Editorial Material
Cardiac & Cardiovascular Systems
Kian C. Banks, Mihir J. Chaudhary, Diana S. Hsu, Colin M. Mooney, Jeffrey B. Velotta
Summary: This report demonstrates the feasibility of salvage resection for progression of MPM after immunotherapy.
ANNALS OF THORACIC SURGERY
(2022)
Article
Surgery
Masatoshi Kanayama, Masataka Mori, Hiroki Matsumiya, Akihiro Taira, Shinji Shinohara, Masaru Takenaka, Koji Kuroda, Fumihiro Tanaka
Summary: This study compared the outcomes and survival of extrapleural pneumonectomy (EPP) and pleurectomy/decortication (P/D) for malignant pleural mesothelioma (MPM). The results showed that compared to EPP, P/D was associated with higher intraoperative bleeding volume and longer duration of postoperative thoracic drainage. However, for epithelioid-type MPM, patients who underwent P/D had better survival rates. Therefore, P/D may be superior to EPP for improving the prognosis of resectable epithelioid-type MPM patients.
Review
Medicine, General & Internal
Sam M. Janes, Doraid Alrifai, Dean A. Fennell
Summary: Mesothelioma, mostly caused by asbestos exposure, has a decreasing incidence but high mortality due to late diagnosis and treatment resistance. Pemetrexed-cisplatin and immune checkpoint inhibitors have shown modest survival extension.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Dong-Seok Lee, Andrea Carollo, Naomi Alpert, Emanuela Taioli, Raja Flores
Summary: Minimally invasive surgery is a feasible alternative to radical surgery in malignant pleural mesothelioma patients, providing improved short-term outcomes and potentially enhancing quality of life.
Article
Oncology
Toshinari Ito, Shota Nakamura, Yuka Kadomatsu, Harushi Ueno, Taketo Kato, Naoki Ozeki, Koichi Fukumoto, Toyofumi Fengshi Chen-Yoshikawa
Summary: This study found that pleural thickness is a significant factor influencing postoperative complications in patients with malignant pleural mesothelioma (MPM). Patients with thicker pleural on the right side have a higher risk of postoperative complications.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Toshinari Ito, Shota Nakamura, Yuka Kadomatsu, Harushi Ueno, Taketo Kato, Naoki Ozeki, Koichi Fukumoto, Toyofumi Fengshi Chen-Yoshikawa
Summary: This study investigated the relationship between postoperative complications and clinical variables in patients with malignant pleural mesothelioma (MPM). The results showed that pleural thickness significantly influences the occurrence of postoperative complications, with patients with thicker pleura on the right side being at greater risk.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Masaki Hashimoto, Hiroyuki Yamamoto, Shunsuke Endo, Morihito Okada, Hiroaki Miyata, Seiki Hasegawa, Masayuki Chida
Summary: This study analyzed the characteristics, surgical outcomes, and risk factors for surgical complications in patients with malignant pleural mesothelioma (MPM) using a nationwide database in Japan. The results showed that pleurectomy/decortication (P/D) was more frequently performed in high-volume centers, while extrapleural pneumonectomy (EPP) was more common in less experienced institutions. The incidence of complications was higher in EPP, but overall mortality rates were low regardless of the surgical procedure.
ANNALS OF THORACIC SURGERY
(2022)
Article
Surgery
Dimitrios E. Magouliotis, Prokopis-Andreas Zotos, Arian Arjomandi Rad, Despoina Koukousaki, Vasiliki Vasilaki, Ioustini Portesi, Kyriakos Spiliopoulos, Thanos Athanasiou
Summary: A review of literature on patients with MPM undergoing EPP or P/D was conducted. The results indicate that P/D is associated with better outcomes in terms of 30-day mortality, median overall survival, and complications compared to EPP. However, the choice of surgical approach should be based on the goal of MCR and patient safety.
UPDATES IN SURGERY
(2022)
Article
Oncology
B. C. John Cho, Laura Donahoe, Penelope A. Bradbury, Natasha Leighl, Shaf Keshavjee, Andrew Hope, Prodipto Pal, Michael Cabanero, Kasia Czarnecka, Karen McRae, Ming-Sound Tsao, Marc de Perrot
Summary: A novel treatment approach called Surgery for Mesothelioma After Radiotherapy (SMART) was developed for managing malignant pleural mesothelioma, with promising results in clinical feasibility. However, minimizing severe treatment-related events is challenging and may impact survival beyond the post-operative period.
Review
Oncology
Anne S. Tsao, Harvey Pass, Andreas Rimner, Aaron S. Mansfield
Summary: Malignant pleural mesothelioma (MPM) is a rare malignancy with limited treatment options. Recent advances have led to changes in treatment standards, including the use of a novel biomedical device in combination with platinum-pemetrexed and the inclusion of immunotherapy as a frontline treatment option. Proper identification of the MPM histology is crucial in determining the optimal treatment plan. Immunotherapy can benefit all MPM patients and should be considered at some point during treatment. Ongoing research is focusing on defining frontline therapy in the unresectable setting and addressing immunotherapy refractory cases.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Giuseppe Mangiameli, Edoardo Bottoni, Umberto Cariboni, Giorgio Maria Ferraroli, Emanuela Morenghi, Veronica Maria Giudici, Emanuele Voulaz, Marco Alloisio, Alberto Testori
Summary: This study compares the perioperative outcomes and long-term survival of malignant pleural mesothelioma (MPM) patients who underwent extended pleurectomy and decortication (eP/D) and extrapleural pneumonectomy (EPP). The results demonstrate that eP/D can be a well-tolerated surgical procedure with comparable oncological outcomes to EPP, especially in carefully selected patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Riccardo Taje, Roberto Fiorito, Alexandro Patirelis, Valentina Marziali, Vincenzo Ambrogi
Summary: This study compared the effects of pleurectomy/decortication and extrapleural pneumonectomy on symptoms and quality of life in patients with high symptom burden mesothelioma. The results showed that while extrapleural pneumonectomy had lower pain at 12 months, it had a higher decrement of forced vital capacity at 24 months compared to pleurectomy/decortication. Both procedures improved many symptoms and quality of life determinants at 3 months, but the improvement lasted longer in the extrapleural pneumonectomy group. There were no differences in chemotherapy compliance and survival between the two groups. Age at presentation and non-epitheliod histology were the only significant prognosticators. These findings suggest that surgery can improve symptoms and quality of life in patients with high symptom burden mesothelioma, with extrapleural pneumonectomy having the most durable effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Mehmet Ali Bedirhan, Yunus Seyrek, Volkan Yaran, Celal Bugra Sezen, Levent Cansever, Muzaffer Metin
Summary: This study examined the impact of metastatic mediastinal lymph node involvement on the prognosis of patients with malignant pleural mesothelioma (MPM) who underwent extrapleural pneumonectomy (EPP) or extended pleurectomy (E/P). The results indicated that metastatic mediastinal lymph node involvement negatively affected the prognosis of patients with T3 MPM.
ACTA CHIRURGICA BELGICA
(2023)
Article
Oncology
Laura V. Klotz, Hans Hoffmann, Rajiv Shah, Florian Eichhorn, Christiane Gruenewald, Elena L. Bulut, Raffaella Griffo, Thomas Muley, Petros Christopoulos, Philip Baum, Peter Huber, Seyer Safi, Marc Kriegsmann, Michael Thomas, Helge Bischoff, Hauke Winter, Martin E. Eichhorn
Summary: This study analyzed a 20-year experience of surgery for malignant pleural mesothelioma (MPM) and found that extended pleurectomy/decortication combined with hyperthermic intrathoracic chemoperfusion and adjuvant chemotherapy resulted in higher overall survival compared to trimodal extrapleural pneumonectomy (EPP). The perioperative morbidity was also lower in the surgery group.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Oncology
Akifumi Nakamura, Nobuyuki Kondo, Toru Nakamichi, Masaki Hashimoto, Teruhisa Takuwa, Seiji Matsumoto, Kozo Kuribayashi, Takashi Kijima, Seiki Hasegawa
Summary: This study retrospectively analyzed the complications of 163 patients with malignant pleural mesothelioma who underwent P/D, finding that approximately one in three patients experienced AL10, with performance status being a potential risk factor associated with AL10.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Liu, Hengrui Liang, Fei Cui, Hui Liu, Chengchu Zhu, Wenhua Liang, Jianxing He
Summary: The study showed that spontaneous ventilation video-assisted thoracic surgery (SV-VATS) is not inferior to mechanical ventilation VATS (MV-VATS) in terms of complication rate for primary spontaneous pneumothorax patients undergoing blebectomy. Additionally, SV-VATS was associated with shorter procedural duration, recovery time, and food intake time.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, Research & Experimental
Pietro G. Signorile, Maria Cassano, Rosa Viceconte, Maria Spyrou, Valentina Marcattilj, Alfonso Baldi
Summary: Endometriosis is a prevalent gynecological disease with uncertainties in its pathogenesis, diagnosis, and therapy. This study analyzed a large number of patients' clinical data and diagnostic results, revealing that MRI has high sensitivity and specificity for ovarian lesions, while laparoscopy is more reliable for detecting peritoneal lesions. Clinical symptoms are crucial for diagnosing deep lesions, and certain biomarkers may have value in monitoring patients' condition.
Article
Pathology
Michele Donati, Petr Martinek, Petr Steiner, Petr Grossmann, Tomas Vanecek, Liubov Kastnerova, Isabel Kolm, Martina Baneckova, Pietro Donati, Irina Kletskaya, Antonina Kalmykova, Josef Feit, Petr Blasch, Diana Szilagyi, Alfonso Baldi, Paolo Persichetti, Anna Crescenzi, Michal Michal, Dmitry V. Kazakov
Summary: BAP1-inactivated melanocytic tumors (BIMT) are characterized by loss of function of the BAP1 gene and often contain BRAF mutations. These tumors show extreme cytomorphological heterogeneity with distinctive morphological variants, and may also exhibit underrecognized microscopic features. Our study identified several novel BAP1 mutations and revealed a progression of BIMTs from conventional BRAF-mutated nevi to epithelioid BAP1-inactivated melanocytes.
Article
Oncology
Donatella Malanga, Carmelo Laudanna, Teresa Mirante, Fabiana Colelli, Simona Migliozzi, Pietro Zoppoli, Gianluca Santamaria, Luca Roberto, Carmela De Marco, Marzia Scarfo, Donatella Montanaro, Orlando Paciello, Serenella Papparella, Chiara Mignogna, Alfonso Baldi, Giuseppe Viglietto
Summary: The gain-of-function mutation AKT1E17K is demonstrated to be a bona fide oncogene for mammary epithelium, capable of efficiently initiating breast cancer in mice. The AKT1E17K strain may serve as an appropriate model for human basal-like breast cancer and may aid in the identification of novel therapies specific to this type of tumor.
Article
Cell Biology
Rossana Cuciniello, Francesco Di Meo, Maria Sulli, Olivia Costantina Demurtas, Mirella Tanori, Mariateresa Mancuso, Clizia Villano, Riccardo Aversano, Domenico Carputo, Alfonso Baldi, Gianfranco Diretto, Stefania Filosa, Stefania Crispi
Summary: Grapevine seeds contain polyphenols that can induce apoptosis and inhibit cancer properties in mesothelioma cells, possibly due to the presence of oligomeric proanthocyanidins. MDM2 was identified as a potential molecular target of AGS, and it was found to act in both a p53-dependent and independent manner. AGS significantly inhibited tumor progression in a mouse model of mesothelioma.
Article
Oncology
Fei Cui, Jun Liu, Ming Du, Junqiang Fan, Junke Fu, Qing Geng, Ming He, Jian Hu, Bin Li, Shanqing Li, Xukai Li, Yong-De Liao, Ling Lin, Feng Liu, Jian Liu, Junhong Lv, Qiang Pu, Lijie Tan, Hui Tian, Mingsong Wang, Tao Wang, Li Wei, Chuan Xu, Shidong Xu, Shun Xu, Haoxian Yang, Ben-Tong Yu, Guangmao Yu, Zhentao Yu, Chang Young Lee, Eugenio Pompeo, Feredun Azari, Hitoshi Igai, Hyun Koo Kim, Marco Andolfi, Masatsugu Hamaji, Massimiliano Bassi, Wolfram Karenovics, Yojiro Yutaka, Yoshihisa Shimada, Yukinori Sakao, Alan D. L. Sihoe, Yi Zhang, Zhenfa Zhang, Jun Zhao, Wenzhao Zhong, Yuming Zhu, Jianxing He
Summary: Research has shown that fluorescence-guided thoracoscopic surgery can address challenges in the resection of pulmonary lesions. This manuscript describes the development of a consensus on ICG fluorescence-guided thoracoscopic resection of pulmonary lesions and provides recommendations for its application in multiple centers.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Stefano Elia, Eugenio Pompeo, Antonella Santone, Rebecca Rigoli, Marcello Chiocchi, Alexandro Patirelis, Francesco Mercaldo, Leonardo Mancuso, Luca Brunese
Summary: Solitary pulmonary nodules (SPNs) are a challenge for thoracic surgeons, especially in elderly patients. Radiomics and artificial intelligence (AI) can assist in predicting malignancy in suspicious nodules and aid in decision-making. In this study, AI analysis of radiomic features achieved a high predictive value for malignancy in elderly patients with SPNs, reducing unnecessary surgery.
Article
Biology
Angelica Perna, Eleonora Hay, Paolo De Blasiis, Marco La Verde, Francesca Caprio, Marco Torella, Maddalena Morlando, Carmine Sellitto, Germano Guerra, Angela Lucariello, Alfonso Baldi, Antonio De Luca
Summary: SARS-CoV-2 infection during pregnancy can lead to adverse outcomes, such as preterm delivery, fetal growth restriction, gestational diabetes, and hypertensive disorders. Infection during the third trimester can result in significant alterations in placental vascular development, including fibrin deposits, lymphocyte infiltration, edema, and thrombi. Further studies are needed to understand the mechanisms involved and develop therapeutic strategies.
Editorial Material
Surgery
Jiaxi He, Eugenio Pompeo
FRONTIERS IN SURGERY
(2023)
Article
Dermatology
Alexander Bianchi, Alfonso Baldi, Andrea Farabini, Lorenzo Nibid, Vincenzo Roberti, Giovanni Pellacani, Dmitry V. Kazakov, Michele Donati
Summary: Kissing nevus is a rare congenital melanocytic neoplasm that occurs in areas of embryological split, such as the eyelid or penis. This case study describes the dermatoscopic, histological, and confocal microscopic analysis of a new case of kissing nevus of the penis in a 57-year-old man. The findings revealed characteristic features of the nevus and suggested cellular activity through confocal microscopy. A conservative treatment approach was adopted, with a planned clinical follow-up after six months.
Article
Medicine, General & Internal
Riccardo Taje, Eleonora Fabbi, Roberto Sorge, Stefano Elia, Mario Dauri, Eugenio Pompeo
Summary: In nonintubated thoracoscopic-surgery, adjuvant transthoracic negative-pressure ventilation is effective in reducing the risks of barotrauma. In patients with severe emphysema or interstitial lung disease, this method improves postoperative lung re-expansion and oxygen saturation. The results show better outcomes in oxygenation measures and lung expansion with transthoracic NPV.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Giuseppe della Vecchia, Alfonso Baldi, Maria Beatrice Passavanti, Angela Lucariello, Antonio De Luca, Paolo De Blasiis
Summary: This study reports a clinical case of acute non-traumatic foot drop caused by peroneal intraneural ganglion and reviews the methodological management of this disease. The results show that careful clinical examination and differential diagnosis can effectively manage acute foot drop caused by peroneal intraneural ganglion and achieve satisfactory motor recovery through surgery and rehabilitation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Pietro G. Signorile, Alfonso Baldi, Rosa Viceconte, Bruno Vincenzi, Marco Montella
Summary: Endometriosis is a pathological condition characterized by the presence of endometrial tissue outside the uterus. It is a genetic polymorphism and estrogen-dependent inflammatory disease, causing significant morbidity and infertility. Research has shown that alterations in the molecular mechanisms of uterine organogenesis are linked to the development and survival of endometriosis lesions.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
(2023)
Article
Biotechnology & Applied Microbiology
Pietro G. Signorile, Rosa Viceconte, Bruno Vincenzi, Alfonso Baldi
Summary: Endometriosis is a common disease characterized by the presence of endometrial tissue outside the uterus. It is estrogen dependent and has significant impacts on fertility and patient morbidity. Studies suggest that altered uterine organogenesis may contribute to the development of endometriosis. This article compared the expression of molecular factors involved in embryonic development between deep endometriotic lesions and normal endometrial tissue, and found differences in the expression of insulin growth factor, prolactin receptor, and growth hormone.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
(2023)
Article
Medicine, Research & Experimental
Pietro G. Signorile, Maria Cassano, Rosa Viceconte, Valentina Marcattilj, Alfonso Baldi
Summary: This retrospective study on 4,083 patients with endometriosis revealed that chronic fatigue syndrome and dyspareunia are among the main symptoms of the disease, while urinary disorders and chronic pelvic pain have a low occurrence. The study also found an increase in symptom incidence from the age group of 25-29 years to 40-44 years, followed by a significant decrease in the age group of 55-59 years. Additionally, employers, graduates, and freelancers had a higher incidence of symptoms, and the number of gestations showed a protective effect on chronic fatigue syndrome.