Article
Cardiac & Cardiovascular Systems
Qiushi Ren, Juemin Yu, Tianyu Chen, Hailong Qiu, Erchao Ji, Tao Liu, Xiaowei Xu, Jianzheng Cen, Shusheng Wen, Jian Zhuang, Xiaobing Liu
Summary: This study reviewed the long-term outcomes of children who underwent aortic valve repair at a certain medical center and found that aortic valve repair remains a safe and durable solution for children with congenital aortic stenosis. Coexisting mitral stenosis, aortic valve anatomy, and certain surgical factors have been identified as risk factors for poor early and long-term outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Lizhi Lv, Xinyue Lang, Simeng Zhang, Cheng Wang, Qiang Wang
Summary: The study compared the prognosis of single-, two- and three-patch repair for patients with supravalvar aortic stenosis (SVAS). Results showed that two-patch repair had the lowest rate of reintervention and relatively reasonable operation time.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
John K. Forrest, G. Michael Deeb, Steven J. Yakubov, Hemal Gada, Mubashir A. Mumtaz, Basel Ramlawi, Tanvir Bajwa, Paul S. Teirstein, Michael DeFrain, Murali Muppala, Bruce J. Rutkin, Atul Chawla, Bart Jenson, Stanley J. Chetcuti, Robert C. Stoler, Marie-France Poulin, Kamal Khabbaz, Melissa Levack, Kashish Goel, Didier Tchetche, Ka Yan Lam, Pim A. L. Tonino, Saki Ito, Jae K. Oh, Jian Huang, Jeffrey J. Popma, Neal Kleiman, Michael J. Reardon, Low Risk Trial Investigators
Summary: This study evaluated the clinical and echocardiographic outcomes of transcatheter aortic valve replacement (TAVR) compared with surgery in low-risk patients at 3 years. It found that TAVR showed durable benefits compared with surgery in terms of reducing the incidence of all-cause mortality or disabling stroke, and also significantly improved valve hemodynamics in patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Surgery
Michael P. Rogers, Haroon Janjua, Emanuel Eguia, Lucian Lozonschi, Paul C. Kuo
Summary: This study evaluated the adoption of transcatheter aortic valve replacement technology in surgical aortic valve procedures in Florida. The findings showed that the introduction of transcatheter aortic valve replacement significantly increased the overall surgical volume and may be associated with lower hospital charges.
Article
Cardiac & Cardiovascular Systems
Ilaria Chirichilli, Raffaele Scaffa, Francesco Giosue Irace, Andrea Salica, Luca Paolo Weltert, Salvatore D'Aleo, Luigi Chiariello, Ruggero De Paulis
Summary: Valve-sparing aortic root replacement with aortic valve reimplantation using the Valsalva graft has shown excellent long-term outcomes, with stable results over a 20-year follow-up period. The use of calliper during surgery may have contributed to further improvement in the outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Mumun Sinha, Nitin Parashar, Niraj N. Pandey, Sanjeev Kumar, Sivasubramanian Ramakrishnan
Summary: Supravalvar aortic stenosis is a rare heart condition that is often associated with pulmonary and coronary arterial involvement, along with aortic valvular abnormalities and other congenital heart defects.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Medicine, General & Internal
Adeline Walter, Brigitte Strizek, Eva Christin Weber, Ingo Gottschalk, Annegret Geipel, Ulrike Herberg, Ulrich Gembruch, Christoph Berg
Summary: The study assessed the course and outcome of FAV in fetuses with SAS and found that FAV has a high technical success rate and a low procedure related mortality when performed by experienced doctors. However, the success rate of biventricular circulation is moderate and depends more on the center's experience and postnatal surgical strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sameer A. Hirji, Zachary Wegermann, Sreekanth Vemulapalli, Paige Newell, Maria Grau-Sepulveda, Sean O'Brien, Vinod H. Thourani, Vinay Badhwar, Tsuyoshi Kaneko
Summary: This study analyzes the 5-year outcomes of isolated surgical aortic valve replacement (SAVR) in patients with bicuspid and tricuspid aortic valve stenosis. The results show that bicuspid patients have significantly lower 5-year mortality rates compared to tricuspid patients, especially in low-risk patients.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Amgad Mentias, Marwan Saad, Milind Y. Desai, Amar Krishnaswamy, Venu Menon, Phillip A. Horwitz, Samir Kapadia, Mary Vaughan Sarrazin
Summary: The study compared outcomes of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in patients with rheumatic aortic stenosis (AS), as well as TAVR in nonrheumatic AS. The results showed similar mortality rates between TAVR and SAVR for rheumatic AS patients, suggesting that TAVR could be a viable alternative to traditional surgery in this patient population.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
John K. Forrest, G. Michael Deeb, Steven J. Yakubov, Joshua D. Rovin, Mubashir Mumtaz, Hemal Gada, Daniel O'Hair, Tanvir Bajwa, Paul Sorajja, John C. Heiser, William Merhi, Abeel Mangi, Douglas J. Spriggs, Neal S. Kleiman, Stanley J. Chetcuti, Paul S. Teirstein, George L. Zorn, Peter Tadros, Didier Tchetche, Jon R. Resar, Antony Walton, Thomas G. Gleason, Basel Ramlawi, Ayman Iskander, Ronald Caputo, Jae K. Oh, Jian Huang, Michael J. Reardon
Summary: The complete 2-year follow-up from the Evolut Low Risk Trial found that TAVR is noninferior to surgery for the primary endpoint of all-cause mortality or disabling stroke.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tadeja Kolar, Nikola Lakic, Alesa Kotnik, David Stubljar, Zlatko Fras, Matjaz Bunc
Summary: This study compared the outcomes of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) in octogenarians. The results showed similar clinical outcomes in terms of clinical endpoints in low- and medium-risk groups, but differences were observed in certain indicators such as paravalvular leak, acute kidney injury, and new onset atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Ahmed Elkoumy, John Jose, Christian Juhl Terkelsen, Henrik Nissen, Sengottuvelu Gunasekaran, Mahmoud Abdelshafy, Ashok Seth, Hesham Elzomor, Sreenivas Kumar, Francesco Bedogni, Alfonso Ielasi, Shahram Arsang-Jang, Santosh Kumar Dora, Sharad Chandra, Keyur Parikh, Daniel Unic, Andreas Baumbach, Patrick Serruys, Osama Soliman
Summary: This study investigated the one-year outcomes of TAVI using the Myval transcatheter heart valve in patients with severe bicuspid AS. The results showed that TAVI treatment is associated with favorable hemodynamic and clinical outcomes in selected patients with bicuspid aortic valve anatomy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Saverio Mennini, Francesco Meucci, Gabriele Pesarini, Pietro Vandoni, Maddalena Lettino, Archita Sarmah, Judith Shore, Michelle Green, Stefano Giardina
Summary: This cost-utility analysis showed that TAVI with SAPIEN 3 is likely to be cost effective compared with SAVR for the treatment of low-risk sSAS patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andreas Martinsson, Susanne J. Nielsen, Milan Milojevic, Bjorn Redfors, Elmir Omerovic, Theis Tonnessen, Tomas Gudbjartsson, Goran Dellgren, Anders Jeppsson
Summary: Surgical risk, age, and perceived life expectancy influence the choice between SAVR and transcatheter aortic valve implantation. This study aimed to determine median survival time in relation to surgical risk and chronological age in SAVR patients. The estimated survival is substantial following SAVR, especially in younger, low-risk patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Wanyu Wen, Xinwei Du, Limin Zhu, Shunmin Wang, Zhiwei Xu, Zhaohui Lu
Summary: The study showed that technical improvements in tracheoplasty for LSCTS patients can significantly improve surgical outcomes, especially by reconstructing a supportive carina and performing tracheobronchial positioning to reduce mechanical ventilation time and mortality rates.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Roi Anteby, Robert D. Sinyard, Kristen M. Jogerst, Sophia K. McKinley, Taylor M. Coe, Emil Petrusa, Roy Phitayakorn, Daniel J. Scott, L. Michael Brunt, Denise W. Gee
Summary: The study revealed that virtual interviews for surgical fellowship programs posed challenges such as perceived data deficiency, superficial personal connections, magnification of non-professionalism, and logistical frustrations for applicants. To optimize this process, applicants recommend program directors to offer more information about the fellowship and facilitate informal independent interactions with current and previous fellows.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Genetics & Heredity
Holly Melland, Fabian Bumbak, Anna Kolesnik-Taylor, Elise Ng-Cordell, Abinayah John, Panayiotis Constantinou, Shelagh Joss, Martin Larsen, Christina Fagerberg, Lone Walentin Laulund, Jenny Thies, Frances Emslie, Marjolein Willemsen, Tjitske Kleefstra, Rolf Pfundt, Rebekah Barrick, Richard Chang, Lucy Loong, Majid Alfadhel, Jasper van der Smagt, Mathilde Nizon, Manju A. Kurian, Daniel J. Scott, Joshua J. Ziarek, Sarah L. Gordon, Kate Baker
Summary: The purpose of this study is to expand the genotypes and phenotypes of SYT1 gene mutations and identify the characteristics of this disorder. By analyzing the evidence, we determined the pathogenicity of these mutations and described the common clinical manifestations. In addition, we found that the clinical spectrum of this disease includes a broader range of severities. This study is of guiding significance for the diagnosis and molecular understanding of this rare neurodevelopmental disorder, and highlights the important role of the SYT1 gene in emotional regulation, motor control, and cognitive function.
GENETICS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Adam L. Valkovic, Martina Kocan, Brad Hoare, Sarah Marshall, Daniel J. Scott, Ross A. D. Bathgate
Summary: This article introduces a new BRET-based cGMP sensor called CYGYEL, which enables efficient and rapid detection of cGMP activity in plate-based assays and successfully detects cGMP signals in different cell types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Melissa N. Hanson, Aurora D. Pryor, D. Rohan Jeyarajah, Rebecca M. Minter, Samer G. Mattar, Daniel J. Scott, L. Michael Brunt, Maria Cummings, Melina Vassiliou, Liane S. Feldman
Summary: This study describes the implementation process of introducing EPAs in a CBME model by the FC and evaluates its feasibility and perceived value. The results show an increasing completion rate of EPAs, but a decreasing engagement rate. The survey indicates that most fellows and program directors recommend the full-scale implementation of the EPA framework.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Madhuri B. Nagaraj, Babak Namazi, Ganesh Sankaranarayanan, Daniel J. Scott
Summary: This study developed Artificial Intelligence (AI) models for video-based assessment of medical students' suturing skills, identifying errors and providing automated ratings. Results showed accuracy rates of 89% for instrument holding and 91% for knot-tying. Future work will focus on optimizing the model to provide specific feedback and improve error identification.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Sara Monfared, Joshua J. Weis, Shinil K. Shah, Daniel J. Scott, Melissa M. Felinski, Erik B. Wilson
Summary: This study evaluated case volumes of bariatric surgeons and found that the number of primary sleeve gastrectomy cases increased significantly in 2010 and then plateaued. Meanwhile, there was an increase in major revisional surgery cases, but the overall number of anastomotic cases did not change significantly. Interestingly, there is a growing disparity between fellowship programs.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Psychiatry
Sarah M. Goodday, Daniel R. Karlin, Stephen H. Friend
Summary: Digital psychiatry has the potential to empower individuals to navigate their personal experiences outside of healthcare visits. Utilizing digital health technologies can revolutionize our understanding of mental health and the daily practice of mental health professionals, enabling patients to take more control over their mental well-being.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Review
Surgery
Madhuri B. Nagaraj, Adnan Alseidi, Ajita S. Prabhu, Jacob A. Greenberg, Michael M. Awad, Joshua J. Weis, Daniel J. Scott
Summary: This study analyzed the case log database to evaluate trends in fellowship exposure to hernia repairs. The results showed that the total number of hernia repairs and robotic-assisted repairs increased over the years, while laparoscopic repairs decreased. This indicates the importance of hernia repairs in fellowship training.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Cell Biology
Fabian Bumbak, Miquel Pons, Asuka Inoue, Juan Carlos Paniagua, Fei Yan, Hongwei Wu, Scott A. Robson, Ross A. D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek
Summary: Nuclear magnetic resonance (NMR) studies have shown that fast methyl sidechain dynamics can provide information about entropically-driven allostery. This study focuses on the fast dynamics of a thermostabilized G protein-coupled receptor (GPCR), neurotensin receptor 1 (NTS1), using 13C epsilon-methionine chemical shift-based global order parameters. The results indicate the presence of substates with different lifetimes in the NTS1 solution ensemble, and the rapid fluctuations of individual methionine residues are correlated with ligand pharmacology, suggesting a role for sub-microsecond dynamics and conformational entropy in GPCR ligand discrimination.
Article
Pharmacology & Pharmacy
Kazem Asadollahi, Daniel J. Scott, Paul R. Gooley
Summary: This review discusses the modulation of activity of over 120 different GPCRs by peptides, which form the largest group of ligands. Linear disordered peptide ligands usually undergo significant conformational changes upon binding, which are crucial for receptor recognition and activation. Conformational selection and induced fit, two mechanisms of coupled folding and binding, can be differentiated by NMR analysis, but the large size of GPCRs in membrane-mimetic environments limits the application of NMR. This review highlights advancements in the field for addressing the coupled folding and binding of peptide ligands to their cognate receptors.
CURRENT OPINION IN PHARMACOLOGY
(2023)
Article
Surgery
Rodrigo E. Alterio, Madhuri B. Nagaraj, Daniel J. Scott, Juan Tellez, Imad Radi, Hayley B. Baker, Herbert J. Zeh, Patricio M. Polanco
Summary: Despite the lack of consensus, the 33 VR drills on the SimNow platform were found to have some validity and were selected as the foundation for a robotic surgery curriculum. However, certain skills were poorly represented in these drills, highlighting the need to add additional drills to address these gaps.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Biochemical Research Methods
Kazem Asadollahi, Katherine Huang, Fei Yan, Lazarus A. de Zhang, Daniel J. Scott, Paul R. Gooley
Summary: Neurotensin (NT) is an endogenous peptide in mammals with neurotransmission and hormonal roles. The expression and purification of NT with native modification is challenging due to the presence of pyro-glutamate (pGlu) at the first residue. In this study, a simple and efficient method using the small ubiquitin-like modifier (SUMO) as a fusion partner and enzymatic conversion of glutamine to pGlu was described for expression and purification of large amounts of NT. The method yielded 13 mg/L and 8 mg/L of pure peptide in rich and minimal media, respectively, and can be adapted for modification of other proteins and peptides in various expression hosts.
PROTEIN EXPRESSION AND PURIFICATION
(2023)
Article
Biochemical Research Methods
Kirill Kolesnik, Philipp Segeritz, Daniel J. Scott, Vijay Rajagopal, David J. Collins
Summary: Acoustofluidic devices can manipulate particles and cells in arbitrary configurations at the microscale without complex patterning. This approach is enabling for cell studies and tissue engineering applications.
Review
Surgery
James K. Hazen, Daniel J. Scott, Carla N. Holcomb
Summary: The skill level of the bedside assistant in robotic surgery is associated with operative time, but not with postoperative outcomes. Future studies should develop metrics to assess the actual technical performance of the bedside assistant.
JOURNAL OF ROBOTIC SURGERY
(2023)
Correction
Health Care Sciences & Services
Sarah M. Goodday, Emma Karlin, Alexandria Alfarano, Alexa Brooks, Carol Chapman, Rachelle Desille, Shazia Rangwala, Daniel R. Karlin, Hoora Emami, Nancy Fugate Woods, Adrien Boch, Luca Foschini, Mackenzie Wildman, Francesca Cormack, Nick Taptiklis, Abhishek Pratap, Marzyeh Ghassemi, Anna Goldenberg, Sujay Nagaraj, Elaine Walsh, Stephen Friend
JMIR FORMATIVE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)