Article
Ophthalmology
Sanna Leinonen
Summary: This perspective aimed to explore the screening of uveitis in Nordic children with JIA, summarizing the predictors and recommendations for JIA-uveitis screening. Younger age, positive antinuclear antibody titre, specific subtypes of JIA, and shorter duration of JIA are predictors of uveitis in JIA. Methotrexate and monoclonal TNF inhibitor treatment can reduce the risk of JIA-uveitis. Guidelines for screening intervals and length were prepared based on known risk factors and the Nordic population.
ACTA OPHTHALMOLOGICA
(2023)
Review
Medicine, General & Internal
Pierre Quartier
Summary: Children with early onset juvenile idiopathic arthritis, especially with positive antinuclear antibodies, may develop chronic anterior uveitis, which requires regular slit lamp examination and prompt treatment. Therapy options range from local steroid treatment to systemic immunomodulatory therapy, tailored to individual patient needs, with involvement of expert ophthalmologists and pediatricians. Treatment should not be easily interrupted and may need to be intensified in certain cases for optimal disease control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Lili Ye, Yingying Jin, Hua Huang, Fei Ding, Xuemei Xu, Chenxi Liu, Shengfang Bao, Jing Wu, Yanliang Jin
Summary: This study explored the role of DKK-1 and SOST in the pathogenesis of JIA. It was found that plasma levels of DKK-1 were significantly higher in JIA patients, especially in those with HLA-B27 positivity. After treatment, DKK-1 levels decreased significantly. However, there was no significant change in SOST levels among different JIA subtypes, before and after treatment, and healthy controls.
PEDIATRIC RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ryan Sol Funk, Mara L. Becker
Summary: Variability in methotrexate efficacy poses a challenge in treating juvenile idiopathic arthritis. This study aimed to explore the impact of methotrexate on plasma metabolome and identify metabolic biomarkers of efficacy in children with JIA. The research revealed diverse metabolic changes following methotrexate initiation, including metabolites associated with microbial metabolism and exogenous sources.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Mikhail M. Kostik, Ekaterina V. Gaidar, Lubov S. Sorokina, Ilya S. Avrusin, Tatiana N. Nikitina, Eugenia A. Isupova, Irina A. Chikova, Yuri Yu. Korin, Elizaveta D. Orlova, Ludmila S. Snegireva, Vera V. Masalova, Margarita F. Dubko, Olga V. Kalashnikova, Vyacheslav G. Chasnyk
Summary: The presence of uveitis is a risk factor for JIA flare, while methotrexate can reduce the cumulative flare probability.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Cecilia Beatrice Chighizola, Matteo Ferrito, Luca Marelli, Irene Pontikaki, Paolo Nucci, Elisabetta Miserocchi, Roberto Caporali
Summary: Juvenile idiopathic arthritis (JIA) and multiple sclerosis (MS) have been associated with each other, possibly triggered by anti-TNF-alpha drugs. However, there have been limited reports on the association between MS and JIA, indicating the need for further research to establish their relationship.
Article
Multidisciplinary Sciences
Juan Carlos Nieto-Gonzalez, Laura Trives-Folguera, Alejandra Melgarejo-Ortuno, Aranzazu Ais, Belen Serrano-Benavente, Maria Sanjurjo, Jose Maria Alvaro-Gracia, Indalecio Monteagudo Saez
Summary: This study found that both persistence and adherence to biological therapy were remarkably high in JIA patients, and adherence to biological treatments could be related to a higher probability of patients achieving remission criteria within 6 months.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Joeri W. van Straalen, Goerkem Akay, Carlyn Kouwenberg, Sytze de Roock, Viera Kalinina Ayuso, Nico M. Wulffraat, Joke de Boer, Joost F. Swart
Summary: This study investigated the effect of methotrexate (MTX) therapy on new-onset uveitis in patients with biological-naive juvenile idiopathic arthritis (JIA). The results showed that MTX was associated with a significantly reduced new-onset uveitis rate in patients with JIA. Clinicians should consider early initiation of MTX in high-risk patients and increase ophthalmologic screening after MTX discontinuation.
Review
Rheumatology
Claas H. Hinze, Dirk Foell, Christoph Kessel
Summary: Systemic juvenile idiopathic arthritis (sJIA) is a disease characterized by severe systemic inflammation and arthritis. It poses challenges to rheumatologists treating pediatric and adult patients worldwide. Although treatment plans exist for classic sJIA, there is still a lack of clear treatment approaches for early sJIA without arthritis and complicated sJIA.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Ana Carolina Londe, Jaqueline Cristina de Amorim, Paulo Rogerio Julio, Nico M. Wulffraat, Roberto Marini, Simone Appenzeller
Summary: The study aimed to translate and validate the Methotrexate (MTX) Intolerance Severity Score (MISS) questionnaire into Brazilian Portuguese for children and adolescents. The findings showed that MISS is a feasible and practical tool for routine clinical care to identify MTX intolerance in JIA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Jelena Vojinovic, Ivan Foeldvari, Joke Dehoorne, Violeta Panaviene, Gordana Susic, Gerd Horneff, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Jonathan Akikusa, Tadej Avcin, Cecilia Borlenghi, Edmund Arthur, Svitlana Y. Tatulych, Chuanbo Zang, Vassilis Tsekouras, Bonnie Vlahos, Alberto Martini, Nicolino Ruperto
Summary: CLIPPER2 is an 8-year study on the safety and efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA). The study found that etanercept treatment was well tolerated and effective in these patients.
Article
Nutrition & Dietetics
Maciej K. Stawicki, Adrian Goralczyk, Justyna Mlynczyk, Anna Kondratiuk, Jerzy Konstantynowicz
Summary: This study evaluated the prevalence of vitamin D deficiency in children with juvenile idiopathic arthritis (JIA) and found that vitamin D deficiency is independent of disease activity or inflammatory markers. However, MTX treatment may lead to inadequate vitamin D levels. Therefore, vitamin D supplementation should be considered for all children receiving long-term MTX therapy.
Article
Ophthalmology
Francesca Tirelli, Maria Elisabetta Zannin, Fabio Vittadello, Jacopo Agnolucci, Monica Mazzarolo, Francesco Zulian
Summary: The study evaluated the long-term efficacy of MTX monotherapy in patients with JIA-U and found that although effective in the early stages, MTX showed poor disease control in the long term, with many patients eventually needing biologic agents for treatment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Rheumatology
Camilla Wibrand, Nini Kyvsgaard, Anne Estmann Christensen, Troels Herlin
Summary: This study aimed to investigate the association between ALT levels during MTX treatment and MTX intolerance in JIA. The results showed no significant difference in ALT levels between the MTX intolerant group and the MTX tolerant group. However, only MTX intolerant girls showed elevated ALT levels. The intolerant girls also had a higher intolerance severity score compared to the intolerant boys.
RHEUMATOLOGY INTERNATIONAL
(2023)
Letter
Rheumatology
Marco Gattorno, Michael Hofer, Federica Vanoni, Silvia Federici, Luca Cantarini, Nicolino Ruperto
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Pierre Quartier, Ekaterina Alexeeva, Tamas Constantin, Vyacheslav Chasnyk, Nico Wulffraat, Karin Palmblad, Carine Wouters, Hermine Brunner, Katherine Marzan, Rayfel Schneider, Gerd Horneff, Alberto Martini, Jordi Anton, Xiaoling Wei, Alan Slade, Nicolino Ruperto, Ken Abrams
Summary: The study evaluated the efficacy and safety of two canakinumab monotherapy tapering regimens to maintain complete clinical remission in children with systemic JIA. Results showed that reducing canakinumab exposure may be feasible in patients who have achieved clinical remission, but consistent interleukin-1 inhibition is necessary to maintain this response.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Gabriella Giancane, Chiara Campone, Maria Francesca Gicchino, Alessandra Alongi, Cecilia Bava, Silvia Rosina, Yaryna Boyko, Neil Martin, Yasser El Miedany, Miroslav Harjacek, Soad Hashad, Maka Ioseliani, Ruben Burgos-Vargas, Rik Joos, Christiaan Scott, Mejbri Manel, Zoilo Morel Ayala, Maria Ekelund, Safiya Al-Abrawi, Maya-Feriel Aiche, Ximena Norambuena, Jose Antonio Melo-Gomes, Nicolino Ruperto, Alessandro Consolaro, Angelo Ravelli
Summary: There is fair concordance between criteria for inactive disease and low disease activity in JIA, with physician and parent global assessments as well as acute-phase reactants being the main drivers of discordance. This highlights the need for further studies to evaluate the impact of subjective perceptions of disease remission and inflammatory activity measures on defining disease activity levels in JIA.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Hermine I. Brunner, Nicolino Ruperto, Zbigniew Zuber, Ruben Cuttica, Vladimir Keltsev, Ricardo M. Xavier, Ruben Burgos-Vargas, Inmaculada Calvo Penades, Earl D. Silverman, Graciela Espada, Manuel Ferrandiz Zavaler, Yukiko Kimura, Carolina Duarte, Chantal Job-Deslandre, Rik Joos, Wendy Douglass, Sunethra Wimalasundera, Kamal N. Bharucha, Chris Wells, Daniel J. Lovell, Alberto Martini, Fabrizio de Benedetti
Summary: This study aimed to report the 2-year efficacy and safety of tocilizumab (TCZ) in patients with polyarticular-course juvenile idiopathic arthritis (JIA). The results showed high-level disease control for up to 2 years in patients treated with TCZ for polyarticular-course JIA, with a safety profile consistent with previous reports.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Silvia Rosina, Giulia C. Varnier, Angela Pistorio, Clarissa Pilkington, Susan Maillard, Adele Civino, Elena Tsitsami, Claudia Bracaglia, Marija Jelusic, Adriana Cespedes-Cruz, Graciela Espada, Rolando Cimaz, Gerard Couillault, Rik Joos, Pierre Quartier, Anand P. Rao, Clara Malattia, Nicolino Ruperto, Alessandro Consolaro, Angelo Ravelli
Summary: The study developed and tested shortened versions of the Manual Muscle Test-8 (MMT-8) in juvenile dermatomyositis (JDM). The MMT-4 and MMT-6 showed strong correlations with MMT-8 and other muscle strength measures, as well as strong ability to discriminate between disease activity states.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Nicolino Ruperto, Hermine Brunner, Nikolay Tzaribachev, Gabriel Vega-Cornejo, Ingrid Louw, Rolando Cimaz, Jason Dare, Graciela Espada, Enrique Faugier, Manuel Ferrandiz, Valeria Gerloni, Pierre Quartier, Clovis Artur Silva, Linda Wagner-Weiner, Yash Gandhi, Julie Passarell, Marleen Nys, Robert Wong, Alberto Martini, Daniel J. Lovell
Summary: In patients aged 2-17 years with pJIA, no evidence of association between higher levels of exposure to IV ABA or SC ABA and incidence of infection was observed.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Petra Doerr, Marie Valentin, Nobumasa Nakashima, Nick Orphanos, Gustavo Santos, Georgios Balkamos, Agnes Saint-Raymond
Summary: Reliance is a crucial concept for enhancing global regulatory efficiency in overseeing medical products; the survey indicates that reliance is widely accepted in the field of medical product oversight; regulatory reliance facilitates approvals and enables earlier patient access to medications.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Janet Nooney, Shannon Thor, Corinne de Vries, John Clements, Leyla Sahin, Wei Hua, Darcie Everett, Cosimo Zaccaria, Robert Ball, Agnes Saint-Raymond, Lynne Yao, June Raine, Sandra Kweder
Summary: Scientists and regulators in Europe and the United States are working to improve knowledge on rational use of medicines for pregnant and breastfeeding populations, recognizing the importance of international collaboration in addressing global public health issues. The health of the child is closely linked to the health of the mother.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pediatrics
Athimalaipet Ramanan, Neena Modi, Saskia N. de Wildt
Summary: The COVID-19 pandemic has stimulated new approaches in pediatric clinical research, which Conect4children recommends retaining for future use to improve efficiency, reduce costs, and promote research equity.
PEDIATRIC RESEARCH
(2022)
Article
Rheumatology
Marta Bustaffa, Isabelle Kone-Paut, Seza Ozen, Gayane Amaryan, Efimia Papadopoulou-Alataki, Romina Gallizzi, Maria Carrabba, Yonatan Butbul Aviel, Luca Cantarini, Maria Alessio, Jordi Anton, Laura Obici, Faysal Gok, Ezgi Deniz Batu, Estefania Moreno, Paul Brogan, Maria Trachana, Gabriele Simonini, Donato Rigante, Yosef Uziel, Antonella Insalaco, Maria Cristina Maggio, Nicolino Ruperto, Marco Gattorno, L. Rossi Semerano
Summary: The new EPCC and INSAID classification of MEFV variants can identify two distinct groups of FMF patients, which differ in clinical characteristics, therapeutic approach, and response to treatment.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Rheumatology
Chiara Trincianti, Evert Hendrik Pieter Van Dijkhuizen, Alessandra Alongi, Marta Mazzoni, Joost F. Swart, Irina Nikishina, Pekka Lahdenne, Lidia Rutkowska-Sak, Tadej Avcin, Pierre Quartier, Violeta Panaviene, Yosef Uziel, Chris Pruunsild, Veronika Vargova, Soamarat Vilaiyuk, Pavla Dolezalova, Sarah Ringold, Marco Garrone, Nicolino Ruperto, Angelo Ravelli, Alessandro Consolaro
Summary: This study developed and validated new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to distinguish different disease activity states in children. Results showed that the cutoffs had good metrologic properties and are suitable for use in clinical trials and routine practice.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Alexandra Vaz, Mariana Roldao Santos, Luther Gwaza, Elena Mezquita Gonzalez, Magdalena Pajewska Lewandowska, Samvel Azatyan, Agnes Saint-Raymond
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Immunology
Agnes Saint-Raymond, Lynne M. Mofenson
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Article
Pharmacology & Pharmacy
Agnes Saint-Raymond, Marie Valentin, Nobumasa Nakashima, Nick Orphanos, Gustavo Santos, Georgios Balkamos, Samvel Azatyan
Summary: This article discusses the importance of collaboration and reliance among regulatory agencies in response to COVID-19. It highlights the role of reliance approaches in authorizing vaccines and other commodities, and emphasizes the benefits of reliance in avoiding duplication and saving resources. The article also presents the results of a survey on reliance approaches during public health emergencies and explores the potential of reliance in real-life implementation.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
E. Monzon, M. Abou Taam, M. C. Pesquidou, P. Bahri, P. Balabanov, L. de Fays, C. A. Herrera, A. Noor, A. Saint-Raymond, S. Straus, A. Inoubli