Editorial Material
Surgery
Shuben Li, Qing Ai, Hengrui Liang, Hui Liu, Chao Yang, Hongsheng Deng, Yunpeng Zhong, Jie Zhang, Jianxing He
Summary: This study reports a novel surgical technique that combines RATS with nonintubated spontaneous ventilation for tracheal/airway surgery. The results show that this combined approach is feasible and safe in selected patients, potentially offering advantages from both techniques.
Article
Oncology
Jianglei Ma, Xiaoyao Li, Shifu Zhao, Jiawei Wang, Wujia Zhang, Guangyuan Sun
Summary: The meta-analysis results showed that RATS had more advantages over VATS in the treatment of NSCLC, including less blood loss, lower conversion rate, more lymph node harvest, and shorter postoperative chest tube drainage time.
Article
Surgery
Jianbo Lin, Yinhe Yin, Yi Zhuo, Xu Li, Fancai Lai
Summary: Transareolar uniportal VATS is a safe and effective therapeutic procedure for male patients with small PPNs, producing good cosmetic outcomes and high patient satisfaction.
UPDATES IN SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Shengcheng Lin, Chenglin Yang, Xiaotong Guo, Yafei Xu, Lixu Wang, Zhe Wang, Xin Yu, Chunguang Wang, Zhentao Yu
Summary: The study evaluated the feasibility and safety of simultaneous bilateral pulmonary resection with uniportal video-assisted thoracic surgery. The results showed that this surgery is feasible and safe for appropriate patients, but simultaneous lobar-sublobar pulmonary resection for bilateral nodules can increase the risk of developing pneumonia.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Oncology
Savvas Lampridis, Alessandro Maraschi, Corinne Le Reun, Tom Routledge, Andrea Bille
Summary: This study compared robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) for lung cancer. RATS took longer but had less bleeding than VATS. The two surgeries had similar outcomes in terms of complications, hospital stay, readmissions, and deaths. Further research is needed to determine the benefits of one surgical approach over the other.
Article
Cardiac & Cardiovascular Systems
Alan D. L. Sihoe
Summary: The greatest disruptive innovation in lung cancer surgery has been the switch from open thoracotomy to video-assisted thoracic surgery (VATS). More recently, the transition from multiportal VATS (MVATS) to uniportal VATS (UVATS) has further reduced surgical access trauma. Numerous promising candidates, including screening, sublobar resections, 3D technology, and multi-modality management, have emerged for the next breakthrough in lung cancer surgery. However, the possibility of uniportal robotic surgery achieving further minimization of surgical access trauma requires systematic evaluation of its benefits and costs.
ANNALS OF CARDIOTHORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Alan D. L. Sihoe
Summary: The switch from open thoracotomy to video-assisted thoracic surgery (VATS) has been the greatest disruptive innovation in modern lung cancer surgery. In recent years, the transition from multiportal VATS (MVATS) to uniportal VATS (UVATS) has further reduced surgical access trauma. Promising candidates for the next breakthrough in lung cancer surgery include screening, sublobar resections, 3D technology, enhanced peri-operative care pathways, ablative therapy, and multi-modality management. However, the possibility of minimizing surgical access trauma even further through uniportal robotic surgery is also being explored. The emergence of a winning candidate will depend on a systematic evaluation of the evidence for the benefits and costs of each approach.
ANNALS OF CARDIOTHORACIC SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chuan-dong Li, Zhen-guo Huang, Hong-liang Sun, Li-tao Wang, Yu-li Wang, Bao-xiang Gao, Min-xing Yang
Summary: This study evaluated the efficacy and safety of marking ground glass nodules (GGNs) with a pulmonary nodules localization needle (PNLN) prior to video-assisted thoracoscopic surgery (VATS). The results showed a high success rate and low complication rate in marking GGNs using PNLNs. All GGNs were successfully removed by VATS, indicating the safety and reliability of this approach.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Shibo Huang, Xiaolong Huang, Zhilong Huang, Raoshan Luo, Weiming Liang
Summary: This meta-analysis compares the clinical outcomes of robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) for patients with lung cancer. The results show that RATS achieves better surgical outcomes compared to VATS in the short-term, particularly in terms of lymphadenectomy and intraoperative bleeding control. However, further large-scale and long-term randomized clinical trials are needed to better demonstrate the advantages of RATS in lung cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Kuang-Cheng Chan, Li-Lin Wu, Su-Chuan Han, Jin-Shing Chen, Ya-Jung Cheng
Summary: This study compared the analgesic and sedative effects of thoracoscopic intercostal nerve blocks (TINBs) during nonintubated and intubated video-assisted thoracic surgery (VATS). The results showed that TINBs reduced the requirement for anesthesia and analgesia in VATS. However, nonintubated VATS had a significantly higher risk of hypotension after TINBs. Real-time data provided by density spectral arrays (DSAs) were beneficial for the preemptive management, especially in nonintubated VATS.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Review
Anesthesiology
Li Ying Koh, Nian Chih Hwang
Summary: With the increasing popularity of Enhanced Recovery After Surgery protocols and advancements in video-assisted thoracoscopic surgery (VATS) equipment, nonintubated thoracoscopic surgery has become more common in recent years. This approach avoids tracheal intubation and general anesthesia, reducing the associated risks. There is evidence suggesting improved postoperative respiratory function, shorter hospital stays, and reduced morbidity and mortality; however, further research is needed to confirm these findings. This review article discusses the benefits of nonintubated VATS, patient selection, anesthetic techniques, surgical considerations, potential complications, and their management.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Respiratory System
Takahiro Ochi, Hidemi Suzuki, Yuki Hirai, Takahiro Yamanaka, Hiroki Matsumoto, Taisuke Kaiho, Terunaga Inage, Takamasa Ito, Kazuhisa Tanaka, Yuichi Sakairi, Ichiro Yoshino
Summary: This study aimed to compare the perioperative outcomes of video-assisted thoracic surgery (VATS) and robot-assisted thoracic surgery (RATS) for mediastinal procedures. The results showed that RATS is as safe as VATS and may result in a shorter operative time and postoperative hospital stay.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Oncology
Guangwen Xu, Gaoxiang Wang, Xinyu Mei, Mingsheng Wu, Tian Li, Mingran Xie
Summary: This study evaluated the effectiveness of sequential pulmonary resections by uniportal video-assisted thoracoscopic surgery (VATS) for bilateral multiple pulmonary nodules (BMPNs). The results showed that this surgical approach was safe and feasible for patients with excellent pulmonary function.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Wei-Hao Chao, Sheng-Hui Tuan, En-Kuei Tang, Yi-Ju Tsai, Jing-Hui Chung, Guan-Bo Chen, Ko-Long Lin
Summary: The study showed that individualized perioperative cardiopulmonary rehabilitation based on risk level did not significantly affect postoperative complications in patients undergoing video-assisted thoracic surgery for lung cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Diego Gonzalez-Rivas, Mugurel Bosinceanu, Natalia Motas, Veronica Manolache
Summary: Robotic-assisted thoracic surgery (RATS) provides advantages of manoeuvrability and three-dimensional view. Pure uniportal robotic-assisted thoracic surgery (U-RATS) is performed through a single intercostal incision without rib spreading. Compared to multiport, U-RATS simplifies the management of possible intraoperative bleeding and offers comfortable surgical experience for surgeons and quick recovery for patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Yi-Chun Lo, Su-Chuan Han, Ching-Kai Lin, Chung-Chih Shih, Ya-Jung Cheng
Summary: Bronchoscopic interventions and airway management for bronchoscopy are high-risk procedures for healthcare workers, as they expose them to COVID-19-containing droplets. Perioperative changes can be made to anesthetic management to reduce the spread of the virus.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Correction
Oncology
Shuenn-Wen Kuo, Pei-Hsing Chen, Tzu-Pin Lu, Ke-Cheng Chen, Hsien-Chi Liao, Kuan-Chuan Tsou, Tung-Ming Tsai, Mong-Wei Lin, Hsao-Hsun Hsu, Jin-Shing Chen
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Shuenn-Wen Kuo, Pei-Hsing Chen, Tzu-Pin Lu, Ke-Cheng Chen, Hsien-Chi Liao, Kuan-Chuan Tsou, Tung-Ming Tsai, Mong-Wei Lin, Hsao-Hsun Hsu, Jin-Shing Chen
Summary: This study investigated the effect of primary lung tumor resection on the survival of patients with stage IV EGFR-mutant NSCLC who did not progress after first-line EGFR-TKI treatment. The results showed that surgery can improve progression-free survival and overall survival better than maintenance EGFR-TKI therapy alone.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mong-Wei Lin, Sung-Liang Yu, Yin-Chen Hsu, Yan-Ming Chen, Yi-Hsuan Lee, Yi-Jing Hsiao, Jing-Wei Lin, Te-Jen Su, Chi-Fu Jeffrey Yang, Xu-Heng Chiang, Hsao-Hsun Hsu, Jin-Shing Chen, Min-Shu Hsieh
Summary: This study evaluated the pathologic and genetic changes of lung adenocarcinoma in patients treated with EGFR TKI therapy and salvage surgery. The results showed the presence of acquired resistant mutations and histologic transformations in treatment-resistant regions, indicating the existence of resistant subclones before TKI treatment progression. Salvage surgery performed before disease progression may improve overall survival by removing TKI-resistant subclones.
ANNALS OF THORACIC SURGERY
(2023)
Article
Biochemical Research Methods
Chi-Ya Shen, Wen-Hsin Chang, Yi-Ju Chen, Chia-Wei Weng, Prabha Regmi, Mickiela K. K. Kier, Kang-Yi Su, Gee-Chen Chang, Jin-Shing Chen, Yu-Ju Chen, Sung-Liang Yu
Summary: This study investigates the role of the uncharacterized protein SEL1L3 in lung adenocarcinoma. Using large-scale tissue proteogenomics data, the researchers found that SEL1L3 is dysregulated in lung adenocarcinoma and its silencing leads to reduced cell viability and activation of stress response pathways. Patients with higher SEL1L3 expression exhibit favorable clinical outcomes and immune profiles in lung adenocarcinoma.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Medicine, General & Internal
Wen-Ying Lin, Feng-Sheng Lin, Chung-Chih Shih, Yi-Jung Sung, An -Yu Chen, Yu -Chin Piao, Jin-Shing Chen, Ya-Jung Cheng
Summary: This study compared the intraoperative oxygenation and perioperative outcomes between non-intubated video-assisted thoracic surgery (NIVATS) with supra-glottic airway devices (SADs) and NIVATS with high flow nasal oxygenation (HFNO). The results showed that the HFNO group had a higher desaturation event rate, lower nadir SPO2, and longer hospitalization. However, propensity score matching analysis revealed no significant between-group difference in the desaturation rate. Smoking and HFNO were associated with intraoperative desaturation.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Surgery
Kuan-Hsun Lian, Chi-Cheng Yang, Fu-Chang Hu, Wen-Ying Lin, Wei-Ling Hsiao, Tzu-Hsin Lin, Rey-Heng Hu, Jin-Shing Chen, Hsien-Chi Liao
Summary: This study aimed to examine and analyze the immediate postoperative outcomes and 6-month quality of life in patients with moderately severe traumatic rib fractures. The results showed that the surgical group had better quality of life and physical component scores in the early postoperative period, and comparable quality of life after 6 months. Linear regression analysis identified factors such as body mass index <=25, age <=36 years, fewer ribs requiring fixation, and diabetes mellitus that positively affected the prediction of the mean physical component score.
Article
Nutrition & Dietetics
Yu-Shun Lin, Yen-Chu Chen, Tzu-En Chen, Mei-Ling Cheng, Ke-Shiuan Lynn, Pramod Shah, Jin-Shing Chen, Rwei-Fen S. Huang
Summary: This study investigates the co-expression network of tumour metabolomics and transcriptomics in relation to biological folate alteration and cancer malignancy in non-small cell lung cancers (NSCLC). Tumour lactate is identified as a top marker for predicting advanced NSCLC. Low folate (LF) tumours show higher glycolytic index and enrichment of specific biological pathways associated with amino sugar and glutathione metabolism. The co-expression network analysis reveals the involvement of LF-responsive metabolic genes in glucose transport, serine synthesis, folate cycle, and glutaminolysis. LF-responsive markers are also associated with poor survival rates in lung cancer patients.
Article
Medicine, General & Internal
Chao-Wen Lu, Mong-Wei Lin, Xu-Heng Chiang, Hsao-Hsun Hsu, Min-Shu Hsieh, Jin-Shing Chen
Summary: This study retrospectively analyzed the clinicopathological features and prognosis of early-stage lung adenocarcinoma patients and compared them based on the epidermal growth factor receptor (EGFR) mutation status. EGFR mutations were found in 60% of the patients, and these patients were older, had non-lepidic histological subtypes, higher CEA levels, more advanced pathological features, and higher histological grade. However, there was no significant difference in PFS or OS between the EGFR mutant and wild-type groups. The study suggests that EGFR mutation may serve as a predictor of treatment response rather than clinical prognosis in early-stage lung adenocarcinoma.
Article
Medicine, General & Internal
Kuang-Cheng Chan, Li-Lin Wu, Su-Chuan Han, Jin-Shing Chen, Ya-Jung Cheng
Summary: This study compared the analgesic and sedative effects of thoracoscopic intercostal nerve blocks (TINBs) during nonintubated and intubated video-assisted thoracic surgery (VATS). The results showed that TINBs reduced the requirement for anesthesia and analgesia in VATS. However, nonintubated VATS had a significantly higher risk of hypotension after TINBs. Real-time data provided by density spectral arrays (DSAs) were beneficial for the preemptive management, especially in nonintubated VATS.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Kuan-Chuan Tsou, Wan-Ting Hung, Yu-Ten Ju, Hsien-Chi Liao, Hsao-Hsun Hsu, Jin-Shing Chen
Summary: This study successfully performed tracheal transplantation using a decellularized porcine aorta as a scaffold, demonstrating the feasibility of cryopreservation for allogeneic aorta transplantation.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Jen-Hao Chuang, Pei-Hsing Chen, Tzu-Pin Lu, Wan-Ting Hung, Hsien-Chi Liao, Tung-Ming Tsai, Mong-Wei Lin, Ke-Cheng Chen, Hsao-Hsun Hsu, Jin-Shing Chen
Summary: This study compared the short- and long-term postoperative outcomes of nonintubated uniportal and multiportal thoracoscopic anatomical resection for non-small cell lung cancer (NSCLC). The results showed that nonintubated uniportal VATS had better perioperative outcomes than multiportal VATS, without compromising the oncological outcomes.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Zhe-Rong Zheng, Hsiu-Ying Ku, Kun-Chieh Chen, Chun-Ju Chiang, Chih-Liang Wang, Chih-Yi Chen, Chun-Ming Tsai, Ming-Shyan Huang, Chong-Jen Yu, Jin-Shing Chen, Teh-Ying Chou, Wen-Chung Lee, Chun-Chieh Wang, Tsang-Wu Liu, Jiun-Yi Hsia, Gee-Chen Chang
Summary: The relationship between smoking and ALK-tyrosine kinase inhibitors (TKIs) on overall survival (OS) of treatment-naive ALK-positive advanced lung adenocarcinoma remains unclear in real-world.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)