Article
Health Care Sciences & Services
Marion Magnol, Berard Eleonore, Rempenault Claire, Benjamin Castagne, Marine Pugibet, Cedric Lukas, Anne Tournadre, Pascale Vergne-Salle, Thomas Barnetche, Marie-Elise Truchetet, Adeline Ruyssen-Witrand
Summary: This study investigated the use of eHealth tools by patients with rheumatoid arthritis in France. It found that a small number of patients used eHealth for disease management, indicating potential for improvement. Factors such as membership in a patient association, use of biologic disease-modifying antirheumatic drugs, and comorbidities were associated with eHealth use for rheumatoid arthritis.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Dimitra Karapetsa, Arianna Consensi, Giulia Castagnoli, Morena Petrini, Matteo Tonelli, Stefano Gennai, Laura Bazzichi, Filippo Graziani
Summary: The study found a high prevalence and severity of periodontitis among Italian patients with rheumatoid arthritis. Patients with both periodontitis and rheumatoid arthritis were more likely to have moderate to severe RA.
Article
Medicine, General & Internal
Gerhard Schmalz, Markus Bartl, Jan Schmickler, Susann Patschan, Daniel Patschan, Dirk Ziebolz
Summary: This cross-sectional study aimed to investigate the potential associations between periodontal inflamed surface area (PISA) and tooth loss with disease-related parameters in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients. The study found that tooth loss is associated with disease activity, especially in RA individuals, while no associations were found between PISA and disease-related parameters in both groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Bethany McDowell, Calum Marr, Clive Holmes, Christopher J. Edwards, Christopher Cardwell, Michelle McHenry, Gary Meenagh, Bernadette McGuinness
Summary: This study found that cognitive impairment is common in older adults with rheumatoid arthritis, and is associated with higher disease activity. The importance lies in emphasizing the control of inflammation to slow down cognitive decline.
Article
Urology & Nephrology
Jiandong Zhou, Weijie Yuan, Yunshan Guo, Yongfang Wang, Yuyang Dai, Ying Shen, Xuan Liu
Summary: The study investigated the relationship between asprosin and metabolic syndrome in hemodialysis patients. Higher levels of asprosin were associated with an increased risk of metabolic syndrome. Fasting serum asprosin could be an independent risk factor for metabolic syndrome in these patients.
Article
Nutrition & Dietetics
Krzysztof Grzechnik, Bozena Targonska-Stepniak
Summary: This study found that the presence of metabolic syndrome (MetS) was associated with higher disease activity in patients with rheumatoid arthritis (RA). There were also correlations between metabolic parameters and indices of RA activity.
Article
Orthopedics
Chonachan Petcharat, Varalak Srinonprasert, Praveena Chiowchanwisawakit
Summary: This study investigated the prevalence of and factors associated with MetS in patients with PsA and AS, finding a significantly higher prevalence of MetS in PsA compared to AS. Structural spine changes were associated with MetS in PsA patients, while age over 40 and BMI over 23 were associated with MetS in AS patients.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Nutrition & Dietetics
Laura Cano-Garcia, Sara Manrique-Arija, Carmen Dominguez-Quesada, Juan Crisostomo Vacas-Perez, Pedro J. J. Armenteros-Ortiz, Desire Ruiz-Vilchez, Jose Maria Martin-Martin, Rocio Redondo-Rodriguez, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Natalia Mena-Vazquez, Antonio Fernandez-Nebro
Summary: The study aimed to describe the prevalence of sarcopenia in rheumatoid arthritis (RA) patients aged =65 years and identify the associated risk factors. The results showed that patients with RA had lower muscle mass and higher adiposity, especially in the central area. Male patients, those with longer disease duration, and poor nutritional status were more likely to develop sarcopenia.
Article
Nutrition & Dietetics
Laura Cano-Garcia, Rocio Redondo-Rodriguez, Sara Manrique-Arija, Carmen Dominguez-Quesada, Juan Crisostomo Vacas, Pedro Armenteros-Ortiz, Desiree Ruiz-Vilchez, Jose Maria Martin-Martin, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Natalia Mena-Vazquez, Antonio Fernandez-Nebro
Summary: This study aims to investigate the frequency and risk factors of malnutrition in older patients with rheumatoid arthritis (RA). The findings show that approximately one-third of older RA patients have impaired nutritional status, which is associated with factors such as age, inflammatory disease activity, and quality of life. The MNA and GNRI are valuable tools for assessing the nutritional status of patients with RA.
Article
Medicine, General & Internal
Francesco Salvatore Iaquinta, Daniele Mauro, Ilenia Pantano, Saverio Naty, Daniela Iacono, Emanuela Gaggiano, Luca Riccio, Francesco Ciccia, Rosa Daniela Grembiale, Rocco Spagnuolo
Summary: Patients with chronic Inflammatory Arthritis (IA), such as Rheumatoid Arthritis (RA) and Spondyloarthritis (SpA), experience higher psychosocial and gastrointestinal impairment. This study aimed to assess these symptoms in an IA population and identify potential associations. The findings suggest the need for a holistic approach to address reported symptoms and improve the overall quality of life in rheumatologic patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andres Reinoso-Cobo, Pekka Anttila, Ana Belen Ortega-Avila, Pablo Cervera-Garvi, Eva Lopezosa-Reca, Ana Marchena-Rodriguez, Laura Ramos-Petersen, Gabriel Gijon-Nogueron
Summary: This study evaluated the types and incidences of foot deformities in patients with RA, finding that pronated foot type was most common but some patients had supinated foot type. Disease progression led to increased severity of foot deformities, such as Hallux Valgus or MTP joints deformity.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mai Hussein, Youssef M. K. Farag, Stephen Sonis
Summary: This study aimed to investigate the association between periodontitis, tooth loss, and rheumatoid arthritis (RA) using a large national dataset. The results showed that RA was associated with a higher likelihood of having non-functional dentition, but there was no association with periodontitis after adjusting for confounding factors.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Rheumatology
Anton Jonatan Landgren, Mats Dehlin, Lennart Jacobsson, Ulrika Bergsten, Eva Klingberg
Summary: The study aimed to compare traditional cardiovascular risk factors among patients with different rheumatic diseases, and found that hypertension was the most common comorbidity, with patients with gout having the highest prevalence of traditional CVRFs. Significant differences in occurrence of CVRFs by sex were also observed among patients with PsA, RA and AS.
Article
Medicine, Research & Experimental
Davide Pietropaoli, Serena Altamura, Eleonora Ortu, Luca Guerrini, Theresa T. Pizarro, Claudio Ferri, Rita Del Pinto
Summary: This study used data from the third National Health and Nutrition Examination Survey (NHANES III) to analyze the relationship between multiple metabolic syndrome (MetS) components and periodontal diseases. The results showed that MetS components were associated with gingival bleeding but not with periodontitis. This association was observed only in women and not in men.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Dorien M. C. F. Sluijsmans, Daphne C. Rohrich, Calin D. Popa, Bart J. F. van den Bemt
Summary: This study investigated the impact of ACEi and ARBs on disease activity in rheumatoid arthritis patients, showing no association between the use of these medications and DAS28-CRP scores. However, ARBs users tended to use lower dosages of bDMARDs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Rheumatology
Ronald F. van Vollenhoven, Sander W. Tas, Michael T. Nurmohamed
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
J. Koers, N. I. L. Derksen, W. J. J. Falkenburg, P. Ooijevaar-de Heer, M. T. Nurmohamed, G. J. Wolbink, T. Rispens
Summary: This study found that anti-hinge antibodies (AHAs) and elevated levels of Fab glycosylation are present not only in patients with rheumatoid arthritis (RA), but also in healthy controls (HCs). These results suggest that extensive Fab glycosylation may develop in response to an inflammatory proteolytic microenvironment, but is not restricted to RA.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
T. Rusman, M. A. C. van der Weijden, M. T. Nurmohamed, C. J. van Denderen, R. B. M. Landewe, P. M. Bet, C. M. A. van der Bijl, C. J. Van der Laken, I. E. van der Horst-Bruinsma
Summary: The study found that 16 weeks of etanercept treatment did not have an impact on disease activity, the chance of biological treatment, or radiographic progression in patients with suspected non-radiographic axial spondyloarthritis.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
J. Ruwaard, M. J. L' Ami, E. L. Kneepkens, C. L. M. Krieckaert, M. T. Nurmohamed, F. Hooijberg, A. W. R. van Kuijk, J. C. van Denderen, L. Burgemeister, T. Rispens, M. Boers, G. J. Wolbink
Summary: In this study, we compared the effects of extending the dosing interval and continuing with the standard dose of etanercept in patients with rheumatic diseases. The results showed that etanercept tapering did not reduce its efficacy and a significant proportion of patients were able to successfully discontinue the medication for at least 6 months.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Henrike J. Westerink, Leanne J. Kosse, Naomi T. Jessurun, Astrid Tubergen, Harald E. Vonkeman, Mike T. Nurmohamed, Bart J. F. van den Bemt, Marieke de Vries
Summary: This study explored the perceptions of inflammatory rheumatic disease patients and healthcare professionals on the burden of adverse drug reactions (ADRs). The findings revealed that both patients and healthcare professionals consider ADRs to have both physical and psychological impacts, with healthcare professionals placing more emphasis on the psychological consequences.
EXPERT OPINION ON DRUG SAFETY
(2023)
Article
Rheumatology
Maria Konsta, Michael T. Nurmohamed, Alexios Iliopoulos, Petros P. Sfikakis, J. Christiaan van Denderen, Ingrid Visman, Grigorios T. Sakelariou, Irene E. van der Horst-Bruinsma
Summary: The study aims to examine the prevalence of hip involvement in patients with ankylosing spondylitis (AS) treated with tumor necrosis factor inhibitors (TNFi) and estimate the effect of TNFi on radiographic progression of hip involvement compared to the spine. The results showed that approximately one-third of AS patients had hip involvement, which seemed to stabilize with TNFi treatment. There were no sex differences in the prevalence or progression of this manifestation.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Laure Gossec, Stefan Siebert, Paul Bergmans, Kurt de Vlam, Elisa Gremese, Beatriz Joven-Ibanez, Tatiana Korotaeva, Frederic Lavie, Wim Noel, Michael T. Nurmohamed, Petros P. Sfikakis, Mohamed Sharaf, Elke Theander, Josef S. Smolen
Summary: This study evaluated the real-world persistence and effectiveness of the IL-12/23 inhibitor ustekinumab or a tumour necrosis factor inhibitor (TNFi) for psoriatic arthritis over 3 years. The results showed that the proportion of patients still on their initial treatments after 3 years was similar with ustekinumab and TNFi, but ustekinumab had a lower rate of adverse events.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Renske C. F. Hebing, Imke H. Bartelink, Helen R. Gosselt, Sandra G. Heil, Mauritis C. F. J. de Rotte, Pascal H. P. de Jong, Mike T. Nurmohamed, Robert de Jonge, Ron A. A. Mathot
Summary: This study investigated the association between red blood cell methotrexate polyglutamates (MTX-PG) concentrations and response in rheumatoid arthritis patients starting methotrexate (MTX) therapy. The results showed that there was an association between RBC-MTX-PG concentrations and Disease Activity Score in 28 joints (DAS28). Based on the findings, it is suggested to increase the dose if MTX-PG concentration is below 9.15 nmol/L at month 1, continue with the same dose if the concentration is above 47 nmol/L, and consider other treatment options if the concentration is above 78 nmol/L from 3 months onwards.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Helen R. R. Gosselt, Jette A. A. van Lint, Leanne J. J. Kosse, Phyllis I. I. Spuls, Harald E. E. Vonkeman, Sander W. W. Tas, Frank Hoentjen, Michael T. T. Nurmohamed, Bart J. F. van den Bemt, Martijn B. A. van Doorn, Naomi T. T. Jessurun
Summary: Sex differences exist in the frequency and nature of ADRs in patients with inflammatory rheumatic diseases, but not in ADR burden.
EXPERT OPINION ON DRUG SAFETY
(2023)
Article
Rheumatology
A. B. Blanken, M. Korteweg, L. van Boheemen, R. F. van Vollenhoven, M. T. Nurmohamed, C. J. van der Laken
Summary: The study aimed to investigate the performance and factors of influence of optical spectral transmission (OST) imaging as a new technique for measuring joint inflammation in rheumatoid arthritis (RA). The results showed significant differences in OST scores between RA patients and the control group, and moderate correlations between OST scores and ultrasound and clinical disease activity.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
M. Sobejana, M. van der Esch, J. van den Hoek, G. Kitas, M. van der Leeden, M. T. Nurmohamed, G. S. Metsios
Summary: In addition to DMARD treatment, exercise is increasingly promoted in patients with RA, but few studies have investigated the combined effects of these interventions on disease activity. This scoping review summarized the evidence on whether a combined effect can be detected in studies where exercise intervention was performed in addition to DMARD treatment. Eleven studies were included, and although some showed significant reductions in disease activity outcomes for the exercise + medication group compared with the medication-only group, most studies had weak methodological quality.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Article
Rheumatology
Mikkel Ostergaard, Ronald F. van Vollenhoven, Anna Rudin, Merete Lund Hetland, Marte Schrumpf Heiberg, Dan C. Nordstrom, Michael T. Nurmohamed, Bjorn Gudbjornsson, Lykke Midtboll Ornbjerg, Pernille Boyesen, Kristina Lend, Kim Horslev-Petersen, Till Uhlig, Tuulikki Sokka, Gerdur Grondal, Simon Krabbe, Joakim Lindqvist, Inger Gjertsson, Daniel Glinatsi, Meliha Crnkic Kapetanovic, Anna-Birgitte Aga, Francesca Faustini, Pinja Parmanne, Tove Lorenzen, Cagnotto Giovanni, Johan Back, Oliver Hendricks, Daisy Vedder, Tuomas Rannio, Emma Grenholm, Maud Kristine Ljosa, Eli Brodin, Hanne Lindegaard, Annika Soderbergh, Milad Rizk, Alf Kastbom, Per Larsson, Line Uhrenholt, Soren Andreas Just, David J. Stevens, Trine Bay Laurbjerg, Gunnstein Bakland, Inge Christoffer Olsen, Espen A. Haavardsholm, Jon Lampa, NORD-STAR Study Grp
Summary: This study compared the clinical and radiographic outcomes of different biological treatments with active conventional therapy in patients with early rheumatoid arthritis (RA). The results showed that abatacept and certolizumab pegol had higher clinical remission rates compared to active conventional therapy, while tocilizumab did not show significant differences. Radiographic progression was low and similar across treatments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
J. van den Hoek, M. Sobejana, F. van Nes, G. Metsios, G. Kitas, M. van der Leeden, M. T. Nurmohamed, M. van der Esch
Summary: The objective of this study was to gain insight into the perceptions and experiences of patients with rheumatoid arthritis and a high cardiovascular disease risk (CVD-RA) undergoing an exercise intervention. The study analyzed data from six patients through face-to-face interviews and identified seven themes related to perceptions and experiences. The findings highlighted the importance of being viewed as a person and feeling safe.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Bart F. F. Seppen, Jimmy Wiegel, Michael T. T. Nurmohamed, Wouter H. H. Bos, Marieke M. M. ter Wee
Summary: Telemonitoring disease activity with ePROs can reduce rheumatic care workload by cutting down on outpatient clinic visits, but low adherence to reporting ePROs is common. This study aimed to identify facilitators and barriers to weekly monitoring of disease activity. Focus group discussions were held with patients who had recently participated in telemonitoring studies using a smartphone app for ePRO completion. Thematic analysis revealed five themes related to adherence: questionnaire frequency, discussing results, physical consultations, patient insight, and user experience. Both barriers and facilitators were found within these themes. The results suggest that maximizing the perceived benefits of completing ePROs and tailoring their frequency based on patients' disease activity or preference, along with training clinicians to discuss the completed ePROs, may improve adherence.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Reinder Raadsen, Romy Hansildaar, Lianne C. Pouw, Femke Hooijberg, Laura Boekel, Gerrit Jan Wolbink, Arno W. R. van Kuijk, Michael T. Nurmohamed
Summary: This study evaluates the cardiovascular disease risk and prevalence of risk factors in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (SpA). The results show that the traditional cardiovascular risk factors are significantly elevated in these patients compared to healthy controls. However, after adjusting for traditional risk factors, the cardiovascular risk was not increased in these patients.