Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 70, Issue 3, Pages 428-433Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2009.123950
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Funding
- Eastern Norway Regional Health Authority
- Research Council of Norway
- Norwegian Rheumatism Association
- Norwegian Women Public Health Association
- Grethe Harbitz Legacy
- Marie and Else Mustad's Legacy
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Objectives To determine whether MRI and conventional (clinical and laboratory) measures of inflammation can predict 3-year radiographic changes measured by the van der Heijde Sharp score in patients with early rheumatoid arthritis (RA). Methods 55 patients with RA with disease duration <1 year participated in this 3-year follow-up study. Patients were evaluated at baseline, 3, 6, 12 and 36 months by swollen and tender joint count, disease activity score based on 28-joint count, erythrocyte sedimentation rate (ESR), C reactive protein, MRI measures of synovitis, bone marrow oedema and tenosynovitis of the dominant wrist, as well as conventional x-rays of the hands and wrists. Results All measures of inflammation decreased during the follow-up period. ESR, MRI synovitis and MRI bone marrow oedema were independent predictors of 3-year radiographic progression adjusted for age, sex and anti-citrullinated protein antibodies. The 1-year cumulative measures of MRI synovitis and bone marrow oedema provided an improved explanation of variation (adjusted R-2) in radiographic change compared with the baseline MRI values (adjusted R-2 = 0.32 and 0.20 vs 0.11 and 0.04, respectively). Conclusions Both baseline and 1-year cumulative measures of MRI synovitis and bone marrow oedema independently predicted 3-year radiographic progression. These results confirm that MRI synovitis and MRI bone marrow oedema precede radiographic progression in patients with early RA.
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