Article
Cardiac & Cardiovascular Systems
Zhizhou Yang, Melanie P. Subramanian, Yan Yan, Bryan F. Meyers, Benjamin D. Kozower, G. Alexander Patterson, Ruben G. Nava, Ramsey R. Hachem, Chad A. Witt, Michael K. Pasque, Derek E. Byers, Hrishikesh S. Kulkarni, Daniel Kreisel, Akinobu Itoh, Varun Puri
Summary: This study analyzed clinical data of lung transplant patients and found an association between center volume and 1-year survival rate. The optimal threshold for volume was identified as 33 cases per year, as exceeding this number did not provide additional benefits.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Nidhi Iyanna, Ernest G. Chan, John P. Ryan, Masashi Furukawa, Jenalee N. Coster, Chadi A. Hage, Pablo G. Sanchez
Summary: This study retrospectively analyzed the trends and outcomes of lung transplants in recipients aged ≥70 years using the UNOS database. The rate of lung transplants in recipients >70 years has increased over time, especially in low-volume centers. Recipients ≥70 years had higher rates of receiving lungs from circulatory death donors and extended criteria donors, and had shorter survival time compared to recipients <70 years. HVCs were associated with a survival advantage in recipients <70, but the survival was similar between HVCs and LVCs in recipients ≥70. The importance of careful recipient selection, donor assessment, and post-transplant care in improving outcomes for recipients ≥70 should be emphasized. Further research is needed to explore perioperative care strategies in centers with low long-term survival for recipients ≥70.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Samantha E. Halpern, Sandra Au, Samuel J. Kesseli, Madison K. Krischak, Danae G. Olaso, Brandi A. Bottiger, John C. Haney, Jacob A. Klapper, Matthew G. Hartwig
Summary: This study found that the use of lung allografts with long ischemic time (>= 8 hours) in lung transplantations is associated with acceptable perioperative outcomes and post-transplant survival. Male recipients and donors after circulatory death are more likely to be allocated to recipients with long ischemic time. After adjustment, long and standard ischemic time recipients had comparable risks of mortality or graft failure.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Computer Science, Information Systems
Mehmet Baygin, Turker Tuncer, Sengul Dogan, Ru-San Tan, U. Rajendra Acharya
Summary: A new arrhythmia classification model based on handcrafted features was developed and validated, achieving high accuracy rates on a large ECG dataset. The model demonstrated excellent classification results at low computational cost, highlighting its potential for real-world applications.
INFORMATION SCIENCES
(2021)
Editorial Material
Oncology
Jean-Lu Teillauo, Marie-Caroline Dieu-Nosjean
Summary: Increased plasma cell signatures are found to be predictive of extended overall survival in non-small-cell lung cancer patients treated with a PD-L1 inhibitor, and these cells are associated with the presence of tertiary lymphoid structures.
Article
Cardiac & Cardiovascular Systems
Matthew Zheng, Ibraheem Yousef, Albert J. Mamary, Huaqing Zhao, James McEldrew, Adam Adika, Norihisa Shigemura, Francis Cordova, Gerald J. Criner, Patrick Mulhall, Jonathan Galli, Kartik Shenoy, James Brown, Nathanial Marchetti, Parth Rali, Sameep Sehgal
Summary: This study reviewed the incidence of VTE post lung transplantation and identified risk factors such as the use of cardiopulmonary bypass (CPB) and interruption of VTE prophylaxis. Measures to ensure consistent and uninterrupted prophylaxis may help decrease VTE incidence after lung transplantation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Xiaodi Ma, Hewei Ming, Lexin Liu, Jiahui Zhu, Lang Pan, Yu Chen, Yang Xiang
Summary: The lungs, as the organ executing gas exchange and facing the external environment, are continuously challenged by various stimuli, leading to the disequilibration of redox homeostasis and the development of pulmonary diseases. The appearance of the oxidative base 8-oxoG, which is considered a marker of DNA oxidative damage, can lead to base mismatch and tumorigenesis. The repair of 8-oxoG is initiated by the enzyme OGG1, which recognizes and excises it from the DNA double strand. Besides its role in DNA damage repair, OGG1 also participates in gene expression regulation and impacts inflammation. OGG1 is believed to be a potential therapeutic target for related diseases.
Article
Cardiac & Cardiovascular Systems
Amalia Guzman-Gomez, Hosam F. Ahmed, Alia Dani, Farhan Zafar, David G. Lehenbauer, Andrew S. Potter, David L. S. Morales, Assem G. Ziady, Don Hayes Jr
Summary: The study aims to determine whether transplant center volume affects ACR-related outcomes in children after lung transplantation. The study found that children treated for ACR at high-volume centers have higher survival rates compared to low-volume centers, but similar survival rates to medium-volume centers. ACR incidence is lowest at high-volume centers, and post-ACR treatment survival outcomes are also superior.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Hematology
Victoria A. Vardell, Daniel A. Ermann, Srinivas K. Tantravahi, Benjamin Haaland, Brian McClune, Amandeep Godara, Ghulam Rehman Mohyuddin, Douglas W. Sborov
Summary: This study aims to evaluate the survival outcomes of patients with multiple myeloma (MM) receiving treatment at academic cancer centers (ACs) compared to non-academic centers (NACs). The results show that MM patients treated at ACs have significantly improved survival.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Xiang Lan, Hai-Li Zhang, Hua Zhang, Yu-Fu Peng, Fei Liu, Bo Li, Yong-Gang Wei
Summary: This study reviewed over 1000 cases of laparoscopic liver resection (LLR) performed at a single center and analyzed surgical details and patient prognosis. The results showed that LLR is a safe and effective treatment method for various liver diseases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Giacomo Germani, Philippe Mathurin, Michael R. Lucey, James Trotter
Summary: In patients with severe acute alcohol-related hepatitis, liver transplantation is the only effective therapy, but there is still limited access to transplantation due to emphasis on pre-transplant abstinence and societal stigma. Therefore, there is a growing need for multicenter studies to improve selection practices and interventions for alcohol use disorder after transplantation.
JOURNAL OF HEPATOLOGY
(2023)
Article
Surgery
Elnaz Payani, Nikolaus Boerner, Dionysios Kolliogiannis, Stefan Brunner, Ingo Klein, Ursula Ehmer, Gerald Denk, Christian M. Lange, Klaudja Ograja, Peter Dietrich, Jens Werner, Markus Guba
Summary: The study aimed to investigate the disparities in access to liver transplantation in Bavaria, Germany. The annual transplantation rate per 1 million inhabitants was determined based on the aggregated postal codes of transplanted patients' place of residence. Variables examined included proximity and travel time to the nearest transplant center, as well as the care category of the regional hospital. Multivariate regression analysis revealed that the liver transplant training of the chief physician (gastroenterologist) at the regional hospital was the most significant independent factor for access to liver transplantation within a district.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Obstetrics & Gynecology
Bo Huang, Shunyuan Zheng, Bingxin Ma, Yongle Yang, Shengping Zhang, Lei Jin
Summary: The study retrospectively analyzed time-lapse data and live birth outcomes of embryo samples from January 2018 to November 2019. A deep learning model was developed to predict live birth outcomes from time-lapse images, achieving an AUC of 0.968 in 5-fold cross-validation.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Surgery
Erik H. Ander, Abul Kashem, Huaqing Zhao, Kelly Montgomery, Gengo Sunagawa, Roh Yanagida, Norihisa Shigemura, Yoshiya Toyoda
Summary: In patients with idiopathic pulmonary fibrosis, lung transplant type and donor age do not significantly affect survival.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Microbiology
Yueyang Yan, Tao Shi, Xin Bao, Yunpeng Gai, Xingxing Liang, Yu Jiang, Qiushi Li
Summary: Our study examines the impact of host and environmental factors on the gastrointestinal microbes of ruminants. We analyze the microbial topology, robustness, and risk of transmission of high-risk metagenome-assembled genomes (MAG) in different ruminant species. We also develop an interpretable machine learning framework to study the complex data of the gastrointestinal microbial genome. Our findings provide new insights for the sustainable development of microbial resources in agriculture.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Surgery
Helen J. Madsen, Robert A. Meguid, Michael R. Bronsert, Adam R. Dyas, Kathryn L. Colborn, Anne Lambert-Kerzner, William G. Henderson
Summary: This study examined the relationships between predicted risks of postoperative complications. The results showed strong correlations between high-risk patients and specific complications, and high-risk patients tended to have more comorbidities and actual adverse outcomes. Therefore, interventions aimed at reducing risks could be targeted at high-risk patients.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Adam R. Dyas, Michael R. Bronsert, Robert A. Meguid, Kathryn L. Colborn, Anne Lambert-Kerzner, Karl E. Hammermeister, Paul D. Rozeboom, Catherine G. Velopulos, William G. Henderson
Summary: The study analyzed data from 2009-2018 using the SURPAS system to define high risk surgical patients, with results showing cutoff points and proportions identified through Hosmer-Lemeshow plots and Youden index. Certain specialties had more high risk patients, indicating the potential benefit of using the SURPAS system to identify high risk surgical populations.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Surgery
Adam R. Dyas, William G. Henderson, Helen J. Madsen, Michael R. Bronsert, Kathryn L. Colborn, Anne Lambert-Kerzner, Robert C. McIntyre, Robert A. Meguid
Summary: This study aimed to develop a prediction model to estimate the risk of conversion from outpatient surgery to inpatient hospitalization. The Surgical Risk Preoperative Assessment System accurately predicted a patient's risk of unplanned outpatient-to-inpatient conversion.
Article
Surgery
Adam R. Dyas, Yaxu Zhuang, Robert A. Meguid, William G. Henderson, Helen J. Madsen, Michael R. Bronsert, Kathryn L. Colborn
Summary: This study developed and validated a detection model for postoperative bleeding complications using structured electronic health records data. The model demonstrated high accuracy and can be used to augment manual chart review for surveillance and reporting of perioperative bleeding complications.
Article
Surgery
Kathryn L. Colborn, Yaxu Zhuang, Adam R. Dyas, William G. Henderson, Helen J. Madsen, Michael R. Bronsert, Michael E. Matheny, Anne Lambert-Kerzner, Quintin W. O. Myers, Robert A. Meguid
Summary: Using structured electronic health records data and simple linear regression models, surveillance and reporting of postoperative infection rates can be implemented for all operations with high accuracy.
Article
Surgery
Emily M. Mason, William G. Henderson, Michael R. Bronsert, Kathryn L. Colborn, Adam R. Dyas, Helen J. Madsen, Anne Lambert-Kerzner, Robert A. Meguid
Summary: This study retrospectively analyzed the American College of Surgeons' National Surgical Quality Improvement Program database and found that the Surgical Risk Preoperative Assessment System (SURPAS) model accurately predicted unplanned reoperation and was internally validated. Unplanned reoperation can be integrated into the SURPAS tool to provide preoperative risk assessment, which could aid patient risk education.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Catherine Alder, Michael R. Bronsert, Robert A. Meguid, Christina M. Stuart, Adam R. Dyas, Kathryn L. Colborn, William G. Henderson
Summary: This study investigated the risk factors for 30-day mortality after outpatient surgery and found that age, cancer, and functional health status were associated with an increased risk. Postoperative complications had a greater impact on mortality than preoperative variables, and there was a higher risk of death for patients over 80 years of age. We recommend considering inpatient surgery for patients aged over 80 with cancer, poor functional health status, or a higher ASA class.
Article
Surgery
Helen J. Madsen, Riley A. Gillette, Kathryn L. Colborn, William G. Henderson, Adam R. Dyas, Michael R. Bronsert, Anne Lambert-Kerzner, Robert A. Meguid
Summary: This study examined the association between obesity and surgical outcomes using a large sample size. The results showed that obese patients were more likely to develop infection, venous thromboembolism, and renal complications during surgery.
Article
Surgery
Adam R. Dyas, Michael R. Bronsert, William G. Henderson, Christina M. Stuart, Nisha Pradhan, Kathryn L. Colborn, Joseph C. Cleveland Jr, Robert A. Meguid
Summary: In this study, the authors developed preoperative prediction models and estimates of postoperative outcomes for cardiac surgery using the ACS-NSQIP dataset. The results showed that the ACS-NSQIP models were almost as accurate as the STS-ACSD models.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Surgery
Quintin W. O. Myers, Anne Lambert-Kerzner, Kathryn L. Colborn, Adam R. Dyas, William G. Henderson, Robert A. Meguid
Summary: This study aimed to assess surgeons' opinions of the Automated Surveillance of Postoperative Infections. The results showed that surgeons perceived the system as valuable for improving clinical outcomes and identified environmental factors and challenges for its implementation.
Article
Surgery
Emily M. Mason, William G. Henderson, Michael R. Bronsert, Kathryn L. Colborn, Adam R. Dyas, Anne Lambert-Kerzner, Robert A. Meguid
Summary: This study aimed to assess the predictive ability of the Surgical Risk Preoperative Assessment System for postoperative length of stay. The results showed that the system variables could accurately predict postoperative length of stay up to 30 days, and the accuracy was comparable to a model using all variables.
Article
Surgery
Michael R. Bronsert, Anne Lambert-Kerzner, William G. Henderson, Karl E. Hammermeister, Chisom Atuanya, Davis M. Aasen, Abhinav B. Singh, Robert A. Meguid
PATIENT SAFETY IN SURGERY
(2020)
Article
Health Care Sciences & Services
Robert A. Meguid, Michael R. Bronsert, Karl E. Hammermeister, David P. Kao, Anne Lambert-Kerzner, Jacob A. Sinex, Jody M. Myers, William G. Henderson
JOURNAL OF PATIENT SAFETY AND RISK MANAGEMENT
(2019)
Article
Surgery
William G. Henderson, Michael R. Bronsert, Karl E. Hammermeister, Anne Lambert-Kerzner, Robert A. Meguid
PATIENT SAFETY IN SURGERY
(2019)
Article
Surgery
Anne Lambert-Kerzner, Kelsey Lynett Ford, Karl E. Hammermeister, William G. Henderson, Michael R. Bronsert, Robert A. Meguid
PATIENT SAFETY IN SURGERY
(2018)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)