the feasibility of convenient, wearable multi-frequency impedance pneumography (IP)-based respiratory monitoring in ambulatory persons. The results showed that this technology performs comparably to traditional, cumbersome IP configurations in estimating tidal volume and respiratory timing during ambulation.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Pediatrics
Brian P. Fallon, Alex J. Thompson, Aaron R. Prater, Skylar Buchan, Trevor Alberts, Mark Hoenerhoff, Alvaro Rojas-Pena, Robert H. Bartlett, Ronald B. Hirschl
Summary: This study evaluated the function of a low-resistance, pumpless artificial lung (MLung) developed specifically for children in healthy animal subjects. The results showed that MLung provides adequate gas exchange at appropriate blood flows in a PA-to-LA configuration. However, further improvements are needed to enhance the biocompatibility of the device.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Surgery
Eric Wise, Daniel Leslie, Stuart Amateau, Kyle Hocking, Adam Scott, Nirjhar Dutta, Sayeed Ikramuddin
Summary: By examining a comprehensive national database, this study identifies patient factors associated with poor outcomes after duodenal switch (DS) and compares the performance of multivariate logistic regression and artificial neural network (ANN) models in predicting these outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
John W. Blackett, Ling Chen, Jianhua Li, Jason D. Wright, Daniel E. Freedberg
Summary: The study found that discharge on inappropriate PPIs was associated with 30-day hospital readmission compared to appropriate PPIs. This may not be due to the direct effects of PPIs, as all patients in the study received PPIs, but rather patients who receive inappropriate PPIs may have additional patient-specific factors that place them at increased risk for hospital readmission.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Medicine, General & Internal
Aadil Ali, Antti I. Nykanen, Erika Beroncal, Edson Brambate, Andrea Mariscal, Vinicius Michaelsen, Aizhou Wang, Mitsuaki Kawashima, Rafaela V. P. Ribeiro, Yu Zhang, Eddy Fan, Laurent Brochard, Jonathan Yeung, Tom Waddell, Mingyao Liu, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Summary: This study demonstrates for the first time the feasibility of three-day lung preservation, leading to excellent early post-transplant outcomes. The combination of cold storage and intermittent ex vivo lung perfusion opens up new opportunities in organ transplantation.
Review
Medicine, General & Internal
Ann-Rong Yan, Indira Samarawickrema, Mark Naunton, Gregory M. Peterson, Desmond Yip, Reza Mortazavi
Summary: This study aims to investigate the available VTE risk assessment tools for ambulatory patients with lung cancer and compare their predictive performance. Systematic evaluation and meta-analysis will be conducted to determine the incidence of VTE and the performance of the risk models included in the studies.
Review
Medicine, General & Internal
Michele Umbrello, John J. J. Marini, Paolo Formenti
Summary: Nutritional support for ARDS patients is important due to the specific metabolic alterations caused by the body's response to illness and the limitations in oxygen supply. This narrative review focuses on the characteristics of metabolic and artificial nutrition in patients with acute respiratory failure, including substrate metabolism, energy consumption, and the effects of macronutrients on lung tissue viability. It also provides suggestions for the ideal methods of metabolic support for critically ill patients with ARDS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Shehan Jayasekera, Edward Hensel, Risa Robinson
Summary: The study assessed the feasibility of using commercially available wearable respiratory monitors (WRMs) for measuring inhalation topography, finding that none of the WRMs fully met all the requirements without modification, indicating the need for further development and adaptation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Biotechnology & Applied Microbiology
Ahad Syed, Sarah Kerdi, Adnan Qamar
Summary: Artificial lung technology is advancing rapidly, offering hope for patients in need of respiratory support. From rehabilitation to transplantation, the search for safe and effective artificial lungs is critical. This review details the key advances in the historical development of artificial lungs, outlining the current state of extracorporeal membrane oxygenation, intravascular lung assists, and other technologies.
BIOENGINEERING-BASEL
(2021)
Review
Cardiac & Cardiovascular Systems
Aakash Shah, Morcos A. Awad, Zhongjun J. Wu, Bartley P. Griffith
Summary: The use of extracorporeal life support (ECLS) has significantly evolved over the decades, becoming a crucial treatment for patients with acute respiratory distress syndrome. With advances in technology, more patients are being treated with ECLS and there is potential for stable patients to receive treatment at home in the future.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Huang MingJun, Dai Yan, Li JiPing, Ma HongSheng
Summary: The study evaluated the 30-day unplanned readmission rate and reasons for readmission after ambulatory laparoscopic cholecystectomy in a tertiary hospital in western China. The unplanned readmission rate was 1.53% with a higher rate of patients diagnosed with cholecystolithiasis with cholecystitis in the readmission group. Majority of readmissions occurred within the first seven days, with wound problems and abdominal pain being the main reasons.Suggestions were made for interventions by clinical professionals to reduce these causes of readmission.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Etienne Charpentier, Gilles Soulat, Antoine Fayol, Anne Hernigou, Marine Livrozet, Teodor Grand, Guillaume Reverdito, Jad al Haddad, Kim Diep Dang Tran, Anne Charpentier, Olivier Clement, Jean-Sebastien Hulot, Elie Mousseaux
Summary: By using chest CT in COVID-19 patients, extensive lung damage can be visually assessed with a score related to 30-day mortality independent of conventional risk factors of the disease. Patients with a vldCTs score of 7 or higher had significantly higher 30-day mortality rates compared to those with a score below 7.
EUROPEAN RADIOLOGY
(2021)
Article
Critical Care Medicine
Anoopindar K. Bhalla, Margaret J. Klein, Guillaume Emeriaud, Yolanda M. Lopez-Fernandez, Natalie Napolitano, Analia Fernandez, Awni M. Al-Subu, Rainer Gedeit, Steven L. Shein, Ryan Nofziger, Deyin Doreen Hsing, George Briassoulis, Stavroula Ilia, Florent Baudin, Byron Enrique Pineres-Olave, Ledys Maria Izquierdo, John C. Lin, Ira M. Cheifetz, Martin C. J. Kneyber, Lincoln Smith, Robinder G. Khemani, Christopher J. L. Newth
Summary: The study described mechanical ventilation management in pediatric acute respiratory distress syndrome and found that nonadherence to lung-protective ventilation principles is common, potentially impacting outcomes. Modifiable factors exist that may improve adherence.
CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Russo, Michele Di Mauro, Guglielmo Saitto, Antonio Lio, Paolo Berretta, Maurizio Taramasso, Roberto Scrofani, Alessandro Della Corte, Sandro Sponga, Ernesto Greco, Matteo Saccocci, Antonio Calafiore, Giacomo Bianchi, Dror B. Leviner, Andrea Biondi, Ester Della Ratta, Ugolino Livi, Erez Sharoni, Paul Werner, Carlo De Vincentiis, Marco Di Eusanio, Alfred Kocher, Carlo Antona, Fabio Miraldi, Giovanni Troise, Marco Solinas, Francesco Maisano, Guenther Laufer, Francesco Musumeci, Martin Andreas
Summary: This study compared the outcomes of isolated tricuspid valve surgery performed with two different approaches. The results showed that surgery performed with a beating heart technique was a safe option and resulted in a trend of increased long-term survival and less need for reoperation compared to the standard arrested heart technique.
ANNALS OF THORACIC SURGERY
(2022)
Article
Engineering, Biomedical
Wenji Sun, Jiafeng Zhang, Aakash Shah, Katherin Arias, Zachary Berk, Bartley P. Griffith, Zhongjun J. Wu
Summary: The study demonstrated that pump-assisted circulation led to neutrophil activation, apoptosis, and functional impairment, which were strongly associated with pump operating condition and duration.
Article
Engineering, Biomedical
Zachary B. K. Berk, Aakash Shah, Wenji Sun, Bartley P. Griffith, Zhongjun J. Wu
Summary: The study found that aPTT had a more reliable correlation to heparin concentration, particularly at lower concentrations, while the correlation between aPTT and ACT values was poor. Further in vivo studies are needed to confirm these results.
Article
Computer Science, Interdisciplinary Applications
Ge He, Lu Han, Jiafeng Zhang, Aakash Shah, David J. Kaczorowski, Bartley P. Griffith, Zhongjun Wu
Summary: LVADs are increasingly used for end-stage heart failure patients, but associated with thromboembolic events. FSI simulation in this study evaluated the effect of LVAD IC orientation on LV hemodynamics, finding that IC towards the MV may reduce the risk of thrombus formation.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Giacomo Bianchi, Giovanni Concistre, Dorela Haxhiademi, Beatrice Caliani, Michele Guarino, Marco Solinas
Summary: This paper describes a method for managing the persistence of the left superior vena cava and the absence of the anonymous vein in minimally invasive mitral surgery.
HEART LUNG AND CIRCULATION
(2022)
Article
Biochemistry & Molecular Biology
Mark F. Pittenger, Saman Eghtesad, Pablo G. Sanchez, Xiaoyan Liu, Zhongjun Wu, Ling Chen, Bartley P. Griffith
Summary: Pretreating MSCs with agents that block apoptotic pathways improves their in vivo survival, leading to improved cardiac function in a myocardial infarct model. This approach has implications for MSC-based cardiac therapies and other indications where increased cell survival is desired.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Russo, Michele Di Mauro, Guglielmo Saitto, Antonio Lio, Paolo Berretta, Maurizio Taramasso, Roberto Scrofani, Alessandro Della Corte, Sandro Sponga, Ernesto Greco, Matteo Saccocci, Antonio Calafiore, Giacomo Bianchi, Dror B. Leviner, Andrea Biondi, Ugolino Livi, Erez Sharoni, Carlo De Vincentiis, Marco Di Eusanio, Carlo Antona, Giovanni Troise, Marco Solinas, Guenther Laufer, Francesco Musumeci, Martin Andreas
Summary: This study retrospectively analyzed the early and long-term outcomes of isolated tricuspid valve surgery, and found that repair surgery had lower early and late mortality rates compared to replacement surgery, with no difference in reoperation rates.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Michele Di Mauro, Marco Russo, Guglielmo Saitto, Antonio Lio, Paolo Berretta, Maurizio Taramasso, Roberto Scrofani, Alessandro Della Corte, Sandro Sponga, Ernesto Greco, Matteo Saccocci, Antonio Calafiore, Giacomo Bianchi, Dror B. Leviner, Andrea Biondi, Ugolino Livi, Erez Sharoni, Carlo De Vincentiis, Marco Di Eusanio, Carlo Antona, Giovanni Troise, Marco Solinas, Guenther Laufer, Francesco Musumeci, Martin Andreas
Summary: This study aimed to analyze the outcomes of isolated tricuspid valve surgery in patients with endocarditis compared to other pathologies. The results showed that patients with endocarditis had lower risk of cardiac death and reoperation within six years, but lower overall survival. Therefore, a multi-disciplinary approach, repair strategy, and early treatment may improve outcomes for these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Concistre, Giacomo Bianchi, Rafik Margaryan, Edoardo Zancanaro, Francesca Chiaramonti, Enkel Kallushi, Tommaso Gasbarri, Michele Murzi, Egidio Varone, Simone Simeoni, Alessandro Leone, Filippo Santarelli, Pierandrea Farneti, Marco Solinas
Summary: This study describes the long-term clinical and echocardiographic outcomes of patients undergoing aortic valve replacement (AVR) using the Perceval bioprosthesis. The results show that the use of Perceval bioprosthesis is associated with good clinical results and excellent hemodynamic performance in a 10-year experience.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Mariani, I-wen Wang, Bas C. T. van Bussel, Samuel Heuts, Dominik Wiedemann, Diyar Saeed, Iwan C. C. van der Horst, Matteo Pozzi, Antonio Loforte, Udo Boeken, Robertas Samalavicius, Karl Bounader, Xiaotong Hou, Jeroen J. H. Bunge, Hergen Buscher, Leonardo Salazar, Bart Meyns, Daniel Herr, Sacha Matteucci, Sandro Sponga, Kollengode Ramanathan, Claudio Russo, Francesco Formica, Pranya Sakiyalak, Antonio Fiore, Daniele Camboni, Giuseppe Maria Raffa, Rodrigo Diaz, Jae-Seung Jung, Jan Belohlavek, Vin Pellegrino, Giacomo Bianchi, Matteo Pettinari, Alessandro Barbone, Jose P. Garcia, Kiran Shekar, Glenn Whitman, Roberto Lorusso
Summary: Intraoperative and postoperative ECMO implantations are associated with different patient characteristics and outcomes, with greater complications and in-hospital mortality after postoperative ECMO.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Giacomo Bianchi, Edoardo Zancanaro, Angela Pucci, Marco Solinas
Summary: This is a rare case of mature cardiomyocyte hamartoma in a young patient, with a complex diagnostic pathway to understand its nature and treatment options. Myocardial bridge was also discovered during the diagnostic process. The final diagnosis was confirmed through coronary unroofing and surgical biopsy.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel Heuts, Silvia Mariani, Bas C. T. van Bussel, Udo Boeken, Robertas Samalavicius, Karl Bounader, Xiaotong Hou, Jeroen J. H. Bunge, Kogulan Sriranjan, Dominik Wiedemann, Diyar Saeed, Matteo Pozzi, Antonio Loforte, Leonardo Salazar, Bart Meyns, Michael A. Mazzeffi, Sacha Matteucci, Sandro Sponga, Vitaly Sorokin, Claudio Russo, Francesco Formica, Pranya Sakiyalak, Antonio Fiore, Daniele Camboni, Giuseppe Maria Raffa, Rodrigo Diaz, I-wen Wang, Jae-Seung Jung, Jan Belohlavek, Vin Pellegrino, Giacomo Bianchi, Matteo Pettinari, Alessandro Barbone, Jose P. Garcia, Kiran Shekar, Glenn Whitman, Roberto Lorusso
Summary: This study evaluated the association between body mass index (BMI) and in-hospital outcomes in cardiac surgery patients requiring postcardiotomy venoarterial extracorporeal membrane oxygenation (V-A ECMO). The results showed that there was no association between BMI and in-hospital outcomes after adjustment for confounders. Therefore, BMI should not be incorporated in the risk stratification for postcardiotomy V-A ECMO.
ANNALS OF THORACIC SURGERY
(2023)
Article
Engineering, Biomedical
Dong Han, Jiafeng Zhang, Ge He, Bartley P. Griffith, Zhongjun J. Wu
Summary: This study developed a new pediatric ECMO system, called PPL, which has excellent biocompatibility and gas exchange performance. Computational and experimental data showed that the PPL's oxygenator has significantly low pressure drop and better hemolysis performance. The PPL has the potential to provide blood pumping and respiratory support for a wide range of pediatric patients.
Article
Medicine, General & Internal
Giovanni Concistre, Tommaso Gasbarri, Marcello Ravani, Anees Al Jabri, Giuseppe Trianni, Giacomo Bianchi, Rafik Margaryan, Francesca Chiaramonti, Michele Murzi, Enkel Kallushi, Egidio Varone, Simone Simeoni, Alessandro Leone, Andrea Farneti, Sergio Berti, Marco Solinas
Summary: This study explores the clinical outcomes and technical aspects of using valve-in-valve transcatheter aortic valve replacement (VIV-TAVR) to treat degenerated Perceval aortic bioprostheses. The results show that this treatment option is safe, effective, and associated with good clinical and hemodynamic results.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Dong Han, Wenji Sun, Kiersten P. Clark, Bartley P. Griffith, Zhongjun J. Wu
Summary: High levels of non-physiological shear stress mainly activate platelets by enhancing the vWF-GPIb alpha interaction. Shear-induced platelet activation and receptor shedding occur through distinct pathways.