Article
Cardiac & Cardiovascular Systems
Domenico Spinelli, Fred A. Weaver, Ali Azizzadeh, Gregory A. Magee, Gabriele Piffaretti, Filippo Benedetto, Charles C. Miller, Harleen K. Sandhu, Dennis R. Gable, Santi Trimarchi
Summary: The study aimed to analyze the outcomes of thoracic endovascular aortic repair for complicated and uncomplicated acute type B aortic dissections. The data from WL Gore's Global Registry for Endovascular Aortic Treatment showed that the 30-day mortality and perioperative complications were equally low for both complicated and uncomplicated type B aortic dissections, and the midterm outcome was positive.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Dan Yi, Xiatian Liu, Libin Fan
Summary: This article presents a rare case of pheochromocytoma combined with aortic dissection. The presence of pheochromocytoma complicates the surgical treatment of aortic dissection. The detection of elevated 24-hour urinary vanillylmandelic acid levels can aid in the diagnosis of pheochromocytoma. Laparoscopic resection of the adrenal mass can be performed after stabilization and control of hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Callum Howard, Jonathan Sheridan, Leonardo Picca, Sihab Reza, Tristan Smith, Anuradha Ponnapalli, Rachel Calow, Olivia Cross, Sashini Iddawela, Melvin George, Deidre Livra Dias, Anand Srinivasan, Wahaj Munir, Mohammad Bashir, Mohammed Idhrees
Summary: This study found that despite significantly higher comorbidities in the co-TBAD cohort, there was no difference in in-hospital mortality between the two groups and the 5-year survival did not have any difference.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Surgery
Daniel J. Torrent, Graeme E. McFarland, Grace Wang, Mahmoud Malas, Benjamin J. Pearce, Victoria Aucoin, Dan Neal, Emily L. Spangler, Zdenek Novak, Salvatore T. Scali, Adam W. Beck
Summary: This analysis examined the correlation between the timing of TEVAR for UATBAD patients and postoperative complications. While timing did not predict mortality or long-term complications, there was a higher risk of reintervention within 1-14 days post-operation. This suggests the importance of further study on optimal timing for intervention in TEVAR trials.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Christopher Lau, Giovanni Soletti, Kendall M. Lawrence, Mohamed Rahouma, Erin Iannacone, Ivancarmine Gambardella, Mario Gaudino, Leonard N. Girardi
Summary: This study compares the outcomes of open repair for acute complicated type B aortic dissection (ACTBAD) with standard repair. The results show that in an experienced center, open repair of ACTBAD can be performed with low rates of operative mortality and morbidity, achieving outcomes similar to elective repair even in high-risk patients.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Surgery
Erin C. Saricilar, Kiraati Patel, Raleene Gatmaitan, Vikram Puttaswamy
Summary: This systematic review found that early intervention in Type B aortic dissections can improve aorta related events in the one year follow up period without changing the mortality rate compared to late intervention. Therefore, performing TEVAR surgery within 3 to 14 days after symptom onset is both safe and beneficial.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Li Cheng, Dongqiao Xiang, Shan Zhang, Chuansheng Zheng, Xiaoyan Wu
Summary: In this retrospective study, reintervention after TEVAR was observed in 11.3% of patients with uncomplicated TBAD, and the main reasons included endoleak, aneurysmal dilation, and dissection progression. Larger initial aortic diameter and excessive proximal landing zone oversizing were identified as significant risk factors for reintervention. Reintervention did not significantly affect long-term survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Mohamad Bashir, Matti Jubouri, Sven Z. C. P. Tan, Damian M. Bailey, Bashi Velayudhan, Idhrees Mohammed, Randolph H. L. Wong, Martin Czerny, Edward P. Chen, Leonard N. Girardi, Joseph S. Coselli, Ian Williams
Summary: This review aims to delineate the literature defining the intervention parameters for UnCoTBAD. While UnCoTBAD is considered uncomplicated, close monitoring and potentially more complex interventions may be required for certain high-risk features.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Medicine, General & Internal
Thierry Carrel, Thoralf M. Sundt, Yskert von Kodolitsch, Martin Czerny
Summary: Despite advancements in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event with high mortality and morbidity rates. Recent research has improved our understanding of the disease's pathophysiology and led to reevaluations of existing classifications. There is a shift towards a unified naming system based on morphology and function. The location and extent of the initial tear, as well as the affected aortic segments, determine the appropriate management approach - emergency surgery, endovascular intervention, or medical treatment. Ongoing scientific evidence continues to shape the management and follow-up of acute aortic dissection, the most severe form of acute aortic syndrome.
Review
Cardiac & Cardiovascular Systems
WenXin Zhao, Yang Yang, ZhiYuan Wu, ZuoGuan Chen, YongPeng Diao, Yong Lan, YongJun Li
Summary: This study conducted a meta-analysis to evaluate the optimal timing for endovascular repair of acute versus subacute uncomplicated Type B Aortic Dissection. The results showed that the acute group had higher rates of 30-day complications, mortality, and 1-year mortality compared to the subacute group. Therefore, endovascular repair at the subacute phase appears to be more favorable than the acute phase.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Antony Aziz, Hannah O'Donnell, Donald G. Harris, Hee Soo Jung, Paul DiMusto
Summary: This study aimed to develop a standardized medical management protocol for uncomplicated acute type B aortic dissection (TBAD) and found that implementing the protocol reduced resource utilization and costs without compromising patient outcomes. The protocol focused on early initiation of oral medications, weaning of anti-hypertensive infusions, and frequent assessment for de-escalation of care. Post-protocol patients had shorter hospital stays, decreased costs, and required less antihypertensive medication at discharge. There was no significant difference in 30-day mortality.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Sheng Su, Jitao Liu, Changjin Wang, Ruirong Chen, Yuan Liu, Wenhui Huang, Songyuan Luo, Fan Yang, Jianfang Luo
Summary: This study reported the results of optimal medical treatment (OMT) and endovascular aortic repair (EVAR) in patients with uncomplicated isolated abdominal aortic dissection (IAAD). The findings showed that OMT can safely manage IAAD, but there is a risk of disease progression. EVAR significantly prevents IAAD progression compared to OMT.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Xiaoli Wang, Xi Liu, E. Liao, Ning Ge, Yaping Hu
Summary: This study investigates the characteristics, diagnosis and treatment plan, and maternal and infant outcomes of pregnancy complicated with aortic dissection. Two pregnant women with persistent back pain were diagnosed with aortic dissection and underwent surgical interventions. Good maternal and infant outcomes were achieved through early identification and treatment.
Article
Medicine, Research & Experimental
Claudina Rudolph, Beate Rikken Lindberg, Timothy Resch, Kevin Mani, Patrick Bjorkman, Elin Hanna Laxdal, Henrik Stovring, Henriette Margrethe Beck, Gunnar Eriksson, Jacob Budtz-Lilly
Summary: This clinical trial aims to evaluate the impact of early TEVAR on the 5-year survival rate of uTBAD patients, as well as collect data on its impact on quality of life and healthcare costs.
Article
Surgery
Tomoki Cho, Keiji Uchida, Shota Yasuda, Ryo Izubuchi, Shotaro Kaneko, Atsushi Matsumoto, Makoto Ikematsu, Sho Kakuta
Summary: This study aimed to examine the mid-term results of pre-emptive thoracic endovascular aortic aneurysm repair (TEVAR) for uncomplicated type B aortic dissection. The study found that zone 2 landing was an independent risk factor for aortic enlargement after pre-emptive TEVAR.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Tim Berger, Andreas Voetsch, Diaa Alaloh, Maximilian Kreibich, Philipp Krombholz-Reindl, Andreas Winkler, Bartosz Rylski, Thomas Wolfgruber, Friedhelm Beyersdorf, Matthias Siepe, Rainald Seitelberger, Martin Czerny, Roman Gottardi
Summary: In patients with traumatic aortic injury (TAI), the diameter of the aorta is significantly reduced at discharge compared to admission. The reduction in aortic diameter may be attributed to substantial blood loss.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Cardiac & Cardiovascular Systems
Philipp Angleitner, Derek R. Brinster, Thomas G. Gleason, Kevin M. Harris, Arturo Evangelista, Raffi Bekeredjian, Daniel G. Montgomery, Harleen K. Sandhu, George J. Arnaoutakis, Marco Di Eusanio, Santi Trimarchi, Christoph A. Nienaber, Eric M. Isselbacher, Kim A. Eagle, Marek P. Ehrlich
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Adelina Plangger, Barbara Rath, Maximilian Hochmair, Martin Funovics, Christoph Neumayer, Robert Zeillinger, Gerhard Hamilton
Summary: The study found that fascaplysin exhibits high cytotoxicity against NSCLC cells with a different activity pattern compared to the standard drug cisplatin. Additionally, the combination of fascaplysin and the EGFR tyrosine kinase inhibitor afatinib could enhance the antitumor effect.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Cardiac & Cardiovascular Systems
Sven R. Hauck, Wolf Eilenberg, Alexander Kupferthaler, Maximilian Kern, Theresa-Marie Dachs, Alexander Wressnegger, Christoph Neumayer, Christian Loewe, Martin A. Funovics
Summary: Using a commercially available steerable sheath allowed successful cannulation of all branches, leading to significantly shorter branch cannulation times. This technique has the potential to lower the risks of stroke and brachial puncture site complications, as well as reduce total intervention time and radiation dose.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sven R. Hauck, Alexander Kupferthaler, Maximilian Kern, Herve Rousseau, Ciro Ferrer, Shinichi Iwakoshi, Shoji Sakaguchi, Marie-Elisabeth Stelzmuller, Marek Ehrlich, Christian Loewe, Martin A. Funovics
Summary: This study compared the results of two commercially available devices for branched thoracic endovascular aortic repair and fenestrated thoracic endovascular aortic repair. The results showed that both methods had excellent technical success and acceptable complication rates, but branched repair tended to have higher stroke rates. Meanwhile, fenestrated repair had a wider range of applicability.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sven R. Hauck, Alexander Kupferthaler, Martin C. Freund, Peter Pichler, Marie-Elisabeth Stelzmueller, Christopher Burghuber, Marek Ehrlich, Harald Teufelsbauer, Christian Loewe, Martin A. Funovics
Summary: This study presents a case series of spontaneous structural failure of bridging stentgrafts (BSGs) after branched endovascular aortic repair (bEVAR), highlighting its limitations and detection challenges. The study found that BSG failure is a serious complication of bEVAR, resulting in high reintervention rates and significant morbidity and mortality. BSG failures typically occur in single-layer types and are clustered in patients. Caution is advised when using BSGs in bEVAR, as it is an off-label use.
INSIGHTS INTO IMAGING
(2022)
Article
Surgery
Sven R. Hauck, Maximilian Kern, Theresa-Marie Dachs, Lukas Haider, Marie-Elisabeth Stelzmueller, Marek Ehrlich, Christian Loewe, Martin A. Funovics
Summary: This study assessed the anatomical and clinical applicability of six commercially available branched/fenestrated stent grafts for endovascular repair of post-type A aortic dissection (PTAD). The results showed high anatomical and clinical applicability for these devices, especially for the combination of fenestrated and branched devices.
JOURNAL OF VASCULAR SURGERY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Christian Loewe
Article
Cardiac & Cardiovascular Systems
Kevin M. Harris, Christoph A. Nienaber, Mark D. Peterson, Elise M. Woznicki, Alan C. Braverman, Santi Trimarchi, Truls Myrmel, Reed Pyeritz, Stuart Hutchison, Craig Strauss, Marek P. Ehrlich, Thomas G. Gleason, Amit Korach, Daniel G. Montgomery, Eric M. Isselbacher, Kim A. Eagle
Summary: This study examined the early mortality rates for patients with TAAAD in the contemporary era and found that the mortality rate for the medical group was 0.5% per hour (23.7% at 48 hours), while for the surgical group, 48-hour mortality decreased to 4.4%.
Article
Surgery
Alexander Kupferthaler, Sven R. Hauck, Michael Schwarz, Maximilian Kern, Julia Deinsberger, Theresa-Marie Dachs, Christoph Neumayer, Maria-Elisabeth Stelzmueller, Marek Ehrlich, Christian Loewe, Martin A. Funovics
Summary: This study reports the long-term outcomes of tubular and scalloped TEVAR in treating PAUs and compares the safety profile in both cohorts. The results show that TEVAR and scTEVAR provide excellent and similar clinical success and aortic survival with acceptable complication and reintervention rates. The clinical impact is that more patients can be treated with endovascular repair by including scTEVAR.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Surgery
Anna Sotir, Johannes Klopf, Florian Wolf, Martin A. Funovics, Christian Loewe, Christoph Domenig, Tilo Koelbel, Christoph Neumayer, Wolf Eilenberg
Summary: This retrospective study evaluated the clinical outcomes of F/B-EVAR procedures performed under biplane angiography guidance. The study found that using biplane angiography significantly reduced operation time. There were no significant differences between the two groups in fluoroscopy time, contrast agent volume, and radiation dose.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Franz Duca, Rene Rettl, Christina Kronberger, Christina Binder, Christopher Mann, Fabian Dusik, Lore Schrutka, Daniel Dalos, Beguem Oeztuerk, Theresa Marie Dachs, Bernhard Cherouny, Luciana Camuz Ligios, Hermine Agis, Renate Kain, Matthias Koschutnik, Carolina Dona, Roza Badr-Eslam, Johannes Kastner, Dietrich Beitzke, Christian Loewe, Christian Nitsche, Christian Hengstenberg, Andreas Anselm Kammerlander, Diana Bonderman
Summary: This study investigated the progression of extracellular volume (ECV) and its prognostic impact in cardiac amyloidosis (CA) patients. The study found that ECV significantly increased over time in all patients, with untreated patients showing a greater change. The change in ECV was a predictor of outcome and could provide important information in evaluating amyloid-specific treatments.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian Kern, Sven R. Hauck, Theresa-Marie Dachs, Lukas Haider, Marie-Elisabeth Stelzmueller, Marek Ehrlich, Christian Loewe, Martin A. Funovics
Summary: This study evaluated the anatomical suitability of currently manufactured stent grafts and valve-carrying devices for the treatment of type A aortic dissection. The results showed that the anatomical feasibility of commercial stent grafts ranged from 4% to 21%, mainly limited by the proximal landing zone diameter, length, and proximity to the sinotubular junction. The anatomical feasibility of valve-carrying conduits ranged from 31% to 80%, with the main limiting factors being the aortic annulus diameter and its distance to the coronary arteries.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Meeting Abstract
Medicine, General & Internal
T. Aschacher, O. Aschacher, K. Schmidt, F. Enzmann, E. Eichmair, B. Winkler, A. Zsuzsanna, F. Nagel, B. Podesser, A. Mitterbauer, B. Messner, M. Grabenwoeger, G. Laufer, M. Ehrlich, M. Bergmann
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kevin M. Harris, Kristen M. Westenfield, Neil Parikh, Thomas G. Gleason, Marc Schermerhorn, Maral Ouzounian, Arturo Evangelista, Joseph S. Coselli, Chih-Wen Pai, Marek Ehrlich, Clayton Allen Kaiser, Valerio Tolva, Marco Di Eusanio, Ibrahim Sultan, Kim A. Eagle, Himanshu J. Patel
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)