Article
Immunology
Bruna Macedo Gois, Rephany Fonseca Peixoto, Isabel Cristina Guerra-Gomes, Pedro Henrique de Sousa Palmeira, Cinthia Nobrega de Sousa Dias, Joselio Maria Galvao Araujo, Robson Cavalcante Veras, Isac Araujo Medeiros, Fatima de Lourdes Assuncao Araujo de Azevedo, Rosemary Jane Boyton, Daniel Martin Altmann, Tatjana Souza Lima Keesen
Summary: This study characterized the molecular mechanisms associated with regulatory T cells (Tregs) in acute and chronic Chikungunya disease for the first time. The results showed that CHIKV infection is associated with reduced frequency of Tregs and impaired expression and production of Treg functional markers. This suggests that Treg cells have poor regulatory capacity during both acute and chronic phases of the disease. These findings provide significant evidence for the role of imbalanced Treg cell response in the pathogenesis of Chikungunya.
MICROBES AND INFECTION
(2022)
Review
Immunology
Angus Hann, Ye H. Oo, M. Thamara P. R. Perera
Summary: The liver possesses unique immunological characteristics but is susceptible to immune mediated injury. Regulatory T cells play a crucial role in preventing tissue damage, and therapies aiming to increase their function have shown efficacy in autoimmune diseases and organ transplantations. Research on the hepatic microenvironment and the role of Tregs in liver diseases is crucial for maintaining immunological balance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yuzhi Lu, Ni Xia, Xiang Cheng
Summary: Regulatory T cells (Tregs) play a crucial role in the development of chronic heart failure, suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the functions and phenotypes of Tregs change, transforming into a cell type that is harmful to the heart.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Christopher S. Anderson, Tatiana Chirkova, Christopher G. Slaunwhite, Xing Qiu, Edward E. Walsh, Larry J. Anderson, Thomas J. Mariani
Summary: This study investigates the transcriptional changes in host epithelial cells induced by RSV infection, specifically focusing on the role of the CX3C motif on the G protein. The results show that engagement of CX3CR1 by RSV leads to induction of genes necessary for virus entry and dysregulation of genes associated with cilia function. Mutation of the CX3C motif on the G protein reverses these effects, suggesting a potential therapeutic target for RSV infection.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: This study found that kidney allograft rejection is associated with an imbalance between immune cells with effector/memory functions and those with regulatory properties, manifested as a decrease in the percentage of circulating B cells and an increase in the ratio of CD28-CD8+ T cells to Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tiong Y. Lim, Elena Perpinan, Maria-Carlota Londono, Rosa Miquel, Paula Ruiz, Ada S. Kurt, Elisavet Kodela, Amy R. Cross, Claudia Berlin, Joanna Hester, Fadi Issa, Abdel Douiri, Felix H. Volmer, Richard Taubert, Evangelia Williams, Anthony J. Demetris, Andrew Lesniak, Gilbert Bensimon, Juan Jose Lozano, Marc Martinez-Llordella, Tim Tree, Alberto Sanchez-Fueyo
Summary: This study investigated the role of low-dose IL-2 (LDIL-2) in maintaining liver allograft tolerance. The results showed that LDIL-2 expanded circulating regulatory T cells (Tregs) but failed to effectively suppress antigen-specific immune responses and promote the accumulation of intrahepatic Tregs. Furthermore, LDIL-2 induced a liver transcriptional response even before immunosuppression weaning. The study was terminated after the first 6 participants failed to reach the primary endpoint, requiring reinstitution of immunosuppression.
JOURNAL OF HEPATOLOGY
(2023)
Article
Immunology
Cen Chen, Xinying Li, Chuling Li, Jiajia Jin, Donghui Wang, Yuan Zhao, Yanli Gu, Meizi Chen, Suhua Zhu, Hongbing Liu, Tangfeng Lv, Fang Zhang, Yong Song
Summary: The study demonstrated that CD39(+) Tregs have a protective effect on acute lung injury and adoptive transfer of these cells may provide a novel method for clinical prevention and treatment of ARDS. The expression of CD39 in Tregs is regulated by autophagy and ERK1/2-FOS pathway, and the frequency of CD39(+) Tregs is decreased in ARDS patients and positively correlated with disease severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Daan K. J. Pieren, Noortje A. M. Smits, Jeroen Hoeboer, Vinitha Kandiah, Rimke J. Postel, Rob Mariman, Josine van Beek, Debbie van Baarle, Jelle de Wit, Teun Guichelaar
Summary: A novel human CD8(+) T-cell subset, KIR(+)RA(+) T cells, has been identified to accumulate with age in healthy individuals and become activated in older adults suffering from acute respiratory viral infections. These cells are associated with longer duration of respiratory symptoms in older adults with influenza A infection, suggesting a potential role in susceptibility to viral respiratory diseases in old age.
Article
Immunology
Saisai Ren, Xiaorong Zhang, Hongbing Guan, Lihong Wu, Miao Yu, Dan Hou, Yongyong Yan, Xuechun Fang
Summary: The study found that the probiotic Lactobacillus acidipiscis in the intestine can suppress the development of multiple sclerosis by inducing the generation of regulatory T cells. This helps to inhibit the progression of the disease and shows potential for treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Satomi Kobayashi, Yasuo Nagafuchi, Mai Okubo, Yusuke Sugimori, Hiroaki Hatano, Saeko Yamada, Masahiro Nakano, Ryochi Yoshida, Yusuke Takeshima, Mineto Ota, Yumi Tsuchida, Yukiko Iwasaki, Keigo Setoguchi, Kanae Kubo, Tomohisa Okamura, Kazuhiko Yamamoto, Hirofumi Shoda, Keishi Fujio
Summary: RNA-seq of immune cells indicated the dysregulation of Fr. II eTregs in early SSc with increased proportion of the activated subpopulation.
Article
Immunology
Marek Sinkora, Miroslav Toman, Katerina Stepanova, Hana Stepanova, Lenka Leva, Jana Sinkorova, Romana Moutelikova, Jiri Salat, Dagmar Srutkova, Martin Schwarzer, Simon Sinkora, Helena Kupcova Skalnikova, Katerina Nechvatalova, Tomas Hudcovic, Petra Hermanova, Sarka Pfeiferova, Mirka Kratochvilova, Lenka Kavanova, Blanka Dusankova, Marek Sinkora
Summary: PRRSV invades the thymus and alters the immune response, resulting in chronic infection. Infected pigs produce antibodies that are unable to neutralize the virus, leading to the inability of the immune system to eliminate the virus.
MICROBES AND INFECTION
(2023)
Article
Surgery
Jiang Bian, Ting Wang, Jijun Sun, Xiaozhen He, Zhijiao Wu, Songmei Zhang, Hao Chi, Tingting Fan, Shaowen Wang, Weiyun Shi, Qingguo Ruan
Summary: Our study revealed that in an inflammatory environment, NF-kappa B c-Rel acts as a key mediator in the conversion of Tregs into effector-like cells by promoting inflammatory cytokine production and glycolysis, impairing Treg function. Targeting NF-kappa B c-Rel improved the immune suppressive function of inflam-Tregs and enhanced their potential to suppress corneal transplantation rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Biology
Scott M. Anthony, Natalija Van Braeckel-Budimir, Steven J. Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M. Hartwig, Isaac J. Jensen, Steven M. Varga, Noah S. Butler, Hai-Hui Xue, Vladimir P. Badovinac, John T. Harty
Summary: IAV infection generates Trm CD8(+)T cells in mice, while repeated antigen exposure produces 4M CD8(+)T cells with enhanced protective capacity. Enhanced protection by 4M cells is associated with increased expression of granzyme A/B and stable maintenance of CD69(+)CD103(+) 4M CD8(+)T cells, improving control of viral infections in mLN.
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Article
Biochemistry & Molecular Biology
Jiadi Chen, Jingru Liu, Huifang Huang
Summary: The tumor suppressor Lkb1 regulates the expression of Foxp3, maintaining the levels of Treg cells important for self-tolerance. However, the effect of Lkb1 in Treg on HSCs in the BM remains unclear. In this study, conditional deletion of Lkb1 in Treg led to the loss of Treg in the BM, causing an imbalance and abnormal expansion of HSCs. This loss of BM Treg also disrupted the differentiation of other progenitors/stem cell populations and impaired HSC engraftment efficiency.
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)