Article
Geriatrics & Gerontology
Hui Shi, Mei-Ling Ge, Birong Dong, Qian-Li Xue
Summary: Higher Framingham CVD risk score was associated with a greater risk of incident frailty among Chinese older adults in this study. However, this association was no longer significant after adjusting for chronological age.
Article
Multidisciplinary Sciences
Zhen He, Guoqiang Wu, Zhiyong Li
Summary: This study investigated the incidence and risk factors of subclinical atherosclerosis (SA) in psoriatic arthritis (PsA) patients and found that PsA patients with smoking habits and a history of cardiovascular events are more likely to develop SA. Age also contributes to increased carotid intima-media thickness (IMT).
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2022)
Article
Health Care Sciences & Services
Minji Kang, Yoosoo Chang, Jeonggyu Kang, Yejin Kim, Seungho Ryu
Summary: The integrated abnormal electrocardiogram (ECG) risk score is associated with the prevalence of coronary artery calcium (CAC), indicating its potential as an early predictor of subclinical cardiovascular disease (CVD). This finding suggests that the integrated ECG scoring can be used to identify individuals requiring lipid-lowering medications, even in young and asymptomatic populations.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Benjamin Huang, Weiting Huang, John Carson Allen, Lijuan Sun, Hui Jen Goh, Siew Ching Kong, Dewaine Lee, Cherlyn Ding, Nabil Bosco, Leonie Egli, Lucas Actis-Goretta, Faidon Magkos, Fabrizio Arigoni, Melvin Khee-Shing Leow, Swee Yaw Tan, Khung Keong Yeo
Summary: Traditional risk assessment methods cannot adequately assess the risk of atherosclerosis in low-risk individuals, while markers of metabolic syndrome and insulin resistance are better at stratifying the risk in this population.
FRONTIERS IN NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Fei Liu, Simei Hui, Tesfaldet H. Hidru, Yinong Jiang, Ying Zhang, Yan Lu, Haichen Lv, Sharen Lee, Yunlong Xia, Xiaolei Yang
Summary: This study found that SCA was highly prevalent in the hypertension population, predominantly affecting the thoracic aorta, and elevated SUA levels were significantly associated with the severity of SCA regardless of territories.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Maria Jamil, Reema Aslam, Aanal Patel, Bakhtawar Nadir, Safeera Khan
Summary: This study found a significant association between Psoriatic arthritis (PsA) and subclinical atherosclerosis, with PsA patients exhibiting higher intima-media thickness (IMT) and impaired endothelial function. PsA patients also had a higher prevalence of cardiovascular risk factors. PsA is independently correlated with increased IMT, disease activity parameters, and conventional atherosclerosis risk factors.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Emer R. McGrath, Alexa S. Beiser, Adrienne O'Donnell, Jayandra J. Himali, Matthew P. Pase, Claudia L. Satizabal, Sudha Seshadri
Summary: The association between vascular risk factors and dementia varies with age. Age-specific dementia risk scores should prioritize including different vascular risk factors at different ages.
Article
Clinical Neurology
Ana Luiza Vieira de Araujo, Raul D. Santos, Marcio Sommer Bittencourt, Roberto Nery Dantas, Carlos Andre Oshiro, Cesar Higa Nomura, Edson Bor-Seng-Shu, Marcelo de Lima Oliveira, Claudia da Costa Leite, Maria da Graca Morais Martin, Maramelia Miranda Alves, Gisele Sampaio Silva, Victor Marinho Silva, Adriana Bastos Conforto
Summary: The frequency of coronary calcification is higher in patients with stroke or transient ischemic attack caused by large-artery atherosclerosis than in controls. CAC scores are even higher in patients with stenosis in both cervical and intracranial arteries.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Ivan Pletikosic, Daniela Marasovic Krstulovic, Darija Bakovic, Zora Susilovic Grabovac, Leida Tandara, Dusanka Martinovic Kaliterna
Summary: This study examined the role of adipokines and pro-inflammatory cytokines in psoriatic arthritis-associated subclinical myocardial dysfunction, as well as their relationship with PsA disease activity. The results showed that PsA patients with moderate and high disease activity had poorer myocardial function, lower adiponectin levels, and higher IL-17A levels.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Steven R. Horbal, Brian A. Derstine, Edward Brown, Grace L. Su, Stewart C. Wang, Sven A. Holcombe
Summary: The evidence supporting aortic calcification as a significant cardiovascular risk factor is increasing rapidly. In this study, the relationship between granular vertebral indexed calcification measurements of the abdominal aorta and Framingham risk scores was evaluated. The results showed a significant association between calcification burden and risk scores. Opportunistically measuring aortic calcification can provide valuable information for cardiovascular risk assessment and surveillance of cardiovascular events.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Yun-Ju Wu, Guang-Yuan Mar, Ming-Ting Wu, Fu-Zong Wu
Summary: This study aimed to develop a prediction nomogram for subclinical coronary atherosclerosis in an Asian population with baseline zero score and compare its discriminatory ability with established risk scores. The nomogram showed good discrimination and calibration ability in predicting the progression of coronary artery calcification, outperforming traditional risk models.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Ovidiu Mitu, Adrian Crisan, Simon Redwood, Ioan-Elian Cazacu-Davidescu, Ivona Mitu, Irina-Iuliana Costache, Viviana Onofrei, Radu-Stefan Miftode, Alexandru-Dan Costache, Cristian Mihai Stefan Haba, Florin Mitu
Summary: This study evaluated the relationship between multiple subclinical atherosclerosis parameters and several CV risk scores in asymptomatic individuals. The results showed that different risk scores were associated with markers of subclinical atherosclerosis, suggesting specific cut-off values for the risk scores to indicate the need for subclinical atherosclerosis assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Cecilia Castro-Diehl, Rachel Ehrbar, Vanesa Obas, Albin Oh, Ramachandran S. Vasan, Vanessa Xanthakis
Summary: The study findings suggest that biomarkers related to oxidative stress, telomere length shortening, endothelial dysfunction, and lower IGF-1 concentrations are associated with subclinical atherosclerosis and all-cause mortality, indicating their potential role in reflecting the aging process in community-dwelling adults.
Article
Immunology
Brandilyn A. Peters, Adam Whalen, Xiaonan Xue, Elizabeth F. Topper, Kathleen M. Weber, Phyllis C. Tien, Seble G. Kassaye, Howard Minkoff, Ervin Fox, Margaret A. Fischl, Lauren F. Collins, Michelle Floris-Moore, Howard N. Hodis, Qibin Qi, David B. Hanna, Anjali Sharma, Kathryn Anastos, Robert C. Kaplan
Summary: This study suggests that menopause may accelerate subclinical atherosclerosis as measured by CIMT in HIV patients.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Geriatrics & Gerontology
Renee M. G. Verdiesen, N. Charlotte Onland-Moret, Carla H. van Gils, Yvonne T. van der Schouw
Summary: Recent research suggests that higher circulating AMH levels in men are associated with lower carotid intima-media thickness (CIMT) and mean carotid aortic plaque burden, indicating a potential link between AMH and local atherosclerosis.
Article
Rheumatology
Sahil Koppikar, Keith Colaco, Paula Harvey, Shadi Akhtari, Vinod Chandran, Dafna D. Gladman, Richard Cook, Lihi Eder
Summary: This study aimed to assess the incidence and risk factors for heart failure in patients with psoriatic disease and describe their electrocardiographic and echocardiographic findings. The results showed that heart failure was associated with a combination of known cardiovascular risk factors and measures of disease activity, particularly in nonischemic heart failure.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Samantha Sarabia, Chandra Farrer, Jensen Yeung, Dana Jerome, Richard J. Cook, Lihi Eder
Summary: Combining MSK-US with a screening questionnaire improves the triage of patients with suspected PsA.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Lihi Eder, Ruth Croxford, Aaron M. Drucker, Arielle Mendel, Bindee Kuriya, Zahi Touma, Sindhu R. Johnson, Richard Cook, Sasha Bernatsky, Nigil Haroon, Jessica Widdifield
Summary: Compared with the general population, patients with immune-mediated inflammatory diseases (IMIDs) were more likely to be tested for SARS-CoV-2, but the infection rate was similar. The odds of SARS-CoV-2 infection varied across different IMID subgroups.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Jessica Widdifield, Lihi Eder, Simon Chen, Jeffrey C. Kwong, Carol Hitchon, Diane Lacaille, J. Antonio Avina-Zubieta, Lawrence W. Svenson, Sasha Bernatsky
Summary: This study assessed the uptake of COVID-19 vaccines among individuals with immune-mediated inflammatory diseases (IMIDs) and the general population in Ontario. The results showed that IMID patients had higher vaccination rates compared to the general population, particularly among those with stronger immune responses.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Lihi Eder, Quan Li, Sara Rahmati, Proton Rahman, Igor Jurisica, Vinod Chandran
Summary: This study identified three imaging sub-phenotypes in patients with active PsA and found distinct biological pathways underlying these sub-phenotypes, suggesting their biological and clinical importance.
Article
Rheumatology
Pamela Diaz, Joy Feld, Iris Eshed, Lihi Eder
Summary: Prevalence of inflammatory and structural lesions in patients with psoriatic disease can be assessed using whole spine MRI, but their correlation with clinical features and axSpA classification criteria is poor.
Article
Rheumatology
Sibel Zehra Aydin, Lihi Eder, Gurjit S. Kaeley
Summary: The use of high-resolution ultrasound is crucial for understanding the complexity of psoriatic arthritis. Recent discussions at the GRAPPA meeting focused on developing ultrasound tools for diagnosis, sonographic evaluation of joints, and extrasynovial lesions in psoriatic arthritis.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Sanjana Tarannum, Jessica Widdifield, C. Fangyun Wu, Sindhu R. Johnson, Paula Rochon, Lihi Eder
Summary: This study compared patterns of healthcare utilization between male and female patients with inflammatory arthritis (IA). The findings showed that female patients had higher healthcare utilization than male patients before and after diagnosis, possibly indicating biological differences in disease course or sociocultural differences in healthcare-seeking behavior.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Lihi Eder, Ashish J. Mathew, Philippe Carron, Heidi Bertheussen, Juan D. Canete, May Azem, Andrea Delle Sedie, Carlo Salvarani, Roberto Ranza, Ashley Elliott, Anthony Turkiewicz, Ricardo Acayaba de Toledo, Hulya Bukulmez, Maria S. Stoenoiu, Arthur M. Mandelin II, Michaela Koehm, Chris A. Lindsay, Evan Siegel, Philip J. Mease
Summary: This article summarizes existing evidence regarding pharmaceutical and nonpharmaceutical interventions for enthesitis in patients with psoriatic arthritis (PsA) to facilitate an evidence-based update of the Group for Research and Assessment in Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for PsA. The article found several classes of systemic conventional and advanced therapies and local measures were recommended for active enthesitis in patients with PsA.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Timothy S. H. Kwok, Bindee Kuriya, Lauren K. King, Lihi Eder, J. Carter Thorne, Zhiyin Li, Therese Stukel, Longdi Fu, Alexander Kopp, Jessica Widdifield
Summary: This study described the changes in service delivery and access to rheumatologists during the COVID-19 pandemic in Ontario, Canada. The study found a significant decrease in outpatient office visits and a rise in telemedicine visits. There was also a decrease in new patient consultations over time, raising concerns for potential delays to diagnosis.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Abel Davtyan, Jennifer J. Y. Lee, Lihi Eder, Gillian A. Hawker, Jin Luo, Claire E. H. Barber, J. Carter Thorne, Jessica Widdifield
Summary: A study found that continuity of rheumatology care influences rates of emergency department visits and hospitalizations in patients with rheumatoid arthritis (RA). Patients who received continuous rheumatology care during the first 5 years after diagnosis had lower rates of ED visits and hospitalizations compared to those who did not receive continuous care. This study provides evidence supporting the value of early and continuous rheumatology care for reducing hospitalizations and ED visits.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Lihi Eder, Dafna D. Gladman, Philip Mease, Remy A. Pollock, Rayana Luna, Sibel Z. Aydin, Alexis Ogdie, Ari Polachek, David Gruben, Mary Jane Cadatal, Cassandra Kinch, Vibeke Strand
Summary: This study evaluated the impact of sex on the efficacy, safety, and persistence of tofacitinib in patients with psoriatic arthritis. The results showed that tofacitinib significantly improved disease symptoms in both male and female patients, with comparable efficacy. However, females had a slightly lower achievement rate of optimal disease control compared to males. There were no significant differences in safety and treatment persistence between sexes.
Article
Rheumatology
Lihi Eder, Ker-Ai Lee, Vinod Chandran, Jessica Widdifield, Aaron M. Drucker, Christopher Ritchlin, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman
Summary: The study aimed to develop a risk prediction model for psoriasis patients to predict their risk of developing psoriatic arthritis (PsA) and evaluate its performance. The results showed that using readily available clinical variables, the development of PsA within clinically meaningful time frames can be predicted with reasonable accuracy for psoriasis patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Keith Colaco, Ker-Ai Lee, Shadi Akhtari, Raz Winer, Vinod Chandran, Paula Harvey, Richard J. Cook, Vincent Piguet, Dafna D. Gladman, Lihi Eder
Summary: This study developed and validated a five-year disease-specific cardiovascular risk prediction model for patients with psoriatic disease (PsD). The results indicate that traditional cardiovascular risk factors alone are effective in predicting cardiovascular risk in PsD patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Ying Ying Leung, Lihi Eder, Ana-Maria Orbai, Laura C. Coates, Maarten de Wit, Josef S. Smolen, Uta Kiltz, Penelope Palominos, Juan D. Canete, Rossana Scrivo, Andra Balanescu, Emanuelle Dernis, Sandra Meisalu, Martin Soubrier, Umut Kalyoncu, Laure Gossec