Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Rheumatology
Berthold Hoppe, Christian Schwedler, Hildrun Haibel, Maryna Verba, Fabian Proft, Mikhail Protopopov, Hans-Gert Heuft, Valeria Rios Rodriguez, Anke Edelmann, Martin Rudwaleit, Joachim Sieper, Denis Poddubnyy
Summary: This study found that in patients with axial spondyloarthritis, there is an association between C-reactive protein levels related to radiographic spinal progression and specific coagulation-related genotypes, especially in individuals predisposed to loose fibrin clots susceptible to fibrinolysis.
Article
Immunology
Shuqiong Zhang, Zhidan Fan, Zijun Ouyang, Haiyan Sun, Yue Song, Haiguo Yu, Qiang Xu, Shijia Liu, Yang Sun, Fenli Shao
Summary: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease that mainly affects the axial skeleton and is characterized by inflammatory back pain, bone structural damage, and pathological new bone formation. This study found increased purine metabolites in the plasma of AS patients and SHP2-deficient chondrocytes, suggesting the potential role of purinergic signaling in promoting ectopic new bone formation. Targeting purinergic signaling, specifically using the purinergic receptor antagonist Suramin, could potentially suppress pathological new bone formation in AS-like bone disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yu Jeong Lee, Moon-Ju Kim, Sungsin Jo, So-Hee Jin, Pu-Reum Park, Kijeong Park, Ho-Chun Song, Jahae Kim, Ji-Young Kim, Seung Cheol Shim, Tae-Hwan Kim, Sung-Jong Hong, Hyundeok Kang, Tae-Jong Kim, Eun Jeong Won
Summary: Helminth infections and their components have the potential to modulate immune responses. Clonorchis sinensis-derived protein (CSp) was found to protect against ankylosing spondylitis (AS) by reducing inflammatory cytokine-producing cells and new bone formation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Mark C. Hwang, MinJae Lee, Lianne S. Gensler, Matthew A. Brown, Amirali Tahanan, Mohammad H. Rahbar, Theresa Hunter, Mingyan Shan, Mariko L. Ishimori, John D. Reveille, Michael H. Weisman, Thomas J. Learch
Summary: This study identified four distinct patterns of spinal disease progression in ankylosing spondylitis patients. Factors associated with higher spinal disease burden groups include male gender, longer disease duration, elevated CRP and smoking history. Independent confirmation in other AS cohorts is needed to confirm these radiographic patterns.
Article
Rheumatology
Mary Lucy Marques, Nuno Pereira da Silva, Desiree van der Heijde, Monique Reijnierse, Xenofon Baraliakos, Juergen Braun, Floris A. van Gaalen, Sofia Ramiro
Summary: Objective: We analyzed the trabecular bone density of patients with r-axSpA using low-dose CT scans and assessed the inter-reader reliability. Our results showed that ldCT measurement of HU is a feasible method to assess vertebral bone density in r-axSpA with excellent inter-reader reliability from C3 to L5.
Article
Rheumatology
Murat Torgutalp, Valeria Rios Rodriguez, Fabian Proft, Mikhail Protopopov, Maryna Verba, Judith Rademacher, Hildrun Haibel, Joachim Sieper, Martin Rudwaleit, Denis Poddubnyy
Summary: This study investigated the longitudinal association between treatment with tumor necrosis factor inhibitors (TNFi) and the progression of radiographic sacroiliitis in patients with early axial spondyloarthritis (SpA). The results showed that receiving TNFi treatment for at least 12 months in the previous 2-year period was associated with a significant decrease in sacroiliitis scores. This effect became evident 2 to 4 years after treatment initiation.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Sungsin Jo, Eun Jeong Won, Moon-Ju Kim, Yu Jeong Lee, So-Hee Jin, Pu-Reum Park, Ho-Chun Song, Jahae Kim, Yoo-Duk Choi, Ji-Young Kim, Seung Cheol Shim, Sung Hoon Choi, Ye-Soo Park, Tae-Hwan Kim, Tae-Jong Kim
Summary: The study demonstrates that stat3-p lnh effectively suppresses chronic inflammation and bone formation in AS. Results show significant reductions in arthritis, enthesitis, spondylitis, and ileitis in the mouse model treated with stat3-p lnh. In vitro experiments also indicate decreased frequencies of inflammatory cytokine-producing cells after stat3-p lnh treatment.
Article
Medicine, General & Internal
Chun-Hsiung Chen, Hung-An Chen, Hsien-Tzung Liao, Chung-Tei Chou, Chen-Hung Chen
Summary: This study investigated the association between blood pressure, hypertension, and disease severity in patients with ankylosing spondylitis. The results showed that blood pressure was associated with disease activity, functional ability, and radiographic damage, while hypertension was associated with radiographic damage, age, and obesity.
Article
Rheumatology
Alexandre Sepriano, Sofia Ramiro, Stephanie Wichuk, Praveena Chiowchanwisawakit, Joel Paschke, Desiree van der Heijde, Robert Landewe, Walter P. Maksymowych
Summary: The study found that TNFi can slow down spinal radiographic progression in patients with radiographic axial SpA, which may be partially related to their effects on inflammation as measured by the ASDAS.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Anne Boel, Victoria Navarro-Compan, Desiree van der Heijde
Summary: The study aimed to assess the test-retest reliability of candidate instruments for the mandatory domains of the Assessment of Spondyloarthritis international Society (ASAS)-Outcome Measures in Rheumatology core set for axial spondyloarthritis (axSpA). The results showed good reliability for most instruments in evaluating disease activity in axSpA patients, with composite measures demonstrating higher reliability than single-item measures.
Article
Rheumatology
Joon-Yong Jung, Moon-Young Kim, Yeon Sik Hong, Sung-Hwan Park, Kwi Young Kang
Summary: The study found that facet joint ankylosis in patients with r-axSpA is associated with functional impairment and spinal mobility. Facet joint ankylosis was most common in the thoracic spine. Scores for the whole spine correlated positively with ASDAS, mSASSS, and syndesmophyte score.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Rheumatology
Bora Nam, Sungsin Jo, So-Young Bang, Youngho Park, Ji Hui Shin, Ye-Soo Park, Seunghun Lee, Kyung Bin Joo, Tae-Hwan Kim
Summary: This study identified clinical and genetic factors associated with severe radiographic damage in patients with ankylosing spondylitis (AS). The results showed that baseline mSASSS, peripheral joint arthritis, uveitis, and smoking were significant clinical factors associated with radiographic damage. The RYR3 gene and the PI3K-Akt signaling pathway were also found to be associated with severe radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Atul Deodhar, Filip Van den Bosch, Denis Poddubnyy, Walter P. Maksymowych, Desiree van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Ricardo Blanco, Yuanyuan Duan, Yihan Li, Aileen L. Pangan, Peter Wung, In-Ho Song
Summary: Upadacitinib demonstrates significant efficacy and safety in patients with non-radiographic axial spondyloarthritis.
Letter
Rheumatology
Walter P. Maksymowych, Robert G. W. Lambert, Mikkel ostergaard, Xenofon Baraliakos
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Desiree van der Heijde, Maxime Dougados, Walter P. Maksymowych, Gina Bergman, Sean P. Curtis, Anjela Tzontcheva, Susan Huyck, George Philip, Joachim Sieper
Summary: In this study, the long-term efficacy and safety of golimumab (GLM) in patients with non-radiographic axial spondyloarthritis (nr-axSpA) were evaluated. It was found that GLM treatment provided sustained improvement in clinical efficacy at 52 weeks and was well tolerated.
Article
Rheumatology
Uta Kiltz, Annelies Boonen, Desiree van der Heijde, Wilson Bautista-Molano, Ruben Burgos Vargas, Praveena Chiowchanwisawakit, Bassel El-Zorkany, Inna Gaydukova, Pal Geher, Laure Gossec, Michele Gilio, Simeon Grazio, Jieruo Gu, Muhammad Asim Khan, Tae-Jong Kim, Walter P. Maksymowych, Helena Marzo-Ortega, Victoria Navarro-Compan, Salih Ozgocmen, Dimos Patrikos, Fernando Manuel Pimentel-Santos, John Reveille, Michael Schirmer, Simon Stebbings, Filip Van den Bosch, Ulrich Weber, Juergen Braun
Summary: This study developed an Environmental contextual factors (EF) Item Set (EFIS) to accompany the Assessment of SpondyloArthritis international Society Health Index (ASAS HI), aiming to interpret ASAS HI results by exploring the interaction between health conditions and contextual factors.
Article
Rheumatology
Zhixiu Li, Sjef M. van der Linden, Muhammad Asim Khan, Heinz Baumberger, Hermine van Zandwijk, Mohammad Kazim Khan, Peter M. Villiger, Matthew A. Brown
Summary: The objective of this study is to assess heterogeneity in axial spondyloarthritis (axSpA) and its sources. The results suggest that women clinically diagnosed with axSpA but without radiographic sacroiliitis have distinct characteristics compared to men with non-radiographic axSpA.
Letter
Genetics & Heredity
Matthew A. Brown, Christopher Wigley, Susan Walker, Deborah Lancaster, Augusto Rendon, Richard Scott
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Rheumatology
Victoria Navarro-Compan, Anne Boel, Annelies Boonen, Philip J. Mease, Maxime Dougados, Uta Kiltz, Robert B. M. Landewe, Xenofon Baraliakos, Wilson Bautista-Molano, Praveena Chiowchanwisawakit, Hanne Dagfinrud, Lara Fallon, Marco Garrido-Cumbrera, Lianne Gensler, Bassel Kamal ElZorkany, Nigil Haroon, Yu Heng Kwan, Pedro M. Machado, Walter Maksymowych, Anna Molto, Natasha de Peyrecave, Denis Poddubnyy, Mikhail Protopopov, Sofia Ramiro, In-Ho Song, Salima van Weely, Desiree van der Heijde
Summary: This study aims to define the instruments for the Assessment of SpondyloArthritis international Society-Outcomes Measures in Rheumatology core domain set for axial spondyloarthritis (axSpA). The study selected core outcome instruments through a systematic literature review and assessment of the instruments' psychometric properties. Additionally, the study endorsed additional instruments to enhance the evaluation of axSpA trials.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Sjef M. van der Linden, Muhammad Asim Khan, Zhixiu Li, Heinz Baumberger, Hermine van Zandwijk, Mohammad Kazim Khan, Peter M. Villiger, Matthew A. Brown
Summary: The lifetime recurrence risk of axSpA is substantial for HLA-B27(+) FDRs, and disease severity and the gender of the proband's children are associated with the risk of developing axSpA.
Article
Rheumatology
Lauren K. Ridley, Mark C. Hwang, John D. Reveille, Lianne S. Gensler, Mariko L. Ishimori, Matthew A. Brown, Mohammad H. Rahbar, Amirali Tahanan, Michael M. Ward, Michael H. Weisman, Thomas J. Learch
Summary: This study investigated a subgroup of patients with ankylosing spondylitis (AS) who had long-standing disease and fused sacroiliac (SI) joints and found that females and males with early symptom onset had less radiographic damage in the SI joints. All 23 patients without syndesmophytes were HLA-B27 positive.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Ryan M. Hum, Pauline Ho, Nisha Nair, Meghna Jani, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Darren Plant, Anne Barton
Summary: This study suggests that higher levels of TNF-a inhibitor serum drug levels (SDLs) are associated with good treatment response in fully adherent patients. Interventions to improve SDLs, such as encouraging adherence, may improve treatment response. The identified SDL cut-offs for adalimumab and certolizumab may be useful in clinical practice.
Article
Cardiac & Cardiovascular Systems
Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jorgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H. F. Rudd, Justin C. Mason, Jason M. Tarkin
Summary: This study investigates the feasibility of using somatostatin receptor 2 (SST2) as a molecular imaging target for inflammation in large vessel vasculitis (LVV), and provides evidence for its potential in the diagnosis and therapeutic monitoring of LVV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Rheumatology
Peter C. Grayson, Cristina Ponte, Ravi Suppiah, Joanna C. Robson, Katherine Bates Gribbons, Andrew Judge, Anthea Craven, Sara Khalid, Andrew Hutchings, Debashish Danda, Raashid A. Luqmani, Richard A. Watts, Peter A. Merkel
Summary: The objective of this study was to develop and validate new classification criteria for Takayasu arteritis (TAK). The study consisted of six phases and resulted in the establishment of validated criteria for TAK classification.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Cristina Ponte, Peter C. Grayson, Joanna C. Robson, Ravi Suppiah, Katherine Bates Gribbons, Andrew Judge, Anthea Craven, Sara Khalid, Andrew Hutchings, Richard A. Watts, Peter A. Merkel, Raashid A. Luqmani
Summary: This study aimed to develop and validate updated classification criteria for giant cell arteritis (GCA). By collecting and analyzing a large number of samples, a set of indicators and weights for the diagnosis and classification of GCA were determined. These classification criteria achieved high sensitivity and specificity in the validation dataset.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Samantha Louise Smith, Sheree Alexander, Nisha Nair, Sebastien Viatte, Stephen Eyre, Kimme L. Hyrich, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, Darren Plant, Anne Barton
Summary: The study aimed to explore whether the inflammatory protein MRP8/14 can serve as a biomarker for treatment response in rheumatoid arthritis (RA) patients receiving tumor necrosis factor (TNF) inhibitors. The results showed that in the 3-component and 2-component models, patients with high pre-treatment levels of MRP8/14 were 1.92 and 2.03 times more likely to be classified as EULAR responders compared to those with low levels. However, no significant associations were observed in the 4-component model. Conclusion: Apart from its correlation with CRP, there is no evidence to suggest that MRP8/14 explains additional variability in response to TNFi in RA patients beyond CRP alone.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Philippa D. K. Curry, Hector Chinoy, Meghna Jani, Darren Plant, Kimmie L. Hyrich, Ann W. Morgan, A. G. Wilson, John D. Isaacs, Andrew P. Morris, Anne Barton, James Bluett
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lisa M. Duff, Andrew F. Scarsbrook, Nishant Ravikumar, Russell Frood, Gijs D. van Praagh, Sarah L. Mackie, Marc A. Bailey, Jason M. Tarkin, Justin C. Mason, Kornelis S. M. van der Geest, Riemer H. J. A. Slart, Ann W. Morgan, Charalampos Tsoumpas
Summary: The aim of this study was to develop and validate an automated pipeline for diagnosing active aortitis using radiomic imaging biomarkers from FDG PET-CT images. The aorta was automatically segmented using a CNN. Radiomic features were extracted, and three different radiomic fingerprints were constructed. The pipeline showed good diagnostic performance across multiple datasets, indicating its potential for generalizability and use in automated clinical decision-making.