Journal
ANNALS OF THORACIC SURGERY
Volume 89, Issue 6, Pages S2090-S2095Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.athoracsur.2010.03.038
Keywords
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Funding
- NCI NIH HHS [R011R01CA093708-01A3, R01 CA093708, R01 CA132566-04, R01 CA132566] Funding Source: Medline
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Although stem cells were discovered more than 50 years ago, we have only recently begun to understand their potential importance in cancer biology. Recent advances in our ability to describe, isolate, and study lung stem cell populations has led to a growing recognition of the central importance cells with stem cell-like properties may have in lung tumorigenesis. This article reviews the major studies supporting the existence and importance of cancer stem cells in lung tumorigenesis. Continued research in the field of lung cancer stem cell biology is vital, as ongoing efforts promise to yield new prognostic and therapeutic targets. (Ann Thorac Surg 2010; 89: S2090-5) (C) 2010 by The Society of Thoracic Surgeons
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