Imaging research results from the Osteoarthritis Initiative (OAI): a review and lessons learned 10 years after start of enrolment

The Effects of Meniscus Injury on the Development of Knee Osteoarthritis

(2013) Jayshiv T. Badlani et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

A novel method for bone area measurement provides new insights into osteoarthritis and its progression

(2013) Michael A Bowes et al.   ANNALS OF THE RHEUMATIC DISEASES

First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort

(2013) Johanne Martel-Pelletier et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of vascular channels as a novel mechanism for subchondral bone damage at cruciate ligament entheses in osteoarthritis and inflammatory arthritis

(2013) D A Binks et al.   ANNALS OF THE RHEUMATIC DISEASES

Meniscus Body Position, Size, and Shape in Persons With and Persons Without Radiographic Knee Osteoarthritis: Quantitative Analyses of Knee Magnetic Resonance Images From the Osteoarthritis Initiative

(2013) Andrea Wenger et al.   ARTHRITIS AND RHEUMATISM

Magnetic Resonance Imaging-Based Three-Dimensional Bone Shape of the Knee Predicts Onset of Knee Osteoarthritis: Data From the Osteoarthritis Initiative

(2013) Tuhina Neogi et al.   ARTHRITIS AND RHEUMATISM

Study of surgical indication for knee arthroplasty by cartilage analysis in three compartments using data from Osteoarthritis Initiative (OAI)

(2013) Eiko Yamabe et al.   BMC MUSCULOSKELETAL DISORDERS

Contribution of regional 3D meniscus and cartilage morphometry by MRI to joint space width in fixed flexion knee radiography—A between-knee comparison in subjects with unilateral joint space narrowing

(2013) K. Bloecker et al.   EUROPEAN JOURNAL OF RADIOLOGY

Focal knee lesions in knee pairs of asymptomatic and symptomatic subjects with OA risk factors—Data from the Osteoarthritis Initiative

(2013) Renu Chundru et al.   EUROPEAN JOURNAL OF RADIOLOGY

T2relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur: Longitudinal data from the osteoarthritis initiative

(2013) Pia M. Jungmann et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Correlation of WOMAC and KOOS scores to tibiofemoral cartilage loss on plain radiography and 3 Tesla MRI: data from the osteoarthritis initiative

(2013) Kenneth David Illingworth et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Texture analysis of bone marrow in knee MRI for classification of subjects with bone marrow lesion — Data from the Osteoarthritis Initiative

(2013) Tong Kuan Chuah et al.   MAGNETIC RESONANCE IMAGING

Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative

(2013) Torben Dannhauer et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI

(2013) D.T. Felson et al.   OSTEOARTHRITIS AND CARTILAGE

Radiofrequency (RF) coil impacts the value and reproducibility of cartilage spin–spin (T2) relaxation time measurements

(2013) B.J. Dardzinski et al.   OSTEOARTHRITIS AND CARTILAGE

Radiographic joint space width is correlated with 4-year clinical outcomes in patients with knee osteoarthritis: data from the osteoarthritis initiative

(2013) S.R. Oak et al.   OSTEOARTHRITIS AND CARTILAGE

T2 texture index of cartilage can predict early symptomatic OA progression: data from the osteoarthritis initiative

(2013) K.L. Urish et al.   OSTEOARTHRITIS AND CARTILAGE

Relationship between knee pain and the presence, location, size and phenotype of femorotibial denuded areas of subchondral bone as visualized by MRI

(2013) S. Cotofana et al.   OSTEOARTHRITIS AND CARTILAGE

Physical activity in relation to knee cartilage T2 progression measured with 3 T MRI over a period of 4 years: data from the Osteoarthritis Initiative

(2013) W. Lin et al.   OSTEOARTHRITIS AND CARTILAGE

Association of trochlear dysplasia with degenerative abnormalities in the knee: data from the Osteoarthritis Initiative

(2013) Pia M. Jungmann et al.   SKELETAL RADIOLOGY

Correlation of semiquantitative vs quantitative MRI meniscus measures in osteoarthritic knees: results from the Osteoarthritis Initiative

(2013) K. Bloecker et al.   SKELETAL RADIOLOGY

Association of Metabolic Risk Factors With Cartilage Degradation Assessed by T2 Relaxation Time at the Knee: Data From the Osteoarthritis Initiative

(2013) P. M. Jungmann et al.   ARTHRITIS CARE & RESEARCH

Association of Frequent Knee Bending Activity With Focal Knee Lesions Detected With 3T Magnetic Resonance Imaging: Data From the Osteoarthritis Initiative

(2013) Warapat Virayavanich et al.   ARTHRITIS CARE & RESEARCH

Thigh Muscle Cross-Sectional Areas and Strength in Advanced Versus Early Painful Osteoarthritis: An Exploratory Between-Knee, Within-Person Comparison in Osteoarthritis Initiative Participants

(2013) Anja Ruhdorfer et al.   ARTHRITIS CARE & RESEARCH

Bone marrow lesion volume reduction is not associated with improvement of other periarticular bone measures: data from the Osteoarthritis Initiative

(2013) Jeffrey B Driban et al.   ARTHRITIS RESEARCH & THERAPY

Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker - longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative

(2013) Jeffrey B Driban et al.   ARTHRITIS RESEARCH & THERAPY

Soft drink intake and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative

(2013) Bing Lu et al.   BMJ Open

Quantitative MRI measures of cartilage predict knee replacement: a case–control study from the Osteoarthritis Initiative

(2012) Felix Eckstein et al.   ANNALS OF THE RHEUMATIC DISEASES

Progression of osteoarthritis as a state of inertia

(2012) David Felson et al.   ANNALS OF THE RHEUMATIC DISEASES

Associations between Statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis

(2012) Daniel L Riddle et al.   ANNALS OF THE RHEUMATIC DISEASES

Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: Findings from the multicenter osteoarthritis study and the osteoarthritis initiative

(2012) David T. Felson et al.   ARTHRITIS AND RHEUMATISM

Extent of Tibiofemoral Osteoarthritis Before Knee Arthroplasty: Multicenter Data from the Osteoarthritis Initiative

(2012) Daniel L. Riddle et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Unsupervised Segmentation and Quantification of Anatomical Knee Features: Data From the Osteoarthritis Initiative

(2012) José G. Tamez-Pena et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

In normal knees, joint space width (JSW) is correlated with the intermargin distance (IMD), a measure of medial tibial plateau alignment. Variations in IMD explain variability in JSW in serial radiographs

(2012) Catherine Mercier et al.   JOINT BONE SPINE

Implementation of subject-specific collagen architecture of cartilage into a 2D computational model of a knee joint-data from the osteoarthritis initiative (OAI)

(2012) Lasse P. Räsänen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Validity of clinical measures of frontal plane knee alignment: Data from the Osteoarthritis Initiative

(2012) Daniel L. Riddle   MANUAL THERAPY

Recent advances in osteoarthritis imaging—the Osteoarthritis Initiative

(2012) Felix Eckstein et al.   Nature Reviews Rheumatology

Validity and Reliability of Radiographic Knee Osteoarthritis Measures by Arthroplasty Surgeons

(2012) Daniel L. Riddle et al.   ORTHOPEDICS

How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative

(2012) F. Eckstein et al.   OSTEOARTHRITIS AND CARTILAGE

Equivalence and precision of knee cartilage morphometry between different segmentation teams, cartilage regions, and MR acquisitions

(2012) E. Schneider et al.   OSTEOARTHRITIS AND CARTILAGE

Bone marrow lesions are associated with altered trabecular morphometry

(2012) J.B. Driban et al.   OSTEOARTHRITIS AND CARTILAGE

Cross-sectional DXA and MR measures of tibial periarticular bone associate with radiographic knee osteoarthritis severity

(2012) G.H. Lo et al.   OSTEOARTHRITIS AND CARTILAGE

Side differences of thigh muscle cross-sectional areas and maximal isometric muscle force in bilateral knees with the same radiographic disease stage, but unilateral frequent pain – data from the osteoarthritis initiative

(2012) M. Sattler et al.   OSTEOARTHRITIS AND CARTILAGE

Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3years – data from the Osteoarthritis Initiative

(2012) G.B. Joseph et al.   OSTEOARTHRITIS AND CARTILAGE

The Osteoarthritis Initiative (OAI) magnetic resonance imaging quality assurance update

(2012) E. Schneider et al.   OSTEOARTHRITIS AND CARTILAGE

Frequency and spatial distribution of cartilage thickness change in knee osteoarthritis and its relation to clinical and radiographic covariates – data from the osteoarthritis initiative

(2012) R.J. Buck et al.   OSTEOARTHRITIS AND CARTILAGE

Direct comparison of fixed flexion, radiography and MRI in knee osteoarthritis: responsiveness data from the Osteoarthritis Initiative

(2012) W. Wirth et al.   OSTEOARTHRITIS AND CARTILAGE

Tibial coverage, meniscus position, size and damage in knees discordant for joint space narrowing – data from the Osteoarthritis Initiative

(2012) K. Bloecker et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage thickening in early radiographic knee osteoarthritis: A within-person, between-knee comparison

(2012) Sebastian Cotofana et al.   ARTHRITIS CARE & RESEARCH

Relationship of intermuscular fat volume in the thigh with knee extensor strength and physical performance in women at risk of or with knee osteoarthritis

(2012) Monica R. Maly et al.   ARTHRITIS CARE & RESEARCH

Correlation of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with body mass index: Thirty-six-month followup data from a longitudinal, observational multicenter study

(2012) Thomas Baum et al.   ARTHRITIS CARE & RESEARCH

Registration of Magnetic Resonance Image Series for Knee Articular Cartilage Analysis

(2012) Kenneth L. Urish et al.   Cartilage

Physical activity is associated with magnetic resonance imaging-based knee cartilage T2 measurements in asymptomatic subjects with and those without osteoarthritis risk factors

(2011) Keegan K. Hovis et al.   ARTHRITIS AND RHEUMATISM

Greater rates of cartilage loss in painful knees than in pain-free knees after adjustment for radiographic disease stage: Data from the Osteoarthritis Initiative

(2011) Felix Eckstein et al.   ARTHRITIS AND RHEUMATISM

Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences

(2011) Daichi Hayashi et al.   BMC MUSCULOSKELETAL DISORDERS

Revision 1 Size and position of the healthy meniscus, and its Correlation with sex, height, weight, and bone area- a cross-sectional study

(2011) Katja Bloecker et al.   BMC MUSCULOSKELETAL DISORDERS

Morphometric Differences between the Medial and Lateral Meniscus in Healthy Men – A Three-Dimensional Analysis Using Magnetic Resonance Imaging

(2011) K. Bloecker et al.   CELLS TISSUES ORGANS

Relationship of 3D meniscal morphology and position with knee pain in subjects with knee osteoarthritis: a pilot study

(2011) Andrea Wenger et al.   EUROPEAN RADIOLOGY

Changes in knee cartilage T2 values over 24 months in subjects with and without risk factors for knee osteoarthritis and their association with focal knee lesions at baseline: Data from the osteoarthritis initiative

(2011) Thomas Baum et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Initial results on development and application of statistical atlas of femoral cartilage in osteoarthritis to determine sex differences in structure: Data from the osteoarthritis initiative

(2011) Hussain Z. Tameem et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Hand Joint Space Narrowing and Osteophytes Are Associated with Magnetic Resonance Imaging-defined Knee Cartilage Thickness and Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative

(2011) I. K. HAUGEN et al.   JOURNAL OF RHEUMATOLOGY

Interobserver reproducibility of quantitative meniscus analysis using coronal multiplanar DESS and IWTSE MR imaging

(2011) Kristina Siorpaes et al.   MAGNETIC RESONANCE IN MEDICINE

Automatic graph-cut based segmentation of bones from knee magnetic resonance images for osteoarthritis research

(2011) Sufyan Y. Ababneh et al.   MEDICAL IMAGE ANALYSIS

MRI-based extended ordered values more efficiently differentiate cartilage loss in knees with and without joint space narrowing than region-specific approaches using MRI or radiography – data from the OA initiative

(2011) W. Wirth et al.   OSTEOARTHRITIS AND CARTILAGE

A novel fast knee cartilage segmentation technique for T2 measurements at MR imaging – data from the Osteoarthritis Initiative

(2011) C. Stehling et al.   OSTEOARTHRITIS AND CARTILAGE

Knee Cartilage T2 Characteristics and Evolution in Relation to Morphologic Abnormalities Detected at 3-T MR Imaging: A Longitudinal Study of the Normal Control Cohort from the Osteoarthritis Initiative

(2011) Judong Pan et al.   RADIOLOGY

Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears

(2011) Verena Stein et al.   RHEUMATOLOGY INTERNATIONAL

Different thresholds for detecting osteophytes and joint space narrowing exist between the site investigators and the centralized reader in a multicenter knee osteoarthritis study—data from the Osteoarthritis Initiative

(2011) Ali Guermazi et al.   SKELETAL RADIOLOGY

Obesity increases the prevalence and severity of focal knee abnormalities diagnosed using 3T MRI in middle-aged subjects—data from the Osteoarthritis Initiative

(2011) Marc A. Laberge et al.   SKELETAL RADIOLOGY

Longitudinal changes in intermuscular fat volume and quadriceps muscle volume in the thighs of women with knee osteoarthritis

(2011) Karen A. Beattie et al.   ARTHRITIS CARE & RESEARCH

Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: Data from the Osteoarthritis Initiative

(2011) Thomas Baum et al.   ARTHRITIS CARE & RESEARCH

Texture analysis of cartilage T2 maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls - data from the osteoarthritis initiative

(2011) Gabby B Joseph et al.   ARTHRITIS RESEARCH & THERAPY

Semiquantitative assessment of focal cartilage damage at 3T MRI: A comparative study of dual echo at steady state (DESS) and intermediate-weighted (IW) fat suppressed fast spin echo sequences

(2010) Frank W. Roemer et al.   EUROPEAN JOURNAL OF RADIOLOGY

LOGISMOS—Layered Optimal Graph Image Segmentation of Multiple Objects and Surfaces: Cartilage Segmentation in the Knee Joint

(2010) Yin Yin et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Statistical shape modeling describes variation in tibia and femur surface geometry between Control and Incidence groups from the Osteoarthritis Initiative database

(2010) Todd L. Bredbenner et al.   JOURNAL OF BIOMECHANICS

Anatomically Anchored Template-Based Level Set Segmentation: Application to Quadriceps Muscles in MR Images from the Osteoarthritis Initiative

(2010) Jeffrey W. Prescott et al.   JOURNAL OF DIGITAL IMAGING

Longitudinal analysis of MRI T2 knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative: A texture approach

(2010) Julio Carballido-Gamio et al.   MAGNETIC RESONANCE IN MEDICINE

Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: Data from the osteoarthritis initiative

(2010) Wolfgang Wirth et al.   MAGNETIC RESONANCE IN MEDICINE

Comparison of BLOKS and WORMS scoring systems part II. Longitudinal assessment of knee MRIs for osteoarthritis and suggested approach based on their performance: data from the Osteoarthritis Initiative

(2010) D.T. Felson et al.   OSTEOARTHRITIS AND CARTILAGE

Reference values and Z-scores for subregional femorotibial cartilage thickness – results from a large population-based sample (Framingham) and comparison with the non-exposed Osteoarthritis Initiative reference cohort

(2010) F. Eckstein et al.   OSTEOARTHRITIS AND CARTILAGE

Alignment of the medial tibial plateau affects the rate of joint space narrowing in the osteoarthritic knee

(2010) E. Vignon et al.   OSTEOARTHRITIS AND CARTILAGE

Comparison of BLOKS and WORMS scoring systems part I. Cross sectional comparison of methods to assess cartilage morphology, meniscal damage and bone marrow lesions on knee MRI: data from the osteoarthritis initiative

(2010) J.A. Lynch et al.   OSTEOARTHRITIS AND CARTILAGE

Subjects with higher physical activity levels have more severe focal knee lesions diagnosed with 3T MRI: analysis of a non-symptomatic cohort of the osteoarthritis initiative

(2010) C. Stehling et al.   OSTEOARTHRITIS AND CARTILAGE

Magnitude and regional distribution of cartilage loss associated with grades of joint space narrowing in radiographic osteoarthritis – data from the Osteoarthritis Initiative (OAI)

(2010) F. Eckstein et al.   OSTEOARTHRITIS AND CARTILAGE

Presence, location, type and size of denuded areas of subchondral bone in the knee as a function of radiographic stage of OA – data from the OA initiative

(2010) R.B. Frobell et al.   OSTEOARTHRITIS AND CARTILAGE

Comparison of 1-year vs 2-year change in regional cartilage thickness in osteoarthritis results from 346 participants from the Osteoarthritis Initiative

(2010) W. Wirth et al.   OSTEOARTHRITIS AND CARTILAGE

Quantification of cartilage loss in local regions of knee joints using semi-automated segmentation software: analysis of longitudinal data from the Osteoarthritis Initiative (OAI)

(2010) T. Iranpour-Boroujeni et al.   OSTEOARTHRITIS AND CARTILAGE

Vastus lateralis/vastus medialis cross-sectional area ratio impacts presence and degree of knee joint abnormalities and cartilage T2 determined with 3T MRI – an analysis from the incidence cohort of the Osteoarthritis Initiative

(2010) J. Pan et al.   OSTEOARTHRITIS AND CARTILAGE

Femorotibial subchondral bone area and regional cartilage thickness: A cross-sectional description in healthy reference cases and various radiographic stages of osteoarthritis in 1,003 knees from the Osteoarthritis Initiative

(2010) Richard B. Frobell et al.   ARTHRITIS CARE & RESEARCH

One-year change in radiographic joint space width in patients with unilateral joint space narrowing: Data from the osteoarthritis initiative

(2010) O. D. Benichou et al.   ARTHRITIS CARE & RESEARCH

Comparison of radiographic joint space width with magnetic resonance imaging cartilage morphometry: Analysis of longitudinal data from the osteoarthritis initiative

(2010) Jeffrey Duryea et al.   ARTHRITIS CARE & RESEARCH

Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the osteoarthritis initiative

(2009) Felix Eckstein et al.   ARTHRITIS AND RHEUMATISM

Longitudinal analysis of MRIT2knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative

(2009) Julio Carballido-Gamio et al.   MAGNETIC RESONANCE IN MEDICINE

Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative

(2009) G.H. Lo et al.   OSTEOARTHRITIS AND CARTILAGE

Intra- and inter-observer reproducibility of volume measurement of knee cartilage segmented from the OAI MR image set using a novel semi-automated segmentation method

(2009) K.T. Bae et al.   OSTEOARTHRITIS AND CARTILAGE

Semi-automated segmentation to assess the lateral meniscus in normal and osteoarthritic knees

(2009) M.S. Swanson et al.   OSTEOARTHRITIS AND CARTILAGE

The relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis

(2009) V. Stein et al.   OSTEOARTHRITIS AND CARTILAGE

Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change?

(2009) D.J. Hunter et al.   OSTEOARTHRITIS AND CARTILAGE

Sensitivity to change of cartilage morphometry using coronal FLASH, sagittal DESS, and coronal MPR DESS protocols – comparative data from the osteoarthritis initiative (OAI)

(2009) W. Wirth et al.   OSTEOARTHRITIS AND CARTILAGE

Knee Cartilage: Efficient and Reproducible Segmentation on High-Spatial-Resolution MR Images with the Semiautomated Graph-Cut Algorithm Method

(2009) Hackjoon Shim et al.   RADIOLOGY

Patellar Cartilage: T2 Values and Morphologic Abnormalities at 3.0-T MR Imaging in Relation to Physical Activity in Asymptomatic Subjects from the Osteoarthritis Initiative

(2009) Christoph Stehling et al.   RADIOLOGY

Magnetic resonance image segmentation using semi-automated software for quantification of knee articular cartilage—initial evaluation of a technique for paired scans

(2009) M. H. Brem et al.   SKELETAL RADIOLOGY

Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative

(2009) Felix Eckstein et al.   ARTHRITIS RESEARCH & THERAPY

Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative

(2008) D J Hunter et al.   ANNALS OF THE RHEUMATIC DISEASES

One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status

(2008) F Eckstein et al.   ANNALS OF THE RHEUMATIC DISEASES

The osteoarthritis initiative (OAI) magnetic resonance imaging quality assurance methods and results

(2008) E. Schneider et al.   OSTEOARTHRITIS AND CARTILAGE

The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee

(2008) C.G. Peterfy et al.   OSTEOARTHRITIS AND CARTILAGE

Strong association of MRI meniscal derangement and bone marrow lesions in knee osteoarthritis: data from the osteoarthritis initiative

(2008) G.H. Lo et al.   OSTEOARTHRITIS AND CARTILAGE

Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort

(2008) W. Wirth et al.   OSTEOARTHRITIS AND CARTILAGE