Review
Medicine, General & Internal
Fei Qi, Yaqi Tan, Amin Yao, Xutong Yang, Yanling He
Summary: Psoriatic disease is a spectrum of diseases affecting both skin and musculoskeletal features, with a considerable number of patients progressing from cutaneous psoriasis to psoriatic arthritis. The use of proteomics technologies provides a unique opportunity to explore potential biomarkers for psoriatic arthritis.
FRONTIERS IN MEDICINE
(2021)
Review
Rheumatology
Robert B. M. Landewe, Desiree van der Heijde
Summary: This article discusses the multidimensionality of rheumatic and musculoskeletal diseases (RMDs) and the importance of composite outcome measures in disease assessment. It highlights the potential issues with multidimensional composites and proposes simple solutions to overcome these challenges.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Philip J. Mease, Mei Liu, Sabrina Rebello, Robert R. McLean, Blessing Dube, Meghan Glynn, Peter Hur, Alexis Ogdie
Summary: Patients with PsA who have nail psoriasis demonstrated worse disease activity, quality of life, and work productivity compared to those without nail involvement, highlighting the importance of identifying and managing nail disease in PsA patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Health Care Sciences & Services
Jing Xu, Jiarui Ou, Chen Li, Zheng Zhu, Jian Li, Hailun Zhang, Junchen Chen, Bin Yi, Wu Zhu, Weiru Zhang, Guanxiong Zhang, Qian Gao, Yehong Kuang, Jiangning Song, Xiang Chen, Hong Liu
Summary: A machine learning model was developed to diagnose Psoriatic arthritis (PsA) and analyze its progression risk using 3961 patients' clinical records. General additive models (GAMs) and the Kaplan-Meier method were applied to analyze the efficacy of various drugs on psoriasis treatment and inhibiting PsA progression. The results showed accurate prediction of PsA and its progression and analysis of drug efficacy.
NPJ DIGITAL MEDICINE
(2023)
Article
Rheumatology
Michelle L. M. Mulder, Mark H. Wenink, Johanna E. Vriezekolk
Summary: Women with PsA in a tightly monitored and treated setting have more severe disease than men. This is demonstrated by worse scores for women in both subjective and objective disease activity measures, in addition to women less often reaching the treatment target. Notably, being overweight is associated with higher disease activity in women, but not men.
Article
Medicine, General & Internal
Pierluigi Macchioni, Antonio Marchesoni, Giovanni Ciancio, Gilda Sandri, Alen Zabotti, Gentiana Vukatana, Luca Montaguti, Mariacristina Focherini, Marcello Govoni, Amelia Spinella, Nazzarena Malavolta, Francesca Zuliani, Marco Bruschi, Fabio Mascella, Carlo Salvarani
Summary: In this multicenter study, Psoriatic arthritis (PsA) patients in a stable state of Minimal Disease Activity (MDA) were examined using ultrasound (US). The results showed that PsA patients in MDA may still have residual inflammation in peripheral articular structures.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Borui Li, Guangtao Li, Xinlei Yang, Zhibo Song, Yu Wang, Zhuoli Zhang
Summary: This study found that NETosis plays an important role in psoriatic arthritis. The level of MPO-DNA complex in serum is associated with disease activity and may be a useful biomarker to predict therapeutic response in PsA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Mariela Geneva-Popova, Stanislava Popova-Belova, Velicka Popova, Nikolay Stoilov
Summary: This study found that the presence of crystals in the synovial fluid of PsA patients is associated with disease activity, disability, and pain. The findings suggest that examining synovial fluid can be helpful in determining treatment options for PsA patients.
Article
Rheumatology
Tin Lok Lai, Chi Kit Au, Ho Yin Chung, Man Chi Leung, Woon Leung Ng, Chak Sing Lau
Summary: PsA patients commonly experience severe fatigue, with factors such as joint pain, skin severity, and disease activity closely associated with its intensity. Achieving remission in disease activity can help alleviate fatigue, but a multidisciplinary approach is necessary for effective management.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Emilce E. Schneeberger, Gustavo Citera, Peter Nash, Josef S. Smolen, Philip J. Mease, Enrique R. Soriano, Claudia Helling, Annette E. Szumski, Rajiv Mundayat, Dario Ponce de Leon
Summary: This study aims to compare the achievement of Disease Activity Index in Psoriatic Arthritis (DAPSA) remission (REM)/low disease activity (LDA) with very low disease activity (VLDA)/minimal disease activity (MDA) targets in tofacitinib-treated patients with psoriatic arthritis (PsA). The results showed that achieving DAPSA-REM/DAPSA-LDA targets was easier compared to VLDA/MDA targets. These data support the use of DAPSA and VLDA/MDA as useful tools for evaluating disease activity and treatment response in PsA.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Flora Farkas, Natsumi Ikumi, Musaab Elmamoun, Agnes Szentpetery, Oliver FitzGerald
Summary: The study identified VLDA as the most stringent remission target for patients with PsA, while achieving the pain VAS target was found to be the most difficult component.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Fan Yang, Chaofan Lu, Huilan Liu, Lei Dou, Yanhong Wang, Hongbin Li, Xinwang Duan, Lijun Wu, Yongfu Wang, Xiuying Zhang, Jian Xu, Jinmei Su, Dong Xu, Jiuliang Zhao, Qingjun Wu, Mengtao Li, Xiaomei Leng, Xiaofeng Zeng
Summary: Enthesitis is common in Chinese patients with PsA, and it is important to evaluate both peripheral and axial sites. Compared with other cohorts, Chinese patients with enthesitis tend to be younger, have a lower body mass index, a higher rate of positive HLA-B27, more frequent dactylitis, and a higher proportion of csDMARDs use.
CHINESE MEDICAL JOURNAL
(2023)
Review
Rheumatology
Chrysoula G. Gialouri, George E. Fragoulis
Summary: Psoriatic arthritis (PsA) is a highly heterogeneous disease with various clinical manifestations, often accompanied by comorbidities such as cardiovascular diseases and mental health disorders. There is a lack of specific markers for diagnosis and monitoring of the disease, leading to a lack of consensus on a disease activity index for PsA. Various indices have been proposed for measuring activity in PsA, but a widely accepted index is still missing.
CLINICAL RHEUMATOLOGY
(2021)
Article
Health Care Sciences & Services
Fausto Salaffi, Marina Carotti, Sonia Farah, Marco Di Carlo
Summary: This study assessed the clinimetric properties of the Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts), a new patient-reported outcome (PRO) for measuring overall health status in PsA patients. The PsA-5Ts showed significant correlations with composite indices of disease activity and PROs and demonstrated good discriminant validity, outperforming the SF-36.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Dermatology
Alice B. Gottlieb, Joseph F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that can lead to psoriatic arthritis, a heterogeneous musculoskeletal disease causing joint damage. Early detection and intervention by dermatologists is crucial in preventing permanent joint damage from psoriatic arthritis, which often manifests after skin symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Medicine, General & Internal
Kieran E. Murray, Louise Moore, Celine O'Brien, Anne Clohessy, Caroline Brophy, Patricia Minnock, Oliver FitzGerald, Eamonn S. Molloy, Anne-Barbara Mongey, Shane Higgins, Mary F. Higgins, Fionnuala M. Mc Auliffe, Douglas J. Veale
IRISH JOURNAL OF MEDICAL SCIENCE
(2019)
Article
Medicine, General & Internal
Kieran Murray, Louise Moore, Celine O'Brien, Anne Clohessy, Caroline Brophy, Oliver FitzGerald, Eamonn S. Molloy, Anne-Barbara Mongey, Shane Higgins, Mary F. Higgins, Patricia Minnock, Joan Lalor, Fionnuala M. McAuliffe, Douglas James Veale
IRISH JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Rheumatology
Katalin Gulyas, Agnes Horvath, Edit Vegh, Anita Pusztai, Agnes Szentpetery, Zsofia Petho, Andrea Vancsa, Nora Bodnar, Peter Csomor, Attila Hamar, Levente Bodoki, Harjit Pal Bhattoa, Balazs Juhasz, Zoltan Nagy, Katalin Hodosi, Tamas Karosi, Oliver FitzGerald, Gabriella Szucs, Zoltan Szekanecz, Szilvia Szamosi, Sandor Szanto
CLINICAL RHEUMATOLOGY
(2020)
Article
Rheumatology
Walter P. Maksymowych, Oliver FitzGerald, Mikkel Ostergaard, Joanne Homik, Desiree van der Heijde, Robert G. Lambert, Ori Elkayam, Sofia Ramiro, J. Carter Thorne, Maggie J. Larche, Gianfranco Ferraccioli, Marina Backhaus, Gerd R. Burmester, Gilles Boire, Bernard Combe, Thierry Schaeverbeke, Alain Saraux, Maxime Dougados, Maurizio Rossini, Marcello Govoni, Luigi Sinigaglia, Alain Cantagrel, Cheryl Barnabe, Clifton O. Bingham, Paul P. Tak, Dirkjan van Schaardenburg, Hilde Berner Hammer, Joel Paschke, Rana Dadashova, Edna Hutchings, Alexandre Sepriano, Robert Landewe
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Rheumatology
Alexandre Sepriano, Sofia Ramiro, Oliver FitzGerald, Mikkel Ostergaard, Joanne Homik, Desiree van der Heijde, Ori Elkayam, J. Carter Thorne, Maggie J. Larche, Gianfranco Ferraccioli, Marina Backhaus, Gerd R. Burmester, Gilles Boire, Bernard Combe, Thierry Schaeverbeke, Alain Saraux, Maxime Dougados, Maurizio Rossini, Marcello Govoni, Luigi Sinigaglia, Alain Cantagrel, Cheryl Barnabe, Clifton O. Bingham, Paul P. Tak, Dirkjan van Schaardenburg, Hilde Berner Hammer, Joel Paschke, Rana Dadashova, Edna Hutchings, Robert Landewe, Walter P. Maksymowych
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Rheumatology
Nicolas Iragorri, Glen Hazlewood, Braden Manns, Laura Bojke, Eldon Spackman
Summary: Screening psoriasis patients for PsA is cost-effective in Canada, with potential cost savings and improved quality of life. Early detection and treatment of PsA may delay disease progression and the need for biologic therapy, leading to better outcomes for patients.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Sofia Ramiro, Robert B. M. Landewe, Desiree van der Heijde, Alexandre Sepriano, Oliver FitzGerald, Mikkel Ostergaard, Joanne Homik, Ori Elkayam, J. Carter Thorne, Margaret Larche, Gianfranco Ferraccioli, Marina Backhaus, Gilles Boire, Bernard Combe, Thierry Schaeverbeke, Alain Saraux, Maxime Dougados, Maurizio Rossini, Marcello Govoni, Luigi Sinigaglia, Alain G. Cantagrel, Cornelia F. Allaart, Cheryl Barnabe, Clifton O. Bingham, Paul P. Tak, Dirkjan van Schaardenburg, Hilde Berner Hammer, Rana Dadashova, Edna Hutchings, Joel Paschke, Walter P. Maksymowych
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Rheumatology
Muhammad Haroon, Agnes Szentpetery, Mohsin Ashraf, Phil Gallagher, Oliver FitzGerald
CLINICAL RHEUMATOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Gerd R. Burmester, Jeffrey R. Curtis, Huifeng Yun, Oliver FitzGerald, Kevin L. Winthrop, Valderilio F. Azevedo, William F. C. Rigby, Keith S. Kanik, Cunshan Wang, Pinaki Biswas, Thomas Jones, Niki Palmetto, Thijs Hendrikx, Sujatha Menon, Ricardo Rojo
Article
Rheumatology
Laura C. Coates, Xenofon Baraliakos, Francisco J. Blanco, Elena Alonso Blanco-Morales, Jurgen Braun, Vinod Chandran, Jose Luis Fernandez-Sueiro, Oliver FitzGerald, Phil Gallagher, Dafna D. Gladman, Elena Gubar, Tatiana Korotaeva, Elena Loginova, Ennio Lubrano, Juan Mulero, Jose Pinto-Tasende, Ruben Queiro, Jesus Sanz Sanz, Agnes Szentpetery, Philip S. Helliwell
Summary: Patients with axial spondyloarthritis (SpA) who are positive for HLA-B27 exhibit more severe radiographic damage, more marginal syndesmophytes, and more frequent syndesmophyte symmetry compared to HLA-B27 negative patients.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rehabilitation
Orna Fennelly, Catherine Blake, Oliver FitzGerald, Aoife Caffrey, Laura Fletcher, Keith Smart, Siobhan Corcoran, Eidin Ni She, Sarah Casserley-Feeney, Francois Desmeules, Caitriona Cunningham
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2020)
Article
Rheumatology
Muhammad Haroon, Phil Gallaghar, Muddassar Ahmad, Oliver FitzGerald
CLINICAL RHEUMATOLOGY
(2020)
Review
Rheumatology
Robert Winchester, Oliver FitzGerald
Article
Rheumatology
Philip J. Mease, Iain B. McInnes, Vibeke Strand, Oliver FitzGerald, Harris A. Ahmad, Yedid Elbez, Subhashis Banerjee
RHEUMATOLOGY INTERNATIONAL
(2020)
Review
Rheumatology
Agnes Szentpetery, Muhammad Haroon, Oliver FitzGerald
RHEUMATOLOGY AND THERAPY
(2020)