Article
Physiology
Christina Svensson, Niclas Bjarnegard, Per Eriksson, Hanna Jonasson, Tomas Stromberg, Christopher Sjowall, Helene Zachrisson
Summary: This study examined the changes in skin microcirculation and vascular hemodynamics in TAK patients. The results showed that regardless of arterial stenosis, TAK patients had impaired skin microcirculation and preserved cerebrovascular reserve capacity. Additionally, signs of arterial stiffness were observed in the brain and central arteries.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Allergy
Alexandre Le Joncour, Anne-Claire Desbois, Aurelie S. Leroyer, Edwige Tellier, Paul Regnier, Anna Maciejewski-Duval, Cloe Comarmond, Stephane Barete, Michel Arock, Patrick Bruneval, Jean-Marie Launay, Pierre Fouret, Ulrich Blank, Michelle Rosenzwajg, David Klatzmann, Mohamed Jarraya, Laurent Chiche, Fabien Koskas, Patrice Cacoub, Gilles Kaplanski, David Saadoun
Summary: This study demonstrated elevated levels of mast cell activation markers in the sera of TAK patients compared to healthy donors, along with increased mast cell expression in aortic lesions of TAK patients. Mast cells stimulated by TAK patient sera supported neoangiogenesis and fibrosis compared to healthy donor sera, indicating their key role in vascular lesions. These findings suggest mast cells may serve as a potential therapeutic target in large vessel vasculitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Barthelemy Poignet, Philippe Bonnin, Julien Gaudric, Ismael Chehaibou, Mathieu Vautier, Ramin Tadayoni, Alain Gaudric, Michel Paques, Bahram Bodaghi, David Saadoun, Sophie Bonnin
Summary: The study found a significant correlation between retinal lesions and vascular stenosis in patients with Takayasu arteritis, suggesting that the number of microaneurysms could be used as a prognostic factor for TA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Kazumasa Oura, Mao Yamaguchi Oura, Ryo Itabashi, Tetsuya Maeda
Summary: Takayasu arteritis (TA) is a large vessel vasculitis that commonly affects young women, with challenging diagnosis and treatment. Early diagnosis and appropriate treatment are crucial in preventing stroke complications, necessitating regular follow-up vascular imaging to monitor disease progression.
Article
Cardiac & Cardiovascular Systems
Kyota Hashimoto, Ryota Sakai, Akiko Shibata, Yusuke Okada, Syoichi Yoshinaga, Takahiko Kurasawa, Tsuneo Kondo, Koichi Amano
Summary: This article presents a case of Takayasu arteritis (TAK) associated with vascular Ehlers-Danlos syndrome (vEDS), resulting in multiple arterial aneurysms and stenosis leading to multi-organ infarction. The patient was successfully treated using anti-inflammatory agents, glucocorticoids, tocilizumab, and interventional radiology. The importance of considering concurrent vasculitis syndrome and non-inflammatory vasculopathy, including hereditary disorders, in cases with multiple aneurysms, stenosis, and dissections leading to multi-organ infarctions is emphasized.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Rheumatology
Yoshikazu Nakaoka, Masahiro Yanagawa, Akinori Hata, Katsuhisa Yamashita, Norihiro Okada, Shinji Yamakido, Hiromitsu Hayashi, David Jayne
Summary: This study found that approximately 60% of TAK patients treated with tocilizumab did not experience progression in wall thickness within 96 weeks, but a few patients experienced progression in dilatation/aneurysm or stenosis/occlusion. Patients with newly progressed lesions may require additional treatment.
Article
Medicine, General & Internal
Simin Almasi, Sanaz Asadian, Leila Hosseini, Nahid Rezaeian, Shakiba Ghasemi Asl, Abdolmohammad Ranjbar, Seyyed-Reza Sadat-Ebrahimi, Behnaz Mahmoodieh, Alireza Salmanipour
Summary: This study aimed to explore the cardiovascular magnetic resonance (CMR) of Takayasu arteritis (TA) and its complications. It was found that TA patients had lower left ventricular ejection fraction and left ventricular global longitudinal strain compared to healthy controls. Aortic mural edema and hyperenhancement were common findings. During follow-up, TA patients experienced major adverse cardiac and cerebrovascular events (MACCEs), with cerebrovascular accidents being the most common. The CMR assessment of left ventricular global longitudinal strain showed the strongest association with complications.
Review
Rheumatology
Florence A. Aeschlimann, Francesca Raimondi, Tim Leiner, Giovanni Donato Aquaro, David Saadoun, Heynric B. Grotenhuis
Summary: Takayasu arteritis is an idiopathic large-vessel vasculitis that affects young adults and children and can lead to ischemia and end-organ damage. Vascular imaging is crucial for diagnosis, assessment of disease extent, and management of the disease.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Immunology
Lingyu Liu, Jing Chen, Jing Li, Yunjiao Yang, Xiaofeng Zeng, Xinping Tian
Summary: This study on Takayasu arteritis identified common and rare variants associated with disease susceptibility through whole exome sequencing. The findings included associations in the HLA region as well as novel susceptibility loci outside the HLA region. The genetic risk score based on these variants was found to be related to pulmonary artery involvement in TAK patients. Further studies are needed to confirm these findings.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huan Yang, Peng Lv, Ranying Zhang, Caixia Fu, Jiang Lin
Summary: The study found that low b-value DWI has significant advantages in detecting inflamed vessels in active Takayasu arteritis, with higher image quality and blood suppression compared to T2-weighted imaging. Additionally, the signal-to-noise ratio and contrast-to-noise ratio of the diseased vessel walls were significantly higher on DWI compared to T2WI.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongbo Zhang, Lei Zhao, Chen Zhang, Jie Tian, Yan Ding, Xinghan Zhao, Xiaohai Ma
Summary: This study investigated the utility of MR-FT as a method to detect cardiac damage in TA patients and found myocardial deformation impairment in the majority of TA patients. MR-FT imaging may be helpful in the early diagnosis and management of TA patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Shanshan Jia, Lu Liu, Jun Ma, Xiaoping Chen
Summary: Takayasu arteritis is a chronic large vessel vasculitis of unknown etiology with variable clinical manifestations, emphasizing the importance of early diagnosis and treatment for improving prognosis. This review focuses on the latest evidence regarding the application progress of multiple imaging modalities.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Rheumatology
Lingying Ma, Bing Wu, Ying Sun, Zhenqi Ding, Xiaomin Dai, Li Wang, Xiaojuan Dai, Lijuan Zhang, Huiyong Chen, Lili Ma, Peng Lv, Hongcheng Shi, Lindi Jiang
Summary: This study investigated the predictive ability of F-18-fluorodeoxyglucose PET/CT for new lesions in Takayasu arteritis. The results showed a strong correlation between PETVAS and inflammatory markers. Patients with higher PETVAS scores had a higher risk of developing new lesions.
Article
Multidisciplinary Sciences
Keiichiro Kadoba, Ryu Watanabe, Takeshi Iwasaki, Toshiki Nakajima, Koji Kitagori, Shuji Akizuki, Kosaku Murakami, Ran Nakashima, Motomu Hashimoto, Masao Tanaka, Koichiro Ohmura, Akio Morinobu, Chikashi Terao, Hajime Yoshifuji
Summary: In TAK, IL12B rs6871626 A allele is significantly associated with aortic regurgitation, hypertension, aortic valve replacement, and vascular damage scores, while LILRA3 rs103294 shows no correlation with vascular damage. Genotyping of IL12B rs6871626 may help identify TAK patients at risk of disease progression.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Hugh D. Alessi, Kaitlin A. Quinn, Mark A. Ahlman, Elaine Novakovich, Babak Saboury, Yiming Luo, Peter C. Grayson
Summary: This study examined and compared disease activity over time in giant cell arteritis (GCA) and Takayasu arteritis (TAK) using multimodal assessment combining clinical, laboratory, and imaging-based testing. The results showed that PET activity in GCA was higher than TAK in both early and late stages of the disease, and decreased over time in GCA but not TAK. Rating: 7 points
ARTHRITIS CARE & RESEARCH
(2023)