Editorial Material
Oncology
Kornelia Polyak
Summary: In this study, the researchers discovered that intracellular bacteria in a breast cancer model can enhance resistance to mechanical stress by reorganizing the cytoskeleton, leading to promotion of tumor metastasis and survival in the circulation.
Editorial Material
Cell Biology
Chun-Liang Pan
Summary: The study shows that mechanosensory ion channels play a crucial role in mediating the effects of cell membrane guidance cues on the morphogenesis of neuronal dendrites.
DEVELOPMENTAL CELL
(2022)
Review
Endocrinology & Metabolism
Miguel Lopez, Manuel Fernandez-Real, Stanislav I. Tomarev
Summary: Classically, the regulation of energy balance has been based on central and peripheral mechanisms sensing energy, nutrients, metabolites, and hormonal cues. Recent data have added more complexity to the homeostatic regulation of metabolism by introducing the key role of olfaction in energy homeostasis. Olfactory inputs contribute to the regulation of feeding, energy expenditure, and whole body metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Chemistry, Medicinal
Cristina Cuadrado, Antonio Hernandez Daranas, Ariel M. M. Sarotti
Summary: This study assessed the impact of force field selection, geometry, and energy cutoffs in NMR data prediction for structure elucidation. A new method called mix-J-DP4 was proposed based on the conclusions, which showed a remarkable increase in the confidence level of complex stereochemical assignments with a modest increment in computational cost.
Editorial Material
Robotics
James Young
Summary: While human-like social robots are designed to support communication, they can also possess dangerously persuasive capabilities.
Review
Immunology
Farah Mustapha, Kheya Sengupta, Pierre-Henri Puech
Summary: Force is an important parameter for cells to adapt to their microenvironment. T lymphocytes use mechano-sensitivity to recognize antigens and carry out immune functions. Traction force microscopy is a technique that has gained interest in the ImmunoBiophysics community for measuring forces exerted by immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Business, Finance
Thomas Hellmann, Veikko Thiele
Summary: This paper reexamines the role of investor power in staged equity financing and discusses how market power can have a reversed effect on valuations in later rounds. Powerful investors, once they become insiders, may use their market power to increase valuations instead of decreasing them. The critical factor is whether the insider invests above or below the pro-rata threshold. Despite initially lowering valuations, companies prefer to bring powerful investors inside to leverage their power in later financing rounds. The paper presents new predictions about valuations and investor returns.
JOURNAL OF CORPORATE FINANCE
(2022)
Article
Chemistry, Multidisciplinary
Olajumoke H. Olubowale, Shanta Biswas, Golam Azom, Benjamin L. Prather, Samuel D. Owoso, Khaleda C. Rinee, Karen Marroquin, Kaelin A. Gates, Matthew B. Chambers, Amy Xu, Jayne C. Garno
Summary: Force volume mapping (FVM) is a technique for measuring the chemical, mechanical, and electrical properties of materials using scanning probe microscopy (SPM). This method can map different interactions between the probe and the sample, such as chemical, electrical, or physical, and can be correlated with topographic images to identify chemical groups. The versatility and diverse measurement protocols of FVM make it a valuable tool for nanoscale material property analysis.
Review
Cell Biology
Mei ElGindi, Jiranuwat Sapudom, Ibrahim Hamed Ibrahim, Mohamed Al-Sayegh, Weiqiang Chen, Anna Garcia-Sabate, Jeremy C. M. Teo
Summary: This review examines the effects of microgravity on cellular aspects of the immune system, emphasizing the gaps in our understanding of immune impairment among humans in space.
Review
Physics, Particles & Fields
W. J. Torres Bobadilla, G. F. R. Sborlini, P. Banerjee, S. Catani, A. L. Cherchiglia, L. Cieri, P. K. Dhani, F. Driencourt-Mangin, T. Engel, G. Ferrera, C. Gnendiger, R. J. Hernandez-Pinto, B. Hiller, G. Pelliccioli, J. Pires, R. Pittau, M. Rocco, G. Rodrigo, M. Sampaio, A. Signer, C. Signorile-Signorile, D. Stoeckinger, F. Tramontano, Y. Ulrich
Summary: This manuscript reports the results of a topical workshop on alternative NNLO strategies in high-energy physics, discussing different frameworks for precise higher-order computations and strategies for dealing with infrared and ultraviolet singularities in quantum field theories. Special emphasis is placed on the local cancellation of these singularities to enhance efficiency and discover novel mathematical properties in quantum field theories.
EUROPEAN PHYSICAL JOURNAL C
(2021)
Review
Biochemistry & Molecular Biology
Camilla Gottlieb Andersen, Laust Bavnhoj, Bjorn Panyella Pedersen
Summary: Given the challenges posed by climate change, it is crucial to enhance our understanding of the fundamental biochemical processes that govern plant physiology in ecosystems. However, the current structural information on plant membrane transporters is limited compared to other organisms, with only a total of 18 unique structures available. To advance our knowledge in plant cell molecular biology and facilitate future breakthroughs, it is essential to gather more structural knowledge on membrane transporters. This review provides an overview of the current status of structural knowledge in the field of plant membrane transporters, focusing on the proton motive force (PMF) and its role in secondary active transport, and discussing recently published structures of symporters, antiporters, and uniporters from plants.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2023)
Article
Microbiology
Michael Maynard, G. L. Drusano, Michael Vicchiarelli, Weiguo Liu, Jenny Myrick, Jocelyn Nole, Brandon Duncanson, David Brown, Arnold Louie
Summary: The study showed that different dosages of polymyxin B (PMB) can prevent the emergence of adaptive resistance, but cannot prevent treatment failure caused by subpopulations expressing higher-level resistance mechanisms.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Editorial Material
Cell Biology
Lisa Heinke
Summary: Cycles of stretch and compression during cell migration stabilize microtubules through the redistribution of CLASP2 protein binding along their lengths.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Review
Physiology
Claudio Viecelli, David Aguayo
Summary: This paragraph introduces the importance of skeletal muscle in the human body and its crucial role in survival. It discusses the evidence-based contribution of resistance exercise to increase muscle mass and strength. The focus is on the mechano-biological descriptors involved in resistance exercise and their impact on muscle mass and strength.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Multidisciplinary Sciences
Fran Hancock, Fernando E. Rosas, Pedro A. M. Mediano, Andrea I. Luppi, Joana Cabral, Ottavia Dipasquale, Federico E. Turkheimer
Summary: This article discusses competing and complementary models of resting-state brain dynamics, emphasizing the importance of complexity science in describing brain functioning and understanding.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
