Article
Obstetrics & Gynecology
Rebecca F. Hamm, Michelle H. Moniz
Summary: This article provides clinicians with the necessary tools to critically read and interpret literature on implementation within obstetrics and gynecology. It describes the process of implementation research, common study designs and outcomes, as well as pitfalls in the design and analysis of implementation studies.
CLINICAL OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Orla Sheil, Fionnuala M. McAuliffe
Summary: The 2020 SARS-CoV-2 pandemic presented challenges to health services, but National Maternity Hospital Dublin successfully reorganized services to care for mothers and babies. Measures included developing a 'hospital within a hospital' approach, creating separate physical and care pathways for positive cases, and delivering virtual outpatient appointments and comprehensive online patient education.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Fisheries
Valentina Wong-Benito, Jill de Rijke, Brian Dixon
Summary: This article summarizes the structural and functional aspects of antigen presentation pathways in vertebrates, with a focus on MHC receptors and other related proteins.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Xiaoyu Ji, Hua Duan, Sha Wang, Yanan Chang
Summary: In the past decade, research on ultrasound therapy in obstetrics and gynecology has developed rapidly. Low-intensity pulsed ultrasound (LIPUS) has emerged as a new trend in clinical applications, providing safe and effective treatment outcomes through non-thermal effects. This study outlines the biological mechanisms and applications of LIPUS in treating various obstetric and gynecologic diseases, aiming to promote its precise application and provide a theoretical basis for its use in the field.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Rossella Fasano, Eleonora Malerba, Marcella Prete, Antonio Giovanni Solimando, Alessio Buonavoglia, Nicola Silvestris, Patrizia Leone, Vito Racanelli
Summary: The liver is a tolerogenic organ that can induce immune tolerance against self-antigens. However, autoimmune liver diseases can disrupt this tolerance due to genetic predisposition, environmental factors, and imbalance in regulatory mechanisms. Liver cells, including conventional and unconventional antigen presenting cells (APCs), present self-antigens to T cells, leading to altered immune responses, liver injury, and inflammation. Understanding the impact of antigen presentation and the role of immune cells in liver inflammation could aid in the development of novel therapeutic strategies for autoimmune liver diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. A. Belogurov Jr, Alexander G. G. Gabibov
Summary: Antigen presentation by MHC-II is crucial for immune response and self-antigen tolerance. Certain MHC-II alleles are associated with autoimmune diseases. The process of MHC-II-mediated presentation plays a significant role in understanding the mechanisms of autoimmune diseases and the protective effect of certain MHC-II alleles.
Article
Computer Science, Interdisciplinary Applications
William Gropp, Rajeev Thakur, Pavan Balaji
Summary: The MPICH project is an example of translational research in computer science that successfully applied the emerging MPI standard to computer systems, enabling the development of scalable parallel applications. The project faced challenges, but by learning from them, it provided valuable lessons for other similar projects.
JOURNAL OF COMPUTATIONAL SCIENCE
(2021)
Article
Obstetrics & Gynecology
Sonal Grover, Adam D. Elwood, Jharna M. Patel, Cande Ananth, Justin S. Brandt
Summary: This study evaluated the correlation between Altmetric Attention Score, absolute citation rate, and Relative Citation Ratio for articles published in obstetrics and gynecology journals from 2004 to 2019. The findings suggest that articles with higher Altmetric Attention Scores tend to have more engagement on social media and public platforms compared to those with higher citation rates. Further research is needed to determine the long-term correlation between alternative metrics and citation rates in obstetrics and gynecology.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jessica Keim-Malpass, Jennifer Phillips, Karen C. Johnston
Summary: This article discusses the dissemination practices in translational science, the role of clinical research workforce, and the use of the Translational Science Benefits Model (TSBM) and engagement science strategies to develop a novel translational dissemination framework. The article proposes using this framework to guide the development of an educational curriculum and outlines the essential domains and evaluation criteria for the clinical and translational research workforce.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Management
Mary Ryder, Elisabeth Jacob
Summary: The study aims to explore a proposed translational research continuum for nurse practitioners, highlighting the importance of integrating scientific processes for evidence-based practice and evaluation of outcomes. A translational research framework has the potential to strengthen nursing research in the nurse practitioner role, placing clinical nursing leaders in an equitable research position with all healthcare professionals. The continuum provides nursing management with a benchmark for nursing research and supports research engagement for nurse practitioners.
JOURNAL OF NURSING MANAGEMENT
(2022)
Review
Oncology
Peng Ge, Yalan Luo, Haiyang Chen, Jiayue Liu, Haoya Guo, Caiming Xu, Jialin Qu, Guixin Zhang, Hailong Chen
Summary: Pancreatic cancer is one of the most common malignant tumors in the digestive tract globally, and significant progress has been made in research on its diagnosis and treatment. However, the current situation is still unsatisfactory, and there is an urgent need for academia to integrate basic research and clinical data.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Emily Eisenhauer, Kathleen C. Williams, Keahna Margeson, Sebastian Paczuski, Mary Clare Hano, Kate Mulvaney
Summary: The study found that integration of social sciences in environmental research can lead to improved problem framing, introduction of new methodologies, and greater stakeholder and public inclusion in the research process. Research outcomes include the inclusion or refinement of social and environmental perspectives, increased translatability of research, and establishment of new partnerships. Barriers to integration include lack of familiarity with social sciences, while facilitators include receptive team members, intentional communication strategies, and organizational commitment to interdisciplinary work.
ENVIRONMENTAL SCIENCE & POLICY
(2021)
Article
Pharmacology & Pharmacy
Calvo Kayla, Phillips Jennifer, Burks Sandra, Karen C. Johnston
Summary: Research administrators play a critical role in supporting sponsored research, but there is a lack of institutional career development and mentoring programs for them. To address this gap, the iTHRIV has developed an innovative program called RAPTR, which provides training, resources, and mentoring for research administrators. This program aims to foster a community of practice where administrators can share ideas and challenges.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Yinghua Zhao, Qinggang Li, Qing Ouyang, Lingling Wu, Xiangmei Chen
Summary: Mesangial cells (MCs) are resident cells of the kidneys that play a crucial role in maintaining glomerular function. They can be affected by changes in the glomerular environment, leading to functional transformation and involvement in the pathogenesis of various kidney diseases. Research suggests that activated MCs can act as antigen-presenting cells (APCs) in renal diseases.
CELLULAR IMMUNOLOGY
(2021)
Review
Obstetrics & Gynecology
Olaf Dammann, Thilo Dork, Peter Hillemanns, Thomas Reydon
Summary: This paper discusses the importance of causation and causal inference in obstetrics and gynecology, and introduces some philosophical concepts related to causation. The authors provide an overview of basic ideas and delve into the metaphysical and epistemological aspects of causality, using examples from obstetrical and gynecologic research and practice. The aim is to deepen the thinking and discourse about causation and causal inference in gynecology and obstetrics.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Transplantation
Rozemarijn Snoek, Richard H. van Jaarsveld, Tri Q. Nguyen, Edith D. J. Peters, Martin G. Elferink, Robert F. Ernst, Maarten B. Rookmaaker, Marc R. Lilien, Eric Spierings, Roel Goldschmeding, Nine V. A. M. Knoers, Bert van der Zwaag, Arjan D. van Zuilen, Albertien M. van Eerde
Summary: Genetic testing in chronic kidney disease patients, especially those with high likelihood of genetic disease, can provide early diagnosis, impact prognosis and treatment, and reduce the need for invasive biopsies.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Immunology
Toshihide Tomosugi, Kenta Iwasaki, Shintaro Sakamoto, Matthias Niemann, Eric Spierings, Isao Nahara, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Asami Takeda, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Takaaki Kobayashi
Summary: Evaluation of shared T cell epitopes can help predict the risk of early de novo DSA formation after kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Dan Koning, Esther D. Quakkelaar, Ingrid M. M. Schellens, Eric Spierings, Debbie van Baarle
Summary: CD8(+) T cells play a significant role in controlling untreated HIV infection. HLA-B*27 and B*57 are associated with delayed HIV disease progression, but the specific factors providing superior immunity against HIV are unclear. This study found that there were no differences in TCR diversity between progressors and slow progressors, and both HLA alleles recruited biased T cell repertoires. These findings suggest that progressors and slow progressors have highly similar T cell repertoires in terms of TCR diversity, usage, and cross-reactivity.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Gautam Kok, Monique M. A. Verstegen, Roderick H. J. Houwen, Edward E. S. Nieuwenhuis, Herold J. Metselaar, Wojciech G. Polak, Luc J. W. van der Laan, Eric Spierings, Caroline M. den Hoed, Sabine A. Fuchs
Summary: This study investigated the relationship between human leukocyte antigen (HLA) matching and liver transplantation outcomes. The results showed that HLA matching is not necessary for liver transplantation for nonautoimmune disease. However, HLA matching may affect the risk of acute rejection and graft loss for patients with autoimmune disease.
LIVER TRANSPLANTATION
(2022)
Article
Hematology
Effie W. Petersdorf, Mats Bengtsson, Mary Horowitz, Caroline McKallor, Stephen R. Spellman, Eric Spierings, Ted A. Gooley, Phil Stevenson
Summary: HLA-DQ heterodimers influence susceptibility to autoimmune diseases, but their role in hematopoietic cell transplantation is unknown. This study found that the presence of G2 heterodimers increased the risk of relapse in HLA-matched and HLA-DQ-mismatched patients undergoing transplantation, and the risk increased with a higher number of G2 molecules.
Article
Medical Laboratory Technology
Hanneke W. M. van Deutekom, Saskia Haitjema
Summary: This paper provides recommendations on organizational structure, standards to use, and documentation for in-house software development compliant with the In Vitro Diagnostics Regulation (IVDR). Practical insights are offered through three examples of novel standard operating procedures. The paper recommends multidisciplinary development teams, use of ISO-15189 in synergy with IEC-62304, and concise documentation.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Raphael Carapito, Ismail Aouadi, Martin Verniquet, Meiggie Untrau, Angelique Pichot, Thomas Beaudrey, Xavier Bassand, Sebastien Meyer, Loic Faucher, Juliane Posson, Aurore Morlon, Irina Kotova, Florent Delbos, Alexandre Walencik, Alice Aarnink, Anne Kennel, Caroline Suberbielle, Jean-Luc Taupin, Benedict M. Matern, Eric Spierings, Nicolas Congy-Jolivet, Arnaud Essaydi, Peggy Perrin, Antoine Blancher, Dominique Charron, Nezih Cereb, Myriam Maumy-Bertrand, Frederic Bertrand, Valerie Garrigue, Vincent Pernin, Laurent Weekers, Maarten Naesens, Nassim Kamar, Christophe Legendre, Denis Glotz, Sophie Caillard, Marc Ladriere, Magali Giral, Dany Anglicheau, Caner Suesal, Seiamak Bahram
Summary: This study investigates the role of the MICA gene in a French multicenter cohort of kidney transplants and finds that MICA mismatches are associated with decreased graft survival. Both before and after transplantation, anti-MICA donor-specific antibodies are strongly associated with increased antibody-mediated rejection. This effect is synergetic with anti-HLA DSA. De novo-developed anti-MICA DSA are the most harmful and associated with reduced graft survival. Evaluation of MICA matching and immunization is warranted for identifying high-risk transplant rejection and loss.
Article
Multidisciplinary Sciences
K. Joeri van der Velde, Gurnoor Singh, Rajaram Kaliyaperumal, Xiaofeng Liao, Sander de Ridder, Susanne Rebers, Hindrik H. D. Kerstens, Fernanda de Andrade, Jeroen van Reeuwijk, Fini E. De Gruyter, Saskia Hiltemann, Maarten Ligtvoet, Marjan M. Weiss, Hanneke W. M. van Deutekom, Anne M. L. Jansen, Andrew P. Stubbs, Lisenka E. L. M. Vissers, Jeroen F. J. Laros, Esther van Enckevort, Daphne Stemkens, Peter A. C. t Hoen, Jeroen A. M. Belien, Marielle E. van Gijn, Morris A. Swertz
Summary: FAIR Genomes aims to facilitate the reuse of genomic data by developing metadata standards and providing templates for data entry and programmatic interfaces. It addresses the challenge of storing and sharing genomic data by offering a semantic schema for data descriptions. With FAIR Genomes, rare disease diagnosis and personalized medicine research can be enhanced.
Review
Immunology
Emma T. M. Peereboom, Benedict M. Matern, Eric Spierings, Kirsten Geneugelijk
Summary: Single-cell technologies play a crucial role in solid organ transplantation research, providing insights into the immunological mechanisms of rejection and tolerance, and facilitating the development of new therapies.
Article
Immunology
Matthias Niemann, Benedict M. Matern, Eric Spierings
Summary: Histocompatibility in solid-organ transplantation greatly affects graft survival. This study proposes an allele-specific solvent accessibility hypothesis for HLA proteins and develops a computational pipeline to predict the solvent accessibility of HLA Class I proteins. Results show that there are variations in solvent accessibility between different HLA proteins, which has important implications for refining B-cell epitope definitions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Michiel G. H. Betjes, Emma T. M. Peereboom, Henny G. Otten, Eric Spierings
Summary: The role of the indirect T-cell recognition pathway in acute T cell-mediated rejection is important, and the Predicted Indirectly ReCognizable HLA Epitopes algorithm can quantify the number of T-cell epitopes. The PIRCHE-II score for donor HLA-DR/DQ is highly associated with vascular rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Gerdien Mijnheer, Nila Hendrika Servaas, Jing Yao Leong, Arjan Boltjes, Eric Spierings, Phyllis Chen, Liyun Lai, Alessandra Petrelli, Sebastiaan Vastert, Rob J. de Boer, Salvatore Albani, Aridaman Pandit, Femke van Wijk, Di Chen
Summary: Autoimmune inflammation is characterized by tissue infiltration and expansion of antigen-specific T cells. In this study, the authors used CyTOF analysis and TCR sequencing to investigate the immune cell composition and expansion of specific T cell clones in juvenile idiopathic arthritis (JIA). They found that the infiltrates in different affected joints of the same patient were similar, and dominant T cell clones, including Tregs, persisted over time. These findings suggest the presence of autoantigen-driven expansion of T cell clones in localized autoimmune disease.
Article
Cell Biology
Jan A. Hofmann, Werner Bochtler, James Robinson, Juergen Sauter, Medhat Askar, Lucie Houdova, Mark Melchers, Alexander H. Schmidt, Eric Spierings, Christine Urban, Alicia Venter, Martin Maiers, Steven G. E. Marsh, Hans-Peter Eberhard
Summary: The guidelines for HLA nomenclature have become a reliable standard for communication of HLA data in the hematopoietic cell transplantation process. With the advent of next-generation sequencing, it is now necessary to discuss how to communicate novel HLA alleles. Until these alleles are officially designated, they need to be handled according to specific rules.
Article
Cell Biology
Benedict M. Matern, Matthias Niemann, Ioannis Nemparis, Andreas Schimanski, Emma T. M. Peereboom, Cynthia S. M. Kramer, Sebastiaan Heidt, Eric Spierings
Summary: The International HLA and Immunogenetics Workshop (IHIW) is a recurring gathering where researchers, technologists and clinicians collaborate on projects and establish standards for representing HLA and immunogenic determinants. The 18th IHIW Database is a cloud-based platform that collects and analyzes project-specific data using established HLA data standards and web technologies.
Article
Cell Biology
Matthias Niemann, Benedict M. Matern, Eric Spierings
Summary: Allorecognition of donor HLA is crucial for kidney graft survival, but the underlying mechanisms remain unclear. The Snowball prediction pipeline, which fits smaller ellipsoids iteratively to substructures, shows higher sensitivity than the ElliPro approach in fine parts of the HLA. The cloud-based web service Snowflake extends the prediction pipeline by considering protein- and position-specific surface area and protrusion ranks.