Review
Immunology
Xiangsu Liu, Jiaqi Li, Leilei Sun, Tong Wang, Wenxia Liang
Summary: The inflammatory response plays a crucial role in joint injury in rheumatoid arthritis (RA), but it is difficult to assess inflammation levels, making diagnosis challenging. The neutrophil-to-lymphocyte ratio (NLR), a novel non-specific inflammatory indicator, reflects the severity of inflammation. This study aimed to explore the role of NLR in RA progression and evaluate its predictive value for response to disease-modifying antirheumatic drugs (DMARDs) therapy.
INFLAMMOPHARMACOLOGY
(2023)
Review
Rheumatology
Mrinalini Dey, Amanda Busby, Helen Elwell, Heidi Lempp, Arthur Pratt, Adam Young, John Isaacs, Elena Nikiphorou
Summary: This review examines the association between socioeconomic status (SES) and rheumatoid arthritis (RA) disease activity. The findings suggest a link between low SES and worse outcomes in RA. Further research is needed to understand the mechanisms underlying this association and to consider bio-bio and bio-social interactions.
Article
Nutrition & Dietetics
Mislav Radic, Ivan Vlak, Marijana Vuckovic, Josipa Radic, Erim Besic, Tonko Vlak
Summary: The aim of this study was to evaluate various factors in patients with rheumatoid arthritis (RA) and examine their associations. The results showed that the patients had long disease duration and high disease activity.
Article
Rheumatology
Vanessa L. Kronzer, Ryan J. Lennon, Jeffrey A. Sparks, Elena Myasoedova, John M. Davis, Cynthia S. Crowson
Summary: This study aimed to evaluate the association of physical activity and dietary factors with the risk of rheumatoid arthritis (RA). The results showed that high-intensity work physical activity was associated with an increased risk of RA, while leisure activity was not. The consumption of high-fat food and fruits/vegetables showed non-significant associations with RA risk.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Biochemistry & Molecular Biology
Shipeng Zhang, Yimeng Lei, Tao Sun, Ziyu Gao, Zhuoqi Li, Hui Shen
Summary: This study found that Metrnl is involved in the pathogenesis of rheumatoid arthritis and the increase in serum Metrnl levels is closely related to disease activity.
Review
Clinical Neurology
Chester Yan Hao Ng, Sen Hee Tay, Roger S. McIntyre, Roger Ho, Wilson W. S. Tam, Cyrus S. H. Ho
Summary: There is a bidirectional association between rheumatoid arthritis (RA) and depression, with a higher risk for elderly individuals. RA patients with depression also face an increased risk of all-cause mortality.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Elena Carrillo-Alvarez, Ana Andres, Jordi Riera-Romani, Dario Novak, Miriam Rodriguez-Monforte, Lluis Costa-Tutusaus, Myriam Guerra-Balic
Summary: This study conducted in Barcelona explores the relationship between social capital and psychological distress in adolescents. The findings suggest that higher levels of family support and teacher-student trust decrease the likelihood of experiencing psychological distress. However, neighborhood informal control may have a negative impact on mental health. Additionally, being female, having lower self-rated health, and higher media use are associated with a higher likelihood of psychological distress.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
Silvia Eiken Alpers, Stale Pallesen, Jorn Henrik Vold, Ellen Haug, Linn-Heidi Lunde, Jens Christoffer Skogen, Asgeir Mamen, Silje Maeland, Lars Thore Fadnes
Summary: This longitudinal study examines the impact of psychological distress and worries related to health and economy on alcohol consumption and physical activity levels during the COVID-19 pandemic in Norway. The results show that individuals with higher levels of psychological distress are more likely to engage in heavy alcohol consumption and have lower levels of physical activity.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Rheumatology
Giovanni Adami, Ombretta Viapiana, Maurizio Rossini, Giovanni Orsolini, Eugenia Bertoldo, Alessandro Giollo, Davide Gatti, Angelo Fassio
Summary: The study found a significant association between high concentrations of air pollutants and the severity and reactivations of RA. Exposure to higher levels of air pollutants was linked to increased CRP levels and a higher risk of arthritis flare-ups, even at low exposure levels.
Article
Public, Environmental & Occupational Health
Rui-Chen Gao, Ni Sang, Cheng-Zhen Jia, Meng-Yao Zhang, Bo-Han Li, Meng Wei, Guo-Cui Wu
Summary: In this study, the causal association between sleep disorders and rheumatoid arthritis (RA) was investigated using Mendelian randomization analysis. The results showed that short sleep duration was causally linked to an increased risk of RA, while other sleep-related traits were not significantly associated with RA.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Vinita M. Alexander, Jillian Ashley-Martin, Joan K. Riley, Amber R. Cooper, Valerie S. Ratts, Emily S. Jungheim
Summary: Women with arthritis have lower AMH levels compared to those without arthritis. Long-term use of methotrexate is not associated with annual AMH decrease.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Immunology
Kang-Jia Yin, Ji-Xiang Huang, Peng Wang, Xiao-Ke Yang, Sha-Sha Tao, Hong-Miao Li, Jing Ni, Hai-Feng Pan
Summary: This study using Mendelian randomization analysis found no causal association between periodontitis and arthritis, despite previous observational studies reporting a link between the two.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Sabine Wiegmann, Gabriele Armbrecht, Diana Borucki, Bjoern Buehring, Frank Buttgereit, Christian Detzer, Desiree Schaumburg, Kim Nikola Zeiner, Roswitha Dietzel
Summary: In patients with rheumatoid arthritis (RA), age, self-reported disability, and physical performance were significantly associated with falls, while there was no association found between sarcopenia and prospective falls. Early assessment including these factors can identify at-risk RA patients for falls in clinical practice.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Rheumatology
Qin-cheng Che, Qian Jia, Xiao-yu Zhang, Shu-ning Sun, Xiao-jie Zhang, Qiang Shu
Summary: This study investigated the association between serum klotho levels and mortality in patients with rheumatoid arthritis (RA). The results showed a U-shaped correlation between serum klotho levels and all-cause mortality, indicating that maintaining a certain level of serum klotho could prevent premature death in RA patients.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Nutrition & Dietetics
Wojciech Tanski, Justyna Wojciga, Beata Jankowska-Polanska
Summary: Rheumatoid arthritis is a progressive joint disease that can affect multiple organs in addition to causing joint damage. Elderly patients with RA often experience pain, fatigue, mood disorders, and other complications, which can significantly impact their quality of life. Malnutrition can worsen frailty, cognitive function, and daily functioning in these patients. Frailty is a major factor contributing to poorer quality of life in elderly RA patients.
Review
Rheumatology
Morten B. Pedersen, Peter Thinggaard, Rinie Geenen, Marianne U. Rasmussen, Maarten De Wit, Lyn March, Philip Mease, Ernest Choy, Philip G. Conaghan, Lee Simon, Anne Faber Hansen, Simon Tarp, Berit Schiottz-Christensen, Carsten B. Juhl, Sabrina M. Nielsen, Kirstine Amris, Robin Christensen
Summary: Biopsychosocial rehabilitation has a significant but clinically small beneficial effect on pain relief among patients with inflammatory arthritis and osteoarthritis (OA), with no difference in harm.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Ana Margarida Pinto, Rinie Geenen, Tor D. Wager, Mark A. Lumley, Winfried Hauser, Eva Kosek, Jacob N. Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, Joao Castelhano, Miguel Castelo-Branco, Leslie J. Crofford, Mary-Ann Fitzcharles, Marina Lopez-Sola, Mariana Luis, Tiago Reis Marques, Philip J. Mease, Filipe Palavra, Jamie L. Rhudy, Lucina Q. Uddin, Paula Castilho, Johannes W. G. Jacobs, Jose A. P. da Silva
Summary: This article presents a new model called FITSS (Fibromyalgia: Imbalance of Threat and Soothing Systems), which proposes that an imbalance in emotion regulation, specifically an overactive 'threat' system and underactive 'soothing' system, may contribute to the development of fibromyalgia. This model provides a new perspective for future research and may stimulate the discovery of novel therapeutic interventions.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Dennis J. S. Makarawung, Mijke J. Boers, Femke van den Brink, Valerie M. Monpellier, Liesbeth Woertman, Aebele Mink B. van der Molen, Rinie Geenen
Summary: This study assessed body image in different weight groups and found that body image concerns may influence weight changing behavior. Among obese individuals, there was a preference for a smaller body and low satisfaction with appearance, but differences in investment in appearance. Among underweight individuals, there was high investment in appearance and a preference for a larger body, but differences in satisfaction with appearance. Different body image profiles exist in all weight groups.
Article
Endocrinology & Metabolism
A. Skvortsova, S. H. Meeuwis, R. C. Vos, H. M. M. Vos, H. van Middendorp, D. S. Veldhuijzen, A. W. M. Evers
Summary: This study investigated the influence of healthcare providers' implicit gender biases (IGBs) and the genders of patients and general practitioners (GPs) on diagnostics and treatment decisions in the context of type 2 diabetes. The results showed that the gender of the GP and the patient had an impact on clinical decisions, and GPs exhibited IGBs. Further research is needed to understand the most significant consequences of IGBs in the context of type 2 diabetes.
Article
Clinical Neurology
Merve Karacaoglu, Kaya J. Peerdeman, Mattijs E. Numans, Martha R. Stolk, Simone Meijer, Regine Klinger, Dieuwke S. Veldhuijzen, Henriet van Middendorp, Andrea W. M. Evers
Summary: This study investigates group differences in experimentally manipulated nocebo hyperalgesia between chronic pain and healthy populations at baseline and 1-month follow-up. The results suggest that patients with fibromyalgia do not have stronger nocebo hyperalgesia and may be less responsive to nocebo manipulations than healthy controls.
Meeting Abstract
Psychiatry
R. Selker, T. Y. Koppert, R. Geenen
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Letter
Rheumatology
Ana Margarida Pinto, Rinie Geenen, Tor D. Wager, Winfried Hauser, Eva Kosek, Jacob N. Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, Joao Castelhano, Miguel Castelo-Branco, Leslie J. Crofford, Mary-Ann Fitzcharles, Marina Lopez-Sola, Mariana Luis, Tiago Reis Marques, Philip J. Mease, Filipe Palavra, Jamie L. Rhudy, Lucina Q. Uddin, Paula Castilho, Johannes W. G. Jacobs, Jose A. P. da Silva
NATURE REVIEWS RHEUMATOLOGY
(2023)
Letter
Rheumatology
Ana Margarida Pinto, Rinie Geenen, Tor D. Wager, Mark A. Lumley, Winfried Haeuser, Eva Kosek, Jacob N. Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, Joao Castelhano, Miguel Castelo-Branco, Leslie J. Crofford, Mary-Ann Fitzcharles, Marina Lopez-Sola, Mariana Luis, Tiago Reis Marques, Philip J. Mease, Filipe Palavra, Jamie L. Rhudy, Lucina Q. Uddin, Paula Castilho, Johannes W. G. Jacobs, Jose A. P. da Silva
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Surgery
Dennis J. S. Makarawung, Phillip J. Dijkhorst, Claire E. E. de Vries, Valerie M. Monpellier, M. J. Wiezer, Ruben N. van Veen, Rinie Geenen, Aebele B. Mink B. van der Molen
Summary: The aim of this study was to determine the association between body image and weight loss in patients after bariatric metabolic surgery. The results showed that body image improved until 12 months but gradually declined afterwards, although it remained better than baseline. Higher baseline body image was associated with less weight loss in the first year. However, body image and change in body image were not associated with weight loss 12 to 36 months after surgery.
Article
Orthopedics
Wendy Walrabenstein, Carlijn A. Wagenaar, Marieke van de Put, Marike van der Leeden, Martijn Gerritsen, Jos W. R. Twisk, Martin van der Esch, Henriet van Middendorp, Peter J. M. Weijs, Leo D. Roorda, Dirkjan van Schaardenburg
Summary: In patients with metabolic syndrome-associated osteoarthritis (MSOA), the Plants for Joints multidisciplinary lifestyle program has shown effectiveness in improving symptoms and physical function, especially in reducing joint pain and stiffness.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Clinical Neurology
Johan (Hans) P. A. van Lennep, Henriet van Middendorp, Dieuwke S. Veldhuijzen, Kaya J. Peerdeman, Joseph S. Blythe, Mia A. Thomaidou, Tom Heyman, Andrea W. M. Evers
Summary: This study investigated the effects of individual and combined application of 3 learning techniques on placebo analgesia and extinction. The results showed that the combination of all 3 learning techniques induced significantly stronger placebo analgesia compared to individual techniques or a control condition. Extinction did not differ between groups. Pain expectancies mediated placebo analgesia.
Review
Behavioral Sciences
Ana Margarida Pinto, Mariana Luis, Rinie Geenen, Filipe Palavra, Mark A. Lumley, Jacob N. Albin, Kirstine Amris, Jaime Branco, Dan Buskila, Joao Castelhano, Miguel Castelo-Branco, Leslie J. Crofford, Mary-Ann Fitzcharles, Winfried Hauser, Eva Kosek, Philip J. Mease, Tiago Reis Marques, Johannes W. G. Jacobs, Paula Castilho, Jose A. P. da Silva
Summary: Research on fibromyalgia has made remarkable progress in understanding the neurobiological and psychosocial mechanisms involved. However, current descriptions of fibromyalgia don't capture the complex interplay between neurophysiological and psychosocial domains. A comprehensive literature review was conducted to synthesize current knowledge, explore multi-level links between different systems, and bridge disparate perspectives. The work of international experts in neurophysiology and psychosocial aspects of fibromyalgia is crucial for developing a model that integrates the main factors, enabling better understanding, assessment, and intervention for fibromyalgia.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Rheumatology
Eduardo Jose Ferreira Santos, Bayram Farisogullari, Emma Dures, Rinie Geenen, Pedro M. Machado
Summary: The objective of this study was to identify the best evidence on the efficacy of non-pharmacological interventions in reducing fatigue in people with inflammatory rheumatic and musculoskeletal diseases (I-RMDs) and to summarise their safety. The study included a systematic review of randomised controlled trials (RCTs) and found that physical activity or exercise and psychoeducational interventions were effective and safe for managing fatigue in people with I-RMDs.
Article
Psychology, Clinical
Kim Hijne, Lotte Gerritsen, Ana M. Pinto, Jose A. P. da Silva, Jonna F. van Eck van der Sluijs, Rinie Geenen
Summary: This study aimed to identify and structure comprehensive overviews of threat and soothing influences that may impact physical symptoms in people with rheumatic and musculoskeletal diseases (RMD) and central sensitivity syndromes (CSS). The results provided a comprehensive taxonomy of threats and soothers in people with RMD or CSS, which can be used in experimental research and clinical practice.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2024)
Article
Public, Environmental & Occupational Health
Heidi Willemse, Rinie Geenen, Marthe R. Egberts, Iris M. Engelhard, Nancy E. Van Loey
Summary: This study investigated the associations between burn severity, age, female gender, body image dissatisfaction, and self-esteem. The findings suggest that there is a moderate association between body image dissatisfaction and self-esteem. Burn severity, female gender, and age are associated with body image dissatisfaction through different pathways. Perceived stigmatization and fear of negative evaluation are also associated with self-esteem.
PSYCHOLOGY & HEALTH
(2023)