Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Victoria Navarro-Compan, Alexandre Sepriano, Bassel El-Zorkany, Desiree van der Heijde
Summary: Axial spondyloarthritis is a chronic inflammatory disease primarily affecting the axial skeleton, leading to symptoms such as chronic back pain and spinal stiffness. Diagnosis relies on recognizing clinical patterns and utilizing clinical, laboratory, and imaging features. Treatment options include non-steroidal anti-inflammatory drugs as first-line therapy, with biologics as a second-line option, showing efficacy in improving disease symptoms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi
Summary: HLA-B27 positive patients with axial spondyloarthritis (AxSpA) tend to have lower disease activity compared to HLA-B27 negative patients, as indicated by higher BASDAI scores. HLA-B27 positive patients with mild back pain are more likely to be diagnosed with AxSpA, suggesting a cognitive bias introduced by the HLA-B27 test.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Robin Kempin, Jutta G. Richter, Anna Schlegel, Xenofon Baraliakos, Styliani Tsiami, Bjoern Buehring, David Kiefer, Juergen Braun, Uta Kiltz
Summary: The study investigates the feasibility of using a health app for patients with axial spondyloarthritis (axSpA), finding that digital patient-reported outcomes (PRO) can be successfully collected. However, adherence to the app after 6 months was poor, indicating a need for improvement.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Haseeb Chaudhary, Clementina Lopez-Medina, Muhammad Asim Khan, Maxime Dougados, Marina Magrey
Summary: In a global axSpA cohort, HLA-B*27 (-) patients had a longer delay in diagnosis, more frequently had peripheral arthritis, enthesitis, IBD, and psoriasis, and were more often treated with csDMARDs compared to the HLA-B*27 (+) subgroup.
Article
Rheumatology
Denis Poddubnyy, Fabian Proft, Laura Spiller, Mikhail Protopopov, Valeria Rios Rodriguez, Burkhard Muche, Judith Rademacher, Murat Torgutalp, Janis Lucas Vahldiek, Joachim Sieper, Imke Redeker
Summary: The diagnostic value of SpA features varies in different patient populations, which should be considered in the diagnostic approach.
Article
Medicine, General & Internal
Atul Deodhar, Filip Van den Bosch, Denis Poddubnyy, Walter P. Maksymowych, Desiree van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Ricardo Blanco, Yuanyuan Duan, Yihan Li, Aileen L. Pangan, Peter Wung, In-Ho Song
Summary: Upadacitinib demonstrates significant efficacy and safety in patients with non-radiographic axial spondyloarthritis.
Review
Microbiology
Tianwen Huang, Yaoyu Pu, Xiangpeng Wang, Yanhong Li, Hang Yang, Yubin Luo, Yi Liu
Summary: Spondyloarthritis (SpA) is a rheumatic disease that causes joint inflammation. Metabolomic profiling studies have provided insights into etiological factors and biomarkers for SpA.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Rheumatology
Mar Blasco-Blasco, Isabel Castrejon, Vega Jovani, Eliseo Pascual, Maria Teresa Ruiz-Cantero
Summary: The study found that disease activity detected using BASDAI was significantly higher in women compared to men, while there were no differences between sexes in disease activity detected using ASDAS. BASDAI and ASDAS may discriminate differently according to sex due to their different evaluations of peripheral disease.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Ophthalmology
Nazife Sule Yasar Bilge, Umut Kalyoncu, Pamir Atagunduz, Ediz Dalkilic, Yavuz Pehlivan, Orhan Kucuksahin, Cemal Bes, Servet Akar, Muhammet Cinar, Hakan Emmungil, Duygu Ersozlu, Askin Ates, Ridvan Mercan, Gezmis Kimyon, Suleyman Serdar Koca, Emel Gonullu, Veli Yazisiz, Emre Tekgoz, Nilufer Alpay-Kanitez, Abdulsamet Erden, Sedat Kiraz, Belkis Nihan Coskun, Burcu Yagiz, Ufuk Ilgen, Omer Karadag, Levent Kilic, Ihsan Ertenli, Timucin Kasifoglu
Summary: The study aimed to analyze the frequency and factors associated with acute anterior uveitis (AAU) in different forms of Spondyloarthritis (SpA) in a large Turkish cohort. It was found that older age, smoking history, delayed diagnosis, longer disease duration, arthritis, positive HLA-B27, family history of SpA, and radiographic damage were associated with a higher prevalence of uveitis in SpA patients. Psoriasis and psoriatic arthritis patients had a lower prevalence of uveitis. Early detection of uveitis can aid in the diagnosis of SpA.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Stefan Lucian Popa, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Maria Delia Florea, Abdulrahman Ismaiel, Laura Mirela Muntean, Simona Grad
Summary: Recent research on spondyloarthritis and immune-mediated diseases associated with HLA-B27 has made significant progress in understanding the pathogenesis and treatment options. The genetic background of spondyloarthritis has been shown to be linked to inflammatory bowel diseases and gut microbiota. The role of diet in these diseases is important and has potential applications in personalized medicine.
Article
Rheumatology
Shao-Hsien Liu, Divya Shridharmurthy, Kate L. Lapane, Catherine E. Dube, Ellen M. Gravallese, Jonathan Kay
Summary: Most participants in the study, regardless of axial or peripheral spondyloarthritis, were well-educated non-Hispanic White men, with about 40% meeting US Department of Health and Human Services physical activity recommendations. While attitudes and beliefs towards exercise were similar among different disease types, those with axial disease showed greater concerns regarding discomfort and joint injuries. Participants with axial spondyloarthritis spent less time in light and moderate activities compared to those with peripheral disease.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Robert D. Inman, Denis Choquette, Majed Khraishi, Dafna D. Gladman, Shamiza Hussein, Drew Neish, Patrick Leclerc
Summary: This study aimed to describe the real-world use of Secukinumab (SEC) in Canadian patients with axSpA. The results showed that SEC was effective in treating axSpA, with improvements in disease activity observed in patients after 12 months of treatment.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Patrick-Pascal Strunz, Maxime Le Maire, Tobias Heusinger, Ludwig Hammel, Michael Gernert, Eva C. Schwaneck, Johanna Callhoff, Jan Portegys, Marc Schmalzing, Hans-Peter Tony, Matthias Froehlich
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Judith Rademacher, Hanna Mullner, Torsten Diekhoff, Hildrun Haibel, Sabrina Igel, Dominika Pohlmann, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Uwe Pleyer, Denis Poddubnyy
Summary: This study aims to analyze the prevalence of spondyloarthritis (SpA) in patients with acute anterior uveitis (AAU), identify parameters associated with SpA, and evaluate referral algorithms for identifying patients with a high probability of having SpA. The study found a high prevalence of SpA in AAU patients, with the majority having predominantly axial SpA. Psoriasis, HLA-B27 positivity, elevated C-reactive protein level, and male sex were associated with the presence of SpA. The Dublin Uveitis Evaluation Tool (DUET) showed higher specificity than the Assessment of SpondyloArthritis international Society (ASAS) tool, but both strategies missed over 20% of AAU patients with SpA.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Uta Kiltz, Eerik P. Ahomaa, Salima F. E. Van Weely, David Kiefer, Bjoern Buehring, Xenofon Baraliakos, Jurgen Braun
Summary: This study aimed to assess the association between self-reported and performance-based physical functioning in patients with axial spondyloarthritis (axSpA), and to identify the most frequently impaired performance tests. The results showed that many axSpA patients had impairments in physical performance tests, particularly in tasks requiring coordination and muscle power of the lower extremity.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Xenofon Baraliakos, Anna Kuehn, Styliani Tsiami, Uta Kiltz, Martin Fruth, Juergen Braun
Summary: Age has different influences on the MRI lesions in the sacroiliac joints of patients with and without axial spondyloarthritis (axSpA). Bone marrow edema (BME) and erosions are more frequent in axSpA patients regardless of age, while fat lesions (FL) are only significantly different in patients over 50 years old.
Article
Rheumatology
Casper Webers, Uta Kiltz, Juergen Braun, Desiree van der Heijde, Annelies Boonen
Summary: Treating active SpA improves depressive symptoms, especially with TNF inhibitors (TNFis) which have a stronger effect mainly due to their impact on disease activity.
Review
Biotechnology & Applied Microbiology
Juergen Braun, Uta Kiltz, Xenofon Baraliakos
Summary: This review focuses on two emerging drugs, bimekizumab and filgotinib, for the treatment of axial spondyloarthritis and psoriatic arthritis. Unlike other IL-17 inhibitors, JAK inhibitors are also effective in rheumatoid arthritis. Further research is needed to determine the efficacy of these drugs in the treatment of axial spondyloarthritis and psoriatic arthritis.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Letter
Rheumatology
Juergen Braun
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Katinka Albrecht, Sebastian Binder, Kirsten Minden, Denis Poddubnyy, Anne C. C. Regierer, Anja Strangfeld, Johanna Callhoff
Summary: This study aimed to update the prevalence estimates of inflammatory rheumatic diseases (IRD) in Germany. A systematic literature search identified original articles on prevalences for the period 2014-2022. The prevalence of IRD in Germany was estimated to be 2.2-3.0%, corresponding to approximately 1.5-2.1 million affected individuals.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Rosalinde Stal, Sofia Ramiro, Xenofon Baraliakos, Juergen Braun, Monique Reijnierse, Rosaline van den Berg, Desiree van der Heijde, Floris A. van Gaalen
Summary: The objective of this study was to assess the construct validity of the CT Syndesmophyte Score (CTSS) for measuring structural spinal damage in patients with radiographic axial spondyloarthritis. The study compared the scores of CTSS and modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) in detecting syndesmophytes and their correlation with spinal mobility. The results demonstrated good agreement between CTSS and mSASSS in detecting syndesmophytes, and higher correlation of CTSS with spinal mobility measures.
Review
Rheumatology
Jueergen Braun, Thomas Mairinger, Oliver Kaschke, Kai Behrendt, Josef Ramsbacher, Kirsten Karberg
Summary: A 68-year-old woman presented with bilateral swelling of the salivary glands, sicca symptoms of eyes and mouth, itching, fatigue and weight gain. After ruling out rheumatic diseases such as Sjoegren's syndrome, IgG4-related disease and sarcoidosis, Kimura's disease was diagnosed due to a high level of IgE. This case and a brief literature review are presented.
Editorial Material
Rheumatology
Juergen Braun, Laura C. Coates
Article
Rheumatology
Ioana Andreica, Iulia Roman, Imke Redeker, Xenofon Baraliakos, Juergen Braun, Uta Kiltz
Summary: This study investigated the attitudes and perceived factors towards vaccination in patients with rheumatic musculoskeletal diseases, including pneumococci, influenza, and SARS-CoV-2 vaccines. The study found that most patients had good knowledge about vaccination and the facilitators were more important than barriers. Patients generally indicated that healthcare professionals' recommendations were a major motivation for vaccination. There were more barriers towards SARS-CoV-2 vaccination, with personal intrapersonal issues being the most common.
Article
Rheumatology
Sevtap Tugce Ulas, Felix Radny, Katharina Ziegeler, Iris Eshed, Juliane Greese, Dominik Deppe, Carsten Stelbrink, Robert Biesen, Hildrun Haibel, Valeria Rios Rodriguez, Judith Rademacher, Mikhail Protopopov, Fabian Proft, Denis Poddubnyy, Torsten Diekhoff
Summary: This study aimed to investigate whether self-reported diagnostic confidence can predict diagnostic accuracy in axial spondyloarthritis imaging. The results showed significant differences in diagnostic confidence between correct and incorrect responses for all imaging modalities, and self-reported diagnostic confidence can serve as useful information to predict diagnostic reliability.
Article
Rheumatology
David Kiefer, Juergen Braun, Uta Kiltz, Varvara Chatzistefanidi, Daniela Adolf, Ilka Schwarze, Maria Kabelitz, Uwe Lange, Jan Brandt-Juergens, Edgar Stemmler, Sabine Sartingen, Xenofon Baraliakos
Summary: This study demonstrates the impact of disease-specific patient-reported outcomes on global functioning in patients with axial spondyloarthritis (axSpA), while objectively assessed spinal mobility scores have limited impact on patient-reported global functioning. The results also suggest that global functioning in this cohort is not highly dependent on the degree of structural damage in the axial skeleton.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Anna Kernder, Katja Thiele, Gamal Chehab, Matthias Schneider, Johanna Callhoff
Summary: This study analyzed the time interval between symptom onset and first presentation to a rheumatologist in Germany to understand the long-term outcome of connective tissue diseases. The results showed that although there has been a reduction in the time interval since 1980, there has been no significant improvement in the past two decades. Older patients and female patients tend to have longer intervals between symptoms and first presentation.
RHEUMATOLOGY INTERNATIONAL
(2023)