Review
Rheumatology
Nanette L. A. Vincken, Deepak M. W. Balak, Andre C. Knulst, Paco M. J. Welsing, Jacob M. van Laar
Summary: While systemic glucocorticoids (SGC) are traditionally discouraged in the treatment of psoriatic arthritis (PsA) and psoriasis, they are frequently prescribed for these patients. However, studies show that the occurrence of psoriatic flares appears to be low upon SGC exposure. In patients with a clear indication for SGC, consideration should be given to the low risk of skin flaring, while also weighing the risks of short- and long-term SGC-related side effects.
Article
Rheumatology
Karoline Baquet-Walscheid, Kai Rothaus, Martina Niewerth, Jens Klotsche, Kirsten Minden, Arnd Heiligenhaus
Summary: Data on uveitis in juvenile psoriatic arthritis (JPsA) are scarce. Patients with JPsA-associated uveitis (JPsA-U) have similar characteristics to uveitis patients in other categories of juvenile idiopathic arthritis (JIA). Children with early-onset JPsA are at a higher risk for ocular involvement.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Fan Yang, Chaofan Lu, Huilan Liu, Lei Dou, Yanhong Wang, Hongbin Li, Xinwang Duan, Lijun Wu, Yongfu Wang, Xiuying Zhang, Jian Xu, Jinmei Su, Dong Xu, Jiuliang Zhao, Qingjun Wu, Mengtao Li, Xiaomei Leng, Xiaofeng Zeng
Summary: Enthesitis is common in Chinese patients with PsA, and it is important to evaluate both peripheral and axial sites. Compared with other cohorts, Chinese patients with enthesitis tend to be younger, have a lower body mass index, a higher rate of positive HLA-B27, more frequent dactylitis, and a higher proportion of csDMARDs use.
CHINESE MEDICAL JOURNAL
(2023)
Article
Rheumatology
Colleen K. Correll, Scott Stryker, David Collier, Thomas A. Phillips, Anne C. Dennos, Stephen J. Balevic, Timothy Beukelman, CARRA Registry Investigators
Summary: This study used data from the CARRA Registry to evaluate the safety and effectiveness of etanercept in treating JPsA. The results showed that etanercept was safe and effective, with only a small number of patients experiencing adverse events.
Review
Immunology
Eric Toussirot, Irene Gallais-Serezal, Francois Aubin
Summary: Psoriasis and psoriatic arthritis are immune-mediated diseases that affect the skin, joints or both. They involve complex pathophysiological mechanisms and increased inflammation. These conditions are also associated with a higher risk of cardiometabolic diseases, which are linked to systemic inflammation and can impact disease severity and treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Review
Immunology
Theo Wirth, Nathalie Balandraud, Laurent Boyer, Pierre Lafforgue, Thao Pham
Summary: PsA diagnosis and treatment is often delayed, resulting in joint damage and disability. Research has identified potential biomarkers to improve PsA diagnosis and prognosis, but further studies are needed to evaluate their performance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Alexis Ogdie, Mei Liu, Meghan Glynn, Kelechi Emeanuru, Leslie R. Harrold, Sven Richter, Benoit Guerette, Philip J. Mease
Summary: The study found that apremilast monotherapy is an effective option for patients with oligoarticular PsA. Apremilast initiators experienced greater disease activity improvements at follow-up compared to MTX initiators.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Immunology
Orsolya Tuende Kovacs, Eszter Toth, Oliver Ozohanics, Eszter Soltesz-Katona, Nikolett Marton, Edit Iren Buzas, Laszlo Hunyady, Laszlo Drahos, Gabor Turu, Gyorgy Nagy
Summary: This study investigated the proteomic changes during osteoclast differentiation in healthy donors, RA, and PsA. The results showed increased expression of proteins involved in metabolic activity, secretory function, and cell polarity during differentiation, while immune signaling pathways were downregulated. The expression differences between healthy donors and RA/PsA patients were most noticeable after the final steps of differentiation. The study provides important insights into the pathophysiology of RA and PsA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hannah A. Blair
Summary: Secukinumab is an effective treatment for PsA across all key domains, with low rates of adverse effects and sustained long-term efficacy. It is a useful alternative to TNFi and other bDMARDs for adult patients with active PsA.
Review
Biochemistry & Molecular Biology
Irmina Olejniczak-Staruch, Magdalena Ciazynska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Achilleas Floudas, Conor M. Smith, Orla Tynan, Nuno Neto, Vinod Krishna, Sarah M. Wade, Megan Hanlon, Clare Cunningham, Viviana Marzaioli, Mary Canavan, Jean M. Fletcher, Ronan H. Mullan, Suzanne Cole, Ling-Yang Hao, Michael G. Monaghan, Sunil Nagpal, Douglas J. Veale, Ursula Fearon
Summary: This study provides a global transcriptomic analysis of the synovial joints in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), revealing the immune-stromal cell interactions in synovial inflammation. The findings highlight the differential transcription profiles and interactions between cell subsets in RA and PsA, suggesting potential targets for targeted therapeutic intervention in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Michele Maria Luchetti Gentiloni, Valentino Paci, Ilaria Cimaroli, Alice Agostinelli, Melania Giannoni, Anna Campanati, Federico Diotallevi, Marina Carotti, Francesco Sessa, Raffaella Sordillo, Cristina Macchini, Federico Fiorini, Leonardo Massaccesi, Monia Ciferri, Marco Gigli, Valentina Marconi, Lucia Perini, Andrea Marani, Andrea Giovagnoni, Gabriele Polonara, Anna Maria Offidani, Devis Benfaremo, Fabian Proft, Denis Poddubnyy, Gianluca Moroncini
Summary: A dermatology-based screening strategy proved to be valuable in detecting and characterizing patients with axial PsA in a cohort of psoriasis patients. It also helped identify a substantial number of undiagnosed peripheral PsA patients.
Review
Cell Biology
Lin-Kun Bai, Ya-Zhen Su, Zong-Di Ning, Cheng-Qiang Zhang, Li-Yun Zhang, Gai-Lian Zhang
Summary: This article reviews the preparation, characteristics and research progress of different animal models for Psoriatic Arthritis (PsA). The experimental animals used to study PsA are mainly rodents, including mice and rats. The retrieved animal models were classified into spontaneous or genetic mutation, transgenic and induced animal models based on the different methods of preparing the models. These PsA animal models involve multiple pathogenesis, and have advantages and disadvantages in terms of lesion appearance, success rate in molding, and reproducibility.
INFLAMMATION RESEARCH
(2023)
Article
Rheumatology
Cecilie Henkel, Unnur Styrkarsdottir, Gudmar Thorleifsson, Lilja Stefansdottir, Gyda Bjornsdottir, Karina Banasik, Soren Brunak, Christian Erikstrup, Khoa Manh Dinh, Thomas Folkmann Hansen, Kaspar Rene Nielsen, Mie Topholm Bruun, Joseph Dowsett, Thorsten Brodersen, Dbds Genomic Consortium, Thorgeir E. Thorgeirsson, Kirill Gromov, Mikael Ploug Boesen, Henrik Ullum, Sisse Rye Ostrowski, Ole Birger Pedersen, Kari Stefansson, Anders Troelsen
Summary: This study aimed to investigate the differences in genetic associations between knee and hip osteoarthritis based on joint replacement status. The results showed that genetic correlations varied between patients with knee and hip osteoarthritis, and joint replacement status influenced the genetic associations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Genetics & Heredity
Jonas Ghouse, Vinicius Tragante, Gustav Ahlberg, Soren A. Rand, Jakob B. B. Jespersen, Eva Birgitte Leinoe, Christoffer Rasmus Vissing, Linea Trudso, Ingileif Jonsdottir, Karina Banasik, Soren Brunak, Sisse R. R. Ostrowski, Ole B. B. Pedersen, Erik Sorensen, Christian Erikstrup, Mie Topholm Bruun, Kaspar Rene Nielsen, Lars Kober, Alex H. H. Christensen, Kasper Iversen, David Jones, Kirk U. U. Knowlton, Lincoln Nadauld, Gisli H. H. Halldorsson, Egil Ferkingstad, Isleifur Olafsson, Solveig Gretarsdottir, Pall T. T. Onundarson, Patrick Sulem, Unnur Thorsteinsdottir, Gudmundur Thorgeirsson, Daniel F. F. Gudbjartsson, Kari Stefansson, Hilma Holm, Morten Salling Olesen, Henning Bundgaard
Summary: This study conducts a genome-wide association analysis of venous thromboembolism (VTE) using a large cohort of cases and controls. They identify 93 risk loci, with 62 loci being newly discovered. The study also demonstrates the effectiveness of a VTE polygenic risk score in identifying individuals at high or low risk for VTE. Additionally, they investigate the shared clinical risk factors between venous and arterial thrombosis.
Article
Hematology
Thorsten Brodersen, Klaus Rostgaard, Cathrine Juel Lau, Knud Juel, Christian Erikstrup, Kasper Rene Nielsen, Sisse Rye Ostrowski, Kjell Titlestad, Susanne G. Saekmose, Ole B. Pedersen, Henrik Hjalgrim
Summary: This study found that blood donors were more likely to participate in health surveys, indicating the presence of the healthy donor effect. Furthermore, blood donation was associated with better self-reported health and healthier lifestyles.
Article
Clinical Neurology
Anja Sofie Petersen, Mads Barloese, Nunu Lund, Adam Friis Pedersen, Marie-Louise Kulas Soborg, Mona Ameri Chalmer, Ida Callesen, Bendik Slagsvold Winsvold, John-Anker Zwart, Sisse Rye DBDS Genomic Consortium, Sisse Rye Ostrowski, Ole Birger Pedersen, Finn Sellebjerg, Helle Bach Sondergaard, Malene Bredahl Hansen, Rigmor Hojland Jensen, Thomas Folkmann Hansen
Summary: This study investigated the association between polygenetic risk, functional variants of CYP3A4, and treatment response in cluster headache patients. The results showed that the response to oxygen, triptans, and verapamil was associated with the chronicity of cluster headache, but not with a high genetic risk. The response to verapamil was also not influenced by functional variants of CYP3A4. Furthermore, no support was found for the genetic variants previously reported to be associated with treatment response. Overall, this study suggests that the clinically relevant variation in treatment response in cluster headache is not influenced by genetic factors.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Josefine U. Melchiorsen, Kimmie Sorensen, Jette Bork-Jensen, Husun S. Kizilkaya, Laerke S. Gasbjerg, Alexander S. Hauser, Jorgen Rungby, Henrik T. Sorensen, Allan Vaag, Jens S. Nielsen, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Anette P. Gjesing, Jens J. Holst, Torben Hansen, Mette M. Rosenkilde, Niels Grarup
Summary: This study identified 36 GLP1R variants in Danish individuals, of which 10 showed a loss of GLP-1-induced signaling. However, no association was found between these variants and type 2 diabetes, although carriers exhibited slightly higher fasting plasma glucose levels. Additionally, the analysis of UK Biobank participants did not reveal substantial associations between GLP1R variants and cardiometabolic phenotypes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Yun Huang, Sara E. Stinson, Helene Baek Juel, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Trine Nielsen, Niels Grarup, Oluf Pedersen, Michael Christiansen, Elizaveta Chabanova, Henrik S. Thomsen, Aleksander Krag, Stefan Stender, Jens-Christian Holm, Torben Hansen
Summary: This study investigated the effects of eight previously reported genome-wide significant steatogenic variants on liver and cardiometabolic traits in children and adolescents. The results showed that these variants were associated with higher liver fat and distinct patterns of plasma lipids. The genetic risk score (GRS) based on these variants was also associated with higher prevalence of hepatic steatosis and had potential clinical utility for risk stratification.
LIVER INTERNATIONAL
(2023)
Correction
Biotechnology & Applied Microbiology
Rosa Lundbye Allesoe, Agnete Troen Lundgaard, Ricardo Hernandez Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Cristina Leal Rodriguez, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan B. Hong, Petra Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe T. Muilwijk, Marieke M. Blom, Leen 't Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstrale, Mark Walker, Ian N. Forgie, Giuseppe Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil W. Dermitzakis, Paul M. Franks, Jochen Schwenk, Jerzy I. Adamski, Mark McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Soren Brunak
NATURE BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Lea A. N. Christoffersen, Dorte Helenius, Michael Schwinn, Christian Erikstrup, Henrik Hjalgrim, Janna Nissen, Karina Banasik, Kaspar Nielsen, Kathrine A. Kaspersen, Khoa M. Dinh, Mie T. Bruun, Sisse R. Ostrowski, Susanne Saekmose, Thomas F. Hansen, Thomas Werge, Maria Didriksen, Ole Birger Pedersen
Summary: This cross-sectional cohort study examined the level of loneliness during the COVID-19 pandemic in Denmark and identified associated behavioral patterns and demographic factors. The findings showed an increase in experienced loneliness during the pandemic, particularly affecting individuals with low well-being, women, and younger individuals.
Article
Microbiology
Yong Fan, Rene Klinkby Stoving, Samar Berreira Ibraim, Tuulia Hyotylainen, Florence Thirion, Tulika Arora, Liwei Lyu, Evelina Stankevic, Tue Haldor Hansen, Pierre Dechelotte, Tim Sinioja, Oddny Ragnarsdottir, Nicolas Pons, Nathalie Galleron, Benoit Quinquis, Florence Levenez, Hugo Roume, Gwen Falony, Sara Vieira-Silva, Jeroen Raes, Loa Clausen, Gry Kjaersdam Telleus, Fredrik Backhed, Matej Oresic, S. Dusko Ehrlich, Oluf Pedersen
Summary: This study investigated the role of gut microbiota in the pathogenesis of anorexia nervosa (AN) by analyzing metagenomics and metabolomics data from AN patients and healthy females. The results showed that AN patients exhibited alterations in gut microbiota composition and function, as well as increased levels of metabolites associated with reduced food intake. Microbiota transplantation experiments further confirmed the contribution of gut microbiota to AN behavior.
NATURE MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nanna Lond Skov Frisk, Anja Elaine Sorensen, Ole Birger Vesterager Pedersen, Louise Torp Dalgaard
Summary: In this study, a systematic review and meta-analysis were conducted to evaluate the global research potential of different circulating miRNAs as an early diagnostic biomarker for ovarian cancer (OC). The primary search resulted in 1887 articles, and 44 relevant studies were identified. Nine miRNAs were found to be dysregulated in OC patients compared to controls, with miR-21, -125, -141, -145, -205, -328, -200a, -200b, and -200c being upregulated. Future studies of circulating miRNAs in relation to OC should consider factors such as sample size, consensus guidelines, and coverage of previously reported miRNAs.
Article
Medicine, General & Internal
Hannes Helgason, Thjodbjorg Eiriksdottir, Magnus O. Ulfarsson, Abhishek Choudhary, Sigrun H. Lund, Erna V. Ivarsdottir, Grimur Hjorleifsson Eldjarn, Gudmundur Einarsson, Egil Ferkingstad, Kristjan H. S. Moore, Narimon Honarpour, Thomas Liu, Huei Wang, Thomas Hucko, Marc S. Sabatine, David A. Morrow, Robert P. Giugliano, Sisse Rye Ostrowski, Ole Birger Pedersen, Henning Bundgaard, Christian Erikstrup, David O. Arnar, Gudmundur Thorgeirsson, Gisli Masson, Olafur Th. Magnusson, Jona Saemundsdottir, Solveig Gretarsdottir, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Anna Helgadottir, Patrick Sulem, Unnur Thorsteinsdottir, Hilma Holm, Daniel Gudbjartsson, Kari Stefansson
Summary: This study aimed to develop protein risk scores for ASCVD risk prediction and compare them with clinical risk factors and polygenic risk scores. The results showed that the protein risk scores were significantly associated with ASCVD events and provided a modest improvement when added to the clinical risk factor model.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Urology & Nephrology
Nessn Azawi, Karina Sif Sondergaard Mosholt, Nathalie Demuth Fryd, Lars Lund, Juan Ignacio Brignone, Nanna Hvid, Helle Wulf-Johansson, Ole Birger Vesterager Pedersen, Susanne Gjorup Saekmose, Saeed Dabestani
Summary: In this study, we investigated the prognostic accuracy of preoperative plasma suPAR in patients with localized ccRCC. The results showed that elevated suPAR levels (≥6 ng/mL) were associated with a higher risk of disease recurrence and lower overall survival. suPAR could be a promising surveillance tool for monitoring ccRCC patients and detecting future recurrences.
Correction
Cardiac & Cardiovascular Systems
Hildur M. Aegisdottir, Rosa B. Thorolfsdottir, Gardar Sveinbjornsson, Olafur A. Stefansson, Bjarni Gunnarsson, Vinicius Tragante, Gudmar Thorleifsson, Lilja Stefansdottir, Thorgeir E. Thorgeirsson, Egil Ferkingstad, Patrick Sulem, Gudmundur Norddahl, Gudrun Rutsdottir, Karina Banasik, Alex Hoerby Christensen, Ole Birger Pedersen, Christina Mikkelsen, Soren Brunak, Mie Topholm Bruun, Christian Erikstrup, Rikke Louise Jacobsen, Kaspar Rene Nielsen, Erik Sorensen, Michael L. Frigge, Kristjan E. Hjorleifsson, Erna Ivarsdottir, Anna Helgadottir, Solveig Gretarsdottir, Valgerdur Steinthorsdottir, Asmundur Oddsson, Hannes P. Eggertsson, Gisli H. Halldorsson, David A. Jones, Jeffrey L. Anderson, Kirk U. Knowlton, Lincoln D. Nadauld, DBDS Genomic Consortium, Magnus Haraldsson, Gudmundur Thorgeirsson, Henning Bundgaard, David O. Arnar, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Sisse R. Ostrowski, Hilma Holm, Kari Stefansson
EUROPEAN HEART JOURNAL
(2023)
Article
Dermatology
Pernille Lindso Andersen, Bente Villumsen, Ditte Marie Lindhardt Saunte, Kristoffer Solvsten Burgdorf, Maria Didriksen, Sisse Rye Ostrowski, Lise Wegner Thorner, Christian Erikstrup, Khoa Manh Dinh, Kaspar Rene Nielsen, Thorsten Brodersen, Mie Topholm Bruun, Karina Banasik, Thomas Folkmann Hansen, Ole Birger Pedersen, Gregor Borut Jemec
Summary: This study explores the possible association between HS and ADHD, and finds a positive correlation between ADHD and HS. This result has significant implications for the research on psychiatric comorbidity of HS.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Pernille Lindso Andersen, Gregor Borut Ernst Jemec, Christian Erikstrup, Maria Didriksen, Khoa Manh Dinh, Susan Mikkelsen, Mie Topholm Bruun, Henrik Hjalgrim, Thomas Folkmann Hansen, Susanne Gjorup Saekmose, Sisse Rye Ostrowski, Ole Birger Pedersen, Ditte Marie Saunte
Summary: This study found two protective HLA alleles, DQB1*06:04 and DRB1*13:02, that can reduce the risk of onychomycosis.
SKIN APPENDAGE DISORDERS
(2023)
