Article
Immunology
Mate Kiss, Els Lebegge, Aleksandar Murgaski, Helena Van Damme, Daliya Kancheva, Jan Brughmans, Isabelle Scheyltjens, Ali Talebi, Robin Maximilian Awad, Yvon Elkrim, Pauline M. R. Bardet, Sana M. Arnouk, Cleo Goyvaerts, Johan Swinnen, Frank Aboubakar Nana, Jo A. Van Ginderachter, Damya Laoui
Summary: This study found that cancer-associated inflammation can enhance the expression of JAM-A on circulating monocytes, but the function of JAM-A in tumor-infiltrating myeloid cells is little understood. Through gene knockout mouse experiments and RNA sequencing, we found that JAM-A is dispensable for the recruitment and transcriptional reprogramming of myeloid cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
E. A. Wong, S. R. Kinstler
Summary: In the small intestine of chickens, JAMA mRNA is highly expressed in the epithelial cells, while JAM2 mRNA is located in the vascular system and lamina propria. These findings suggest that JAMA is the appropriate gene to assess the tight junctions between intestinal epithelial cells.
Review
Chemistry, Analytical
Leilei Yao, Caixia Yin, Fangjun Huo
Summary: The identification and detection of malignant tumors are of great significance for human survival and development. Fluorescence imaging technology has the potential to be used for diagnosing and treating malignant tumors, as it allows for the identification and detection of substances that are abnormally expressed in tumors.
Article
Immunology
Alice Cole, Rhys Thomas, Nina Goldman, Kevin Howell, Kuntal Chakravarty, Christopher P. Denton, Voon H. Ong
Summary: This article reports a case of diffuse cutaneous systemic sclerosis in a 70-year-old male following COVID-19 vaccination. The authors suspect a possible adverse reaction to the vaccine resulting in an atypical presentation of systemic sclerosis. The article discusses the potential mechanisms of autoimmune reactions triggered by vaccination in rheumatology.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Rheumatology
Kristina Elizabeth Neergaard Clark, Corrado Campochiaro, Eszter Csomor, Adam Taylor, Katherine Nevin, Nicholas Galwey, Mary A. Morse, Jennifer Singh, Yee Voan Teo, Voon H. Ong, Emma Derrett-Smith, Nicolas Wisniacki, Shaun M. Flint, Christopher P. Denton
Summary: Clinical heterogeneity is a key feature of systemic sclerosis (SSc), with hallmark SSc autoantibodies playing a central role in diagnosis and associating with distinct patterns of complications. This study used high-dimensional transcriptional and proteomic analysis to reveal a molecular spectrum of SSc based on skin gene expression and serum protein analysis, showing differences in fibrosis markers and gene expression profiles between different autoantibody specificities. Individual patient pathway analysis identified overlapping and distinct disease processes within SSc subgroups.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Christopher Mendoza, Dario Mizrachi
Summary: Decades of evidence suggest that alterations in cell adhesion properties contribute to the invasive and migratory phenotype of neoplastic cells. The role of tight junction proteins in the tumor microenvironment is crucial. Reprogramming immune cells using CAR-T cells to target and eliminate tumors has been approved as a therapy. Researchers have developed a new biologic that specifically targets cancer cells and reduces proliferation and metastasis.
Article
Medicine, Research & Experimental
Qian Wu, Rui Li, Qing-Xiang Wang, Meng-Yu Zhang, Ting-Ting Liu, Yi-Qing Qu
Summary: Our study revealed the oncogenic role of JAML in LUAD, showing that elevated JAML expression is positively correlated with pT and pTNM. Silencing JAML significantly inhibited malignant behaviors of LUAD cells, induced cell cycle arrest at G(0)/G(1) phase, and promoted apoptosis, possibly through inactivation of the Wnt/beta-catenin pathway in LUAD cells. Rescue experiments confirmed the effects of JAML could be reversed by Wnt/beta-catenin pathway activator in A549 cells. This suggests that JAML may serve as a predictive biomarker and potential therapeutic target for LUAD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Qian Wu, Yong-bin Wang, Xiao-wen Che, Hui Wang, Wei Wang
Summary: JAML protein is an oncogenic protein in lung adenocarcinoma (LUAD) and may serve as a novel therapeutic target. The flavonoid kaempferol inhibits JAML, leading to suppression of proliferation, migration, and invasion of LUAD cells, and partially inhibits epithelial-mesenchymal transition (EMT) through the PI3K/AKT/mTOR pathway. These findings suggest that JAML is a new target for kaempferol in LUAD cells.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Rheumatology
Hanxiao You, Dong Xu, Yong Hou, Jiaxin Zhou, Qian Wang, Mengtao Li, Xiaofeng Zeng
Summary: The study analyzed the effectiveness of tofacitinib in treating refractory skin thickening in dcSSc patients, showing improvements in skin score in a short period and a better performance compared to the control group. Tofacitinib-treated patients had a significantly shorter response time and higher response rates than the comparators.
Article
Oncology
Miki Yamaguchi, Sachie Hirai, Masashi Idogawa, Toshiyuki Sumi, Hiroaki Uchida, Naoki Fujitani, Motoko Takahashi, Yuji Sakuma
Summary: There is a need for novel and effective treatments for small cell lung carcinoma (SCLC). This study investigated the use of an antibody-drug conjugate (ADC) targeting junctional adhesion molecule 3 (JAM3) as a potential therapy for SCLC. The results showed that JAM3 mRNA was expressed at higher levels in SCLC cell lines and tissues compared to lung adenocarcinoma. The ADC specifically targeting JAM3 exhibited dose- and time-dependent antitumor effects on SCLC cells. Silencing JAM3 alone suppressed the growth of SCLC cells. These findings suggest that targeting JAM3 with an ADC could be a promising approach for treating SCLC.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Lewis W. Francis, Seydou N. Yao, Lydia C. Powell, Sean Griffiths, Alexander Berquand, Thomas Piasecki, William Howe, Andrea S. Gazze, Mary C. Farach-Carson, Pamela Constantinou, Daniel Carson, Lavinia Margarit, Deya Gonzalez, R. Steven Conlan
Summary: This study reveals the important role of MUC1 in the intrinsic and extrinsic adhesive properties of human endometrial epithelial cell surfaces. It demonstrates that an optimal level of MUC1 with highly glycosylated decoration is critical for high affinity L-selectin binding.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Reproductive Biology
Chie-Pein Chen, Liang-Kai Wang, Chen-Yu Chen, Chia-Yu Chen, Yi-Hsiu Kuo, Yi-Hsin Wu
Summary: The protein JAM3 is involved in the structure and regulation of placental cells, affecting their fusion, differentiation, proliferation, apoptosis, and motility. Dysregulation of JAM3 expression is crucial in the development of preeclampsia.
BIOLOGY OF REPRODUCTION
(2022)
Article
Oncology
Yuying Fang, Jianmin Yang, Guohong Zu, Changsheng Cong, Shuai Liu, Fei Xue, Shuzhen Ma, Jie Liu, Yuping Sun, Meili Sun
Summary: JAML, a newly discovered junctional adhesion molecule, plays a critical role in promoting gastric cancer cell migration and proliferation, potentially serving as a novel diagnostic biomarker and therapeutic target for gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Miguel S. Marques, Ana C. Costa, Hugo Osorio, Marta L. Pinto, Sandra Relvas, Mario Dinis-Ribeiro, Fatima Carneiro, Marina Leite, Ceu Figueiredo
Summary: Helicobacter pylori infects approximately half of the world's population and is a major risk factor for peptic ulcer disease and gastric cancer. It disrupts epithelial integrity by targeting the junctional adhesion molecule-A (JAM-A) and uses a unique strategy to do so. This study identified PqqE (HP1012) as the virulence factor responsible for cleaving JAM-A, providing new insights into the pathogenesis of this infection.
Article
Immunology
Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J. J. Tschumperlin, Petra Hirsova, Samar H. H. Ibrahim
Summary: The study reveals that VCAM1 not only functions as a scaffold for leukocyte adhesion during liver injury, but also modulates LSEC capillarization and liver fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Rheumatology
Christopher Wasson, Rebecca Ross, Ruth Morton, Jamel Mankouri, Francesco Del Galdo
Article
Biology
Cristina Antinozzi, Paolo Sgro, Francesco Marampon, Daniela Caporossi, Francesco Del Galdo, Ivan Dimauro, Luigi Di Luigi
Summary: Oxidative stress is crucial in the pathogenesis of systemic sclerosis (SSc), affecting the inflammatory state, fibrosis, and tissue damage. Studies show that the phosphodiesterase type 5 inhibitor sildenafil can reduce the expression and secretion of pro-inflammatory chemokines in dermal fibroblasts of SSc patients.
Review
Rheumatology
Fabian A. Mendoza, Sergio A. Jimenez
Summary: Serine/threonine kinases mediate phosphorylation of intracellular protein targets and play a crucial role in regulating cellular functions, including fibrosis development and maintenance in diseases. Drugs targeting and inhibiting these kinases have been developed and may serve as potential therapeutic agents for fibrotic diseases.
Article
Cell Biology
Christopher W. Wasson, Begona Caballero-Ruiz, Justin Gillespie, Emma Derrett-Smith, Jamel Mankouri, Christopher P. Denton, Gianluca Canettieri, Natalia A. Riobo-Del Galdo, Francesco Del Galdo
Summary: This study reveals that CLIC4 expression is regulated by the signaling crosstalk between TGF-beta, Wnt-3a, and Hh, and that it strongly correlates with the expression of the pro-fibrotic marker alpha-smooth muscle actin. Further investigations demonstrate that inhibiting CLIC4 can reverse morphogen-dependent fibroblast activation.
Article
Dermatology
Giuseppina Abignano, Lorraine Green, Sookhoe Eng, Paul Emery, Francesco Del Galdo
Summary: This study aimed to determine whether dynamic-optical coherence tomography (D-OCT) can provide information on microvasculopathy in patients with systemic sclerosis compared to the current gold standard, nailfold video-capillaroscopy (NVC). In conclusion, D-OCT provided qualitative and quantitative information on nailfold microvasculopathy, showing a correlation between microvascular flow density and NVC scores. The development of D-OCT as a standardized imaging technique could provide a quantitative outcome measure in clinical trials and practice.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Rheumatology
Christopher P. Denton, Francesco Del Galdo, Dinesh Khanna, Madelon C. Vonk, Lorinda Chung, Sindhu R. Johnson, John Varga, Daniel E. Furst, Jane Temple, Chiara Zecchin, Eszter Csomor, Amy Lee, Nicolas Wisniacki, Shaun M. Flint, Juliet Reid
Summary: This study aimed to explore the feasibility of inhibiting SSc progression using the anti-OSM monoclonal antibody GSK2330811. The results showed that GSK2330811 treatment did not demonstrate significant mechanistic effects on inflammation or fibrosis, and there were no meaningful differences between GSK2330811 and placebo for any clinical efficacy endpoints. Furthermore, adverse events related to decreases in hemoglobin and platelet count were observed in the 300 mg dose group.
Article
Rheumatology
Paola Cipriani, Piero Ruscitti, Ilenia Di Cola, Marta Vomero, Franca Abbruzzese, Elena Di Nino, Rebecca Ross, Francesco Del Galdo, Roberto Giacomelli
Summary: CD248 has anti-angiogenic effects in vitro by reducing tube formation and inducing apoptosis in endothelial cells. Increased expression of CD248 in SSc may contribute to the observed microvascular rarefaction at the tissue level. Our results suggest a pathogenic role for CD248-MMNR-2 in SSc.
Review
Rheumatology
Sergio A. Jimenez, Sonsoles Piera-Velazquez
Summary: SSc is a systemic autoimmune disease characterized by progressive fibrosis that affects the skin and internal organs, leading to severe disability and high mortality. Recent research suggests that the extension of fibrosis may be mediated by exosome microvesicles released from SSc-affected cells.
Article
Multidisciplinary Sciences
Sonsoles Piera-Velazquez, Simon T. Dillon, Xuesong Gu, Towia A. Libermann, Sergio A. Jimenez
Summary: The analysis of serum exosomes using aptamer proteomics can help identify differentially expressed proteins between patients with Raynaud's Phenomenon at high risk of evolving into Systemic Sclerosis (SSc) and those with Primary Raynaud's Phenomenon. Some of these proteins are involved in relevant biological pathways related to SSc pathogenesis, including inflammatory responses, immune cell activation, and vascular abnormalities.
Editorial Material
Rheumatology
Silvia Laura Bosello, Edward M. Vital, Francesco Del Galdo
Article
Dermatology
Anto J. U. K. John, Francesco Del Galdo, Rodney Gush, Peter R. R. Worsley
Summary: This study aimed to evaluate non-invasive tools for assessing the mechanical and functional properties of skin in different body regions. Significant differences in these properties were observed between skin sites. The results suggest that these parameters can be reliably measured and used to assess and monitor changes in the skin during health and disease.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Review
Rheumatology
Enrico De Lorenzis, Christopher William Wasson, Francesco Del Galdo
Summary: The alveolar epithelial-to-mesenchymal transition is a process that involves the conversion of differentiated epithelial cells into mesenchymal-like cells through functional and morphological changes. This transition can indirectly contribute to lung fibrosis by stimulating surrounding cells, as well as directly increasing pulmonary fibroblasts and extracellular matrix deposition. Directly demonstrating this transition in scleroderma-related interstitial lung disease is challenging due to technical limitations and limited availability of lung tissue samples. However, pre-clinical and clinical evidence suggests that epithelial-to-mesenchymal transition may play a role in the development and progression of lung fibrosis in this disease.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Article
Rheumatology
Raluca B. Dumitru, Lesley-Anne Bissell, Bara Erhayiem, Graham Fent, Ananth Kidambi, Giuseppina Abignano, John P. Greenwood, John Biglands, Francesco Del Galdo, Sven Plein, Maya H. Buch
Summary: This study aimed to investigate the progression of subclinical systemic sclerosis (SSc) primary heart involvement over time. The results showed that a small number of patients had an increase or new findings of cardiac abnormalities, but most of the abnormalities remained stable during follow-up.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Rheumatology
Christopher P. Denton, Enrico De Lorenzis, Elen Roblin, Nina Goldman, Begonya Alcacer-Pitarch, Emma Blamont, Maya Buch, Maresa Carulli, Caroline Cotton, Francesco del Galdo, Emma Derrett-Smith, Karen Douglas, Sue Farrington, Kim Fligelstone, Luke Gompels, Bridget Griffiths, Ariane Herrick, Michael Hughes, Clare Pain, Georgina Pantano, John Pauling, Athiveeraramapandian Prabu, Nuala O'Donoghue, Elisabetta Renzoni, Jeremy Royle, Muditha Samaranayaka, Julia Spierings, Aoife Tynan, Louise Warburton, Voon Ong
Summary: This guideline provides practical roadmap for the management of SSc, covering general approaches to management as well as treatment of specific complications.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2022)
Review
Rheumatology
Alain Lescoat, Susan L. Murphy, David Roofeh, John D. Pauling, Michael Hughes, Robert Sandler, Francois Zimmermann, Rachel Wessel, Whitney Townsend, Lorinda Chung, Christopher P. Denton, Peter A. Merkel, Virginia Steen, Yannick Allanore, Francesco Del Galdo, Dominique Godard, David Cella, Sue Farrington, Maya H. Buch, Dinesh Khanna
Summary: Systemic sclerosis presents with a diverse range of clinical manifestations and is classified into limited and diffuse cutaneous subgroups. While diffuse cutaneous systemic sclerosis has been the focus of clinical trials, limited cutaneous systemic sclerosis also has significant morbidity and impact on quality of life. The lack of interventional studies for limited cutaneous systemic sclerosis is partly due to a lack of outcome measures, but a proposed composite index specifically for this subgroup could improve clinical trial representation and response to outcomes.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2021)
