Review
Cardiac & Cardiovascular Systems
Long Cao, Hongpeng Zhang, Yangyang Ge, Wei Guo
Summary: Early postoperative stroke remains a challenging complication in endovascular aortic arch repair, with varying incidence rates among different techniques and devices. Preidentifying high-risk patients and careful perioperative management are crucial in reducing stroke incidence. Further research is needed to develop specific intraoperative prevention methods and optimize endovascular techniques for aortic arch treatment.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Lian Duan, Chengliang Zhang, Xuliang Chen, E. Wang, Zhi Ye, Yanying Duan, Lingjin Huang
Summary: This study investigated the cardiovascular protective effects of the myocardial priority strategy or traditional selective cerebral perfusion in acute type A aortic dissection with coronary artery disease. The results showed that the myocardial priority strategy significantly shortened myocardial ischemic time, improved perfusion flow and pressure, and promoted postoperative recovery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Georg Stachel, Felix J. Woitek, Lisa Crusius, Stephan Haussig, Philipp Kiefer, Sergey Leontyev, Florian Schlotter, Aileen Spindler, Robert Hollriegel, Jennifer Hommel, Michael A. Borger, Holger Thiele, David Holzhey, Axel Linke, Norman Mangner
Summary: The study investigated the prevalence and predictors of LAAT in patients undergoing TF-TAVI, finding that LAAT was not associated with an increase in periprocedural complications or predict 2-year mortality.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Matthias Linder, Moritz Seiffert
Summary: This article summarizes different approaches and strategies to prevent perioperative strokes in patients undergoing transcatheter aortic valve implantation and discusses unanswered questions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Rosamaria Tricarico, Scott A. A. Berceli, Roger Tran-Son-Tay, Yong He
Summary: This study proposes a pipeline for estimating the parameters of three-element Windkessel (WK3) models for the aortic arch arteries. By optimizing flow rate and pressure waveforms, patient-specific WK3 model parameters can be estimated, which can then be used to estimate parameters for other patients using non-invasive methods. The estimated WK3 parameters showed high tolerance to patient-specific flow rate waveforms.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Surgery
Yixiao Zhang, Yulin Wang, Jinmiao Chen, Jun Li, Yongxin Sun, Hao Lai, Chunsheng Wang, Qiang Ji
Summary: An extended arch repair for elderly patients with acute type A aortic dissection (ATAAD) remains challenging. However, this study found that extended arch repair in septuagenarians with ATAAD is safe and effective, with in-hospital and midterm outcomes comparable to those in patients aged less than 70 years.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Alexander Lind, Rolf Alexander Janosi, Matthias Totzeck, Arjang Ruhparwar, Tienush Rassaf, Fadi Al-Rashid
Summary: This study evaluated the safety and efficacy of cerebral embolic protection devices (CEPDs) during transcatheter aortic valve replacement (TAVR) in nonagenarian patients. The results showed that the use of CEPDs did not increase access site complications and was feasible and safe in nonagenarian TAVR patients. Age alone is no longer a contraindication for TAVR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer Chung, Louis-Mathieu Stevens, Michael W. A. Chu, Francois Dagenais, Mark D. Peterson, Munir Boodhwani, John Bozinovski, Ismail El-Hamamsy, Michael H. Yamashita, Rony Atoui, Bindu Bittira, Darrin Payne, Maral Ouzounian
Summary: The study found that older patients have higher rates of complications and mortality after aortic arch surgery, supporting a more cautious approach when evaluating elderly patients. Further research is needed on the age-related natural history of thoracic aneurysms and size thresholds for intervention.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Yan Yan, Xuebing Zhang, Yuntai Yao
Summary: This study investigated the incidence and risk factors of postoperative pulmonary complications (PPCs) in patients with acute type A aortic dissection (ATAAD) who underwent total aortic arch replacement combined with the frozen elephant trunk (TAR + FET). The results showed that the incidence of PPCs was 29.2%, and the risk factors included a history of diabetes and renal dysfunction, preoperative SpO2 <90%, cardiopulmonary bypass duration, fresh frozen plasma volume, and platelet concentrates volume. Patients with PPCs had longer postoperative ventilation duration, length of stay in the intensive care unit, and hospital stay.
Article
Medicine, General & Internal
Hidetake Kawajiri, Nishant Saran, Joseph A. Dearani, Hartzell V. Schaff, Richard C. Daly, Jason K. Viehman, Katherine S. King, Alberto Pochettino
Summary: The addition of retrograde whole-body perfusion (RBP) to hypothermic circulatory arrest (HCA) technique provides excellent neurological protection in the treatment of open distal arch repair via a lateral thoracotomy.
MAYO CLINIC PROCEEDINGS
(2023)
Review
Medicine, General & Internal
Andrea Montisci, Giulia Maj, Corrado Cavozza, Andrea Audo, Stefano Benussi, Fabrizio Rosati, Sergio Cattaneo, Lorenzo Di Bacco, Federico Pappalardo
Summary: Complex ascending and aortic arch surgery requires different cerebral protection strategies, including deep or moderate hypothermia and various cerebral perfusion techniques, to prevent brain damage. The etiology of the damage involves multiple factors, such as cerebral embolism, hypoperfusion, hypoxia, and inflammatory response. This narrative review describes the pathophysiology of cerebral damage during aortic surgery, analyzes the options for brain protection, and discusses the current systems of intraoperative brain monitoring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Qiang Xie, Chengnan Li, Yongliang Zhong, Congcong Luo, Rutao Guo, Yongmin Liu, Jun Zheng, Yipeng Ge, Lizhong Sun, Junming Zhu
Summary: This study evaluated the impact of transfusing different blood products on postoperative mechanical ventilation time in patients with ATAAD. The study found that transfusion of pRBCs and PC, as well as age, were independent risk factors for prolonged mechanical ventilation after surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Yanyan Song, Li Liu, Bo Jiang, Yun Wang
Summary: The study identified risk factors for cerebral neurological complications after surgery for Stanford type A aortic arch surgery, including DHCA time >40 min, plasma transfusion >800 ml, erythrocyte suspension transfusion >6 U, history of stroke, and carotid plaque or stenosis. Patients with these risk factors should receive intervention during treatment to reduce neurological complications.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Peter Stachon, Klaus Kaier, Timo Heidt, Dennis Wolf, Daniel Duerschmied, Dawid Staudacher, Manfred Zehender, Christoph Bode, Constantin von zur Muehlen
Summary: This study analyzed TAVR procedures in Germany and found that cerebral protection devices were infrequently used. While the use of these devices was associated with lower in-hospital mortality, it did not reduce the risk of stroke or delirium. Future studies are needed to confirm these findings.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Surgery
Guoqing Zhang, Zhulin Wang, Jia Jiao, Yipiao Liu, Dabo Pan, Hang Yang, Mengyao Zhan, Fuping Yan, Huijie Li, Yan Zhang, Jindong Li, Xiangnan Li
Summary: This study analyzed the surgical treatment of esophageal cancer in patients with RAA and DAA, and found similarities and differences in patient characteristics and surgical details between RAA and DAA. Most patients in both groups had a good postoperative recovery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Cardiac & Cardiovascular Systems
Mateo Marin-Cuartas, Suzanne de Waha, Diyar Saeed, Martin Misfeld, Philipp Kiefer, Michael A. Borger
Summary: Reoperative valve surgery has become more common in recent decades due to the increased use of bioprosthetic valves, a higher incidence of prosthetic valve endocarditis, and an aging population. Although historically associated with poorer outcomes, advancements in cardiac surgery techniques and perioperative care have significantly improved postoperative results. This review provides an overview of preoperative assessment, perioperative management, and technical surgical aspects to maximize successful outcomes in this challenging patient population.
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Review
Cardiac & Cardiovascular Systems
Yousif Ahmad, Mahesh Madhavan, Suzanne J. Baron, John K. Forrest, Michael A. Borger, Jonathon A. Leipsic, Joao L. Cavalcante, Dee Dee Wang, Patrick McCarthy, Molly Szerlip, Samir Kapadia, Raj Makkar, Michael J. Mack, Martin B. Leon, David J. Cohen
Summary: This article summarizes the high prevalence of bicuspid aortic valve disease (BAVD) in patients referred for surgical aortic valve replacement (SAVR) and the lack of randomized controlled trials (RCTs) comparing transcatheter aortic valve replacement (TAVR) to SAVR in this population. The review outlines the challenges and potential approaches for conducting RCTs in patients with BAVD, as well as proposing future directions in clinical research for TAVR in BAVD. This includes the development of disease phenotyping parameters and risk scores to inform clinical decision-making.
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Article
Medicine, Research & Experimental
Ali El-Sayed Ahmad, Miriam Silaschi, Michael Borger, Vahid Seidiramool, Marwan Hamiko, Sergey Leontyev, Andreas Zierer, Mirko Doss, Christian D. Etz, Peter Benedikt, Peter Bramlage, Farhad Bakhtiary
Summary: This study reports the outcomes of using a new generation hybrid prosthesis (E-vita (R) OPEN NEO) for frozen elephant trunk repair. The results showed that it was safe and effective, with few bleeding events and no increase in oozing.
ADVANCES IN THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Misfeld, Mateo Marin-Cuartas, Paulina Ramirez, Katharina Wehrmann, Katharina Renatus, Salil Deo, Robin F. Gohmann, Josephina Haunschild, Sergey Leontyev, Michael A. Borger, Christian D. Etz
Summary: Early postoperative intraluminal thrombosis is a frequent complication after FET surgery. Smaller stent graft sizes, larger or partially covered aneurysms, and major bleeding are associated with early thrombosis. Slight FET oversizing, prompt thoracic endovascular aortic repair completion, and early reintervention for major bleeding may prevent early thrombosis.
ANNALS OF THORACIC SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Christian D. Etz, Michael A. Borger
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Josephina Haunschild, Antonia van Kampen, Martin Misfeld, Konstantin Von Aspern, Joerg Ender, Waseem Zakhary, Michael A. Borger, Christian D. Etz
Summary: This study retrospectively analyzed a group of patients who underwent Bentall procedures between 2000 and 2018 at our institution. The results showed that perioperative fast-track (FT) management, under the guidance of experienced anesthesiologists, was comparable to conventional management in terms of safety while significantly reducing postoperative length of stay and ventilation time.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
M. Nozdrzykowski, F. Fahr, U. Schulz, M. A. Borger, D. Saeed
Summary: Heart transplantation is the most effective treatment for terminal heart failure, with over 4000 adult heart transplantations performed annually worldwide. Primary graft dysfunction occurs within 24 hours after transplantation and is influenced by various risk factors. Treatment involves supportive care, inotropes or phosphodiesterase inhibitors, and mechanical circulatory support for severe cases. Early identification of indications is crucial for improving outcomes and shifting the focus from bridging to successful weaning from support.
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE
(2023)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu Sa, Xander Jacquemyn, Jef Van den Eynde, Ozgun Erten, Tulio Caldonazo, Torsten Doenst, Mateo Marin-Cuartas, Michael A. Borger, Marie-Annick Clavel, Philippe Pibarot, Roberto Rodriguez, Basel Ramlawi, Scott Goldman
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Review
Cardiac & Cardiovascular Systems
Piotr Mazur, Mateo Marin-Cuartas, Arman Arghami, Thilo Noack, Juan A. Crestanello, Michael A. Borger
Summary: With the increasing use of transcatheter aortic valve replacement (TAVR) in low-risk patients, the incidence of surgical re-interventions and complications after TAVR is also growing. This review highlights the importance of understanding indications, methods, and outcomes of cardiac operations post-TAVR in order to improve results in a rapidly expanding patient population.
KARDIOLOGIA POLSKA
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandro Hoyer, Thilo Noack, Philipp Kiefer, Jagdip Kang, Martin Misfeld, Michael Andrew Borger
Summary: This study compared the efficacy of crystalloid (Bretschneider) and blood (Calafiore) cardioplegia solutions on outcomes of triple valve surgery (TVS). The results showed that the outcomes in TVS patients who received HTK cardioplegia were equivalent to those who received BCP cardioplegia. However, patients with reduced left ventricular ejection fraction had a higher 30-day mortality rate when using HTK cardioplegia.
Article
Cardiac & Cardiovascular Systems
Tulio Caldonazo, Hristo Kirov, Dobromir Dobrev, Michael A. Borger, Michael Kiehntopf, Torsten Doenst
Summary: Background: Postoperative atrial fibrillation (POAF) after cardiac surgery is common and has been associated with stroke. Objective: This study aimed to evaluate the association of POAF with perioperative and long-term outcomes in cardiac surgery. Methods: A systematic review and meta-analysis of 57 studies involving 246,340 patients were conducted. Results: POAF was associated with increased perioperative mortality, stroke, myocardial infarction, acute renal failure, hospital and ICU stay, as well as long-term mortality, stroke, and chronic atrial fibrillation. Conclusion: POAF in cardiac surgery is associated with an increased occurrence of short-term and long-term adverse cardiovascular events.
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE
(2023)
Article
Cardiac & Cardiovascular Systems
Mateo Marin-Cuartas, Suzanne de Waha, Stefanie Naumann, Salil Deo, Jagdip Kang, Thilo Noack, Alexandro Hoyer, David Holzhey, Sergey Leontyev, Diyar Saeed, Martin Misfeld, Massimiliano Meineri, Joerg Ender, Mohamed Abdel-Wahab, Steffen Desch, Holger Thiele, Michael A. Borger, Philipp Kiefer
Summary: This study aimed to evaluate early and midterm outcomes following emergency open-heart surgery (E-OHS) in patients undergoing transcatheter aortic valve implant (TAVI). The study found that in low/intermediate risk patients, those who underwent E-OHS had significantly higher in-hospital and 1-year survival rates compared to high-risk patients. Therefore, an on-site cardiac surgical department with immediately available E-OHS capabilities is crucial in a TAVI team.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Endocrinology & Metabolism
Eva Katharina Messer, Anna Lassia Meyer, Kristin Klaeske, Franz Sieg, Sandra Eifert, Dominik Schmiedel, Josephina Haunschild, Khalil Jawad, Diyar Saeed, Lea Hildebrandt, Michael Andrew Borger, Maja-Theresa Dieterlen
Summary: This study investigated the impact of overweight or obesity on immune parameters, specifically CD8(+) T cells and natural killer (NK) cells, in patients with left ventricular assist device (LVAD) implantation. It found that obesity led to lower proportions of CD8(+) T cells and higher proportions of NK cells in the first year after LVAD implantation.
Article
Biochemistry & Molecular Biology
Sarah J. Barnard, Josephina Haunschild, Linda Heiser, Maja T. Dieterlen, Kristin Klaeske, Michael A. Borger, Christian D. Etz
Summary: This study analyzed the tissue of patients with bicuspid and tricuspid aortic valve, finding increased expression of RAGE, AGE, and S100A6 in bicuspid patients, which may promote apoptosis through upregulation of caspase-3 activity. Additionally, increased expression of the 48 kDa fragment of vimentin was detected in BAV patients, while increased expression of Bcl-2 was observed in TAV patients, suggesting better protection against apoptosis. Autophagy-related proteins p62 and ERK1/2 were increased in BAV patients, indicating a higher likelihood of apoptotic cell death in bicuspid tissue, leading to changes in the aortic wall and aortopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Bart Meuris, Jean-Christian Roussel, Michael A. Borger, Matthias Siepe, Pierluigi Stefano, Guenther Laufer, Thierry Langanay, Alexis Theron, Martin Grabenwoeger, Konrad Binder, Philippe Demers, Renzo Pessotto, Wouter van Leeuwen, Thierry Bourguignon, Sergio Canovas, Giovanni Mariscalco, Enrico Coscioni, Francois Dagenais, Olaf Wendler, Gianluca Polvani, Matthias Eden, Beate Botta, Peter Bramlage, Ruggero De Paulis
Summary: This study reports the 1-year safety and clinical outcomes of patients under 60 years old who underwent bioprosthetic surgical aortic valve intervention. The results showed good safety, excellent haemodynamic performance, and improved quality of life after the surgery.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)