Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Irina Gessl, Mihaela Popescu, Victoria Schimpl, Gabriela Supp, Thomas Deimel, Martina Durechova, Miriam Hucke, Michaela Loiskandl, Paul Studenic, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: Clinical tenderness may not always indicate active inflammation in RA, PsA, and OA. While tenderness in early arthritis may be more associated with inflammation, established disease is better explained by joint damage and malalignment.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Acoustics
Kawther Ben Abdelghani, Hiba Boussaa, Saoussen Miladi, Leith Zakraoui, Alia Fazaa, Ahmed Laatar
Summary: Ultrasonography of the hands can be useful in distinguishing psoriatic arthritis (PsA) from rheumatoid arthritis (RA). PsA patients show more extensor tenosynovitis and soft tissue edema, while RA patients have more ligamentous synovitis and vascular inflammation. These extrasynovial ultrasound findings are helpful in differentiating PsA from RA, especially in patients with immunonegative polyarthritis and no evidence of psoriasis.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Rheumatology
Pinar Kaya Subasi, Tuba Guler, Fatma Gul Yurdakul, Sebnem Ataman, Hatice Bodur
Summary: This study investigated the occurrence of carpal tunnel syndrome in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), comparing electrophysiological and ultrasonographic findings. The findings suggest that both RA and PsA patients have higher frequency of CTS compared to healthy controls, with median nerve cross-sectional area being a significant factor in CTS diagnosis. The study also indicates a potential higher prevalence of CTS in PsA patients compared to RA.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Rheumatology
Jeanette Trickey, Ilfita Sahbudin, Mads Ammitzboll-Danielsen, Irene Azzolin, Carina Borst, Alessandra Bortoluzzi, George A. W. Bruyn, Philippe Carron, Coziana Ciurtin, Georgios Filippou, Jacek Flicinski, Daniela Fodor, Helene Gouze, Marwin Gutierrez, Hilde Berner Hammer, Ellen-Margrethe Hauge, Annamaria Iagnocco, Kei Ikeda, Rositsa Karalilova, Helen Isobel Keen, Marion Kortekaas, Giuliana La Paglia, Gustavo Leon, Peter Mandl, Mihaela Maruseac, Marcin Milchert, Mohamed Atia Mortada, Esperanza Naredo, Sarah Ohrndorf, Carlos Pineda, Mads Nyhuus Bendix Rasch, Cristina Reategui-Sokolova, Garifallia Sakellariou, Teodora Serban, Cesar A. Sifuentes-Cantu, Maria S. Stoenoiu, Takeshi Suzuki, Lene Terslev, Ilaria Tinazzi, Florentin Ananu Vreju, Ruth Wittoek, Maria-Antonietta D'Agostino, Andrew Filer
Summary: The study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects across the age range. Results showed that tendon abnormalities detected by ultrasound are rare in healthy subjects and can be markers of active inflammatory disease, especially in newly presenting rheumatoid arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Achilleas Floudas, Conor M. Smith, Orla Tynan, Nuno Neto, Vinod Krishna, Sarah M. Wade, Megan Hanlon, Clare Cunningham, Viviana Marzaioli, Mary Canavan, Jean M. Fletcher, Ronan H. Mullan, Suzanne Cole, Ling-Yang Hao, Michael G. Monaghan, Sunil Nagpal, Douglas J. Veale, Ursula Fearon
Summary: This study provides a global transcriptomic analysis of the synovial joints in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), revealing the immune-stromal cell interactions in synovial inflammation. The findings highlight the differential transcription profiles and interactions between cell subsets in RA and PsA, suggesting potential targets for targeted therapeutic intervention in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Emilio Filippucci, Gianluca Smerilli, Andrea Di Matteo, Walter Grassi
Summary: Enthesitis plays a crucial role in the diagnosis and management of patients with spondyloarthritis and psoriatic arthritis, but clinical assessment is often inaccurate due to poor specificity. Ultrasound has the potential to improve the evaluation of enthesitis and enhance patient management in this context. Reviewing the OMERACT definitions for ultrasound enthesitis can help identify current limitations and their potential implications for rheumatology research and clinical practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Rheumatology
Ari Polachek, Victoria Furer, Mirna Zureik, Sharon Nevo, Liran Mendel, David Levartovsky, Jonathan Wollman, Valerie Aloush, Reut Tzemach, Ofir Elalouf, Marina Anouk, Mark Berman, Ilana Kaufman, Or Carmi, Yael Lahat, Tali Eviatar, Hagit Padova, Hagit Sarbagil-Maman, Sara Borok, Adi Broyde, Lihi Eder, Daphna Paran, Ori Elkayam
Summary: This study found that ultrasound has a significantly greater value than composite clinical scores in the assessment of disease activity in PsA patients with FMS. Patients with both PsA and FMS had significantly higher clinical composite indices scores, while their ultrasound scores were similar to those without FMS.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Sayam Dubash, Oras A. Alabas, Xabier Michelena, Leticia Garcia-Montoya, Richard J. Wakefield, Philip S. Helliwell, Paul Emery, Dennis G. McGonagle, Ai Lyn Tan, Helena Marzo-Ortega
Summary: Dactylitis in DMARD-naive early psoriatic arthritis signifies a more severe disease phenotype independently associated with increased disease burden, presenting with greater tender and swollen joint counts, C reactive protein levels, and more prevalent ultrasound-detected synovitis and bone erosions.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Orsolya Tuende Kovacs, Eszter Toth, Oliver Ozohanics, Eszter Soltesz-Katona, Nikolett Marton, Edit Iren Buzas, Laszlo Hunyady, Laszlo Drahos, Gabor Turu, Gyorgy Nagy
Summary: This study investigated the proteomic changes during osteoclast differentiation in healthy donors, RA, and PsA. The results showed increased expression of proteins involved in metabolic activity, secretory function, and cell polarity during differentiation, while immune signaling pathways were downregulated. The expression differences between healthy donors and RA/PsA patients were most noticeable after the final steps of differentiation. The study provides important insights into the pathophysiology of RA and PsA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Milena L. Pachowsky, Maria Gabriella Raimondo, Cong Xu, Simon Rauber, Koray Tascilar, Hannah Labinsky, Mario Vogg, Mina Saad Aziz Saad, David Simon, Juergen Rech, Alina Soare, Lars Braeuer, Arnd Kleyer, Georg Schett, Andreas Ramming
Summary: A minimally invasive biopsy technique was established to retrieve entheseal tissue in patients with psoriatic arthritis. Label-free second harmonic generation microscopy was used to analyze the biopsies, which showed high fraction of entheseal tissue and immune cell infiltration. The technique provides a reliable way to study entheseal tissue in psoriatic arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Tariq Aslam, Farrouq Mahmood, Anetha Sabanathan, Robin Waxman, Philip S. Helliwell
Summary: This study compared the clinical and radiographic phenotypes of PsA patients of South Asian and North European origin, finding that South Asian patients tended to have more severe disease and worse impact on their quality of life compared to North European patients.
Review
Rheumatology
Nadia M. T. Roodenrijs, Melinda Kedves, Attila Hamar, Gyorgy Nagy, Jacob M. van Laar, Desiree van der Heijde, Paco M. J. Welsing
Summary: This study summarized the evidence on diagnostic issues in difficult-to-treat rheumatoid arthritis (D2T RA) and found a scarcity of high-quality studies, no diagnostic tests with sufficient validity and accuracy identified, with ultrasonography (US) showing promise for assessing inflammatory activity.